| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| O Sader-Mazbar, Y Loboda, M J Rabey, J P M Finber. Increased L-DOPA-derived dopamine following selective MAO-A or -B inhibition in rat striatum depleted of dopaminergic and serotonergic innervation. British journal of pharmacology. vol 170. issue 5. 2014-08-08. PMID:23992249. |
increased l-dopa-derived dopamine following selective mao-a or -b inhibition in rat striatum depleted of dopaminergic and serotonergic innervation. |
2014-08-08 |
2023-08-12 |
rat |
| Simon Glerup, Ditte Olsen, Christian B Vaegter, Camilla Gustafsen, Susanne S Sjoegaard, Guido Hermey, Mads Kjolby, Simon Molgaard, Maj Ulrichsen, Simon Boggild, Sune Skeldal, Anja N Fjorback, Jens R Nyengaard, Jan Jacobsen, Dirk Bender, Carsten R Bjarkam, Esben S Sørensen, Ernst-Martin Füchtbauer, Gregor Eichele, Peder Madsen, Thomas E Willnow, Claus M Petersen, Anders Nykjae. SorCS2 regulates dopaminergic wiring and is processed into an apoptotic two-chain receptor in peripheral glia. Neuron. vol 82. issue 5. 2014-08-08. PMID:24908487. |
sorcs2- or p75(ntr)-deficient in mice caused reduced dopamine levels and metabolism and dopaminergic hyperinnervation of the frontal cortex. |
2014-08-08 |
2023-08-13 |
mouse |
| Theresa A Zesiewicz, Pablo Martinez-Marti. Effects of rotigotine transdermal system on non-motor symptoms in Parkinson's disease: an overview. Expert review of neurotherapeutics. vol 13. issue 12. 2014-08-06. PMID:24236902. |
there is evidence that dopaminergic therapy, including dopamine agonists, may alleviate some nms, such as anxiety and depression. |
2014-08-06 |
2023-08-12 |
Not clear |
| Shuxian Hu, Wen S Sheng, R Bryan Roc. CB2 receptor agonists protect human dopaminergic neurons against damage from HIV-1 gp120. PloS one. vol 8. issue 10. 2014-08-05. PMID:24147028. |
recent work suggests that the nigrostriatal dopaminergic area is a critical brain region for the neuronal dysfunction and death seen in hand and that human dopaminergic neurons have a particular sensitivity to gp120-induced damage, manifested as reduced function (decreased dopamine uptake), morphological changes, and reduced viability. |
2014-08-05 |
2023-08-12 |
human |
| Shuxian Hu, Wen S Sheng, R Bryan Roc. CB2 receptor agonists protect human dopaminergic neurons against damage from HIV-1 gp120. PloS one. vol 8. issue 10. 2014-08-05. PMID:24147028. |
using a human mesencephalic neuronal/glial culture model, which contains dopaminergic neurons, microglia, and astrocytes, we were able to show that the cb1/cb2 agonist win55,212-2 blunts gp120-induced neuronal damage as measured by dopamine transporter function, apoptosis and lipid peroxidation; these actions were mediated principally by the cb2 receptor. |
2014-08-05 |
2023-08-12 |
human |
| H F Clarke, R N Cardinal, R Rygula, Y T Hong, T D Fryer, S J Sawiak, V Ferrari, G Cockcroft, F I Aigbirhio, T W Robbins, A C Robert. Orbitofrontal dopamine depletion upregulates caudate dopamine and alters behavior via changes in reinforcement sensitivity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 22. 2014-08-05. PMID:24872570. |
to test the hypothesis that ofc dopaminergic dysfunction disrupts caudate dopamine function, we selectively depleted dopamine from the ofc of marmoset monkeys and measured striatal extracellular dopamine levels (using microdialysis) and dopamine d2/d3 receptor binding (using positron emission tomography), while modeling reinforcement-related behavior in a discrimination learning paradigm. |
2014-08-05 |
2023-08-13 |
monkey |
| Annalisa Fico, Antoine de Chevigny, Christophe Melon, Manon Bohic, Lydia Kerkerian-Le Goff, Flavio Maina, Rosanna Dono, Harold Creme. Reducing glypican-4 in ES cells improves recovery in a rat model of Parkinson's disease by increasing the production of dopaminergic neurons and decreasing teratoma formation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 24. 2014-08-04. PMID:24920634. |
in contrast to wild-type cells, these differentiating gpc4-mutant cells expressed high levels of dopa decarboxylase and the dopamine transporter, two markers expressed by fully mature dopaminergic neurons. |
2014-08-04 |
2023-08-13 |
mouse |
| Takayuki Watanabe, Hisayo Sadamoto, Hitoshi Aonum. Molecular basis of the dopaminergic system in the cricket Gryllus bimaculatus. Invertebrate neuroscience : IN. vol 13. issue 2. 2014-08-01. PMID:23539475. |
to elucidate the molecular basis of the dopaminergic system in the field cricket gryllus bimaculatus degeer, we identified genes involved in dopamine biosynthesis, signal transduction, and dopamine re-uptake in the cricket. |
2014-08-01 |
2023-08-12 |
cricket |
| George F Koob, Cara L Buck, Ami Cohen, Scott Edwards, Paula E Park, Joel E Schlosburg, Brooke Schmeichel, Leandro F Vendruscolo, Carrie L Wade, Timothy W Whitfield, Olivier Georg. Addiction as a stress surfeit disorder. Neuropharmacology. vol 76 Pt B. 2014-07-29. PMID:23747571. |
excessive activation of the nucleus accumbens via the release of mesocorticolimbic dopamine or activation of opioid receptors has long been hypothesized to subsequently activate the dynorphin-κ opioid system, which in turn can decrease dopaminergic activity in the mesocorticolimbic dopamine system. |
