| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C S Lee, M A Cenci, M Schulzer, A Björklun. Embryonic ventral mesencephalic grafts improve levodopa-induced dyskinesia in a rat model of Parkinson's disease. Brain : a journal of neurology. vol 123 ( Pt 7). 2000-08-07. PMID:10869049. |
we conclude that embryonic dopamine neuronal grafts may improve levodopa-induced dyskinesia by restoring altered activities of postsynaptic neurons, resulting not only from dopamine denervation, but also from levodopa therapy, provided that the density of striatal dopaminergic nerve terminals is restored above a 'threshold' level. |
2000-08-07 |
2023-08-12 |
rat |
| G Gerra, A Zaimovic, M Timpano, U Zambelli, R Delsignore, F Brambill. Neuroendocrine correlates of temperamental traits in humans. Psychoneuroendocrinology. vol 25. issue 5. 2000-08-03. PMID:10818282. |
studies investigating temperament traits in humans and their biological correlates have found high levels of novelty seeking (ns) linked with dopaminergic system changes, and particularly a deficit of dopamine transporter. |
2000-08-03 |
2023-08-12 |
human |
| A M Lin, L T H. Melatonin suppresses iron-induced neurodegeneration in rat brain. Free radical biology & medicine. vol 28. issue 6. 2000-08-02. PMID:10802221. |
an increase in lipid peroxidation in the infused substantia nigra and reductions in dopamine levels and dopaminergic terminals in the ipsilateral striatum were observed 7 d after iron infusion. |
2000-08-02 |
2023-08-12 |
rat |
| D Offen, Y Sherki, E Melamed, M Fridkin, D E Brenneman, I Goze. Vasoactive intestinal peptide (VIP) prevents neurotoxicity in neuronal cultures: relevance to neuroprotection in Parkinson's disease. Brain research. vol 854. issue 1-2. 2000-07-27. PMID:10784133. |
similarly, dopamine and its oxidation products were suggested to trigger dopaminergic nigral cell death in parkinson's disease. |
2000-07-27 |
2023-08-12 |
human |
| J H Rehders, W Löscher, A Richte. Evidence for striatal dopaminergic overactivity in paroxysmal dystonia indicated by microinjections in a genetic rodent model. Neuroscience. vol 97. issue 2. 2000-07-27. PMID:10799758. |
since striatal injections of compounds which enhance dopaminergic activity aggravated dystonia, while coinjections of dopamine d1 and d2 receptor antagonists reduced the severity of dystonia, the present findings clearly support the hypothesis that striatal dopaminergic overactivity plays a crucial role for the manifestation of dystonic attacks in the hamster model of paroxysmal dystonia. |
2000-07-27 |
2023-08-12 |
Not clear |
| D D Song, S N Habe. Striatal responses to partial dopaminergic lesion: evidence for compensatory sprouting. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 13. 2000-07-26. PMID:10864967. |
dopaminergic lesions result in the acute loss of striatal dopamine content, the loss of tyrosine hydroxylase-immunoreactive fibers, upregulation of preproenkephalin mrna expression, and compensatory changes in the synthesis and metabolism of dopamine. |
2000-07-26 |
2023-08-12 |
Not clear |
| S J Augood, Z R Hollingsworth, D G Standaert, P C Emson, J B Penne. Localization of dopaminergic markers in the human subthalamic nucleus. The Journal of comparative neurology. vol 421. issue 2. 2000-07-24. PMID:10813785. |
as weak d1-like binding is detected in the subthalamic nucleus, and subthalamic neurons do not express dopamine d1 or d2 receptor mrnas, together these data suggest that the effects of dopaminergic agents on the activity of human subthalamic neurons may be indirect and mediated via interaction with dopamine d1-like receptors. |
2000-07-24 |
2023-08-12 |
human |
| T Büttner, T Müller, W Kuh. Effects of apomorphine on visual functions in Parkinson's disease. Journal of neural transmission (Vienna, Austria : 1996). vol 107. issue 1. 2000-07-21. PMID:10809406. |
the improvement of basal visual functions by dopaminergic stimulation with apomorphine underlines the role of dopamine deficiency for visual dysfunction in pd. |
2000-07-21 |
2023-08-12 |
Not clear |
| B Ongali, A R Ase, C Hébert, F Amdiss, T A Reade. Dopamine D(1) and D(2) receptors in the forebrain of dystonia musculorum mutant mice: an autoradiographic survey in relation to dopamine contents. Synapse (New York, N.Y.). vol 37. issue 1. 2000-07-17. PMID:10842346. |
this neurological mutant has been proposed as an animal model of human cerebellar ataxia, in particular of the friedreich's type; thus, it was deemed of interest to examine the endogenous contents of dopamine (da) and metabolites as well as the distribution of da receptors of the d(1) and d(2) subtypes, in order to delimit the biochemical characteristics of this pathological disorder, and determine an eventual dopaminergic dysfunction in this mutant. |
2000-07-17 |
2023-08-12 |
mouse |
| E J Heyer, P Floo. Droperidol suppresses spontaneous electrical activity in neurons cultured from ventral midbrain. Implications for neuroleptanesthesia. Brain research. vol 863. issue 1-2. 2000-07-14. PMID:10773189. |
