| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Thomas McLaughlin, Kenneth Blum, Bruce Steinberg, Edward J Modestino, Lyle Fried, David Baron, David Siwicki, Eric R Braverman, Rajendra D Badgaiya. Pro-dopamine regulator, KB220Z, attenuates hoarding and shopping behavior in a female, diagnosed with SUD and ADHD. Journal of behavioral addictions. vol 7. issue 1. 2018-09-04. PMID:29316800. |
we, therefore, propose that dopamine homeostasis may be the preferred goal in combating such challenging and unwanted behaviors, when simple dopaminergic activation through potent agonists may not provide any resolution. |
2018-09-04 |
2023-08-13 |
human |
| Haixia Liu, Lu Jia, Xiaoyan Chen, Limin Shi, Junxia Xi. The Kv7/KCNQ channel blocker XE991 protects nigral dopaminergic neurons in the 6-hydroxydopamine rat model of Parkinson's disease. Brain research bulletin. vol 137. 2018-08-31. PMID:29174294. |
the excitability of dopaminergic neurons in the substantia nigra pars compacta (snc) that supply the striatum with dopamine (da) determines the function of the nigrostriatal system for motor coordination. |
2018-08-31 |
2023-08-13 |
rat |
| Qiaoling Cui, Qian Li, Hongyan Geng, Lei Chen, Nancy Y Ip, Ya Ke, Wing-Ho Yun. Dopamine receptors mediate strategy abandoning via modulation of a specific prelimbic cortex-nucleus accumbens pathway in mice. Proceedings of the National Academy of Sciences of the United States of America. vol 115. issue 21. 2018-08-29. PMID:29735678. |
this ability is dependent on an intact dopaminergic tone in the nac, as local dopamine denervation impaired the performance of the animal in the switching of tasks. |
2018-08-29 |
2023-08-13 |
mouse |
| Da Meng, Hui-Quan Li, Karl Deisseroth, Stefan Leutgeb, Nicholas C Spitze. Neuronal activity regulates neurotransmitter switching in the adult brain following light-induced stress. Proceedings of the National Academy of Sciences of the United States of America. vol 115. issue 20. 2018-08-28. PMID:29686073. |
here, we demonstrate that elevated activity of dopaminergic neurons in the paraventricular nucleus of the hypothalamus (pavn) in the adult rat is required for the loss of dopamine expression after long-day photoperiod exposure. |
2018-08-28 |
2023-08-13 |
rat |
| Da Meng, Hui-Quan Li, Karl Deisseroth, Stefan Leutgeb, Nicholas C Spitze. Neuronal activity regulates neurotransmitter switching in the adult brain following light-induced stress. Proceedings of the National Academy of Sciences of the United States of America. vol 115. issue 20. 2018-08-28. PMID:29686073. |
the transmitter switch occurs exclusively in pavn dopaminergic neurons that coexpress vesicular glutamate transporter 2 (vglut2), is accompanied by a loss of dopamine type 2 receptors (d2rs) on corticotrophin-releasing factor (crf) neurons, and can lead to increased release of crf. |
2018-08-28 |
2023-08-13 |
rat |
| Bhagwant R Mittal, Apurva Sood, Jaya Shukla, Rakhee Vatsa, Priya Bhusari, Ritu Shree, Sahil Mehta, Manoj Goyal, Manish Mod. 99mTc-TRODAT-1 SPECT/CT imaging as a complementary biomarker in the diagnosis of parkinsonian syndromes. Nuclear medicine communications. vol 39. issue 4. 2018-08-24. PMID:29381583. |
technetium-99m-labeled tropane derivative (tc-trodat-1) binds to the dopamine transporters present in the presynaptic membrane of the dopaminergic nerve terminal. |
2018-08-24 |
2023-08-13 |
Not clear |
| Adelaide Greco, Antonella Zannetti, Sabina Pappatà, Sandra Albanese, Anna R Coda, Monica Ragucci, Anna Nardelli, Arturo Brunetti, Alberto Cuocolo, Marco Salvator. Measurement of [123I]FP-CIT binding to the dopamine transporter (DAT) in healthy mouse striatum using dedicated small animal SPECT imaging: feasibility, optimization and validation. The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of.... vol 62. issue 1. 2018-08-17. PMID:26329495. |
