| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jian Huang, Zhaomin Zhong, Mingyong Wang, Xifeng Chen, Yicheng Tan, Shuqing Zhang, Wei He, Xiong He, Guodong Huang, Haiping Lu, Ping Wu, Yi Che, Yi-Lin Yan, John H Postlethwait, Wenbiao Chen, Han Wan. Circadian modulation of dopamine levels and dopaminergic neuron development contributes to attention deficiency and hyperactive behavior. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 6. 2015-04-13. PMID:25673850. |
we found that the circadian clock directly regulates dopamine-related genes monoamine oxidase and dopamine β hydroxylase, and acts via genes important for the development or maintenance of dopaminergic neurons to regulate their number and organization in the ventral diencephalic posterior tuberculum. |
2015-04-13 |
2023-08-13 |
mouse |
| Jaclyn Nicole Le Grand, Laura Gonzalez-Cano, Maria Angeliki Pavlou, Jens C Schwambor. Neural stem cells in Parkinson's disease: a role for neurogenesis defects in onset and progression. Cellular and molecular life sciences : CMLS. vol 72. issue 4. 2015-04-10. PMID:25403878. |
moreover, adult neurogenesis is affected in both pd patients and pd animal models and is regulated by dopamine and dopaminergic (da) receptors, by chronic neuroinflammation, such as that observed in pd, and by differential expression of wild-type or mutant forms of pd-related genes. |
2015-04-10 |
2023-08-13 |
Not clear |
| Milky Kohno, Dara G Ghahremani, Angelica M Morales, Chelsea L Robertson, Kenji Ishibashi, Andrew T Morgan, Mark A Mandelkern, Edythe D Londo. Risk-taking behavior: dopamine D2/D3 receptors, feedback, and frontolimbic activity. Cerebral cortex (New York, N.Y. : 1991). vol 25. issue 1. 2015-04-06. PMID:23966584. |
decision-making involves frontolimbic and dopaminergic brain regions, but how prior choice outcomes, dopamine neurotransmission, and frontostriatal activity are integrated to affect choices is unclear. |
2015-04-06 |
2023-08-12 |
human |
| Guoshuai Feng, Zhijian Zhang, Qingqing Bao, Zaijun Zhang, Libing Zhou, Jie Jiang, Sha L. Protective effect of chinonin in MPTP-induced C57BL/6 mouse model of Parkinson's disease. Biological & pharmaceutical bulletin. vol 37. issue 8. 2015-04-06. PMID:24871044. |
consistently, chinonin reduced loss of dopaminergic neurons in the substantia nigra and prevented depletion of dopamine and its metabolites 3-methoxy-4-hydroxy-phenylacetic acid and homovanillic acid in the striatum of mice. |
2015-04-06 |
2023-08-13 |
mouse |
| Soyeon Kim, Mohamed Al-Haj, Samantha Chen, Stuart Fuller, Umesh Jain, Marisa Carrasco, Rosemary Tannoc. Colour vision in ADHD: part 1--testing the retinal dopaminergic hypothesis. Behavioral and brain functions : BBF. vol 10. 2015-04-06. PMID:25344625. |
to test the retinal dopaminergic hypothesis, which posits deficient blue color perception in adhd, resulting from hypofunctioning cns and retinal dopamine, to which blue cones are exquisitely sensitive. |
2015-04-06 |
2023-08-13 |
Not clear |
| Xianmin Zeng, Larry A Coutur. Pluripotent stem cells for Parkinson's disease: progress and challenges. Stem cell research & therapy. vol 4. issue 2. 2015-03-30. PMID:23672848. |
the motor symptoms of pd are caused mainly by a progressive loss of dopaminergic neurons from the substania nigra, resulting in a loss of dopamine production. |
2015-03-30 |
2023-08-12 |
human |
| Qing He, Wenbo Yu, Jianjun Wu, Chan Chen, Zhiyin Lou, Qiong Zhang, Jian Zhao, Jian Wang, Baoguo Xia. Intranasal LPS-mediated Parkinson's model challenges the pathogenesis of nasal cavity and environmental toxins. PloS one. vol 8. issue 11. 2015-03-30. PMID:24250796. |
these mice display a progressive hypokinesia, selective loss of dopaminergic neurons, and reduction in striatal dopamine (da) content, as well as α-synuclein aggregation in the sn, without systemic inflammatory and immune responses. |
