| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mani Sugumar, Murugan Sevanan, Sathiya Seka. Neuroprotective effect of naringenin against MPTP-induced oxidative stress. The International journal of neuroscience. vol 129. issue 6. 2019-08-12. PMID:30433834. |
parkinson's disease is the most common neurodegenerative disorder, characterized by loss of dopaminergic neurons in substantia nigra and depletion of dopamine in striatum due to excitotoxicity, oxidative stress and many other factors may contribute to mptp- and pd-related neurodegeneration. |
2019-08-12 |
2023-08-13 |
mouse |
| Yuji K Takahashi, Thomas A Stalnaker, Yasmin Marrero-Garcia, Ray M Rada, Geoffrey Schoenbau. Expectancy-Related Changes in Dopaminergic Error Signals Are Impaired by Cocaine Self-Administration. Neuron. vol 101. issue 2. 2019-08-12. PMID:30653935. |
these areas provide critical input to midbrain dopamine neurons regarding expected outcomes, suggesting that effects on learning may result from changes in dopaminergic error signaling. |
2019-08-12 |
2023-08-13 |
rat |
| Takaya Ogasawara, Masafumi Nejime, Masahiko Takada, Masayuki Matsumot. Primate Nigrostriatal Dopamine System Regulates Saccadic Response Inhibition. Neuron. vol 100. issue 6. 2019-08-08. PMID:30415993. |
although this ability, called response inhibition, is impaired in neurological/psychiatric disorders with dopaminergic dysfunctions, how dopamine regulates response inhibition remains unclear. |
2019-08-08 |
2023-08-13 |
monkey |
| Takaya Ogasawara, Masafumi Nejime, Masahiko Takada, Masayuki Matsumot. Primate Nigrostriatal Dopamine System Regulates Saccadic Response Inhibition. Neuron. vol 100. issue 6. 2019-08-08. PMID:30415993. |
subsets of dopamine neurons in the substantia nigra and striatal neurons receiving the dopaminergic input were activated when the monkey was required to cancel a planned saccadic eye movement. |
2019-08-08 |
2023-08-13 |
monkey |
| Ryuhei Araki, Kazuko Hayashi, Teiji Saw. Dopamine D2-receptor Antagonist Droperidol Deepens Sevoflurane Anesthesia. Anesthesiology. vol 128. issue 4. 2019-08-06. PMID:29251645. |
although midbrain dopaminergic pathways are known to contribute to arousal and emergence from anesthesia, few reports exist regarding the anesthetic effects of dopamine d2 receptor antagonism in humans. |
2019-08-06 |
2023-08-13 |
Not clear |
| Bolton K H Chau, Huw Jarvis, Chun-Kit Law, Trevor T-J Chon. Dopamine and reward: a view from the prefrontal cortex. Behavioural pharmacology. vol 29. issue 7. 2019-08-02. PMID:30188354. |
these regions receive projections from midbrain dopamine (da) neurons and, in turn, project to other key dopaminergic regions such as the striatum. |
2019-08-02 |
2023-08-13 |
Not clear |
| M Skirzewski, I Karavanova, A Shamir, L Erben, J Garcia-Olivares, J H Shin, D Vullhorst, V A Alvarez, S G Amara, A Buonann. ErbB4 signaling in dopaminergic axonal projections increases extracellular dopamine levels and regulates spatial/working memory behaviors. Molecular psychiatry. vol 23. issue 11. 2019-07-31. PMID:28727685. |
erbb4 signaling in dopaminergic axonal projections increases extracellular dopamine levels and regulates spatial/working memory behaviors. |
2019-07-31 |
2023-08-13 |
mouse |
| Natasha L Mason, Eef L Theunissen, Nadia R P W Hutten, Desmond H Y Tse, Stefan W Toennes, Peter Stiers, Johannes G Ramaeker. Cannabis induced increase in striatal glutamate associated with loss of functional corticostriatal connectivity. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 29. issue 2. 2019-07-30. PMID:30553697. |
rodent studies suggest that Δ9-tetrahydrocannabinol (thc) activates dopaminergic neurons in the limbic system, subsequently enhancing dopamine, which is implicated in the rewarding effects of cannabis. |
2019-07-30 |
2023-08-13 |
Not clear |
| Teodora Djikic, Yasmina Martí, Francesca Spyrakis, Thorsten Lau, Paolo Benedetti, Gavin Davey, Patrick Schloss, Kemal Yelekc. Human dopamine transporter: the first implementation of a combined in silico/in vitro approach revealing the substrate and inhibitor specificities. Journal of biomolecular structure & dynamics. vol 37. issue 2. 2019-07-29. PMID:29334320. |
new drugs targeting the dopaminergic neurons by specific uptake through the human dopamine transporter (hdat) could represent a viable strategy for establishing selective neuroprotection. |
2019-07-29 |
2023-08-13 |
human |
| Teodora Djikic, Yasmina Martí, Francesca Spyrakis, Thorsten Lau, Paolo Benedetti, Gavin Davey, Patrick Schloss, Kemal Yelekc. Human dopamine transporter: the first implementation of a combined in silico/in vitro approach revealing the substrate and inhibitor specificities. Journal of biomolecular structure & dynamics. vol 37. issue 2. 2019-07-29. PMID:29334320. |
molecules able to increase the bioactive amount of extracellular dopamine, thereby enhancing and compensating a loss of dopaminergic neurotransmission, and to exert neuroprotective response because of their accumulation in the cytoplasm, are required. |
2019-07-29 |
2023-08-13 |
human |
