| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anastasiia Bohush, Grazyna Niewiadomska, Anna Filipe. Role of Mitogen Activated Protein Kinase Signaling in Parkinson's Disease. International journal of molecular sciences. vol 19. issue 10. 2019-01-07. PMID:30274251. |
a shortage of dopamine, which is predominantly produced by the dopaminergic neurons within the substantia nigra, causes clinical symptoms such as reduction of muscle mass, impaired body balance, akinesia, bradykinesia, tremors, postural instability, etc. |
2019-01-07 |
2023-08-13 |
Not clear |
| Cihan Kaya, Mary H Cheng, Ethan R Block, Tom M Bartol, Terrence J Sejnowski, Alexander Sorkin, James R Faeder, Ivet Baha. Heterogeneities in Axonal Structure and Transporter Distribution Lower Dopamine Reuptake Efficiency. eNeuro. vol 5. issue 1. 2019-01-02. PMID:29430519. |
efficient clearance of dopamine (da) from the synapse is key to regulating dopaminergic signaling. |
2019-01-02 |
2023-08-13 |
Not clear |
| Federica Bono, Paola Savoia, Adele Guglielmi, Massimo Gennarelli, Giovanna Piovani, Sandra Sigala, Damiana Leo, Stefano Espinoza, Raul R Gainetdinov, Paola Devoto, PierFranco Spano, Cristina Missale, Chiara Fiorentin. Role of Dopamine D2/D3 Receptors in Development, Plasticity, and Neuroprotection in Human iPSC-Derived Midbrain Dopaminergic Neurons. Molecular neurobiology. vol 55. issue 2. 2019-01-01. PMID:28092083. |
role of dopamine d2/d3 receptors in development, plasticity, and neuroprotection in human ipsc-derived midbrain dopaminergic neurons. |
2019-01-01 |
2023-08-13 |
human |
| Federica Bono, Paola Savoia, Adele Guglielmi, Massimo Gennarelli, Giovanna Piovani, Sandra Sigala, Damiana Leo, Stefano Espinoza, Raul R Gainetdinov, Paola Devoto, PierFranco Spano, Cristina Missale, Chiara Fiorentin. Role of Dopamine D2/D3 Receptors in Development, Plasticity, and Neuroprotection in Human iPSC-Derived Midbrain Dopaminergic Neurons. Molecular neurobiology. vol 55. issue 2. 2019-01-01. PMID:28092083. |
the role of dopamine d2 and d3 receptors (d2r/d3r), located on midbrain dopaminergic (da) neurons, in the regulation of da synthesis and release and in da neuron homeostasis has been extensively investigated in rodent animal models. |
2019-01-01 |
2023-08-13 |
human |
| Amit Kumar Chauhan, Namrata Mittra, Devendra Kumar Patel, Chetna Sing. Cyclooxygenase-2 Directs Microglial Activation-Mediated Inflammation and Oxidative Stress Leading to Intrinsic Apoptosis in Zn-Induced Parkinsonism. Molecular neurobiology. vol 55. issue 3. 2018-12-31. PMID:28290146. |
zn reduced the neurobehavioral activities, striatal dopamine content, tyrosine hydroxylase (th) expression and number of dopaminergic neurons. |
2018-12-31 |
2023-08-13 |
rat |
| Viet-Duc Phung, Won-Sik Jung, Thuy-An Nguyen, Jong-Hoon Kim, Sang-Wha Le. Reliable and quantitative SERS detection of dopamine levels in human blood plasma using a plasmonic Au/Ag nanocluster substrate. Nanoscale. vol 10. issue 47. 2018-12-19. PMID:30480292. |
accurate and rapid blood-based detection of dopamine levels can aid in the diagnosis and monitoring of diseases related to dopaminergic dysfunction. |
2018-12-19 |
2023-08-13 |
human |
| Sorabh Sharma, Rajeev Taliya. High fat diet feeding induced insulin resistance exacerbates 6-OHDA mediated neurotoxicity and behavioral abnormalities in rats. Behavioural brain research. vol 351. 2018-12-18. PMID:29842916. |