in-vivo imaging of dopamine transporter (dat), a reliable marker of degeneration of nigrostriatal dopaminergic innervation, has gained increasing interest in preclinical neurodegenerative research for studying disease mechanisms and testing new therapeutic strategies. |
2018-08-17 |
2023-08-13 |
mouse |
| Luigi Trojano, Costanza Papagn. Cognitive and behavioral disorders in Parkinson's disease: an update. II: behavioral disorders. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 39. issue 1. 2018-08-15. PMID:29038946. |
symptoms can be present since early stages of the disease, sometimes even before the appearance of classical motor symptoms, likely in relation to dopamine depletion in basal ganglia and/or to dysfunctions of other neurotrasmitter systems, and others can develop later, in some cases in relation to dopaminergic treatment. |
2018-08-15 |
2023-08-13 |
Not clear |
| Masahiro Nomoto, Hirotaka Iwaki, Hiroyuki Kondo, Masaya Sakura. Efficacy and safety of rotigotine in elderly patients with Parkinson's disease in comparison with the non-elderly: a post hoc analysis of randomized, double-blind, placebo-controlled trials. Journal of neurology. vol 265. issue 2. 2018-08-13. PMID:29164312. |
rotigotine-a non-ergot dopamine agonist-has two advantages; it can stimulate all dopamine receptors (d1-d5) like innate dopamine, and its transdermal administration provides continuous dopaminergic stimulation. |
2018-08-13 |
2023-08-13 |
Not clear |
| Giulia Costa, Micaela Morelli, Nicola Simol. Progression and Persistence of Neurotoxicity Induced by MDMA in Dopaminergic Regions of the Mouse Brain and Association with Noradrenergic, GABAergic, and Serotonergic Damage. Neurotoxicity research. vol 32. issue 4. 2018-08-07. PMID:28597409. |
in order to characterize how the number of administrations influenced the severity of mdma-induced dopaminergic damage and to describe the localization and persistence of this damage, we evaluated the changes in tyrosine hydroxylase (th) and dopamine transporter (dat) in different regions of the mouse brain. |
2018-08-07 |
2023-08-13 |
mouse |
| Kert Mätlik, Helena Vihinen, Ali Bienemann, Jaan Palgi, Merja H Voutilainen, Sigrid Booms, Maria Lindahl, Eija Jokitalo, Mart Saarma, Henri J Huttunen, Mikko Airavaara, Urmas Arumä. Intrastriatally Infused Exogenous CDNF Is Endocytosed and Retrogradely Transported to Substantia Nigra. eNeuro. vol 4. issue 1. 2018-07-31. PMID:28275710. |
cerebral dopamine neurotrophic factor (cdnf) protects the nigrostriatal dopaminergic (da) neurons in rodent models of parkinson's disease and restores da circuitry when delivered after these neurons have begun to degenerate. |
2018-07-31 |
2023-08-13 |
human |
| Polymnia Georgiou, Panos Zanos, Shambhu Bhat, J Kathleen Tracy, Istvan J Merchenthaler, Margaret M McCarthy, Todd D Goul. Dopamine and Stress System Modulation of Sex Differences in Decision Making. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 43. issue 2. 2018-07-30. PMID:28741626. |
to test whether pharmacological manipulations targeting the dopaminergic and stress systems affect decision making in a sex-dependent manner, male and female rats received injections of a dopamine d |
2018-07-30 |
2023-08-13 |
rat |
| Panagiotis Perdikaris, Martha Tsarouchi, Eleni Fanarioti, Evangelos Natsaridis, Ada Mitsacos, Panagiotis Giompre. Long lasting effects of chronic WIN55,212-2 treatment on mesostriatal dopaminergic and cannabinoid systems in the rat brain. Neuropharmacology. vol 129. 2018-07-27. PMID:29113897. |
the present study evaluated in rodents, the effects of acute and chronic (20 days) win55,212-2 administration, a non-selective cb1r agonist, on dopamine uptake and synthesis in the mesolimbic and nigrostriatal dopaminergic pathways and associate them to its effects on the endocannabinoid system. |
2018-07-27 |
2023-08-13 |
rat |
