| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ryul Kim, Beomseok Jeo. Nonmotor Effects of Conventional and Transdermal Dopaminergic Therapies in Parkinson's Disease. International review of neurobiology. vol 134. 2018-04-27. PMID:28805592. |
although a range of nms have a dopaminergic pathophysiological basis, this fact is underrecognized, and thus, they are often regarded as dopamine unresponsive symptoms. |
2018-04-27 |
2023-08-13 |
Not clear |
| Roberta Biundo, Eleonora Fiorenzato, Angelo Antonin. Nonmotor Symptoms and Natural History of Parkinson's Disease: Evidence From Cognitive Dysfunction and Role of Noninvasive Interventions. International review of neurobiology. vol 133. 2018-04-26. PMID:28802926. |
some nms fluctuate in response to dopaminergic treatment and are relieved by dopamine replacement therapy, other are insensitive to current therapeutic strategies. |
2018-04-26 |
2023-08-13 |
Not clear |
| Hemalatha Sasidharakurup, Nidheesh Melethadathil, Bipin Nair, Shyam Diwaka. A Systems Model of Parkinson's Disease Using Biochemical Systems Theory. Omics : a journal of integrative biology. vol 21. issue 8. 2018-04-26. PMID:28816645. |
simulations suggest that dopamine levels were reduced significantly due to an increase in dopaminergic quinones and 3,4-dihydroxyphenylacetaldehyde (dopal) relating to imbalances compared to control during pd progression. |
2018-04-26 |
2023-08-13 |
Not clear |
| Amy R Dunn, Kristen A Stout, Minagi Ozawa, Kelly M Lohr, Carlie A Hoffman, Alison I Bernstein, Yingjie Li, Minzheng Wang, Carmelo Sgobio, Namratha Sastry, Huaibin Cai, W Michael Caudle, Gary W Mille. Synaptic vesicle glycoprotein 2C (SV2C) modulates dopamine release and is disrupted in Parkinson disease. Proceedings of the National Academy of Sciences of the United States of America. vol 114. issue 11. 2018-04-23. PMID:28246328. |
these data establish sv2c as a mediator of dopamine neuron function and suggest that sv2c disruption is a unique feature of pd that likely contributes to dopaminergic dysfunction. |
2018-04-23 |
2023-08-13 |
mouse |
| Flavia Maria Sutera, Libero Italo Giannola, Denise Murgia, Viviana De Car. Assessment of in vivo organ-uptake and in silico prediction of CYP mediated metabolism of DA-Phen, a new dopaminergic agent. Computational biology and chemistry. vol 71. 2018-04-23. PMID:28985485. |
as a consequence, it is possible to assume that da-phen acts as dopaminergic modulator per se and not as a dopamine prodrug, thus avoiding peripheral release and toxic side effects due to the endogenous neurotransmitter. |
2018-04-23 |
2023-08-13 |
human |
| Sebastian Markett, Marcel A de Reus, Martin Reuter, Christian Montag, Bernd Weber, Jan-Christoph Schoene-Bake, Martijn P van den Heuve. Variation on the dopamine D2 receptor gene (DRD2) is associated with basal ganglia-to-frontal structural connectivity. NeuroImage. vol 155. 2018-04-20. PMID:28392487. |
common variation on the dopamine d2 receptor (drd2) gene has been linked to individual differences in dopaminergic signaling and was also repeatedly associated to cognitive markers. |
2018-04-20 |
2023-08-13 |
human |
| Sebastian Markett, Marcel A de Reus, Martin Reuter, Christian Montag, Bernd Weber, Jan-Christoph Schoene-Bake, Martijn P van den Heuve. Variation on the dopamine D2 receptor gene (DRD2) is associated with basal ganglia-to-frontal structural connectivity. NeuroImage. vol 155. 2018-04-20. PMID:28392487. |
our results indicate that structural connectivity could serve as a conceptual link between genetically determined individual differences in dopaminergic activity and effects of dopamine challenges on executive functioning. |
2018-04-20 |
2023-08-13 |
