| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhi Dong Zhou, Fathima Shaffra Refai, Shao Ping Xie, Shin Hui Ng, Christine Hui Shan Chan, Patrick Ghim Hoe Ho, Xiao Dong Zhang, Tit Meng Lim, Eng King Ta. Mutant PINK1 upregulates tyrosine hydroxylase and dopamine levels, leading to vulnerability of dopaminergic neurons. Free radical biology & medicine. vol 68. 2014-10-21. PMID:24374372. |
in this study we demonstrate that the extramitochondrial pink1 can regulate tyrosine hydroxylase (th) expression and dopamine (da) content in dopaminergic neurons in a pink1 kinase activity-dependent manner. |
2014-10-21 |
2023-08-12 |
Not clear |
| Hiroshige Fujishir. Effects of gabapentin enacarbil on restless legs syndrome and leg pain in dementia with Lewy bodies. Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society. vol 14. issue 2. 2014-10-20. PMID:24528871. |
both rls and dlb can be effectively treated by dopaminergic medications, suggesting the role of dopamine dysfunction in the pathogenesis of both diseases. |
2014-10-20 |
2023-08-12 |
Not clear |
| Alan D Pickering, Francesca Pesol. Modeling dopaminergic and other processes involved in learning from reward prediction error: contributions from an individual differences perspective. Frontiers in human neuroscience. vol 8. 2014-10-17. PMID:25324752. |
in particular, variations in the strength of connections carrying excitatory reward drive inputs to midbrain dopaminergic cells were considered plausible candidates, along with variations in a parameter which scales the effects of dopamine cell firing bursts on synaptic modification in ventral striatum. |
2014-10-17 |
2023-08-13 |
Not clear |
| Hiroshi Kawaguchi, Takayuki Obata, Harumasa Takano, Tsuyoshi Nogami, Tetsuya Suhara, Hiroshi It. Relation between dopamine synthesis capacity and cell-level structure in human striatum: a multi-modal study with positron emission tomography and diffusion tensor imaging. PloS one. vol 9. issue 1. 2014-10-15. PMID:24498218. |
assuming that mean diffusivity reflects the density of wide-spreading axonal terminals in the striatum, the result suggests that dopamine synthesis may be related to the density of dopaminergic neuronal fibers. |
2014-10-15 |
2023-08-12 |
human |
| Omar Ouachikh, Wisam Dieb, Franck Durif, Aziz Hafid. Anterior ventral tegmental area dopaminergic neurons are not involved in the motivational effects of bromocriptine, pramipexole and cocaine in drug-free rats. Behavioural brain research. vol 262. 2014-10-14. PMID:24361908. |
dopamine dysregulation syndrome in parkinson's disease has been attributed to dopamine replacement therapies and/or a lesion of the dopaminergic system. |
2014-10-14 |
2023-08-12 |
rat |
| Sandra Oster, Khaled Radad, Dieter Scheller, Marlen Hesse, Wladimir Balanzew, Heinz Reichmann, Gabriele Gill. Rotigotine protects against glutamate toxicity in primary dopaminergic cell culture. European journal of pharmacology. vol 724. 2014-10-14. PMID:24365490. |
in the present study we investigated mechanisms of glutamate toxicity and the neuroprotective potential of the dopamine agonist rotigotine towards dopaminergic neurones in mouse mesencephalic primary culture. |
2014-10-14 |
2023-08-12 |
mouse |
| Marco Bisaglia, Roberta Filograna, Mariano Beltramini, Luigi Bubacc. Are dopamine derivatives implicated in the pathogenesis of Parkinson's disease? Ageing research reviews. vol 13. 2014-10-14. PMID:24389159. |
one of the main pathological hallmarks of pd is the preferential degeneration of dopaminergic neurons, which supports a direct role of dopamine itself in promoting the disorder. |
2014-10-14 |
2023-08-12 |
Not clear |
| Na Ni, Yaohua Hu, Huixia Ren, Chuanming Luo, Peng Li, Jian-Bo Wan, Huanxing S. Self-assembling peptide nanofiber scaffolds enhance dopaminergic differentiation of mouse pluripotent stem cells in 3-dimensional culture. PloS one. vol 8. issue 12. 2014-10-13. PMID:24376815. |
consistent with the increase in the number of dopaminergic neurons differentiated from r1 or ttf-1 in the self-assembling peptide nanofiber scaffold (sapns), both the expression levels of genes that involve in dopaminergic differentiation and maturation and the dopamine release in sapns culture were significantly elevated. |
2014-10-13 |
2023-08-12 |
mouse |
| Pierpaolo Alongi, Leonardo Iaccarino, Daniela Peran. PET Neuroimaging: Insights on Dystonia and Tourette Syndrome and Potential Applications. Frontiers in neurology. vol 5. 2014-10-08. PMID:25295029. |
for example, presynaptic and post-synaptic dopaminergic studies with pet have shown alterations compatible with dysfunction or loss of d2-receptors bearing neurons, increased synaptic dopamine levels, or both. |
2014-10-08 |
2023-08-13 |
Not clear |
| Insop Shim, Thomas R Stratford, David Wirtshafte. Dopamine is differentially involved in the locomotor hyperactivity produced by manipulations of opioid, GABA and glutamate receptors in the median raphe nucleus. Behavioural brain research. vol 261. 2014-10-06. PMID:24333380. |
