| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R Grondin, Z Zhang, G A Gerhardt, D M Gas. Dopaminergic therapy improves upper limb motor performance in aged rhesus monkeys. Annals of neurology. vol 48. issue 2. 2000-08-28. PMID:10939577. |
the potential of dopaminergic treatments to improve upper limb motor movements was tested in 7 aged rhesus monkeys using l-3,4-dihydroxyphenylalanine (l-dopa) or the selective dopamine uptake inhibitor 1-2(bis[4-fluorophenyl] methoxy]ethyl)-4-(3-phenylpropyl) piperazine hydrochloride (gbr-12909). |
2000-08-28 |
2023-08-12 |
monkey |
| R Dall'Olio, O Gandolfi, R Gagg. Blockade of the serotonergic system counteracts the dizocilpine-induced changes in dopaminergic function. Behavioural pharmacology. vol 11. issue 1. 2000-08-24. PMID:10821206. |
both the non-selective 5ht1/5ht2 antagonist methysergide, and ketanserin, which more specifically blocks 5ht2 receptors, given at doses inhibiting serotonin-mediated behaviours but which did not affect spontaneous motility and dopaminergic behaviours, hampered the dizocilpine-induced potentiation of responses elicited by the stimulation of d1 or d1/d2 dopamine receptors and counteracted the dizocilpine-induced reduction of hyperactivity observed following quinpirole administration. |
2000-08-24 |
2023-08-12 |
rat |
| R H Mach, M A Nader, R L Ehrenkaufer, H D Gage, S R Childers, L M Hodges, M M Hodges, H M Davie. Fluorine-18-labeled tropane analogs for PET imaging studies of the dopamine transporter. Synapse (New York, N.Y.). vol 37. issue 2. 2000-08-24. PMID:10881032. |
both compounds possessed a high affinity and selectivity for the dopamine transporter and had a higher accumulation in the basal ganglia, a brain region having a high density of the dopamine transporter (dat) than the cerebellum, a reference region devoid of dopaminergic terminals. |
2000-08-24 |
2023-08-12 |
Not clear |
| A P Payne, J M Campbell, D Russell, G Favor, R G Sutcliffe, N K Bennett, R W Davies, T W Ston. The AS/AGU rat: a spontaneous model of disruption and degeneration in the nigrostriatal dopaminergic system. Journal of anatomy. vol 196 ( Pt 4). 2000-08-22. PMID:10923993. |
subsequently a depletion of whole tissue dopamine levels occurs and, later still, loss of dopaminergic cells in the substantia nigra pars compacta. |
2000-08-22 |
2023-08-12 |
rat |
| I Nir, R Haque, P M Iuvon. Diurnal metabolism of dopamine in the mouse retina. Brain research. vol 870. issue 1-2. 2000-08-21. PMID:10869508. |
in the present study we carried out a comprehensive analysis of dopamine metabolism during the light phase of the diurnal cycle and evaluated the presence of diurnal and circadian rhythms of dopaminergic activity in the mouse retina. |
2000-08-21 |
2023-08-12 |
mouse |
| E P Nobl. Addiction and its reward process through polymorphisms of the D2 dopamine receptor gene: a review. European psychiatry : the journal of the Association of European Psychiatrists. vol 15. issue 2. 2000-08-17. PMID:10881203. |
in effect, one form of the drd2 gene, the a1 allele, renders the dopaminergic system inefficient and rewards substance abuse that increases brain dopamine levels. |
2000-08-17 |
2023-08-12 |
human |
| M L Vizuete, M Merino, J L Venero, M Santiago, J Cano, A Machad. Histamine infusion induces a selective dopaminergic neuronal death along with an inflammatory reaction in rat substantia nigra. Journal of neurochemistry. vol 75. issue 2. 2000-08-17. PMID:10899929. |