some dopamine receptors are on dopaminergic neurons and therefore are called autoreceptors, while others are on nondopaminergic neurons, such as gaba producing (gabaergic) neurons. |
2000-07-14 |
2023-08-12 |
Not clear |
| G Tosini, J C Dirde. Dopamine inhibits melatonin release in the mammalian retina: in vitro evidence. Neuroscience letters. vol 286. issue 2. 2000-07-14. PMID:10825651. |
in this study using a flow-through culture apparatus we investigated melatonin release from cultured retinas of golden hamster (mesocricetus auratus) in the presence of dopamine or dopaminergic agonists and antagonists. |
2000-07-14 |
2023-08-12 |
Not clear |
| G Tosini, J C Dirde. Dopamine inhibits melatonin release in the mammalian retina: in vitro evidence. Neuroscience letters. vol 286. issue 2. 2000-07-14. PMID:10825651. |
taken together, these results directly demonstrate for the first time that in the retina of mammals dopamine may suppress melatonin, and that suppression is mediated by d2/d4 dopaminergic receptors. |
2000-07-14 |
2023-08-12 |
Not clear |
| S Akhondzadeh, E Shasavand, H Jamilian, O Shabestari, A Kamalipou. Dipyridamole in the treatment of schizophrenia: adenosine-dopamine receptor interactions. Journal of clinical pharmacy and therapeutics. vol 25. issue 2. 2000-07-14. PMID:10849191. |
adenosine plays a role opposite to dopamine in the striatum and adenosine antagonists, like caffeine, produce similar effects to increased dopaminergic neurotransmission in the striatum. |
2000-07-14 |
2023-08-12 |
Not clear |
| T C Yen, C S Lu, K Y Tzen, S P Wey, Y H Chou, Y H Weng, P F Kao, G Tin. Decreased dopamine transporter binding in Machado-Joseph disease. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 41. issue 6. 2000-07-07. PMID:10855623. |
the aim of this study was to use 99mtc-trodat-1 brain spect for investigation of the binding of dopamine transporter (dat) in the nigrostriatal dopaminergic pathway of symptomatic machado-joseph disease (mjd) and to compare the results with the abnormal cytidylate, adenylate, and guanylate (cag) expansion in the mjd1 gene and other clinical factors. |
2000-07-07 |
2023-08-12 |
Not clear |
| G Tanda, S R Goldber. Alteration of the behavioral effects of nicotine by chronic caffeine exposure. Pharmacology, biochemistry, and behavior. vol 66. issue 1. 2000-07-06. PMID:10837843. |
in particular, recent experiments are reviewed in which chronic exposure to caffeine in the drinking water of rats facilitated acquisition of self-adminstration behavior, enhanced nicotine-induced increases in dopamine levels in the shell of the nucleus accumbens and altered the dopaminergic component of a nicotine discrimination. |
2000-07-06 |
2023-08-12 |
rat |
| F Nava, G Carta, G L Gess. Permissive role of dopamine D(2) receptors in the hypothermia induced by delta(9)-tetrahydrocannabinol in rats. Pharmacology, biochemistry, and behavior. vol 66. issue 1. 2000-07-06. PMID:10837859. |
moreover, delta(9)-tetrahydrocannabinol (9-thc) and synthetic cannabinoids stimulate dopaminergic neurons and increase dopamine release in different brain areas. |
2000-07-06 |
2023-08-12 |
rat |
| L Zimmer, S Delpal, D Guilloteau, J Aïoun, G Durand, S Chalo. Chronic n-3 polyunsaturated fatty acid deficiency alters dopamine vesicle density in the rat frontal cortex. Neuroscience letters. vol 284. issue 1-2. 2000-07-03. PMID:10771153. |
this reduction in the dopaminergic vesicle pool constitutes the first structural support for the previously described modifications of dopamine metabolism in the frontal cortex. |
2000-07-03 |
2023-08-12 |
rat |
| D S Kim, M S Szczypka, R D Palmite. Dopamine-deficient mice are hypersensitive to dopamine receptor agonists. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 12. 2000-06-30. PMID:10844009. |
the acute behavioral response of da-/- mice to a dopamine d1 receptor agonist was correlated with c-fos induction in the striatum, a brain nucleus that receives dense dopaminergic input. |
2000-06-30 |
2023-08-12 |
mouse |
| G Yadid, N Fitoussi, N Kinor, R Geffen, I Gispa. Astrocyte line SVG-TH grafted in a rat model of Parkinson's disease. Progress in neurobiology. vol 59. issue 6. 2000-06-30. PMID:10845756. |
the striatum in pd that lacks the dopaminergic projection from the substantia nigra metabolizes and releases dopamine differently from normal tissue and may react to different factors released by the grafted cells. |
2000-06-30 |
2023-08-12 |
human |
| Y Furukawa, O Hornykiewicz, S Fahn, S J Kis. Striatal dopamine in early-onset primary torsion dystonia with the DYT1 mutation. Neurology. vol 54. issue 5. 2000-06-28. PMID:10720299. |
although nigrostriatal dopaminergic dysfunction has been suggested in early onset primary torsion dystonia (ptd) with the dyt1 mutation, the actual status of brain dopamine (da) is unknown. |
2000-06-28 |
2023-08-12 |
Not clear |