2015-03-30 |
2023-08-12 |
mouse |
| Daniel Rial, Fabrício A Pamplona, Eduardo L G Moreira, Karin M Moreira, Débora Hipolide, Diana I Rodrigues, Patrícia A Dombrowski, Claudio Da Cunha, Paula Agostinho, Reinaldo N Takahashi, Roger Walz, Rodrigo A Cunha, Rui D Predige. Cellular prion protein is present in dopaminergic neurons and modulates the dopaminergic system. The European journal of neuroscience. vol 40. issue 3. 2015-03-30. PMID:24766164. |
this indicates that prp(c) affects the homeostasis of the dopaminergic system by interfering differently in different brain areas with dopamine synthesis, content, receptor density and signaling pathways. |
2015-03-30 |
2023-08-13 |
mouse |
| Chelsea A Vadnie, David J Hinton, Sun Choi, YuBin Choi, Christina L Ruby, Alfredo Oliveros, Miguel L Prieto, Jun Hyun Park, Doo-Sup Cho. Activation of neurotensin receptor type 1 attenuates locomotor activity. Neuropharmacology. vol 85. 2015-03-30. PMID:24929110. |
since nts1 is known to modulate dopaminergic signaling, we examined whether pd149163 blocks dopamine receptor-mediated hyperactivity. |
2015-03-30 |
2023-08-13 |
mouse |
| Beth Lute, William Jou, Dalya M Lateef, Margalit Goldgof, Cuiying Xiao, Ramón A Piñol, Alexxai V Kravitz, Nicole R Miller, Yuning George Huang, Clemence Girardet, Andrew A Butler, Oksana Gavrilova, Marc L Reitma. Biphasic effect of melanocortin agonists on metabolic rate and body temperature. Cell metabolism. vol 20. issue 2. 2015-03-30. PMID:24981835. |
the hypometabolism/hypothermia was prevented by dopamine antagonists, and mtii selectively activated arcuate nucleus dopaminergic neurons, suggesting that these neurons may contribute to the hypometabolism/hypothermia. |
2015-03-30 |
2023-08-13 |
mouse |
| Marcelo Roberto Choi, Natalia Lucía Rukavina Mikusic, Nicolás Martín Kouyoumdzian, María Cecilia Kravetz, Belisario Enrique Fernánde. Atrial natriuretic peptide and renal dopaminergic system: a positive friendly relationship? BioMed research international. vol 2014. 2015-03-30. PMID:25013796. |
renal dopaminergic tonus can be modulated at different steps of dopamine metabolism (synthesis, uptake, release, catabolism, and receptor sensitization) which can be regulated by the atrial natriuretic peptide. |
2015-03-30 |
2023-08-13 |
Not clear |
| Ekaterina Dobryakova, Helen M Genova, John DeLuca, Glenn R Wyli. The dopamine imbalance hypothesis of fatigue in multiple sclerosis and other neurological disorders. Frontiers in neurology. vol 6. 2015-03-27. PMID:25814977. |
further, dopaminergic psychostimulant medication has been shown to alleviate fatigue in individuals with traumatic brain injury, chronic fatigue syndrome, and in cancer patients, also indicating that dopamine might play an important role in fatigue perception. |
2015-03-27 |
2023-08-13 |
Not clear |
| Garret D Stuber, Alice M Stamatakis, Pranish A Kanta. Considerations when using cre-driver rodent lines for studying ventral tegmental area circuitry. Neuron. vol 85. issue 2. 2015-03-24. PMID:25611514. |
while vta dopaminergic neurons have previously been targeted and defined by the expression of single genes important for aspects of dopamine neurotransmission, many vta and neighboring cells display dynamic gene expression phenotypes that are partially consistent with both classically described dopaminergic and non-dopaminergic neurons. |
2015-03-24 |
2023-08-13 |
mouse |
| Yue-Hua Wang, Zhao-Hong Xuan, Shuo Tian, Guan-Hua D. Echinacoside Protects against 6-Hydroxydopamine-Induced Mitochondrial Dysfunction and Inflammatory Responses in PC12 Cells via Reducing ROS Production. Evidence-based complementary and alternative medicine : eCAM. vol 2015. 2015-03-19. PMID:25788961. |
6-hydroxydopamine (6-ohda), a dopamine analog, specifically damages dopaminergic neurons. |