interestingly, we found that exposure to hfd exacerbated the effects of 6-ohda on striatal dopamine loss and behavioral parameters in rats, indicating that hfd-induced insulin resistance is associated with a diminished capacity of dopaminergic neurons to cope with 6-ohda mediated neurotoxicity. |
2018-12-18 |
2023-08-13 |
rat |
| Heng Dai, Chad R Jackson, Gwynne L Davis, Randy D Blakely, Douglas G McMaho. Is dopamine transporter-mediated dopaminergic signaling in the retina a noninvasive biomarker for attention-deficit/ hyperactivity disorder? A study in a novel dopamine transporter variant Val559 transgenic mouse model. Journal of neurodevelopmental disorders. vol 9. issue 1. 2018-12-17. PMID:29281965. |
is dopamine transporter-mediated dopaminergic signaling in the retina a noninvasive biomarker for attention-deficit/ hyperactivity disorder? |
2018-12-17 |
2023-08-13 |
mouse |
| Liana Basova, Julia A Najera, Nikki Bortell, Di Wang, Rosita Moya, Alexander Lindsey, Svetlana Semenova, Ronald J Ellis, Maria Cecilia Garibaldi Marconde. Dopamine and its receptors play a role in the modulation of CCR5 expression in innate immune cells following exposure to Methamphetamine: Implications to HIV infection. PloS one. vol 13. issue 6. 2018-12-17. PMID:29944719. |
however, we found that the main factor that modifies the ccr5 gene promoter at the epigenetic level towards transcription is dopamine (da), a neurotransmitter that is produced primarily in brain regions that are rich in dopaminergic neurons. |
2018-12-17 |
2023-08-13 |
human |
| Muhammad Saad Khan, Isabelle Boileau, Nathan Kolla, Romina Mizrah. A systematic review of the role of the nociceptin receptor system in stress, cognition, and reward: relevance to schizophrenia. Translational psychiatry. vol 8. issue 1. 2018-12-12. PMID:29391391. |
first, aberrant glutamatergic and striatal dopaminergic function are associated with psychotic symptoms, and the nociceptin receptor system has been shown to regulate dopamine and glutamate transmission. |
2018-12-12 |
2023-08-13 |
Not clear |
| Jun Zhu, Subramaniam Ananthan, Chang-Guo Zha. The role of human dopamine transporter in NeuroAIDS. Pharmacology & therapeutics. vol 183. 2018-12-11. PMID:28987321. |
the presynaptic dopamine (da) transporter (dat) is essential for da homeostasis and dopaminergic modulation of the brain function including cognition. |
2018-12-11 |
2023-08-13 |
human |
| Agnieszka Wąsik, Irena Romańska, Agnieszka Zelek-Molik, Lucyna Antkiewicz-Michalu. Multiple Administration of Endogenous Amines TIQ and 1MeTIQ Protects Against a 6-OHDA-Induced Essential Fall of Dopamine Release in the Rat Striatum: In Vivo Microdialysis Study. Neurotoxicity research. vol 33. issue 3. 2018-12-11. PMID:29076060. |
the results obtained from the in vivo microdialysis study suggest that multiple treatment with both endogenous amines, tiq and 1metiq, protects dopaminergic neurons against a 6-ohda-induced deficit of dopamine release. |
2018-12-11 |
2023-08-13 |
rat |
| Li Li, Yun-Xiao Kang, Xiao-Ming Ji, Ying-Kun Li, Shuang-Cheng Li, Xiang-Jian Zhang, Hui-Xian Cui, Ge-Ming Sh. Finasteride inhibited brain dopaminergic system and open-field behaviors in adolescent male rats. CNS neuroscience & therapeutics. vol 24. issue 2. 2018-12-11. PMID:29214729. |
the present study therefore investigates the effects of finasteride in adolescent and early developmental rats on dopaminergic system, including contents of dopamine and its metabolites (dihydroxy phenyl acetic acid and homovanillic acid) and tyrosine hydroxylase expressions both at gene and protein levels. |
2018-12-11 |
2023-08-13 |
rat |
