| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T Baptista, A Lacruz, A Acosta, C Colasante, M de Quijada, S de Mendoza, J M Mendoza, L Hernánde. Naltrexone does not prevent the weight gain and hyperphagia induced by the antipsychotic drug sulpiride in rats. Appetite. vol 34. issue 1. 2000-06-27. PMID:10744894. |
most antipsychotic drugs block dopamine receptors, and both the brain dopaminergic and opioid systems appear to be involved in initiation and maintenance of feeding behavior, respectively. |
2000-06-27 |
2023-08-12 |
rat |
| M Fedrowitz, H Potschka, A Richter, W Lösche. A microdialysis study of striatal dopamine release in the circling rat, a genetic animal model with spontaneous lateralized rotational behavior. Neuroscience. vol 97. issue 1. 2000-06-23. PMID:10771340. |
we have previously found that ci2 rats of both genders have a lower tissue content of dopamine in the striatum ipsilateral to the preferred direction of rotation, indicating that the rats turn away from the brain hemisphere with higher striatal dopaminergic activity. |
2000-06-23 |
2023-08-12 |
rat |
| J F Chen, M Beilstein, Y H Xu, T J Turner, R Moratalla, D G Standaert, V J Aloyo, J S Fink, M A Schwarzschil. Selective attenuation of psychostimulant-induced behavioral responses in mice lacking A(2A) adenosine receptors. Neuroscience. vol 97. issue 1. 2000-06-23. PMID:10771351. |
the extent of dopaminergic innervation and expression of dopamine receptors in the striatum were indistinguishable between a(2a) receptor knockout and wild-type mice. |
2000-06-23 |
2023-08-12 |
mouse |
| D I Finkelstein, D Stanic, C L Parish, D Tomas, K Dickson, M K Horn. Axonal sprouting following lesions of the rat substantia nigra. Neuroscience. vol 97. issue 1. 2000-06-23. PMID:10877666. |
it appears that dopaminergic neurons were responsible for this sprouting because the density of dopamine transporter immunoreactive varicosities in the caudate-putamen was maintained until about a 70% loss of neurons. |
2000-06-23 |
2023-08-12 |
rat |
| E F Field, I Q Whishaw, S M Pelli. Sex differences in catalepsy: evidence for hormone-dependent postural mechanisms in haloperidol-treated rats. Behavioural brain research. vol 109. issue 2. 2000-06-21. PMID:10762690. |
catalepsy, a symptom of parkinson's disease and related disorders can be produced in rats and other laboratory animals by the blockade of nigrostriatal dopamine using dopaminergic antagonists such as haloperidol. |
2000-06-21 |
2023-08-12 |
human |
| F Espaze, J Hamon, H Hirbec, J Vignon, J M Kamenk. The low affinity PCP sites in the rat cerebellum not only bind TCP-like but also BTCP-like structures. European journal of medicinal chemistry. vol 35. issue 3. 2000-06-20. PMID:10785558. |
congeners of the potent dopamine (da) re-uptake inhibitor 1-[1-(2-benzo[b]thiophenyl)cyclohexyl]piperidine (btcp) are unexpectedly able to bind in the rat cerebellum, although this structure is devoid of dopaminergic nerve endings. |
2000-06-20 |
2023-08-12 |
rat |
| L R Faro, J L do Nascimento, J M San José, M Alfonso, R Durá. Intrastriatal administration of methylmercury increases in vivo dopamine release. Neurochemical research. vol 25. issue 2. 2000-06-14. PMID:10786706. |
in previous works, we have discussed the effects of chronic and acute administration of mehg on striatal dopaminergic system assessing changes in both release and metabolism of striatal dopamine (da). |
2000-06-14 |
2023-08-12 |
rat |
| A Aib. [Dopamine receptor knockout mice]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. vol 19. issue 5. 2000-06-13. PMID:10803208. |
dopaminergic systems are transmitted by dopamine receptors which couple to gtp binding proteins. |
2000-06-13 |
2023-08-12 |
mouse |
| H Ishiguro, T Saito, H Shibuya, T Arinam. Association study between genetic polymorphisms in the 14-3-3 eta chain and dopamine D4 receptor genes and alcoholism. Alcoholism, clinical and experimental research. vol 24. issue 3. 2000-06-12. PMID:10776673. |
as part of our ongoing studies on the association between alcoholism and dopaminergic genes, we report herein a mutation analysis of the 14-3-3 eta chain gene (ywhah) and an association study between alcoholism and the ywhah and dopamine d4 receptor gene (drd4) polymorphisms. |
2000-06-12 |
2023-08-12 |
Not clear |
| M S Szczypka, M A Rainey, R D Palmite. Dopamine is required for hyperphagia in Lep(ob/ob) mice. Nature genetics. vol 25. issue 1. 2000-06-12. PMID:10802666. |
dopamine-deficient mice (dbh(th/+), th-/-; hereafter dd mice) cannot synthesize dopamine in dopaminergic neurons. |
2000-06-12 |
2023-08-12 |
mouse |