2014-07-29 |
2023-08-12 |
Not clear |
| Mickael Decressac, Nikolaos Volakakis, Anders Björklund, Thomas Perlman. NURR1 in Parkinson disease--from pathogenesis to therapeutic potential. Nature reviews. Neurology. vol 9. issue 11. 2014-07-28. PMID:24126627. |
in parkinson disease (pd), affected midbrain dopamine (da) neurons lose specific dopaminergic properties before the neurons die. |
2014-07-28 |
2023-08-12 |
Not clear |
| Gabrielle D Briggs, Gyorgy M Nagy, Phillip W Dickso. Mechanism of action of salsolinol on tyrosine hydroxylase. Neurochemistry international. vol 63. issue 8. 2014-07-22. PMID:24083987. |
here, we have investigated th inhibition by a dopamine metabolite found in dopaminergic brain regions, salsolinol (sal). |
2014-07-22 |
2023-08-12 |
rat |
| S K Sudakov, V G Bashkatov. Effect of peripheral D₂ dopamine receptor antagonist domperidone on metabolism, feeding behavior, and locomotor activity of rats. Bulletin of experimental biology and medicine. vol 155. issue 6. 2014-07-22. PMID:24288745. |
we studied the possibility of activation of the central dopaminergic system compartment by modulating activity of d2 dopamine receptors in the gastrointestinal tract with domperidone, an antagonist not crossing the blood-brain barrier. |
2014-07-22 |
2023-08-12 |
rat |
| S K Sudakov, V G Bashkatov. Effect of peripheral D₂ dopamine receptor antagonist domperidone on metabolism, feeding behavior, and locomotor activity of rats. Bulletin of experimental biology and medicine. vol 155. issue 6. 2014-07-22. PMID:24288745. |
our results indicate that physiological functions associated with activity of the central dopaminergic system can be modulated through peripheral dopamine receptors. |
2014-07-22 |
2023-08-12 |
rat |
| Yue-Hua Wang, Hai-Tao Yu, Xiao-Ping Pu, Guan-Hua D. Baicalein prevents 6-hydroxydopamine-induced mitochondrial dysfunction in SH-SY5Y cells via inhibition of mitochondrial oxidation and up-regulation of DJ-1 protein expression. Molecules (Basel, Switzerland). vol 18. issue 12. 2014-07-18. PMID:24288000. |
6-hydroxydopamine (6-ohda) is a dopamine analog which specifically damages dopaminergic neurons. |
2014-07-18 |
2023-08-12 |
rat |
| William Galbavy, Elham Safaie, Mario J Rebecchi, Michelino Puopol. Inhibition of tetrodotoxin-resistant sodium current in dorsal root ganglia neurons mediated by D1/D5 dopamine receptors. Molecular pain. vol 9. 2014-07-17. PMID:24283218. |
dopaminergic fibers originating from area a11 of the hypothalamus project to different levels of the spinal cord and represent the major source of dopamine. |
2014-07-17 |
2023-08-12 |
Not clear |
| Baris Bingol, Joy S Tea, Lilian Phu, Mike Reichelt, Corey E Bakalarski, Qinghua Song, Oded Foreman, Donald S Kirkpatrick, Morgan Shen. The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy. Nature. vol 510. issue 7505. 2014-07-17. PMID:24896179. |
knockdown of usp30 in dopaminergic neurons protects flies against paraquat toxicity in vivo, ameliorating defects in dopamine levels, motor function and organismal survival. |
2014-07-17 |
2023-08-13 |
Not clear |
| María García-Amado, Lucía Prens. Distribution of dopamine transporter immunoreactive fibers in the human amygdaloid complex. The European journal of neuroscience. vol 38. issue 11. 2014-07-16. PMID:24102648. |
to determine the specific distribution of the dopaminergic input through the different nuclei and nuclear subdivisions of this structure we used stereological tools to quantify the fibers containing the dopamine transporter (used to signal the dopaminergic phenotype) in post-mortem samples from control individuals. |
2014-07-16 |
2023-08-12 |
human |
| María García-Amado, Lucía Prens. Distribution of dopamine transporter immunoreactive fibers in the human amygdaloid complex. The European journal of neuroscience. vol 38. issue 11. 2014-07-16. PMID:24102648. |
dopaminergic axons targeted every nucleus of the amygdaloid complex, and the density of dopamine transporter-containing axons varied considerably among its nuclear groups. |
2014-07-16 |
2023-08-12 |
human |
| Henrik H Hansen, Majbrit M Jensen, Agnete Overgaard, Pia Weikop, Jens D Mikkelse. Tesofensine induces appetite suppression and weight loss with reversal of low forebrain dopamine levels in the diet-induced obese rat. Pharmacology, biochemistry, and behavior. vol 110. 2014-07-15. PMID:23932919. |
in conclusion, tesofensine produces weight loss together with reversal of lowered forebrain dopamine levels in dio rats, suggesting that tesofensine's anti-obesity effects, at least in part, are associated with positive modulation of central dopaminergic activity. |
2014-07-15 |
2023-08-12 |
rat |
| Ji Seon Kim, Jong Min Kim, Yu Kyeong Kim, Sang Eun Kim, Ji Young Yun, Beom S Jeo. Striatal dopaminergic functioning in patients with sporadic and hereditary spastic paraplegias with parkinsonism. Journal of Korean medical science. vol 28. issue 11. 2014-07-14. PMID:24265532. |
in the present study, the clinical features of patients with ssp/hsp were investigated, and nigrostriatal dopaminergic binding potential was assessed using dopamine transporter (dat) single-photon emission computer tomography (spect). |
2014-07-14 |
2023-08-12 |
human |