injection of 100 and 250 nmol of histamine in substantia nigra produced a selective damage in dopaminergic neurons evidenced by the loss of tyrosine hydroxylase mrna-expressing cells, tyrosine hydroxylase-immunolabeled-positive cell bodies, and dopamine and 3,4-dihydroxyphenylacetic acid levels. |
2000-08-17 |
2023-08-12 |
rat |
| A C Teisman, H Buikema, D J van Veldhuisen, D de Zeeuw, W H van Gils. Direct vasodilating effects of the new dopaminergic agonist Z1046 in human arteries. Journal of cardiovascular pharmacology. vol 35. issue 4. 2000-08-16. PMID:10774789. |
this study evaluates the dopaminergic and adrenergic (vasodilating) properties of z1046, epinine (the active metabolite of ibopamine), and dopamine. |
2000-08-16 |
2023-08-12 |
human |
| K S Bankiewicz, J L Eberling, M Kohutnicka, W Jagust, P Pivirotto, J Bringas, J Cunningham, T F Budinger, J Harvey-Whit. Convection-enhanced delivery of AAV vector in parkinsonian monkeys; in vivo detection of gene expression and restoration of dopaminergic function using pro-drug approach. Experimental neurology. vol 164. issue 1. 2000-08-16. PMID:10877910. |
in addition, the imbalance in dopamine production between the nigrostriatal and mesolimbic dopaminergic systems can be corrected by using aadc gene delivery to the striatum. |
2000-08-16 |
2023-08-12 |
monkey |
| S J Cragg, D J Clarke, S A Greenfiel. Real-time dynamics of dopamine released from neuronal transplants in experimental Parkinson's disease. Experimental neurology. vol 164. issue 1. 2000-08-16. PMID:10877925. |
intrastriatal transplantation of foetal midbrain dopamine (da) neurons ameliorates the fundamental symptoms of dopaminergic denervation in clinical and experimental parkinsonism despite providing only restricted reinnervation. |
2000-08-16 |
2023-08-12 |
Not clear |
| I Strömberg, J Kehr, B Andbjer, K Fux. Fetal ventral mesencephalic grafts functionally reduce the dopamine D2 receptor supersensitivity in partially dopamine reinnervated host striatum. Experimental neurology. vol 164. issue 1. 2000-08-16. PMID:10877926. |
grafting of ventral mesencephalic tissue in parkinson's disease results in a partial dopaminergic reinnervation of host brain and dopamine agonist-induced rotational behavior is not completely reversed. |
2000-08-16 |
2023-08-12 |
Not clear |
| A Kask, J Harr. Inhibition of amphetamine- and apomorphine-induced behavioural effects by neuropeptide Y Y(1) receptor antagonist BIBO 3304. Neuropharmacology. vol 39. issue 7. 2000-08-15. PMID:10760371. |
we propose that the effects of bibo 3304 on amphetamine/apomorphine-induced locomotion and apomorphine-induced aggressiveness are due to modulation of postsynaptic dopaminergic responses rather than direct effects of npy y(1) receptor antagonists on dopamine or npy release. |
2000-08-15 |
2023-08-12 |
rat |
| F Blandini, G Nappi, C Tassorelli, E Martignon. Functional changes of the basal ganglia circuitry in Parkinson's disease. Progress in neurobiology. vol 62. issue 1. 2000-08-15. PMID:10821982. |
current therapeutic strategies rely on the use of l-dopa and/or dopamine agonists to correct the dopaminergic deficit. |
2000-08-15 |
2023-08-12 |
Not clear |
| M Reuben, S Boye, P B Clark. Nicotinic receptors modulating somatodendritic and terminal dopamine release differ pharmacologically. European journal of pharmacology. vol 393. issue 1-3. 2000-08-11. PMID:10770996. |
somatodendritic nicotinic cholinoceptors on dopaminergic neurons were studied using a dendrosomal [3h]dopamine release assay and also in locomotor activity tests. |