human |
| Jesús M López, Agustín Gonzále. Organization of the catecholaminergic systems in the brain of lungfishes, the closest living relatives of terrestrial vertebrates. The Journal of comparative neurology. vol 525. issue 14. 2018-04-19. PMID:28649777. |
hypothalamic and diencephalic groups were detected and, in particular, the dopaminergic nucleus of the periventricular organ was evidenced with dopamine antibodies but not with anti-tyrosine hydroxylase. |
2018-04-19 |
2023-08-13 |
Not clear |
| Peter J Gaskill, Douglas R Miller, Joyonna Gamble-George, Hideaki Yano, Habibeh Khoshboue. HIV, Tat and dopamine transmission. Neurobiology of disease. vol 105. 2018-04-18. PMID:28457951. |
specifically, data indicate that tat may directly impact dopaminergic neurotransmission, by modulating the function of the dopamine transporter and specifically damaging dopamine-rich regions of the cns. |
2018-04-18 |
2023-08-13 |
human |
| Andrea Herrera-Solis, Wendy Herrera-Morales, Luis Nunez-Jaramillo, Oscar Arias-Carrio. Dopaminergic Modulation of Sleep-Wake States. CNS & neurological disorders drug targets. vol 16. issue 4. 2018-04-16. PMID:28322171. |
the effects of dopaminergic agents, nevertheless, are mediated by two families of dopamine receptors, d1 and d2-like receptors; the first family increases adenylyl cyclase activity and the second inhibits adenylyl cyclase. |
2018-04-16 |
2023-08-13 |
Not clear |
| Kimberly A Kempadoo, Eugene V Mosharov, Se Joon Choi, David Sulzer, Eric R Kande. Dopamine release from the locus coeruleus to the dorsal hippocampus promotes spatial learning and memory. Proceedings of the National Academy of Sciences of the United States of America. vol 113. issue 51. 2018-04-13. PMID:27930324. |
we have explored this apparent paradox using optogenetic, biochemical, and behavioral approaches and found that dopaminergic axons and subsequent dopamine release in the dorsal hippocampus originate from neurons of the locus coeruleus (lc). |
2018-04-13 |
2023-08-13 |
Not clear |
| Guillermo Gervasini, Luz M González, Carmen Gamero-Villarroel, Sonia Mota-Zamorano, Juan Antonio Carrillo, Isalud Flores, Angustias García-Herrái. Effect of dopamine receptor D4 (DRD4) haplotypes on general psychopathology in patients with eating disorders. Gene. vol 654. 2018-04-13. PMID:29455021. |
among the many candidate genes analyzed in eating disorder (ed) patients, those involved in dopaminergic functions may be of special relevance, as dopamine is known to play a significant role in feeding behavior, the distortion of body image, hyperactivity and reward and reinforcement processes. |
2018-04-13 |
2023-08-13 |
Not clear |
| Jung-Hoon Koo, Yong-Chul Jang, Dong-Ju Hwang, Hyun-Seob Um, Nam-Hee Lee, Jae-Hoon Jung, Joon-Yong Ch. Treadmill exercise produces neuroprotective effects in a murine model of Parkinson's disease by regulating the TLR2/MyD88/NF-κB signaling pathway. Neuroscience. vol 356. 2018-04-12. PMID:28527958. |
parkinson's disease (pd) is characterized by progressive dopamine depletion and a loss of dopaminergic neurons in the substantia nigra pars compacta (snpc). |
2018-04-12 |
2023-08-13 |
mouse |
| Kinan Muhammed, Sanjay Manohar, Michael Ben Yehuda, Trevor T-J Chong, George Tofaris, Graham Lennox, Marko Bogdanovic, Michele Hu, Masud Husai. Reward sensitivity deficits modulated by dopamine are associated with apathy in Parkinson's disease. Brain : a journal of neurology. vol 139. issue Pt 10. 2018-04-10. PMID:27452600. |
thirty patients were examined on and off their dopaminergic medication in two counterbalanced sessions, so that the effect of dopamine on reward sensitivity could be assessed. |
2018-04-10 |
2023-08-13 |
human |
