| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P Izurieta-Sánchez, S Sarre, G Ebinger, Y Michott. Muscarinic antagonists in substantia nigra influence the decarboxylation of L-dopa in striatum. European journal of pharmacology. vol 399. issue 2-3. 2000-09-22. PMID:10884514. |
this in vivo study demonstrates that anticholinergic drugs perfused at the level of the substantia nigra can modulate dopamine and gaba levels and attenuate the l-dopa decarboxylation in the striatum, possibly via modulation of the nigrostriatal dopaminergic system. |
2000-09-22 |
2023-08-12 |
rat |
| M Arvin, L Fedorkova, K A Disshon, D E Dluzen, R E Leipheime. Estrogen modulates responses of striatal dopamine neurons to MPP(+): evaluations using in vitro and in vivo techniques. Brain research. vol 872. issue 1-2. 2000-09-20. PMID:10924688. |
results of this study demonstrate that: (1) mpp(+) evokes striatal dopamine release and this effect is significantly reduced in the presence of estrogen as determined by both in vivo electrochemistry and in vitro superfusion: (2) similar, albeit attenuated effects are observed in the nucleus accumbens as determined with in vivo electrochemistry; (3) estrogen acts to inhibit the clearance of dopamine in both the striatum and nucleus accumbens; and (4) estrogen may function as a neuroprotectant by reducing the uptake of neurotoxin into dopaminergic neurons. |
2000-09-20 |
2023-08-12 |
rat |
| H Yu, H Matsubayashi, T Amano, J Cai, M Sas. Activation by nicotine of striatal neurons receiving excitatory input from the substantia nigra via dopamine release. Brain research. vol 872. issue 1-2. 2000-09-20. PMID:10924698. |
these findings suggested that nicotine enhances dopamine release from the sn-derived dopaminergic nerve terminals by activating the neurons via d2 receptors. |
2000-09-20 |
2023-08-12 |
rat |
| W R Wu, Z T Zhu, X Z Zh. Differential effects of L-deprenyl on MPP+- and MPTP-induced dopamine overflow in microdialysates of striatum and nucleus accumbens. Life sciences. vol 67. issue 3. 2000-09-19. PMID:10983868. |
the striatal dopamine efflux of rats was gradually restored by itself after the overflow caused by 2-h perfusion of the dopaminergic neurotoxins, while l-deprenyl could not accelerate the recovery. |
2000-09-19 |
2023-08-12 |
rat |
| C H Lammers, J Diaz, J C Schwartz, P Sokolof. Selective increase of dopamine D3 receptor gene expression as a common effect of chronic antidepressant treatments. Molecular psychiatry. vol 5. issue 4. 2000-09-14. PMID:10889548. |
here we examined the effects of chronic administration of antidepressants of several classes (amitriptyline, desipramine, imipramine, fluoxetine and tranylcypromine) and repeated electroconvulsive shock treatments (ect) on dopamine d3 receptor expression in the shell of the nucleus accumbens, a major projection area of the mesolimbic dopaminergic system. |
2000-09-14 |
2023-08-12 |
Not clear |
| E Tahir, Y Yazgan, B Cirakoglu, F Ozbay, I Waldman, P J Asherso. Association and linkage of DRD4 and DRD5 with attention deficit hyperactivity disorder (ADHD) in a sample of Turkish children. Molecular psychiatry. vol 5. issue 4. 2000-09-14. PMID:10889550. |
the search for genetic factors predisposing to attention deficit hyperactivity disorder (adhd) has focused on genes that regulate dopaminergic pathways such as dopamine receptors and enzymes that regulate levels of dopamine in the synapse. |
2000-09-14 |
2023-08-12 |
Not clear |
| R Kaiser, M Könneker, M Henneken, M Dettling, B Müller-Oerlinghausen, I Roots, J Brockmölle. Dopamine D4 receptor 48-bp repeat polymorphism: no association with response to antipsychotic treatment, but association with catatonic schizophrenia. Molecular psychiatry. vol 5. issue 4. 2000-09-14. PMID:10889553. |
the dopamine d4 receptor (drd4) may play a role in the pathogenesis of neuropsychiatric disease and in the action of dopaminergic drugs. |
2000-09-14 |
2023-08-12 |
human |
| S Callier, M Morissette, M Grandbois, T Di Paol. Stereospecific prevention by 17beta-estradiol of MPTP-induced dopamine depletion in mice. Synapse (New York, N.Y.). vol 37. issue 4. 2000-09-14. PMID:10891861. |
under the present paradigm in retired breeder male mice, our results show dopaminergic and stereospecificity of estradiol to augment dopamine levels in mptp-lesioned mice without protecting against the extensive loss of dopamine terminals and moderate cell body loss. |
2000-09-14 |
2023-08-12 |
mouse |
| A Mehta, K Thermos, M F Chessele. Increased behavioral response to dopaminergic stimulation of the subthalamic nucleus after nigrostriatal lesions. Synapse (New York, N.Y.). vol 37. issue 4. 2000-09-14. PMID:10891867. |
the increased behavioral response observed after unilateral dopamine denervation suggests that the subthalamic nucleus is tonically regulated by dopaminergic projections from the substantia nigra. |
2000-09-14 |
2023-08-12 |
rat |
| S Y Si. Dopamine agonists in the treatment of Parkinson s disease past, present and future. Current pharmaceutical design. vol 6. issue 12. 2000-09-14. PMID:10903391. |
