| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Michele Polett. The dark side of dopaminergic therapies in Parkinson's disease: shedding light on aberrant salience. CNS spectrums. vol 23. issue 6. 2019-10-01. PMID:28264738. |
psychotic subjects and patients with parkinson's disease (pd) "on" dopaminergic drugs, especially on dopamine agonists, present a hyperdopaminergic state that interferes with learning processing. |
2019-10-01 |
2023-08-13 |
human |
| Michele Polett. The dark side of dopaminergic therapies in Parkinson's disease: shedding light on aberrant salience. CNS spectrums. vol 23. issue 6. 2019-10-01. PMID:28264738. |
herein is discussed the speculative hypothesis that the hyperdopaminergic state induced by dopaminergic treatments, especially with dopamine agonists, may also facilitate the attribution of salience to neutral stimuli in pd patients, altering the physiological attribution of salience. |
2019-10-01 |
2023-08-13 |
human |
| Chao Wang, Bing Liu, Xiaolong Zhang, Yue Cui, Chunshui Yu, Tianzi Jian. Multilocus genetic profile in dopaminergic pathway modulates the striatum and working memory. Scientific reports. vol 8. issue 1. 2019-09-30. PMID:29599495. |
our findings may shed light on the biological mechanism underlying the "dopamine hypothesis" of schizophrenia and provide some implications regarding the polygenic effects on the dopaminergic activity in the risk for schizophrenia. |
2019-09-30 |
2023-08-13 |
human |
| PeiPei Chau, Helga H Lidö, Bo Söderpalm, Mia Ericso. Acamprosate's ethanol intake-reducing effect is associated with its ability to increase dopamine. Pharmacology, biochemistry, and behavior. vol 175. 2019-09-30. PMID:30266455. |
here we wanted to explore the interaction of ethanol and acamprosate on nac dopamine and investigate whether dopaminergic transmission may be related to the ethanol intake-reducing effects. |
2019-09-30 |
2023-08-13 |
rat |
| Yuan-Hao Chen, Tung-Tai Kuo, Jen-Hsin Kao, Eagle Yi-Kung Huang, Tsung-Hsun Hsieh, Yu-Ching Chou, Barry J Hoffe. Exercise Ameliorates Motor Deficits and Improves Dopaminergic Functions in the Rat Hemi-Parkinson's Model. Scientific reports. vol 8. issue 1. 2019-09-27. PMID:29507426. |
to determine the influences of exercise on motor deficits and dopaminergic transmission in a hemiparkinson animal model, we measured the effects of exercise on the ambulatory system by estimating spatio-temporal parameters during walking, striatal dopamine (da) release and reuptake and synaptic plasticity in the corticostriatal pathway after unilateral 6-ohda lesions. |
2019-09-27 |
2023-08-13 |
rat |
| Tiago V Maia, Vasco A Conceiçã. Dopaminergic Disturbances in Tourette Syndrome: An Integrative Account. Biological psychiatry. vol 84. issue 5. 2019-09-27. PMID:29656800. |
existing hypotheses suggest that ts involves 1) supersensitive dopamine receptors, 2) overactive dopamine transporters that cause low tonic but high phasic dopamine, 3) presynaptic dysfunction in dopamine neurons, or 4) dopaminergic hyperinnervation. |
2019-09-27 |
2023-08-13 |
Not clear |
| Tiago V Maia, Vasco A Conceiçã. Dopaminergic Disturbances in Tourette Syndrome: An Integrative Account. Biological psychiatry. vol 84. issue 5. 2019-09-27. PMID:29656800. |
dopaminergic hyperinnervation likely causes increased tonic and phasic dopamine. |
2019-09-27 |
2023-08-13 |
Not clear |
