| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hui-Ju Huang, Yi-Ting Wang, Hui-Ching Lin, Yi-Hsuan Lee, Anya Maan-Yuh Li. Soluble Epoxide Hydrolase Inhibition Attenuates MPTP-Induced Neurotoxicity in the Nigrostriatal Dopaminergic System: Involvement of α-Synuclein Aggregation and ER Stress. Molecular neurobiology. vol 55. issue 1. 2019-05-08. PMID:28822080. |
compared with the mptp-treated wt mice, mptp-induced reductions in striatal dopamine content and nigral tyrosine hydroxylase level (th, a biomarker of dopaminergic neurons) were less significant in the treated seh mice. |
2019-05-08 |
2023-08-13 |
mouse |
| Andrea Varrone, Maria Teresa Pellecchi. SPECT Molecular Imaging in Familial Parkinson's Disease. International review of neurobiology. vol 142. 2019-05-08. PMID:30409254. |
dopamine transporter (dat) imaging with single-photon emission computed tomography (spect) is a diagnostic tool to study the integrity of the dopaminergic system in patients with parkinsonism and uncertain diagnosis. |
2019-05-08 |
2023-08-13 |
human |
| Tetsuya Maeda, Kazuhiro Iwaoka, Yasuo Terayam. Conceptual definition in the metamorphosing Parkinson's disease. Nihon rinsho. Japanese journal of clinical medicine. vol 75. issue 1. 2019-05-08. PMID:30566288. |
the discovery of lewy bodies in the substantia nigra and dopamine deficiency in the nigro- striatal dopaminergic system have confirmed the disease concept of parkinson's disease. |
2019-05-08 |
2023-08-13 |
Not clear |
| Kazushi Takahash. The therapy of the motor symptoms in the advanced stage of Parkinson's disease. Nihon rinsho. Japanese journal of clinical medicine. vol 75. issue 1. 2019-05-08. PMID:30566298. |
levodopa still remains the gold standard for the treatment of motor symptoms of pd in advanced stage, but dopamine agonists, monoamine oxidase b inhibitors and catechol-o-methyltransferase inhibitors have--also been developed to provide more continuous oral delivery of dopaminergic stimulation in order to prevent and improve levodopa-induced motor complications, including wearing off phenomenon and peak-dose dyskinesia. |
2019-05-08 |
2023-08-13 |
Not clear |
| Christopher T Smith, Linh C Dang, Leah L Burgess, Scott F Perkins, M Danica San Juan, Darcy K Smith, Ronald L Cowan, Nam T Le, Robert M Kessler, Gregory R Samanez-Larkin, David H Zal. Lack of consistent sex differences in D-amphetamine-induced dopamine release measured with [ Psychopharmacology. vol 236. issue 2. 2019-05-07. PMID:30350220. |
lack of consistent sex differences in d-amphetamine-induced dopamine release measured with [ sex differences in the dopaminergic response to psychostimulants could have implications for drug abuse risk and other psychopathology involving the dopamine system, but human data are limited and mixed. |
2019-05-07 |
2023-08-13 |
human |
| Mark Z Kos, Jubao Duan, Alan R Sanders, Lucy Blondell, Eugene I Drigalenko, Melanie A Carless, Pablo V Gejman, Harald H H Görin. Dopamine perturbation of gene co-expression networks reveals differential response in schizophrenia for translational machinery. Translational psychiatry. vol 8. issue 1. 2019-05-06. PMID:30546022. |
the dopaminergic hypothesis of schizophrenia (sz) postulates that positive symptoms of sz, in particular psychosis, are due to disturbed neurotransmission via the dopamine (da) receptor d2 (drd2). |
2019-05-06 |
2023-08-13 |
Not clear |
| Lisa Y So, Stephanie J Munger, Julie E Mille. Social context-dependent singing alters molecular markers of dopaminergic and glutamatergic signaling in finch basal ganglia Area X. Behavioural brain research. vol 360. 2019-05-02. PMID:30521933. |
social context-dependent singing alters molecular markers of dopaminergic and glutamatergic signaling in finch basal ganglia area x. dopamine (da) is an important neuromodulator of motor control across species. |