| Reinis Svarcbahs, Ulrika H Julku, Susanna Norrbacka, Timo T Myöhäne. Removal of prolyl oligopeptidase reduces alpha-synuclein toxicity in cells and in vivo. Scientific reports. vol 8. issue 1. 2018-12-11. PMID:29367610. |
animal behavior was studied by locomotor activity and cylinder tests, microdialysis and hplc were used to analyze dopamine levels, and different asyn forms and loss of dopaminergic neurons were studied by immunostainings. |
2018-12-11 |
2023-08-13 |
mouse |
| Elke Edelmann, Volkmar Lessman. Dopaminergic innervation and modulation of hippocampal networks. Cell and tissue research. vol 373. issue 3. 2018-12-11. PMID:29470647. |
while the role and importance of dopaminergic modulation of hippocampal networks have been unequivocally proven, there is still a lack of detailed molecular and cellular mechanistic understanding of how dopamine orchestrates these hippocampal processes. |
2018-12-11 |
2023-08-13 |
Not clear |
| Nicole D Harriott, John P Williams, Evan B Smith, Haig P Bozigian, Dimitri E Grigoriadi. VMAT2 Inhibitors and the Path to Ingrezza (Valbenazine). Progress in medicinal chemistry. vol 57. issue 1. 2018-12-11. PMID:29680151. |
drugs that modify the dopaminergic system by modulating the activity of dopamine have been successful in demonstrating clinical efficacy by providing treatments for these diseases. |
2018-12-11 |
2023-08-13 |
Not clear |
| Daniela Molina-Mateo, Nicolás Fuenzalida-Uribe, Sergio Hidalgo, Claudia Molina-Fernández, Jorge Abarca, Rafaella V Zárate, Marcela Escandón, Reinaldo Figueroa, María Florencia Tevy, Jorge M Campusan. Characterization of a presymptomatic stage in a Drosophila Parkinson's disease model: Unveiling dopaminergic compensatory mechanisms. Biochimica et biophysica acta. Molecular basis of disease. vol 1863. issue 11. 2018-11-26. PMID:28716706. |
these compensatory changes are associated to specific components of the dopaminergic system: the biosynthetic enzymes, tyrosine hydroxylase and dopa decarboxylase, and the dopamine transporter, a plasma membrane protein involved in maintaining dopamine extracellular levels at physiologically relevant levels. |
2018-11-26 |
2023-08-13 |
drosophila_melanogaster |
| J P Kesby, D W Eyles, J J McGrath, J G Scot. Dopamine, psychosis and schizophrenia: the widening gap between basic and clinical neuroscience. Translational psychiatry. vol 8. issue 1. 2018-11-26. PMID:29382821. |
our contemporary knowledge regarding dopamine dysfunction has clarified where and when dopaminergic alterations may present in schizophrenia. |
2018-11-26 |
2023-08-13 |
human |
| Meng-Yang Zh. Noradrenergic Modulation on Dopaminergic Neurons. Neurotoxicity research. vol 34. issue 4. 2018-11-26. PMID:29572781. |
it is now well accepted that there is a close relationship between noradrenergic and dopaminergic neurons in the brain, especially referring to the modulation of the locus coeruleus-norepinephrine (lc-ne) system on dopamine transmission. |
2018-11-26 |
2023-08-13 |
Not clear |
| Vívian T da Silveira, Jivago Röpke, Ana L Matosinhos, Ana C Issy, Elaine A Del Bel, Antônio C de Oliveira, Fabrício A Moreir. Effects of the monoamine stabilizer (-)-OSU6162 on locomotor and sensorimotor responses predictive of antipsychotic activity. Naunyn-Schmiedeberg's archives of pharmacology. vol 391. issue 7. 2018-11-26. PMID:29691608. |
the dopamine stabilizer (-)-osu6162 prevents the hyperactivity induced by dopaminergic and anti-glutamatergic drugs at doses that preserve motor functions, although it failed in the ppi test. |
2018-11-26 |
2023-08-13 |
mouse |