| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lihui Si, Tianmin Xu, Fengzhang Wang, Qun Liu, Manhua Cu. X-box-binding protein 1-modified neural stem cells for treatment of Parkinson's disease. Neural regeneration research. vol 7. issue 10. 2015-03-04. PMID:25737695. |
these results indicate that transplantation of x-box-binding protein 1-transfected neural stem cells can promote stem cell survival and differentiation into dopaminergic neurons, increase dopamine and 3,4-dihydroxyphenylacetic acid levels, reduce α-synuclein aggregation in the substantia nigra, and improve the symptoms of parkinson's disease in rats. |
2015-03-04 |
2023-08-13 |
rat |
| M L Firsov, L A Astakhov. [Role of dopamine as a regulator of vertebrate photoreceptors]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova. vol 100. issue 7. 2015-03-03. PMID:25669103. |
dopamine is cyclically synthesized by special populations of dopaminergic amacrine cells in the retina and its content increases during the day and decreases at night. |
2015-03-03 |
2023-08-13 |
Not clear |
| Morvarid Karimi, Joel S Perlmutte. The role of dopamine and dopaminergic pathways in dystonia: insights from neuroimaging. Tremor and other hyperkinetic movements (New York, N.Y.). vol 5. 2015-02-25. PMID:25713747. |
the role of dopamine and dopaminergic pathways in dystonia: insights from neuroimaging. |
2015-02-25 |
2023-08-13 |
Not clear |
| Meghan R Hennis, Katherine W Seamans, Marian A Marvin, Bradford H Casey, Matthew S Goldber. Behavioral and neurotransmitter abnormalities in mice deficient for Parkin, DJ-1 and superoxide dismutase. PloS one. vol 8. issue 12. 2015-02-23. PMID:24386432. |
surprisingly, mice bearing similar loss-of-function mutations in parkin and dj-1 do not show age-dependent loss of nigral dopaminergic neurons or depletion of dopamine in the striatum. |
2015-02-23 |
2023-08-12 |
mouse |
| Meghan R Hennis, Katherine W Seamans, Marian A Marvin, Bradford H Casey, Matthew S Goldber. Behavioral and neurotransmitter abnormalities in mice deficient for Parkin, DJ-1 and superoxide dismutase. PloS one. vol 8. issue 12. 2015-02-23. PMID:24386432. |
our studies demonstrate that on a parkin/dj-1 null background, mice that are also deficient for major antioxidant proteins do not have progressive loss of dopaminergic neurons but have behavioral and striatal dopamine abnormalities. |
2015-02-23 |
2023-08-12 |
mouse |
| Erik Svensson, Alex Proekt, Jian Jing, Klaudiusz R Weis. PKC-mediated GABAergic enhancement of dopaminergic responses: implication for short-term potentiation at a dual-transmitter synapse. Journal of neurophysiology. vol 112. issue 1. 2015-02-23. PMID:24717352. |
although only dopamine acts as the fast excitatory transmitter at the b20-to-b8 synapse, gaba increases the size of these dopaminergic epsps. |
2015-02-23 |
2023-08-13 |
aplysia |
| Yan Dong, Gang Ning, Andrew G Ewing, Michael L Heie. Pituitary adenylate cyclase activating polypeptide modulates catecholamine storage and exocytosis in PC12 cells. PloS one. vol 9. issue 3. 2015-02-21. PMID:24603879. |
compared to l-dopa, pacap may produce multiple favorable effects on dopaminergic neurons, including protecting dopaminergic neurons against neurodegeneration and potentially regulating dopamine storage and release, making it a promising therapeutic agent for the treatment of pd. |
2015-02-21 |
2023-08-12 |
Not clear |
| I Bonoldi, O D Howe. Presynaptic dopaminergic function: implications for understanding treatment response in psychosis. CNS drugs. vol 28. issue 7. 2015-02-21. PMID:24919790. |