2019-05-02 |
2023-08-13 |
Not clear |
| Somayeh Torabi Delshad, Siyavash Soltanian, Hassan Sharifiyazdi, Peter Bossie. Effect of catecholamine stress hormones (dopamine and norepinephrine) on growth, swimming motility, biofilm formation and virulence factors of Yersinia ruckeri in vitro and an in vivo evaluation in rainbow trout. Journal of fish diseases. vol 42. issue 4. 2019-05-02. PMID:30694560. |
indeed, the effects of catecholamines were inhibited by chlorpromazine (the dopaminergic receptor antagonist) for dopamine, labetalol (α-and β-adrenergic receptor antagonist) and phenoxybenzamine (the α-adrenergic receptor antagonist) for norepinephrine, but propranolol (the β-adrenergic receptor antagonist) showed no effect. |
2019-05-02 |
2023-08-13 |
Not clear |
| Hao Liu, Lin Zhong, Chunling Zhao, Xiaolei Tang, Jun Yang, Lei Gon. Quantitative analysis on secretion level of CDNF regulated by two key α-helices in CDNF protein. Cell biology international. vol 43. issue 2. 2019-04-30. PMID:30548741. |
cerebral dopamine neurotrophic factor (cdnf) has been considered as potent candidates for the therapy of parkinson's disease (pd) for which can promote the survival of midbrain dopaminergic neurons. |
2019-04-30 |
2023-08-13 |
Not clear |
| Roberto De Gregorio, Salvatore Pulcrano, Claudia De Sanctis, Floriana Volpicelli, Ezia Guatteo, Lars von Oerthel, Emanuele Claudio Latagliata, Roberta Esposito, Rosa Maria Piscitelli, Carla Perrone-Capano, Valerio Costa, Dario Greco, Stefano Puglisi-Allegra, Marten P Smidt, Umberto di Porzio, Massimiliano Caiazzo, Nicola Biagio Mercuri, Meng Li, Gian Carlo Bellench. miR-34b/c Regulates Wnt1 and Enhances Mesencephalic Dopaminergic Neuron Differentiation. Stem cell reports. vol 10. issue 4. 2019-04-23. PMID:29526736. |
induced dopaminergic (ida) cells synthesize dopamine and show spontaneous electrical activity, reversibly blocked by tetrodotoxin, consistent with the electrophysiological properties featured by brain dopaminergic neurons. |
2019-04-23 |
2023-08-13 |
Not clear |
| Wendy K Adams, Anna M D'souza, Jacob L Sussman, Sukhbir Kaur, Timothy J Kieffer, Catharine A Winstanle. Enhanced amphetamine-induced motor impulsivity and mild attentional impairment in the leptin-deficient rat model of obesity. Physiology & behavior. vol 192. 2019-04-22. PMID:29601831. |
these data suggest that leptin deficiency enhances impulsive action under conditions of dopaminergic challenge, yet this seems independent of overt changes in the expression of post-synaptic markers of dopamine signalling in striatal regions. |
2019-04-22 |
2023-08-13 |
human |
| Yuan Fan, Yan Chen, Se Zhang, Mengbing Huang, Shengdong Wang, Ye Li, Jie Ba. Morphine reverses the effects of 1-methyl-4-phenylpyridinium in PC12 cells through activating PI3K/Akt. The International journal of neuroscience. vol 129. issue 1. 2019-04-22. PMID:29936883. |
it is caused by the degeneration of dopaminergic neurons and the dopamine (da) deletion in the substantia nigra pars compacta (snpc). |
2019-04-22 |
2023-08-13 |
Not clear |
| Liqin Jiang, Sen Zhang, Rongfang Chen, Li Ma, Xiaojun Wang, Yingying Wen, Jia Qu, Xiangtian Zho. Effects of the Tyrosinase-Dependent Dopaminergic System on Refractive Error Development in Guinea Pigs. Investigative ophthalmology & visual science. vol 59. issue 11. 2019-04-19. PMID:30372732. |
to determine if myopia in albino guinea pigs is linked to altered ocular dopamine (da) levels in both the retinal and uveal dopaminergic systems. |
2019-04-19 |
2023-08-13 |
Not clear |
| Ekaterina Zhurakovskaya, Juuso Leikas, Tiina Pirttimäki, Francesc Casas Mon, Mikko Gynther, Rubin Aliev, Tomi Rantamäki, Heikki Tanila, Markus M Forsberg, Olli Gröhn, Jaakko Paasonen, Aaro J Jalkane. Sleep-State Dependent Alterations in Brain Functional Connectivity under Urethane Anesthesia in a Rat Model of Early-Stage Parkinson's Disease. eNeuro. vol 6. issue 1. 2019-04-18. PMID:30838323. |