2000-08-11 |
2023-08-12 |
rat |
| G L Gessa, R Agabio, M A Carai, C Lobina, M Pani, R Reali, G Colomb. Mechanism of the antialcohol effect of gamma-hydroxybutyric acid. Alcohol (Fayetteville, N.Y.). vol 20. issue 3. 2000-08-11. PMID:10869869. |
relevant similarities are: (1) stimulation of firing rate of dopaminergic neurons and dopamine release in specific rat brain areas; (2) development of cross-tolerance to the motor-impairing effects after repeated administration in rats; 3) abuse potential, as indicated by self-administration of pharmacologically relevant doses of gamma-hydroxybutyric acid in rats and mice; (4) induction of anxiolytic effects in rats; and (5) induction of similar discriminative stimulus effects, as evidenced by symmetrical generalization in a drug discrimination study in rats. |
2000-08-11 |
2023-08-12 |
mouse |
| A Abi-Dargham, J Rodenhiser, D Printz, Y Zea-Ponce, R Gil, L S Kegeles, R Weiss, T B Cooper, J J Mann, R L Van Heertum, J M Gorman, M Laruell. Increased baseline occupancy of D2 receptors by dopamine in schizophrenia. Proceedings of the National Academy of Sciences of the United States of America. vol 97. issue 14. 2000-08-10. PMID:10884434. |
the classical dopamine hypothesis of schizophrenia postulates a hyperactivity of dopaminergic transmission at the d(2) receptor. |
2000-08-10 |
2023-08-12 |
human |
| A Abi-Dargham, J Rodenhiser, D Printz, Y Zea-Ponce, R Gil, L S Kegeles, R Weiss, T B Cooper, J J Mann, R L Van Heertum, J M Gorman, M Laruell. Increased baseline occupancy of D2 receptors by dopamine in schizophrenia. Proceedings of the National Academy of Sciences of the United States of America. vol 97. issue 14. 2000-08-10. PMID:10884434. |
this finding provides direct evidence of increased stimulation of d(2) receptors by dopamine in schizophrenia, consistent with increased phasic activity of dopaminergic neurons. |
2000-08-10 |
2023-08-12 |
human |
| T Hallikainen, H Lachman, T Saito, J Volavka, J Kauhanen, J T Salonen, O P Ryynänen, M Koulu, M K Karvonen, T Pohjalainen, E Syvälahti, J Hietala, J Tiihone. Lack of association between the functional variant of the catechol-o-methyltransferase (COMT) gene and early-onset alcoholism associated with severe antisocial behavior. American journal of medical genetics. vol 96. issue 3. 2000-08-10. PMID:10898913. |
addictive drugs, including ethanol, increase the brain's dopaminergic transmission, and catechol-o-methyltransferase (comt) enzyme has a crucial role in dopamine inactivation. |
2000-08-10 |
2023-08-12 |
human |
| N K Mello, S S Negu. Interactions between kappa opioid agonists and cocaine. Preclinical studies. Annals of the New York Academy of Sciences. vol 909. 2000-08-10. PMID:10911926. |
kappa opioid agonists inhibit dopamine release from mesolimbic dopaminergic neurons and attenuate some behavioral effects of cocaine in rodents. |
2000-08-10 |
2023-08-12 |
monkey |
| W Zhou, M S Hurlbert, J Schaack, K N Prasad, C R Free. Overexpression of human alpha-synuclein causes dopamine neuron death in rat primary culture and immortalized mesencephalon-derived cells. Brain research. vol 866. issue 1-2. 2000-08-07. PMID:10825478. |
in this report, we have investigated the toxic effects of adenovirus-mediated alpha-synuclein overexpression on dopamine neurons in rat primary mesencephalic cultures and in a rat dopaminergic cell line - the large t-antigen immortalized, mesencephalon-derived 1rb3an27 (n27). |
2000-08-07 |
2023-08-12 |
human |