2015-03-19 |
2023-08-13 |
Not clear |
| E A Fedosova, K Iu Sarkisova, V S Kudrin, V B Narkevich, P M Klodt, A S Bazia. [Concentrations of monoamines in the brain structures and features of behavior in the two-month old WAG/Rij rats]. Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova. vol 64. issue 5. 2015-03-17. PMID:25710077. |
extensive absence epilepsy in 5-6 months-old wag/rij rats is accompanied by decreases in dopamine and its metabolites concentrations in the meso-cortico-limbic and nigro-striatal dopaminergic brain systems, resulting in the expression of depression-like behavioral symptoms. |
2015-03-17 |
2023-08-13 |
rat |
| Javier Ganz, Ina Arie, Sigal Buch, Tali Ben Zur, Yael Barhum, Sammy Pour, Shareef Araidy, Sandu Pitaru, Daniel Offe. Dopaminergic-like neurons derived from oral mucosa stem cells by developmental cues improve symptoms in the hemi-parkinsonian rat model. PloS one. vol 9. issue 6. 2015-03-12. PMID:24945922. |
soluble developmental factors induced a reproducible neuronal-like morphology in the majority of homsc, downregulated stem cells markers, upregulated the expression of the neuronal and dopaminergic markers that resulted in dopamine release capabilities. |
2015-03-12 |
2023-08-13 |
human |
| Lucas A de Azeredo, Diego L Rovaris, Nina R Mota, Evelise R Polina, Francine Z Marques, Verônica Contini, Eduardo S Vitola, Paulo Belmonte-de-Abreu, Luis A Rohde, Eugenio H Grevet, Claiton H D Ba. Further evidence for the association between a polymorphism in the promoter region of SLC6A3/DAT1 and ADHD: findings from a sample of adults. European archives of psychiatry and clinical neuroscience. vol 264. issue 5. 2015-03-09. PMID:24487615. |
the dopamine transporter (slc6a3/dat1) plays a key role in the regulation of dopaminergic neurotransmission and is the major site of action for methylphenidate, a first-line medication for attention deficit hyperactivity disorder (adhd). |
2015-03-09 |
2023-08-12 |
Not clear |
| Steven J O'dell, John F Marshal. Running wheel exercise before a binge regimen of methamphetamine does not protect against striatal dopaminergic damage. Synapse (New York, N.Y.). vol 68. issue 9. 2015-03-06. PMID:24899064. |
repeated administration of methamphetamine (mamph) to rodents in a single-day "binge" dosing regimen produces long-lasting damage to forebrain dopaminergic nerve terminals as measured by decreases in tissue dopamine (da) content and levels of the plasmalemmal da transporter (dat). |
2015-03-06 |
2023-08-13 |
rat |
| Jintao Li, Qi Yan, Yiliu Ma, Zhongtang Feng, Tinghua Wan. Directional induction of dopaminergic neurons from neural stem cells using substantia nigra homogenates and basic fibroblast growth factor. Neural regeneration research. vol 7. issue 7. 2015-03-06. PMID:25745437. |
experimental findings indicate that the homogenate supernatant of the substantia nigra from adult rats and basic fibroblast growth factor could directionally induce neural stem cells derived from the subventricular zone of embryonic rats to differentiate into dopaminergic neurons in the substantia nigra with the ability to secrete dopamine. |
2015-03-06 |
2023-08-13 |
rat |
| Vladimir Shalgunov, Jan-Peter van Wieringen, Henk M Janssen, P Michel Fransen, Rudi A J O Dierckx, Martin C Michel, Jan Booij, Philip H Elsing. Synthesis and evaluation in rats of the dopamine D2/3 receptor agonist 18F-AMC20 as a potential radioligand for PET. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 56. issue 1. 2015-03-05. PMID:25476538. |
dopamine d(2/3) receptor (d(2/3)r) agonist pet tracers are better suited for the imaging of synaptic dopaminergic neurotransmission than d(2/3)r antagonists and may also offer the opportunity to study in vivo the high-affinity state of d(2/3)r (d(2/3)rhigh). |
2015-03-05 |
2023-08-13 |
rat |