| Vinod Kumar, Deepali Singh, Brajesh Kumar Singh, Shweta Singh, Namrata Mittra, Rakesh Roshan Jha, Devendra Kumar Patel, Chetna Sing. Alpha-synuclein aggregation, Ubiquitin proteasome system impairment, and L-Dopa response in zinc-induced Parkinsonism: resemblance to sporadic Parkinson's disease. Molecular and cellular biochemistry. vol 444. issue 1-2. 2018-07-25. PMID:29198021. |
zn treatment caused neurobehavioral anomalies, striatal dopamine decline, and dopaminergic neuronal cell loss accompanied with a marked increase in α-synuclein expression/aggregation and ubiquitin-conjugated protein levels in the exposed groups. |
2018-07-25 |
2023-08-13 |
rat |
| Vinod Kumar, Deepali Singh, Brajesh Kumar Singh, Shweta Singh, Namrata Mittra, Rakesh Roshan Jha, Devendra Kumar Patel, Chetna Sing. Alpha-synuclein aggregation, Ubiquitin proteasome system impairment, and L-Dopa response in zinc-induced Parkinsonism: resemblance to sporadic Parkinson's disease. Molecular and cellular biochemistry. vol 444. issue 1-2. 2018-07-25. PMID:29198021. |
l-dopa treatment rescued from zn-induced neurobehavioral deficits and restored dopamine levels towards normalcy; however, zn-induced dopaminergic neuronal loss, reduction in tyrosine hydroxylase expression, and increase in oxidative stress were unaffected. |
2018-07-25 |
2023-08-13 |
rat |
| Hideo Hoshi, Fumi Sat. The morphological characterization of orientation-biased displaced large-field ganglion cells in the central part of goldfish retina. The Journal of comparative neurology. vol 526. issue 2. 2018-07-16. PMID:28921532. |
we further illustrated that the processes of dopaminergic neurons often terminated next to intersections between processes of ganglion cells, close to where dopamine d1 receptors were localized. |
2018-07-16 |
2023-08-13 |
Not clear |
| Kumaresan Jayaraman, Alex N Morley, Daniel Szöllősi, Tsjerk A Wassenaar, Harald H Sitte, Thomas Stockne. Dopamine transporter oligomerization involves the scaffold domain, but spares the bundle domain. PLoS computational biology. vol 14. issue 6. 2018-07-13. PMID:29874235. |
the human dopamine transporter (hdat) is located on presynaptic neurons, where it plays an essential role in limiting dopaminergic signaling by temporarily curtailing high neurotransmitter concentration through rapid re-uptake. |
2018-07-13 |
2023-08-13 |
human |
| Xueting Li, Jia Yu, Yanping Wu, Baixiang L. Effect on the dopaminergic metabolism induced by oral exposure to simazine during the prepubertal period in rats. International journal of molecular medicine. vol 41. issue 1. 2018-07-09. PMID:29115391. |
studies have shown that simazine inhibits the proliferation of dopaminergic cells and affects the developmental differentiation of dopamine neurons. |
2018-07-09 |
2023-08-13 |
rat |
| A A Kolacheva, M V Ugrumo. Dopamine Synthesis as a Mechanism of Brain Plasticity in Nigrostriatal System Pathology. Doklady. Biochemistry and biophysics. vol 479. issue 1. 2018-07-05. PMID:29779103. |
using an experimental parkinson's disease model (symptoms develop in mice after the injection of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine), we studied the characteristics of the synthesis of dopamine as a possible compensatory mechanism aimed at maintaining the dopamine level in the dopaminergic neurons that survived in this pathology. |
2018-07-05 |
2023-08-13 |
mouse |
| Luuk van der Velden, Martin Vinck, Taco R Werkman, Wytse J Wadma. Tuning of Neuronal Interactions in the Lateral Ventral Tegmental Area by Dopamine Sensitivity. Neuroscience. vol 366. 2018-06-29. PMID:29037597. |
the ventral tegmental area (vta) contains a considerable population of rhythmically firing dopaminergic neurons, which are influenced by auto-inhibition due to extra-synaptic dopamine release resulting in volume transmission. |
2018-06-29 |
2023-08-13 |
rat |