| Edward D Levin, Amir H Rezvani, Corinne Wells, Susan Slade, Venkata M Yenugonda, Yong Liu, Milton L Brown, Yingxian Xiao, Kenneth J Kella. α4β2 Nicotinic receptor desensitizing compounds can decrease self-administration of cocaine and methamphetamine in rats. European journal of pharmacology. vol 845. 2019-07-29. PMID:30529197. |
nicotinic receptors on the dopaminergic neurons in the ventral tegmental area play an important role in controlling the activity of these neurons and release of dopamine in the nucleus accumbens, which is critical mechanism for reinforcing value of drugs of abuse. |
2019-07-29 |
2023-08-13 |
rat |
| Michael P Saddoris, Kayla A Siletti, Katherine J Stansfield, Maria Florencia Bercu. Heterogeneous dopamine signals support distinct features of motivated actions: implications for learning and addiction. Learning & memory (Cold Spring Harbor, N.Y.). vol 25. issue 9. 2019-07-26. PMID:30115763. |
we propose that these spatiotemporally parallel dopaminergic signals are simultaneously available to the animal, but that these circuits are impaired following prolonged drug experience by disrupting the location and content of dopamine signals in afferent target regions. |
2019-07-26 |
2023-08-13 |
Not clear |
| Daniela Mercatelli, Clarissa Anna Pisanò, Salvatore Novello, Michele Morar. NOP Receptor Ligands and Parkinson's Disease. Handbook of experimental pharmacology. vol 254. 2019-07-26. PMID:30689087. |
endogenous n/ofq negatively regulates motor behavior and dopamine transmission through nop receptors expressed by dopaminergic neurons of the substantia nigra compacta. |
2019-07-26 |
2023-08-13 |
human |
| Daniela Mercatelli, Clarissa Anna Pisanò, Salvatore Novello, Michele Morar. NOP Receptor Ligands and Parkinson's Disease. Handbook of experimental pharmacology. vol 254. 2019-07-26. PMID:30689087. |
consistent with the existence of an n/ofq tone over dopaminergic transmission, blockade of nop receptor antagonists increases striatal dopamine release. |
2019-07-26 |
2023-08-13 |
human |
| G Gervasini, L M Gonzalez, S Mota-Zamorano, C Gamero-Villarroel, J A Carrillo, I Flores, A Garcia-Herrai. Association of COMT Val158Met Polymorphism with Psychopathological Symptoms in Patients with Eating Disorders. Current molecular medicine. vol 18. issue 1. 2019-07-25. PMID:29879886. |
dopamine physiological functions make dopaminergic genes suitable candidates for association studies in eating disorders (ed). |
2019-07-25 |
2023-08-13 |
Not clear |
| Andrea L Rosso, Nicolaas I Bohnen, Lenore J Launer, Howard J Aizenstein, Kristine Yaffe, Caterina Rosan. Vascular and dopaminergic contributors to mild parkinsonian signs in older adults. Neurology. vol 90. issue 3. 2019-07-22. PMID:29247072. |
mild parkinsonian signs (mps) are an underappreciated neurologic condition in older adults; we assessed associations of mps with measures of dopaminergic (catechol-o-methyltransferase [comt] genotype, an indicator of synaptic dopamine levels) and vascular (white matter hyperintensities [wmh], an indicator of cerebral small vessel disease) factors. |
2019-07-22 |
2023-08-13 |
Not clear |
| Jin Gyu Choi, Eugene Huh, In Gyoung Ju, Namkwon Kim, Jason Yun, Myung Sook O. 1-Methyl-4-phenyl-1,2,3,6 tetrahydropyridine/probenecid impairs intestinal motility and olfaction in the early stages of Parkinson's disease in mice. Journal of the neurological sciences. vol 392. 2019-07-18. PMID:30031172. |
we also found the reduction of dopaminergic neuronal cell numbers in the sn and striatal dopamine transporter levels starting from the asymptomatic stage. |
2019-07-18 |
2023-08-13 |
mouse |
| D Luke Fischer, Fredric P Manfredsson, Christopher J Kemp, Allyson Cole-Strauss, Jack W Lipton, Megan F Duffy, Nicole K Polinski, Kathy Steece-Collier, Timothy J Collier, Sara E Gombash, Daniel J Buhlinger, Caryl E Sortwel. Subthalamic Nucleus Deep Brain Stimulation Does Not Modify the Functional Deficits or Axonopathy Induced by Nigrostriatal α-Synuclein Overexpression. Scientific reports. vol 7. issue 1. 2019-07-12. PMID:29180681. |
a low titer of raav2/5 α-syn results in progressive forelimb asymmetry, loss of striatal dopaminergic terminal density and modest loss of snpc dopamine neurons after eight weeks, corresponding to robust human-snca expression and no effect on rat-snca, th, bdnf or trk2. |
2019-07-12 |
2023-08-13 |
human |
| Ricardo Titze-de-Almeida, Simoneide Souza Titze-de-Almeid. miR-7 Replacement Therapy in Parkinson's Disease. Current gene therapy. vol 18. issue 3. 2019-07-12. PMID:29714132. |
depletion of mir-7 in the substantia nigra of clinical samples is related to α-syn accumulation, loss of dopaminergic cells, and reduction of dopamine in the striatum. |
2019-07-12 |
2023-08-13 |
Not clear |
| Kyoko Mashima, Shinichi Takahashi, Kazushi Minami, Yoshikane Izawa, Takato Abe, Naoki Tsukada, Takako Hishiki, Makoto Suematsu, Mayumi Kajimura, Norihiro Suzuk. Neuroprotective Role of Astroglia in Parkinson Disease by Reducing Oxidative Stress Through Dopamine-Induced Activation of Pentose-Phosphate Pathway. ASN neuro. vol 10. 2019-07-11. PMID:29768946. |
although released dopamine at the synaptic terminal is mostly reabsorbed by dopaminergic neurons, some dopamine is presumably taken up by astroglia. |
2019-07-11 |
2023-08-13 |
mouse |