| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| David S Goldstein, Yunden Jinsmaa, Patti Sullivan, Yehonatan Sharab. N-Acetylcysteine Prevents the Increase in Spontaneous Oxidation of Dopamine During Monoamine Oxidase Inhibition in PC12 Cells. Neurochemical research. vol 42. issue 11. 2018-06-26. PMID:28840582. |
the catecholaldehyde hypothesis for the pathogenesis of parkinson's disease proposes that the deaminated dopamine metabolite 3,4-dihydroxyphenylacetaldehyde (dopal) is toxic to nigrostriatal dopaminergic neurons. |
2018-06-26 |
2023-08-13 |
rat |
| B Fimm, W Sturm, A Esser, T Schettgen, K Willmes, J Lang, P M Gaum, T Krau. Neuropsychological effects of occupational exposure to polychlorinated biphenyls. Neurotoxicology. vol 63. 2018-06-25. PMID:28947237. |
results are discussed in terms of (1) a decrease of cerebral dopamine (da) with non-coplanar pcbs resulting in an impact on fronto-striatal cerebral structures subserving verbal fluency and motor processing, (2) a pcb-induced reduction of norepinephrine leading to the time-on-task effect with verbal fluency, and (3) adverse effects of pcbs on dopaminergic receptors in the cerebellum resulting in impaired fine motor function. |
2018-06-25 |
2023-08-13 |
human |
| Xueting Li, Jia Yu, Jianan Li, Yanping Wu, Baixiang L. Dopaminergic Dysfunction in Mammalian Dopamine Neurons Induced by Simazine Neurotoxicity. International journal of molecular sciences. vol 18. issue 11. 2018-06-22. PMID:29137186. |
dopaminergic dysfunction in mammalian dopamine neurons induced by simazine neurotoxicity. |
2018-06-22 |
2023-08-13 |
Not clear |
| D Bäckström, M Eriksson Domellöf, G Granåsen, J Linder, S Mayans, E Elgh, H Zetterberg, K Blennow, L Forsgre. Polymorphisms in dopamine-associated genes and cognitive decline in Parkinson's disease. Acta neurologica Scandinavica. vol 137. issue 1. 2018-06-20. PMID:28869277. |
this study investigates whether genotypes associated with reduced prefrontal dopaminergic tone and/or reduced dopamine d2-receptor availability (catechol-o-methyltransferase [comt] val |
2018-06-20 |
2023-08-13 |
Not clear |
| Mohammad Naderi, Arash Salahinejad, Maud C O Ferrari, Som Niyogi, Douglas P Chiver. Dopaminergic dysregulation and impaired associative learning behavior in zebrafish during chronic dietary exposure to selenium. Environmental pollution (Barking, Essex : 1987). vol 237. 2018-06-20. PMID:29482023. |
an increase in brain dopamine levels associated with altered expression of dopaminergic cell markers was evident in different treatment groups. |
2018-06-20 |
2023-08-13 |
zebrafish |
| Kirsty J McMillan, Tracey K Murray, Nora Bengoa-Vergniory, Oscar Cordero-Llana, Jane Cooper, Amy Buckley, Richard Wade-Martins, James B Uney, Michael J O'Neill, Liang F Wong, Maeve A Caldwel. Loss of MicroRNA-7 Regulation Leads to α-Synuclein Accumulation and Dopaminergic Neuronal Loss In Vivo. Molecular therapy : the journal of the American Society of Gene Therapy. vol 25. issue 10. 2018-06-18. PMID:28927576. |
we have also shown that depletion of mir-7 using a mir-decoy produces a loss of nigral dopaminergic neurons accompanied by a reduction of striatal dopamine content. |
2018-06-18 |
2023-08-13 |
Not clear |
| A Quiroga-Varela, E Aguilar, E Iglesias, J A Obeso, C Mari. Short- and long-term effects induced by repeated 6-OHDA intraventricular administration: A new progressive and bilateral rodent model of Parkinson's disease. Neuroscience. vol 361. 2018-06-14. PMID:28823819. |
the pathological hallmark of parkinson's disease (pd) is the progressive degeneration of dopaminergic neurons in the substantia nigra pars compacta (snpc), and the resulting striatal dopamine deficiency, which are responsible for the classic motor features. |