| Tiago V Maia, Vasco A Conceiçã. Dopaminergic Disturbances in Tourette Syndrome: An Integrative Account. Biological psychiatry. vol 84. issue 5. 2019-09-27. PMID:29656800. |
there is therefore a plausible mechanistic link between dopaminergic hyperinnervation and ts via increased tonic and phasic dopamine. |
2019-09-27 |
2023-08-13 |
Not clear |
| Christian Panitz, Matthias F J Sperl, Juergen Hennig, Tim Klucken, Christiane Hermann, Erik M Muelle. Fearfulness, neuroticism/anxiety, and COMT Val158Met in long-term fear conditioning and extinction. Neurobiology of learning and memory. vol 155. 2019-09-26. PMID:29883709. |
as previous research suggests a prominent role of dopamine for the retention of conditioned and extinguished fear, dopaminergic gene polymorphisms may also relate to individual differences in fear stability. |
2019-09-26 |
2023-08-13 |
human |
| LuLu Bai, Qianghu Tang, Zhen Zou, Pan Meng, Baijie Tu, Yinyin Xia, Shuqun Cheng, Lina Zhang, Kai Yang, Shaoyu Mu, Xuefeng Wang, Xia Qin, Bo Lv, Xianqing Cao, Qizhong Qin, Xuejun Jiang, Chengzhi Che. m6A Demethylase FTO Regulates Dopaminergic Neurotransmission Deficits Caused by Arsenite. Toxicological sciences : an official journal of the Society of Toxicology. vol 165. issue 2. 2019-09-25. PMID:29982692. |
we also were the first to reveal that the reduction in dopamine content induced by arsenite mainly resulted from deficits in dopaminergic neurotransmission in the synaptic cleft. |
2019-09-25 |
2023-08-13 |
mouse |
| Do-Young Kwon, Yuri Kwon, Ji-Won Ki. Quantitative analysis of finger and forearm movements in patients with off state early stage Parkinson's disease and scans without evidence of dopaminergic deficit (SWEDD). Parkinsonism & related disorders. vol 57. 2019-09-16. PMID:30072245. |
scans without evidence of dopaminergic deficit (swedd) is a radiological nomenclature which refers to patients with a normal dopamine transporter scan presumed to have parkinsonism. |
2019-09-16 |
2023-08-13 |
Not clear |
| Jonathan P Wiso. Dopamine and Wakefulness: Pharmacology, Genetics, and Circuitry. Handbook of experimental pharmacology. vol 253. 2019-09-13. PMID:29616340. |
for some time, a relatively minor role in regulating sleep and wake states was ascribed to dopamine and the dopamine-producing cells of the ventral tegmental area, despite the fact that dopaminergic signaling is a major target, if not the primary target, for wake-promoting agents. |
2019-09-13 |
2023-08-13 |
human |
| Sunaina Sharma, Puneet Kumar, Rahul Deshmuk. Neuroprotective potential of spermidine against rotenone induced Parkinson's disease in rats. Neurochemistry international. vol 116. 2019-09-10. PMID:29501454. |
the neurochemical analysis revealed a significant decrease in serotonin, norepinephrine, dopamine and their metabolites accompanied by a significant loss of dopaminergic neurons in the snpc following rot injection. |
2019-09-10 |
2023-08-13 |
rat |
| Mohaddeseh Ebrahimi-Ghiri, Mohammad Nasehi, Mohammad-Reza Zarrindas. The modulatory role of accumbens and hippocampus D2 receptors in anxiety and memory. Naunyn-Schmiedeberg's archives of pharmacology. vol 391. issue 10. 2019-09-10. PMID:30003299. |
the present study investigated the role of dopamine d2 receptors (d2rs) of the dorsal hippocampus (dh) and the nucleus accumbens (nac) and the effect of their dopaminergic activities on anxiety-like behavior and aversive learning using a test-retest elevated plus-maze (epm) paradigm in male wistar rats. |
2019-09-10 |
2023-08-13 |
rat |
