| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Christopher J Fitzpatrick, Lakshmikripa Jagannathan, Elijah D Lowenstein, Terry E Robinson, Jill B Becker, Jonathan D Morro. Single prolonged stress decreases sign-tracking and cue-induced reinstatement of cocaine-seeking. Behavioural brain research. vol 359. 2019-04-03. PMID:30077578. |
because dopaminergic activity in the nucleus accumbens is known to play a central role in many cue-directed behaviors, including both sign-tracking and cue-induced reinstatement, experiment 3 used in vivo microdialysis to measure the effect of sps on baseline and evoked dopamine levels in the nucleus accumbens. |
2019-04-03 |
2023-08-13 |
human |
| Ming-Chung Chou, Ping-Hong Lai, Jie-Yuan L. Early white matter injuries associated with dopamine transporter dysfunction in patients with acute CO intoxication: A diffusion kurtosis imaging and Tc-99m TRODAT-1 SPECT study. European radiology. vol 29. issue 3. 2019-04-03. PMID:30143836. |
we aimed to investigate the relationship between wm injuries of dopaminergic pathways and dopamine transporter dysfunctions of the striatum in patients with acute co intoxication using both diffusion kurtosis imaging (dki) and single photon-emission computed tomography (spect). |
2019-04-03 |
2023-08-13 |
Not clear |
| A M da Rocha, L W Kist, E A Almeida, D G H Silva, C D Bonan, S Altenhofen, C G Kaufmann, M R Bogo, D M Barros, S Oliveira, V Geraldo, R G Lacerda, A S Ferlauto, Luiz Orlando Ladeira, J M Monserra. Neurotoxicity in zebrafish exposed to carbon nanotubes: Effects on neurotransmitters levels and antioxidant system. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. vol 218. 2019-04-01. PMID:30543862. |
cholinergic, serotonergic, and dopaminergic systems, through ache activity and serotonin and dopamine levels, respectively were affected by swcnt in the zebrafish brain. |
2019-04-01 |
2023-08-13 |
zebrafish |
| Rajib Paul, Ankumoni Dutta, Banashree Chetia Phukan, Muhammed Khairujjaman Mazumder, Arokiasamy Justin-Thenmozhi, Thamilarasan Manivasagam, Pallab Bhattacharya, Anupom Bora. Accumulation of Cholesterol and Homocysteine in the Nigrostriatal Pathway of Brain Contributes to the Dopaminergic Neurodegeneration in Mice. Neuroscience. vol 388. 2019-03-29. PMID:30075243. |
the animals were subjected to parkinsonian motor behavioral tests and sacrificed to estimate the levels of cholesterol, homocysteine and dopamine in brain, and to assess dopaminergic neuronal status. |
2019-03-29 |
2023-08-13 |
mouse |
| Katarzyna Kuter, Manuela Kratochwil, Klemencja Berghauzen-Maciejewska, Urszula Głowacka, Michiru D Sugawa, Krystyna Ossowska, Norbert A Denche. Adaptation within mitochondrial oxidative phosphorylation supercomplexes and membrane viscosity during degeneration of dopaminergic neurons in an animal model of early Parkinson's disease. Biochimica et biophysica acta. vol 1862. issue 4. 2019-03-28. PMID:26844379. |
we observed loss of dopaminergic phenotype in sn and decreased dopamine level in striatum (str) before actual death of neurons in sn. |
2019-03-28 |
2023-08-13 |
rat |
| S Sandoval-Avila, N F Diaz, U Gómez-Pinedo, A A Canales-Aguirre, Y K Gutiérrez-Mercado, E Padilla-Camberos, A L Marquez-Aguirre, N E Díaz-Martíne. Neuroprotective effects of phytochemicals on dopaminergic neuron cultures. Neurologia (Barcelona, Spain). vol 34. issue 2. 2019-03-28. PMID:27342389. |
parkinson's disease is a progressive neurodegenerative disorder characterised by a loss of dopaminergic neurons in the substantia nigra pars compacta, which results in a significant decrease in dopamine levels and consequent functional motor impairment. |
2019-03-28 |
2023-08-13 |
Not clear |
| Xiaoqing Peng, Lisa A Brenner, Ashwin J Mathai, Thomas B Cook, Dietmar Fuchs, Nadine Postolache, Maureen W Groer, Janardan P Pandey, Farooq Mohyuddin, Ina Giegling, Abhishek Wadhawan, Annette M Hartmann, Bettina Konte, Lena Brundin, Marion Friedl, John W Stiller, Christopher A Lowry, Dan Rujescu, Teodor T Postolach. Moderation of the relationship between Toxoplasma gondii seropositivity and trait impulsivity in younger men by the phenylalanine-tyrosine ratio. Psychiatry research. vol 270. 2019-03-26. PMID:30057257. |