2018-06-14 |
2023-08-13 |
human |
| Qizhi Fu, Runluo Song, Zhongxi Yang, Qi Shan, Wenna Che. 6-Hydroxydopamine induces brain vascular endothelial inflammation. IUBMB life. vol 69. issue 11. 2018-06-14. PMID:29048735. |
6-hydroxydopamine (6-ohda) is a synthetic dopamine derivate often used to model pd as it results in retrograde degeneration of striatal dopaminergic (da) terminals. |
2018-06-14 |
2023-08-13 |
human |
| Ashley L Green, Le Zhan, Aseel Eid, Helmut Zarbl, Grace L Guo, Jason R Richardso. Valproate increases dopamine transporter expression through histone acetylation and enhanced promoter binding of Nurr1. Neuropharmacology. vol 125. 2018-06-12. PMID:28743636. |
the dopamine transporter (dat) is the key regulator of dopaminergic transmission and is a target of several xenobiotics, including pesticides and pharmacological agents. |
2018-06-12 |
2023-08-13 |
rat |
| Marta Celorrio, Estefanía Rojo-Bustamante, Diana Fernández-Suárez, Elena Sáez, Ander Estella-Hermoso de Mendoza, Christa E Müller, María J Ramírez, Julen Oyarzábal, Rafael Franco, María S Aymeric. GPR55: A therapeutic target for Parkinson's disease? Neuropharmacology. vol 125. 2018-06-12. PMID:28807673. |
although abn-cbd protected dopaminergic cell bodies, it failed to prevent degeneration of the terminals or preserve dopamine levels in the striatum. |
2018-06-12 |
2023-08-13 |
mouse |
| B Fernández-López, D Sobrido-Cameán, R Anadón, M C Rodicio, A Barreiro-Iglesia. Restricted co-localization of glutamate and dopamine in neurons of the adult sea lamprey brain. Journal of anatomy. vol 231. issue 5. 2018-06-11. PMID:28791699. |
moreover, co-localization of dopamine and glutamate was found in dopaminergic fibres in a few brain regions including the lateral pallium, striatum, and the preoptic and postoptic areas but not in the brainstem. |
2018-06-11 |
2023-08-13 |
Not clear |
| David Bäckström, Magdalena Eriksson Domellöf, Gabriel Granåsen, Jan Linder, Sofia Mayans, Eva Elgh, Susanna Jakobson Mo, Lars Forsgre. PITX3 genotype and risk of dementia in Parkinson's disease: A population-based study. Journal of the neurological sciences. vol 381. 2018-06-11. PMID:28991698. |
this study investigates whether a common polymorphism in the pitx3 gene (rs2281983), which is of importance for the function of dopaminergic neurons, affects the risk of developing dementia in pd and whether it affects dopamine transporter (dat) uptake. |
2018-06-11 |
2023-08-13 |
Not clear |
| Gwynne L Davis, Adele Stewart, Gregg D Stanwood, Raajaram Gowrishankar, Maureen K Hahn, Randy D Blakel. Functional coding variation in the presynaptic dopamine transporter associated with neuropsychiatric disorders drives enhanced motivation and context-dependent impulsivity in mice. Behavioural brain research. vol 337. 2018-06-08. PMID:28964912. |
in keeping with studies suggesting dopaminergic contributions to attention-deficit hyperactivity disorder (adhd), bipolar disorder (bpd) and autism spectrum disorder (asd), subjects with these diagnoses have been found to express a rare, functional coding substitution in the dopamine (da) transporter (dat), ala559val. |
2018-06-08 |
2023-08-13 |
mouse |
| Bernard Ng, Gael Varoquaux, Jean Baptiste Poline, Bertrand Thirion, Michael D Greicius, Kathleen L Posto. Distinct alterations in Parkinson's medication-state and disease-state connectivity. NeuroImage. Clinical. vol 16. 2018-06-08. PMID:28971008. |
our results suggest that dopaminergic medications do not simply 'normalize' abnormal brain connectivity associated with parkinson's disease, but rather dopamine drives distinct connectivity changes, only some of which are associated with improved motor symptoms. |