parkinson's disease (pd) is characterized by the gradual degeneration of dopaminergic neurons in the substantia nigra, leading to striatal dopamine depletion. |
2019-04-18 |
2023-08-13 |
rat |
| Linfang Chen, Liujun Xue, Jinlong Zheng, Xiangyang Tian, Yingdong Zhang, Qiang Ton. PPARß/δ agonist alleviates NLRP3 inflammasome-mediated neuroinflammation in the MPTP mouse model of Parkinson's disease. Behavioural brain research. vol 356. 2019-04-16. PMID:29885849. |
our results show that gw501516 reduced movement impairment in pd mice; furthermore, it attenuated dopaminergic neurodegeneration in the midbrain and the depletion of dopamine in the striatum and it inhibited inflammatory reactions and nlrp3 inflammasome activation in the midbrain of pd mice. |
2019-04-16 |
2023-08-13 |
mouse |
| I L Kovalenko, D A Smagin, A G Galyamina, Yu L Orlov, N N Kudryavtsev. [Changes in the Expression of Dopaminergic Genes in Brain Structures of Male Mice Exposed to Chronic Social Defeat Stress: An RNA-seq Study]. Molekuliarnaia biologiia. vol 50. issue 1. 2019-04-11. PMID:27028825. |
whole-transcriptome analysis (rna-seq) has been used to analyze changes in the expression of dopaminergic genes that encode proteins involved in the synthesis, inactivation, and neurotransmission of dopamine in the striatum, ventral tegmental area, raphe nuclei of the midbrain, hypothalamus, and hippocampus of male mice subjected to chronic social defeat. |
2019-04-11 |
2023-08-13 |
mouse |
| Edoardo R de Natale, Flavia Niccolini, Heather Wilson, Marios Politi. Molecular Imaging of the Dopaminergic System in Idiopathic Parkinson's Disease. International review of neurobiology. vol 141. 2019-04-11. PMID:30314595. |
several radiotracers have been developed targeting the synthesis and metabolism of dopamine and dopaminergic receptors to investigate the nigrostriatal pathway in vivo. |
2019-04-11 |
2023-08-13 |
Not clear |
| Phuong-Tram Nguyen, Eun-Joo Shin, Duy-Khanh Dang, Hai-Quyen Tran, Choon-Gon Jang, Ji Hoon Jeong, Yu Jeung Lee, Hyo Jong Lee, Yong Sup Lee, Kiyofumi Yamada, Toshitaka Nabeshima, Hyoung-Chun Ki. Role of dopamine D1 receptor in 3-fluoromethamphetamine-induced neurotoxicity in mice. Neurochemistry international. vol 113. 2019-04-10. PMID:29197543. |
moreover, 3-fma significantly produced dopaminergic impairments [i.e., increase in dopamine (da) turnover rate and decreases in da level, and in the expression of tyrosine hydroxylase (th), dopamine transporter (dat), and vesicular monoamine transporter 2 (vmat-2)] with behavioral impairments. |
2019-04-10 |
2023-08-13 |
mouse |
| Phuong-Tram Nguyen, Eun-Joo Shin, Duy-Khanh Dang, Hai-Quyen Tran, Choon-Gon Jang, Ji Hoon Jeong, Yu Jeung Lee, Hyo Jong Lee, Yong Sup Lee, Kiyofumi Yamada, Toshitaka Nabeshima, Hyoung-Chun Ki. Role of dopamine D1 receptor in 3-fluoromethamphetamine-induced neurotoxicity in mice. Neurochemistry international. vol 113. 2019-04-10. PMID:29197543. |
therefore, our results suggest that the activation of dopamine d1 receptor is critical to 3-fma-induced neurotoxicity, while both dopamine d1 and d2 receptors (dopamine d2 receptor > dopamine d1 receptor) mediate ma-induced dopaminergic neurotoxicity. |
2019-04-10 |
2023-08-13 |
mouse |
| Cristiano Chiamulera, Marzia di Chio, Laura Cavalleri, Marco Venniro, Laura Padovani, Ginetta Coll. Ketamine effects on mammalian target of rapamycin signaling in the mouse limbic system depend on functional dopamine D3 receptors. Neuroreport. vol 29. issue 8. 2019-04-08. PMID:29570499. |
recent in-vitro data on primary neuronal cultures showed that ketamine activates mtor also in dopaminergic neurons, and this activation depends on the presence of functional dopamine d3 receptors. |
2019-04-08 |
2023-08-13 |
mouse |