as dopaminergic and serotonergic signaling regulate impulsivity, and as t. gondii directly and indirectly affects dopaminergic signaling and induces activation of the kynurenine pathway leading to the diversion of tryptophan from serotonin production, we investigated if dopamine and serotonin precursors or the tryptophan metabolite kynurenine interact with the t. gondii-impulsivity association. |
2019-03-26 |
2023-08-13 |
human |
| José Luis Pérez-López, Rubén Contreras-López, Josué O Ramírez-Jarquín, Fatuel Tecuapetl. Direct Glutamatergic Signaling From Midbrain Dopaminergic Neurons Onto Pyramidal Prefrontal Cortex Neurons. Frontiers in neural circuits. vol 12. 2019-03-25. PMID:30210308. |
the dopaminergic neurons of the ventral tegmental area (vta) have been identified with the ability to co-release dopamine and glutamate. |
2019-03-25 |
2023-08-13 |
Not clear |
| Andreia Moreira da Silva Santos, John P Kelly, Peter Dockery, Karen M Doyl. Effect of a binge-like dosing regimen of methamphetamine on dopamine levels and tyrosine hydroxylase expressing neurons in the rat brain. Progress in neuro-psychopharmacology & biological psychiatry. vol 89. 2019-03-25. PMID:30296469. |
this study examined the effect of binge-like methamphetamine (ma) dosing (4 × 4 mg/kg, s.c., 2 h apart) on regional dopamine and dopaminergic metabolite levels in rat brain at a range of early time points after final dose (2-48 h). |
2019-03-25 |
2023-08-13 |
rat |
| Kathrin Koblinger, Céline Jean-Xavier, Sandeep Sharma, Tamás Füzesi, Leanne Young, Shane E A Eaton, Charlie Hong Ting Kwok, Jaideep Singh Bains, Patrick J Whela. Optogenetic Activation of A11 Region Increases Motor Activity. Frontiers in neural circuits. vol 12. 2019-03-25. PMID:30364230. |
we find that in addition to dopaminergic neurons within the a11 region, there is another neuronal subtype which expresses the monoenzymatic aromatic l-amino acid decarboxylase (aadc), but not th, a key enzyme involved in the synthesis of catecholamines including dopamine. |
2019-03-25 |
2023-08-13 |
mouse |
| Ina Skyt, Kurosh Moslemi, Cathrine Baastrup, Kasper Grosen, Fabrizio Benedetti, Gitte L Petersen, Donald D Price, Kathryn T Hall, Ted J Kaptchuk, Peter Svensson, Troels S Jensen, Lene Vas. Dopaminergic tone does not influence pain levels during placebo interventions in patients with chronic neuropathic pain. Pain. vol 159. issue 2. 2019-03-21. PMID:29068872. |
patients with neuropathic pain are highly motivated for pain relief, and as motivational factors such as expectations of reward, as well as pain processing in itself, are related to the dopaminergic system, it can be speculated that dopamine release contributes to placebo effects in neuropathic pain. |
2019-03-21 |
2023-08-13 |
Not clear |
| Yongchul Jang, Insu Kwon, Wankeun Song, Ludmila M Cosio-Lima, Youngil Le. Endurance Exercise Mediates Neuroprotection Against MPTP-mediated Parkinson's Disease via Enhanced Neurogenesis, Antioxidant Capacity, and Autophagy. Neuroscience. vol 379. 2019-03-18. PMID:29559387. |
our biochemical data showed that ee-induced neuroprotection occurs in combination with multiple synergic neuroprotective pathways: (1) increased neurogenesis shown by an increase in brdu-positive neurons; (2) diminished loss of dopaminergic neurons evidenced by upregulated tyrosine hydroxylase (th) and dopamine transporter (dat) levels; (3) increased antioxidant capacity (e.g., cuznsod, catalase, gpx1/2, ho-1, dj1 and prxiii); and (4) enhanced autophagy (lc3 ii, p62, beclin1, bnip3, lamp2, cathepsin l and tfeb). |
2019-03-18 |
2023-08-13 |
mouse |
| Jiayi Shou, Angelica Tran, Natasha Snyder, Eric Bleem, Seonil Ki. Distinct Roles of GluA2-lacking AMPA Receptor Expression in Dopamine D1 or D2 Receptor Neurons in Animal Behavior. Neuroscience. vol 398. 2019-03-18. PMID:30537522. |