the destruction of dopaminergic neurons with projections to the striatum results in the diminishing striatal dopamine levels. |
2000-09-14 |
2023-08-12 |
Not clear |
| F Grünhage, T G Schulze, D J Müller, M Lanczik, E Franzek, M Albus, M Borrmann-Hassenbach, M Knapp, S Cichon, W Maier, M Rietschel, P Propping, M M Nöthe. Systematic screening for DNA sequence variation in the coding region of the human dopamine transporter gene (DAT1). Molecular psychiatry. vol 5. issue 3. 2000-09-12. PMID:10889530. |
the dopamine transporter (dat) plays a central role in dopaminergic neurotransmission in the human brain. |
2000-09-12 |
2023-08-12 |
human |
| J Behr, T Gloveli, D Schmitz, U Heineman. Dopamine depresses excitatory synaptic transmission onto rat subicular neurons via presynaptic D1-like dopamine receptors. Journal of neurophysiology. vol 84. issue 1. 2000-09-07. PMID:10899189. |
the high clinical potency of antipsychotics that act as antagonists at dopamine (da) receptors indicate a hyperfunction of the dopaminergic system. |
2000-09-07 |
2023-08-12 |
rat |
| D W Smith, T Friedman. Characterization of the dopamine defect in primary cultures of dopaminergic neurons from hypoxanthine phosphoribosyltransferase knockout mice. Molecular therapy : the journal of the American Society of Gene Therapy. vol 1. issue 5 Pt 1. 2000-09-07. PMID:10933970. |
characterization of the dopamine defect in primary cultures of dopaminergic neurons from hypoxanthine phosphoribosyltransferase knockout mice. |
2000-09-07 |
2023-08-12 |
mouse |
| D W Smith, T Friedman. Characterization of the dopamine defect in primary cultures of dopaminergic neurons from hypoxanthine phosphoribosyltransferase knockout mice. Molecular therapy : the journal of the American Society of Gene Therapy. vol 1. issue 5 Pt 1. 2000-09-07. PMID:10933970. |
to facilitate the study of mechanism(s) by which hprt deficiency causes the dopamine defect, we have compared the survival and dopamine phenotype of primary cultures of dopamine neurons derived from hprt-deficient mice with the dopaminergic neurons from wild-type mice. |
2000-09-07 |
2023-08-12 |
mouse |
| D W Smith, T Friedman. Characterization of the dopamine defect in primary cultures of dopaminergic neurons from hypoxanthine phosphoribosyltransferase knockout mice. Molecular therapy : the journal of the American Society of Gene Therapy. vol 1. issue 5 Pt 1. 2000-09-07. PMID:10933970. |
the survival of dopaminergic neurons from both sources was promoted to an equal extent by glial cell line-derived neurotrophic factor (gdnf), a potent survival factor for dopamine neurons in vitro. |
2000-09-07 |
2023-08-12 |
mouse |
| J K Walker, R R Gainetdinov, A W Mangel, M G Caron, M A Shetzlin. Mice lacking the dopamine transporter display altered regulation of distal colonic motility. American journal of physiology. Gastrointestinal and liver physiology. vol 279. issue 2. 2000-09-05. PMID:10915639. |
the mechanisms by which dopamine (da) influences gastrointestinal (gi) tract motility are incompletely understood and complicated by tissue- and species-specific differences in dopaminergic function. |
2000-09-05 |
2023-08-12 |
mouse |
| I S Shim, J S Won, J K Lee, D K Song, S E Kim, S O Huh, Y H Kim, H W Su. Modulatory effect of ginseng total saponin on dopamine release and tyrosine hydroxylase gene expression induced by nicotine in the rat. Journal of ethnopharmacology. vol 70. issue 2. 2000-09-01. PMID:10771206. |
in an attempt to investigate whether the effect of gts is through its inhibitory action on the elevated dopaminergic transmission, we examined the effect of gts on nicotine-induced dopamine (da) release in the nucleus accumbens (na) of freely moving rats using in vivo microdialysis. |
2000-09-01 |
2023-08-12 |
rat |
| E Guatteo, F R Fusco, P Giacomini, G Bernardi, N B Mercur. The weaver mutation reverses the function of dopamine and GABA in mouse dopaminergic neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 16. 2000-08-31. PMID:10934250. |
the weaver mutation reverses the function of dopamine and gaba in mouse dopaminergic neurons. |
2000-08-31 |
2023-08-12 |
mouse |
| E Guatteo, F R Fusco, P Giacomini, G Bernardi, N B Mercur. The weaver mutation reverses the function of dopamine and GABA in mouse dopaminergic neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 16. 2000-08-31. PMID:10934250. |
in the present study, we characterized the intrinsic electrophysiological properties and the membrane currents activated by dopamine (da) d(2) and gaba(b) receptors in midbrain dopaminergic neurons, maintained in vitro in a slice preparation, from wild-type and homozygous weaver (wv/wv) mice. |
2000-08-31 |
2023-08-12 |
mouse |
| S D Glick, R E Haskew, I M Maisonneuve, J N Carlson, T P Jeruss. Enantioselective behavioral effects of sibutramine metabolites. European journal of pharmacology. vol 397. issue 1. 2000-08-29. PMID:10844103. |
locomotor activity (2.5-10 mg/kg, i. p., for all drugs), a dopamine dependent behavior, was also measured in view of some uncertainty regarding dopaminergic effects of sibutramine. |
2000-08-29 |
2023-08-12 |
rat |