| J F Bowyer, G D Newport, W Slikker, B Gough, S A Ferguson, J Tor-Agbidy. An evaluation of l-ephedrine neurotoxicity with respect to hyperthermia and caudate/putamen microdialysate levels of ephedrine, dopamine, serotonin, and glutamate. Toxicological sciences : an official journal of the Society of Toxicology. vol 55. issue 1. 2000-06-09. PMID:10788568. |
l-ephedrine may not be as neurotoxic to dopaminergic terminals as d-amphetamine, because non-lethal doses of l-ephedrine do not sufficiently increase the cpu dopamine levels within nerve terminals or the extracellular space to those necessary for a more pronounced long-term dopamine depletion. |
2000-06-09 |
2023-08-12 |
rat |
| C Colosimo, M De Michel. Motor fluctuations in Parkinson's disease: pathophysiology and treatment. European journal of neurology. vol 6. issue 1. 2000-06-06. PMID:10209344. |
the hypothesis of reversible postsynaptic changes as the main mechanism underlying a fluctuating response to ld lends itself to a possible pharmacological manipulation of the dopaminergic response to reverse, or even avoid, motor fluctuations (initial monotherapy with dopamine agonists and early combination ld/dopamine agonists). |
2000-06-06 |
2023-08-12 |
human |
| J Behr, T Gloveli, D Schmitz, U Heineman. Dopamine depresses polysynaptic inhibition in rat subicular neurons. Brain research. vol 861. issue 1. 2000-06-06. PMID:10751576. |
to clarify whether an enhanced dopaminergic activity alters the hippocampal output, the effect of dopamine (da) on inhibitory postsynaptic responses (ipsps) in subicular neurons was examined. |
2000-06-06 |
2023-08-12 |
rat |
| M V Ugryumo. The differentiation of dopaminergic neurons in situ, in vivo, and in transplants. Neuroscience and behavioral physiology. vol 30. issue 1. 2000-06-02. PMID:10768370. |
four stages were identified in the differentiation of dopaminergic neurons from rat hypothalamus: a) formation of neurons from neuroepithelial precursor cells, b) expression of specific synthetic products (enzymes and dopamine itself) and mechanisms for transmembrane dopamine transport (reuptake and secretion in response to membrane depolarization), c) formation of permanent and transient efferent connections, and d) formation of afferent innervation and synaptogenesis. |
2000-06-02 |
2023-08-12 |
human |
| M V Ugryumo. The differentiation of dopaminergic neurons in situ, in vivo, and in transplants. Neuroscience and behavioral physiology. vol 30. issue 1. 2000-06-02. PMID:10768370. |
along with dopaminergic neurons, rat fetuses contained neurons expressing only one of the dopamine-synthesizing enzymes and probably taking part in in situ dopamine synthesis. |
2000-06-02 |
2023-08-12 |
human |
| M V Ugryumo. The differentiation of dopaminergic neurons in situ, in vivo, and in transplants. Neuroscience and behavioral physiology. vol 30. issue 1. 2000-06-02. PMID:10768370. |
differentiation of dopaminergic neurons was sexually dimorphic in terms of the dynamics of neuron formation and expression of enzymes involved in dopamine synthesis. |
2000-06-02 |
2023-08-12 |
human |
| M V Ugryumo. The differentiation of dopaminergic neurons in situ, in vivo, and in transplants. Neuroscience and behavioral physiology. vol 30. issue 1. 2000-06-02. PMID:10768370. |
as regards the dopaminergic neurons of the substantia nigra, expression of their specific phenotype in human fetuses started with the synthesis of tyrosine hydroxylase and co-maturation of the specific dopamine reuptake mechanism during the sixth week of development. |
2000-06-02 |
2023-08-12 |
human |
| D C Jones, P G Gunasekar, J L Borowitz, G E Iso. Dopamine-induced apoptosis is mediated by oxidative stress and Is enhanced by cyanide in differentiated PC12 cells. Journal of neurochemistry. vol 74. issue 6. 2000-06-02. PMID:10820189. |
dopamine (da) oxidation and the generation of reactive oxygen species (ros) may contribute to the degeneration of dopaminergic neurons underlying various neurological conditions. |
2000-06-02 |
2023-08-12 |
Not clear |
| P V Holme. Olfactory bulbectomy increases prepro-enkephalin mRNA levels in the ventral striatum in rats. Neuropeptides. vol 33. issue 3. 2000-05-31. PMID:10657493. |
the findings are consistent with previously-reported effects of dopamine lesions on striatal gene expression, suggesting that the observed effects may be mediated by deafferentation-induced alterations in dopaminergic transmission in the ot. |
2000-05-31 |
2023-08-12 |
rat |
| G Forloni, I Bertani, A M Calella, F Thaler, R Invernizz. Alpha-synuclein and Parkinson's disease: selective neurodegenerative effect of alpha-synuclein fragment on dopaminergic neurons in vitro and in vivo. Annals of neurology. vol 47. issue 5. 2000-05-31. PMID:10805334. |
the number of dopaminergic neurons and dopamine content were both reduced with no effect on the general viability of the cells. |
2000-05-31 |
2023-08-12 |
rat |