| Nicola Romanò, Anne Guillou, David J Hodson, Agnès O Martin, Patrice Mollar. Multiple-scale neuroendocrine signals connect brain and pituitary hormone rhythms. Proceedings of the National Academy of Sciences of the United States of America. vol 114. issue 9. 2018-04-10. PMID:28193889. |
here, we show that the temporal organization of dopamine (da) release events in freely behaving animals relies on a set of characteristic features that are adapted to the dynamic dopaminergic control of pituitary prolactin secretion, a key reproductive hormone. |
2018-04-10 |
2023-08-13 |
Not clear |
| Francisco José Sanz, Cristina Solana-Manrique, Verónica Muñoz-Soriano, Pablo Calap-Quintana, María Dolores Moltó, Nuria Parici. Identification of potential therapeutic compounds for Parkinson's disease using Drosophila and human cell models. Free radical biology & medicine. vol 108. 2018-04-09. PMID:28455141. |
it is caused by a loss of dopaminergic neurons in the substantia nigra pars compacta, leading to a decrease in dopamine levels in the striatum and thus producing movement impairment. |
2018-04-09 |
2023-08-13 |
human |
| Kelly M Lohr, Merry Chen, Carlie A Hoffman, Miranda J McDaniel, Kristen A Stout, Amy R Dunn, Minzheng Wang, Alison I Bernstein, Gary W Mille. Vesicular Monoamine Transporter 2 (VMAT2) Level Regulates MPTP Vulnerability and Clearance of Excess Dopamine in Mouse Striatal Terminals. Toxicological sciences : an official journal of the Society of Toxicology. vol 153. issue 1. 2018-04-02. PMID:27287315. |
in mice, low vmat2 levels causes catecholaminergic cell loss and behaviors resembling parkinson's disease, while high levels of vmat2 increase dopamine release and protect against dopaminergic toxicants. |
2018-04-02 |
2023-08-13 |
mouse |
| S E Kirk, T Y Xie, F J Steyn, D R Grattan, S J Bun. Restraint stress increases prolactin-mediated phosphorylation of signal transducer and activator of transcription 5 in the hypothalamus and adrenal cortex in the male mouse. Journal of neuroendocrinology. vol 29. issue 6. 2018-04-02. PMID:28425631. |
its rate of secretion is primarily regulated by a negative-feedback mechanism where prolactin stimulates the activity of the tuberoinfundibular dopaminergic (tida) neurones, increasing their release of dopamine, which accesses the pituitary via the median eminence to suppress further prolactin secretion. |
2018-04-02 |
2023-08-13 |
mouse |
| Andrea Herrera-Soto, Gabriela Díaz-Veliz, Sergio Mora, Patricia Muñoz, Pablo Henny, Harry W M Steinbusch, Juan Segura-Aguila. On the Role of DT-Diaphorase Inhibition in Aminochrome-Induced Neurotoxicity In Vivo. Neurotoxicity research. vol 32. issue 1. 2018-03-27. PMID:28285345. |
because of a recent report that substantia nigra pars compacta (snpc) tyrosine hydroxylase (t-oh) levels were unaltered by aminochrome when there was cell shrinkage of dopaminergic neurons along with a reduction in striatal dopamine release, the following study was conducted to more accurately determine the role of dt-diaphorase in aminochrome neurotoxicity. |
2018-03-27 |
2023-08-13 |
rat |
| Kamal Awad, Abdelrahman Ibrahim Abushouk, Ahmed Helal AbdelKarim, Maged Mohammed, Ahmed Negida, Ali S Shalas. Bee venom for the treatment of Parkinson's disease: How far is it possible? Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 91. 2018-03-26. PMID:28477460. |
parkinson's disease (pd) is the second most common neurodegenerative disease, characterized by progressive loss of dopaminergic neurons in the substantia nigra pars compacta leading to depletion of striatal dopamine and motor symptoms as bradykinesia, resting tremors, rigidity, and postural instability. |
2018-03-26 |
2023-08-13 |
bee |