in the dopaminergic circuits, there are two classes of neurons that can be differentiated by their expression of dopamine receptors, d1 or d2 receptors (d1rs or d2rs). |
2019-03-18 |
2023-08-13 |
Not clear |
| Woong-Woo Lee, Beomseok Jeon, Ryul Ki. Expanding the Spectrum of Dopa-Responsive Dystonia (DRD) and Proposal for New Definition: DRD, DRD-plus, and DRD Look-alike. Journal of Korean medical science. vol 33. issue 28. 2019-03-15. PMID:29983692. |
however, there have been many reports of dystonia responsive to dopaminergic drugs that do not fit into drd or drd-plus (genetic defects in the dopamine synthetic pathway without nigral cell loss). |
2019-03-15 |
2023-08-13 |
Not clear |
| Woong-Woo Lee, Beomseok Jeon, Ryul Ki. Expanding the Spectrum of Dopa-Responsive Dystonia (DRD) and Proposal for New Definition: DRD, DRD-plus, and DRD Look-alike. Journal of Korean medical science. vol 33. issue 28. 2019-03-15. PMID:29983692. |
examples of dystonia that is responsive to dopaminergic drugs include the following: transportopathies (dopamine transporter deficiency; vesicular monoamine transporter 2 deficiency); |
2019-03-15 |
2023-08-13 |
Not clear |
| Tanara V Peres, Leticia P Arantes, Mahfuzur R Miah, Julia Bornhorst, Tanja Schwerdtle, Aaron B Bowman, Rodrigo B Leal, Michael Aschne. Role of Caenorhabditis elegans AKT-1/2 and SGK-1 in Manganese Toxicity. Neurotoxicity research. vol 34. issue 3. 2019-03-14. PMID:29882004. |
dopaminergic function was evaluated with the basal slowing response behavioral test and dopaminergic neuron integrity was evaluated using worms expressing green fluorescent protein (gfp) under the dopamine transporter (dat-1) promoter. |
2019-03-14 |
2023-08-13 |
caenorhabditis_elegans |
| Hwei-Hsien Chen, Pei-Chi Chang, Shiaw-Pyng Wey, Pei-Mei Chen, Chinpiao Chen, Ming-Huan Cha. Therapeutic effects of honokiol on motor impairment in hemiparkinsonian mice are associated with reversing neurodegeneration and targeting PPARγ regulation. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 108. 2019-03-14. PMID:30223096. |
recovery of motor function was correlated with reversal of nigrostriatal dopaminergic neuronal loss, accompanied by higher tyrosine hydroxylase (th) density, dopamine transporter (dat) expression and vesicular monoamine transporter-2 (vmat2) levels. |
2019-03-14 |
2023-08-13 |
mouse |
| Ning Song, Junxia Xi. Iron, Dopamine, and α-Synuclein Interactions in at-Risk Dopaminergic Neurons in Parkinson's Disease. Neuroscience bulletin. vol 34. issue 2. 2019-03-13. PMID:29380248. |
iron, dopamine, and α-synuclein interactions in at-risk dopaminergic neurons in parkinson's disease. |
2019-03-13 |
2023-08-13 |
Not clear |
| Sanders A McDougall, Matthew G Apodaca, Alena Mohd-Yusof, Adrian D Mendez, Caitlin G Katz, Angie Teran, Israel Garcia-Carachure, Anthony T Quiroz, Cynthia A Crawfor. Ontogeny of cocaine-induced behaviors and cocaine pharmacokinetics in male and female neonatal, preweanling, and adult rats. Psychopharmacology. vol 235. issue 7. 2019-03-13. PMID:29671013. |
ontogenetic differences in the behavioral responsiveness to cocaine have often been attributed to the maturation of dopaminergic elements (e.g., dopamine transporters, d2 |
2019-03-13 |
2023-08-13 |
rat |
| M A van der Kooij, F Hollis, L Lozano, I Zalachoras, S Abad, O Zanoletti, J Grosse, I Guillot de Suduiraut, C Canto, C Sand. Diazepam actions in the VTA enhance social dominance and mitochondrial function in the nucleus accumbens by activation of dopamine D1 receptors. Molecular psychiatry. vol 23. issue 3. 2019-03-12. PMID:28727688. |
our data support the view that diazepam disinhibits vta dopaminergic neurons, leading to the release of dopamine into the nac where activation of d1-signaling transiently facilitates mitochondrial function, that is, increased respiration and enhanced atp levels, which ultimately enhances social competitive behavior. |
2019-03-12 |
2023-08-13 |
rat |