other studies have indicated that the mr exerts an inhibitory influence on ascending dopamine systems, suggesting that mr induced alterations in activity may be mediated through changes in dopaminergic transmission. |
2014-10-06 |
2023-08-12 |
Not clear |
| Christopher Snyder, Kirk Mantion. The effects of morphine on Parkinson's-related genes PINK1 and PARK2. Medical science monitor basic research. vol 20. 2014-10-06. PMID:24800761. |
dopamine, the neurotransmitter produced from dopaminergic neurons, is a major precursor of endogenous morphine. |
2014-10-06 |
2023-08-13 |
Not clear |
| Freja H Hansen, Tina Skjørringe, Saiqa Yasmeen, Natascha V Arends, Michelle A Sahai, Kevin Erreger, Thorvald F Andreassen, Marion Holy, Peter J Hamilton, Viruna Neergheen, Merete Karlsborg, Amy H Newman, Simon Pope, Simon J R Heales, Lars Friberg, Ian Law, Lars H Pinborg, Harald H Sitte, Claus Loland, Lei Shi, Harel Weinstein, Aurelio Galli, Lena E Hjermind, Lisbeth B Møller, Ulrik Gethe. Missense dopamine transporter mutations associate with adult parkinsonism and ADHD. The Journal of clinical investigation. vol 124. issue 7. 2014-10-06. PMID:24911152. |
for dat-asp421asn, substrate efflux experiments revealed a constitutive, anomalous efflux of dopamine, and electrophysiological analyses identified a large cation leak that might further perturb dopaminergic neurotransmission. |
2014-10-06 |
2023-08-13 |
Not clear |
| Nian Yang, Kai-Yuan Zhang, Fu-Fan Wang, Zhi-An Hu, Jun Zhan. Dopamine inhibits neurons from the rat dorsal subcoeruleus nucleus through the activation of α2-adrenergic receptors. Neuroscience letters. vol 559. 2014-09-28. PMID:24304869. |
these results suggest that the central dopaminergic system may play a role in the regulation of rem sleep through the effect of dopamine on subcd neurons. |
2014-09-28 |
2023-08-12 |
rat |
| Takafumi Hasegaw. Tyrosinase-expressing neuronal cell line as in vitro model of Parkinson's disease. International journal of molecular sciences. vol 11. issue 3. 2014-09-25. PMID:20480001. |
oxidized metabolites of dopamine known as dopamine quinone derivatives are thought to play a pivotal role in the degeneration of nigrostriatal dopaminergic neurons in parkinson's disease. |
2014-09-25 |
2023-08-12 |
human |
| P O Fernagut, W G Meissner, M Biran, M Fantin, F Bassil, J M Franconi, F Tiso. Age-related motor dysfunction and neuropathology in a transgenic mouse model of multiple system atrophy. Synapse (New York, N.Y.). vol 68. issue 3. 2014-09-23. PMID:24243499. |
to assess if oligodendroglial expression of human wild-type alpha-synuclein in mice (proteolipid promoter, plp-syn) could be associated with age-related deficits, plp-syn and wild-type mice were assessed for motor function, brain morphometry, striatal levels of dopamine and metabolites, dopaminergic loss, and distribution of gcis. |
2014-09-23 |
2023-08-12 |
mouse |
| P O Fernagut, W G Meissner, M Biran, M Fantin, F Bassil, J M Franconi, F Tiso. Age-related motor dysfunction and neuropathology in a transgenic mouse model of multiple system atrophy. Synapse (New York, N.Y.). vol 68. issue 3. 2014-09-23. PMID:24243499. |
mild dopaminergic cell loss was associated with decreased dopamine turnover at 18 months. |
2014-09-23 |
2023-08-12 |
mouse |
| Henry Lin, Leonard H Epstei. Living in the moment: effects of time perspective and emotional valence of episodic thinking on delay discounting. Behavioral neuroscience. vol 128. issue 1. 2014-09-22. PMID:24512061. |
working memory capacity, inhibitory control, the genotypes of 3 functional dopaminergic polymorphisms (drd1 rs686, drd2 rs1800497, and comt rs4680), as well as an additive dopamine genetic risk score were assessed as potential moderators. |
2014-09-22 |
2023-08-12 |
human |
| Hannah Fuhrer, Andreas Kupsch, Thomas D Hälbig, Ute A Kopp, Peter Scherer, Doreen Grube. Levodopa inhibits habit-learning in Parkinson’s disease. Journal of neural transmission (Vienna, Austria : 1996). vol 121. issue 2. 2014-09-19. PMID:23959161. |
mixed dopaminergic medication, comprising dopamine agonists and levodopa, may affect habit-learning in patients with parkinson’s disease (pd). |
2014-09-19 |
2023-08-12 |
Not clear |
| Patricia J Allen, Andrew Feigi. Gene-based therapies in Parkinson's disease. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. vol 11. issue 1. 2014-09-19. PMID:24129887. |
parkinson's disease (pd) is a progressive neurological disorder characterized primarily by the degeneration of nigrostriatal dopaminergic neurons and diminution of the neurotransmitter dopamine. |
2014-09-19 |
2023-08-12 |
human |
| Patricia J Allen, Andrew Feigi. Gene-based therapies in Parkinson's disease. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. vol 11. issue 1. 2014-09-19. PMID:24129887. |
though dopamine replacement therapies such as levodopa can improve the symptoms of pd, the benefits may be overshadowed by side effects and the onset of symptoms not responsive to dopaminergic treatments (e.g., autonomic symptoms, gait and balance problems, and cognitive impairment). |
2014-09-19 |
2023-08-12 |
human |