| Ebony T Gilbreath, Lakshmikripa Jaganathan, Madhan Subramanian, Priya Balasubramanian, Katrina D Linning, Sheba M J MohanKumar, Puliyur S MohanKuma. Chronic estrogen affects TIDA neurons through IL-1β and NO: effects of aging. The Journal of endocrinology. vol 240. issue 2. 2019-09-09. PMID:30400030. |
we hypothesized that chronic exposure to low levels of estradiol-17β (e2) can induce inflammatory and degenerative changes in the tuberoinfundibular dopaminergic (tida) system leading to reduced dopamine synthesis and hyperprolactinemia. |
2019-09-09 |
2023-08-13 |
mouse |
| Nicolas Arlicot, Johnny Vercouillie, Cécile Malherbe, Rudy Bidault, Valérie Gissot, Serge Maia, Laurent Barantin, Jean-Philippe Cottier, Jean-Bernard Deloye, Denis Guilloteau, Maria-Joao Ribeir. PET imaging of Dopamine Transporter with [18F]LBT-999: initial evaluation in healthy volunteers. The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of.... 2019-09-09. PMID:31496203. |
to evaluate in healthy human brain the distribution, uptake, and kinetics of [18f]lbt-999, a pet ligand targeting the dopamine transporter, to assess its ability to explore dopaminergic innervation, using a shorter protocol, more convenient for patients than currently with [123i]ioflupane. |
2019-09-09 |
2023-08-13 |
human |
| Salvatore Novello, Ludovico Arcuri, Sandra Dovero, Nathalie Dutheil, Derya R Shimshek, Erwan Bezard, Michele Morar. G2019S LRRK2 mutation facilitates α-synuclein neuropathology in aged mice. Neurobiology of disease. vol 120. 2019-09-06. PMID:30172844. |
motor behavior, transgene expression, α-syn and pser129 α-syn load, number of nigral dopamine neurons and density of striatal dopaminergic terminals were evaluated. |
2019-09-06 |
2023-08-13 |
mouse |
| Marcello D'Amelio, Laura Serra, Marco Bozzal. Ventral Tegmental Area in Prodromal Alzheimer's Disease: Bridging the Gap between Mice and Humans. Journal of Alzheimer's disease : JAD. vol 63. issue 1. 2019-08-26. PMID:29630556. |
dopaminergic signals are required for encoding hippocampal memory for new events and the ventral tegmental area (vta), together with the locus coeruleus, are the primary sources of dopamine acting on dopaminergic receptors in the hippocampus. |
2019-08-26 |
2023-08-13 |
mouse |
| Dennis Paliga, Fabian Raudzus, Stephen H Leppla, Rolf Heumann, Sebastian Neuman. Lethal Factor Domain-Mediated Delivery of Nurr1 Transcription Factor Enhances Tyrosine Hydroxylase Activity and Protects from Neurotoxin-Induced Degeneration of Dopaminergic Cells. Molecular neurobiology. vol 56. issue 5. 2019-08-13. PMID:30121937. |
addition of the nurr1 fusion protein to dopaminergic sh-sy5y cells generated a cleaved, cytosolic nurr1-containing fragment which was associated with increased levels of tyrosine hydroxylase, the rate-limiting enzyme in dopamine synthesis. |
2019-08-13 |
2023-08-13 |
mouse |
| C E Wiers, P C Towb, C A Hodgkinson, P-H Shen, C Freeman, G Miller, E Lindgren, E Shokri-Kojori, Ş B Demiral, S W Kim, D Tomasi, H Sun, G-J Wang, D Goldman, N D Volko. Association of genetic ancestry with striatal dopamine D2/D3 receptor availability. Molecular psychiatry. vol 23. issue 8. 2019-08-12. PMID:29112197. |
despite ethnic differences in allele frequencies of variants in dopaminergic genes associated with dopamine d2/d3 receptor availability (d2r), no study to date has investigated the relationship between genetic ancestry and striatal d2r. |
2019-08-12 |
2023-08-13 |
Not clear |