the lack of normalization of the abnormal presynaptic function could explain why discontinuation is likely to lead to relapse, because the major dopaminergic function persists, meaning that once treatment stops there is nothing to oppose the dysregulated dopamine function reinstating symptoms. |
2015-02-21 |
2023-08-13 |
Not clear |
| Adriana Galvan, Annaelle Devergnas, Thomas Wichman. Alterations in neuronal activity in basal ganglia-thalamocortical circuits in the parkinsonian state. Frontiers in neuroanatomy. vol 9. 2015-02-20. PMID:25698937. |
most of the mentioned electrophysiologic changes are probably related to the degeneration of diencephalic dopaminergic neurons, leading to dopamine loss in the striatum and other basal ganglia nuclei, although degeneration of non-dopaminergic cell groups may also have a role. |
2015-02-20 |
2023-08-13 |
Not clear |
| Kaustuv Saha, Danielle Sambo, Ben D Richardson, Landon M Lin, Brittany Butler, Laura Villarroel, Habibeh Khoshboue. Intracellular methamphetamine prevents the dopamine-induced enhancement of neuronal firing. The Journal of biological chemistry. vol 289. issue 32. 2015-02-19. PMID:24962577. |
we further examined the unique mechanisms by which amphetamine and methamphetamine regulate dat function and dopamine neurotransmission; in the present study we examined the impact of extracellular and intracellular amphetamine and methamphetamine on the spontaneous firing of cultured midbrain dopaminergic neurons and isolated dat-mediated current. |
2015-02-19 |
2023-08-13 |
Not clear |
| Kaustuv Saha, Danielle Sambo, Ben D Richardson, Landon M Lin, Brittany Butler, Laura Villarroel, Habibeh Khoshboue. Intracellular methamphetamine prevents the dopamine-induced enhancement of neuronal firing. The Journal of biological chemistry. vol 289. issue 32. 2015-02-19. PMID:24962577. |
in dopaminergic neurons the spontaneous firing rate was enhanced by extracellular application of amphetamine > dopamine > methamphetamine and was dat-dependent. |
2015-02-19 |
2023-08-13 |
Not clear |
| Erin S Calipari, Haiguo Sun, Khalil Eldeeb, Deborah J Luessen, Xin Feng, Allyn C Howlett, Sara R Jones, Rong Che. Amphetamine self-administration attenuates dopamine D2 autoreceptor function. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 39. issue 8. 2015-02-12. PMID:24513972. |
dopamine d2 autoreceptors located on the midbrain dopaminergic neurons modulate dopamine (da) neuron firing, da release, and da synthesis through a negative-feedback mechanism. |
2015-02-12 |
2023-08-12 |
Not clear |
| Rejwi Acharya Dahal, Akula Bala Pramod, Babita Sharma, Danielle Krout, James D Foster, Joo Hwan Cha, Jianjing Cao, Amy Hauck Newman, John R Lever, Roxanne A Vaughan, L Keith Henr. Computational and biochemical docking of the irreversible cocaine analog RTI 82 directly demonstrates ligand positioning in the dopamine transporter central substrate-binding site. The Journal of biological chemistry. vol 289. issue 43. 2015-02-12. PMID:25179220. |
the dopamine transporter (dat) functions as a key regulator of dopaminergic neurotransmission via re-uptake of synaptic dopamine (da). |
2015-02-12 |
2023-08-13 |
rat |
| Mélanie Bourque, Marc Morissette, Thérèse Di Paol. Raloxifene activates G protein-coupled estrogen receptor 1/Akt signaling to protect dopamine neurons in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mice. Neurobiology of aging. vol 35. issue 10. 2015-02-09. PMID:24726471. |