2018-06-08 |
2023-08-13 |
human |
| Hongyoon Choi, Seunggyun Ha, Hyung Jun Im, Sun Ha Paek, Dong Soo Le. Refining diagnosis of Parkinson's disease with deep learning-based interpretation of dopamine transporter imaging. NeuroImage. Clinical. vol 16. 2018-06-08. PMID:28971009. |
dopaminergic degeneration is a pathologic hallmark of parkinson's disease (pd), which can be assessed by dopamine transporter imaging such as fp-cit spect. |
2018-06-08 |
2023-08-13 |
human |
| Pavel Jerabek, Tereza Havlickova, Nina Puskina, Chrysostomos Charalambous, Marek Lapka, Petr Kacer, Magdalena Sustkova-Fiserov. Ghrelin receptor antagonism of morphine-induced conditioned place preference and behavioral and accumbens dopaminergic sensitization in rats. Neurochemistry international. vol 110. 2018-06-06. PMID:28958601. |
pretreatment with jmv2959 significantly and dose dependently reduced the morphine-induced conditioned place preference and significantly and dose dependently reduced the challenge-morphine-induced dopaminergic sensitization and affected concentration of by-products associated with dopamine metabolism in the nucleus accumbens. |
2018-06-06 |
2023-08-13 |
rat |
| Regina Rumpel, Mesbah Alam, Lisa M Schwarz, Andreas Ratzka, Xingxing Jin, Joachim K Krauss, Claudia Grothe, Kerstin Schwab. Neuronal firing activity in the basal ganglia after striatal transplantation of dopamine neurons in hemiparkinsonian rats. Neuroscience. vol 360. 2018-06-05. PMID:28790019. |
the loss of nigral dopaminergic neurons and the resulting dopamine (da) depletion in the striatum (str) lead to altered neuronal activity and enhanced beta activity in various regions of the basal ganglia (bg) motor loop in patients with parkinson's disease and in rodents in the 6-hydroxydopamine (6-ohda)-lesioned rat model. |
2018-06-05 |
2023-08-13 |
human |
| Hiroshi Ito, Hiroshi Kawaguchi, Fumitoshi Kodaka, Hiroyuki Takuwa, Yoko Ikoma, Hitoshi Shimada, Yasuyuki Kimura, Chie Seki, Hitoshi Kubo, Shiro Ishii, Harumasa Takano, Tetsuya Suhar. Normative data of dopaminergic neurotransmission functions in substantia nigra measured with MRI and PET: Neuromelanin, dopamine synthesis, dopamine transporters, and dopamine D NeuroImage. vol 158. 2018-06-01. PMID:28655632. |
normative data of dopaminergic neurotransmission functions in substantia nigra measured with mri and pet: neuromelanin, dopamine synthesis, dopamine transporters, and dopamine d the central dopaminergic system is of major importance in the pathophysiology of parkinson's disease, schizophrenia, and other neuropsychiatric disorders. |
2018-06-01 |
2023-08-13 |
Not clear |
| Hiroshi Ito, Hiroshi Kawaguchi, Fumitoshi Kodaka, Hiroyuki Takuwa, Yoko Ikoma, Hitoshi Shimada, Yasuyuki Kimura, Chie Seki, Hitoshi Kubo, Shiro Ishii, Harumasa Takano, Tetsuya Suhar. Normative data of dopaminergic neurotransmission functions in substantia nigra measured with MRI and PET: Neuromelanin, dopamine synthesis, dopamine transporters, and dopamine D NeuroImage. vol 158. 2018-06-01. PMID:28655632. |
in the present study, the normative data of dopaminergic neurotransmission functions in the midbrain, consisting of neuromelanin, dopamine synthesis, dopamine transporters and dopamine d |
2018-06-01 |
2023-08-13 |
Not clear |
| Nicolas Nicastro, Valentina Garibotto, Pierre R Burkhar. 123I-FP-CIT SPECT Accurately Distinguishes Parkinsonian From Cerebellar Variant of Multiple System Atrophy. Clinical nuclear medicine. vol 43. issue 2. 2018-05-31. PMID:29215405. |
dopamine transporter spect imaging is a valuable tool to estimate the integrity of presynaptic dopaminergic pathways in degenerative parkinsonisms. |
2018-05-31 |
2023-08-13 |
Not clear |