striatal concentrations of dopamine, 3,4-dihydroxyphenylacetic acid, homovanillic acid to dopamine ratio as well as dopamine transporter and vesicular monoamine transporter 2 showed that raloxifene neuroprotection of dopaminergic neurons was blocked by g15. |
2015-02-09 |
2023-08-13 |
mouse |
| Arvind K Shukla, Prakash Pragya, Hitesh S Chaouhan, D K Patel, M Z Abdin, Debapratim Kar Chowdhur. Mutation in Drosophila methuselah resists paraquat induced Parkinson-like phenotypes. Neurobiology of aging. vol 35. issue 10. 2015-02-09. PMID:24819147. |
exposed mth(1) flies exhibit significant resistance against pq-induced parkinson's phenotypes and behavior in terms of oxidative stress, dopaminergic neuronal degeneration, locomotor performance, dopamine content, phosphorylated jnk, pfoxo, hid, and cleaved caspase-3 levels. |
2015-02-09 |
2023-08-13 |
drosophila_melanogaster |
| Ming-Kai Pan, Chun-Hwei Tai, Wen-Chuan Liu, Ju-Chun Pei, Wen-Sung Lai, Chung-Chin Ku. Deranged NMDAergic cortico-subthalamic transmission underlies parkinsonian motor deficits. The Journal of clinical investigation. vol 124. issue 10. 2015-02-09. PMID:25202982. |
moreover, application of a dopaminergic agent via a microinfusion cannula localized the therapeutic effect to the stn, without correcting striatal dopamine deficiency. |
2015-02-09 |
2023-08-13 |
mouse |
| Tanuja Bordia, Matthew McGregor, Roger L Papke, Michael W Decker, J Michael McIntosh, Maryka Qui. The α7 nicotinic receptor agonist ABT-107 protects against nigrostriatal damage in rats with unilateral 6-hydroxydopamine lesions. Experimental neurology. vol 263. 2015-02-09. PMID:25261754. |
the striatal dopamine transporter (dat), a marker of dopaminergic integrity, was reduced ~70% with lesioning. |
2015-02-09 |
2023-08-13 |
rat |
| Ching-Chi Chiu, Tu-Hsueh Yeh, Szu-Chia Lai, Yah-Huei Wu-Chou, Che-Hong Chen, Daria Mochly-Rosen, Yin-Cheng Huang, Yu-Jie Chen, Chao-Lang Chen, Ya-Ming Chang, Hung-Li Wang, Chin-Song L. Neuroprotective effects of aldehyde dehydrogenase 2 activation in rotenone-induced cellular and animal models of parkinsonism. Experimental neurology. vol 263. 2015-02-09. PMID:25263579. |
within dopaminergic neurons, dopamine is metabolized by monoamine oxidase to yield 3,4-dihydroxyphenylacetaldehyde (dopal) then converts to a less toxic acid product by aldh. |
2015-02-09 |
2023-08-13 |
Not clear |
| Yi-Hsien Tsou, Ching-Ting Shih, Cheng-Hsin Ching, Jui-Yen Huang, Chauying J Jen, Lung Yu, Yu-Min Kuo, Fong-Sen Wu, Jih-Ing Chuan. Treadmill exercise activates Nrf2 antioxidant system to protect the nigrostriatal dopaminergic neurons from MPP+ toxicity. Experimental neurology. vol 263. 2015-02-09. PMID:25286336. |
we found that mpp(+) induced early decreases in total glutathione level and nrf2/γgclc (catalytic subunit of γgcl) expression, but late upregulation of ho-1 expression in association with loss of nigral dopaminergic neurons and downregulation of tyrosine hydroxylase and dopamine transporter expression in the striatum. |
2015-02-09 |
2023-08-13 |
rat |
| Murad Hossain, Rochelle N Wickramasekara, Lucia Carvell. β-Phenylethylamine requires the dopamine transporter to increase extracellular dopamine in Caenorhabditis elegans dopaminergic neurons. Neurochemistry international. vol 73. 2015-02-02. PMID:24161617. |
β-phenylethylamine requires the dopamine transporter to increase extracellular dopamine in caenorhabditis elegans dopaminergic neurons. |
2015-02-02 |
2023-08-12 |
caenorhabditis_elegans |