| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L S Kegeles, A Abi-Dargham, Y Zea-Ponce, J Rodenhiser-Hill, J J Mann, R L Van Heertum, T B Cooper, A Carlsson, M Laruell. Modulation of amphetamine-induced striatal dopamine release by ketamine in humans: implications for schizophrenia. Biological psychiatry. vol 48. issue 7. 2000-12-05. PMID:11032974. |
it has long been hypothesized that dysregulation of subcortical dopamine systems in schizophrenia might result from a failure of the prefrontal cortex (pfc) to adequately control subcortical dopaminergic function. |
2000-12-05 |
2023-08-12 |
Not clear |
| A Fink-Jense. Novel pharmacological approaches to the treatment of schizophrenia. Danish medical bulletin. vol 47. issue 3. 2000-11-30. PMID:10913983. |
the microdialysis technique was used to investigate the regional dopaminergic effects of the above mentioned antipsychotic compounds by measuring interstitial levels of the dopamine metabolite dihydroxyphenylacetic acid ([dopac]i) in pfc, nac and dlst. |
2000-11-30 |
2023-08-12 |
human |
| E Schlicker, M Morar. Nociceptin/orphanin FQ and neurotransmitter release in the central nervous system. Peptides. vol 21. issue 7. 2000-11-30. PMID:10998536. |
in the rat in vivo, nociceptin diminishes acetylcholine release in the striatum, reduces dopamine release, and prevents the stimulatory effect of morphine on this transmitter in the nucleus accumbens and also elevates extracellular glutamate and gamma-aminobutyric acid levels in mesencephalic dopaminergic areas. |
2000-11-30 |
2023-08-12 |
mouse |
| A Feigenspan, S Gustincich, E Raviol. Pharmacology of GABA(A) receptors of retinal dopaminergic neurons. Journal of neurophysiology. vol 84. issue 4. 2000-11-30. PMID:11024062. |
in the intact retina, dopamine release can be pharmacologically manipulated with agonists and antagonists at gaba(a) receptors, and dopaminergic (da) cells receive input from gabaergic amacrines. |
2000-11-30 |
2023-08-12 |
mouse |
| C Neusch, V Böhme, N Riesland, M Althaus, A Mose. The dopamine D2 receptor agonist alpha-dihydroergocryptine modulates voltage-gated sodium channels in the rat caudate-putamen. Journal of neural transmission (Vienna, Austria : 1996). vol 107. issue 5. 2000-11-30. PMID:11072749. |
alpha-dihydroergocryptine (alpha-dhec), a dopamine (da) d2 receptor agonist, is widely used as dopaminergic drug in the treatment of parkinson's disease. |
2000-11-30 |
2023-08-12 |
rat |
| V M Goettl, T A Wemlinger, T G Fong, N H Neff, M Hadjiconstantino. Retinal cholinergic and dopaminergic deficits of aged rats are improved following treatment with GM1 ganglioside. Brain research. vol 877. issue 1. 2000-11-28. PMID:10980236. |
the dopaminergic markers, tyrosine hydroxylase, aromatic l-amino acid decarboxylase, dopamine, 3,4-dihydroxyphenylacetic acid and homovanillic acid were comparable in the young and aged animals and gm1 treatment did not alter them. |
2000-11-28 |
2023-08-12 |
rat |
| J Kulisevsk. Role of dopamine in learning and memory: implications for the treatment of cognitive dysfunction in patients with Parkinson's disease. Drugs & aging. vol 16. issue 5. 2000-11-13. PMID:10917074. |
this paper reviews the dopaminergic brain circuitry, and preclinical and clinical evidence supporting the regulation of prefrontal cortex activity by dopamine, and the role of dopamine in cognitive impairment in patients with pd. |
2000-11-13 |
2023-08-12 |
human |
| J Kulisevsk. Role of dopamine in learning and memory: implications for the treatment of cognitive dysfunction in patients with Parkinson's disease. Drugs & aging. vol 16. issue 5. 2000-11-13. PMID:10917074. |
enhancement and impairment of cognitive function with dopaminergic treatment is incomplete and task-specific, suggesting the need to integrate the above dopamine facts with other neurotransmitter systems findings in pd. |
2000-11-13 |
2023-08-12 |
human |
| M G Murer, G Dziewczapolski, P Salin, M Vila, K Y Tseng, M Ruberg, M Rubinstein, M A Kelly, D K Grandy, M J Low, E Hirsch, R Raisman-Vozari, O Gershani. The indirect basal ganglia pathway in dopamine D(2) receptor-deficient mice. Neuroscience. vol 99. issue 4. 2000-11-07. PMID:10974427. |
this reduction contrasts with the lack of change or increase in glutamate decarboxylase-67 messenger rna expression found in animals depleted of dopamine after lesions of the mesostriatal dopaminergic system. |
2000-11-07 |
2023-08-12 |
mouse |
| M Park, K Kitahama, M Geffard, T Maed. Postnatal development of the dopaminergic neurons in the rat mesencephalon. Brain & development. vol 22 Suppl 1. 2000-11-07. PMID:10984659. |
the two mesencephalic dopaminergic systems in the developing rat brain were investigated immunohistochemically by dopamine and tyrosine hydroxylase and the results were quantitatively analyzed with a computer. |
2000-11-07 |
2023-08-12 |
rat |
| K Kobayashi, H San. Dopamine deficiency in mice. Brain & development. vol 22 Suppl 1. 2000-11-07. PMID:10984662. |
lack of th expression in dopaminergic neurons resulted in a marked reduction of dopamine accumulation. |
2000-11-07 |
2023-08-12 |
mouse |
| K Kobayashi, H San. Dopamine deficiency in mice. Brain & development. vol 22 Suppl 1. 2000-11-07. PMID:10984662. |
in contrast, development of pituitary gland as well as production and secretion of the pituitary peptide hormones dependent on hypothalamic dopaminergic control were normally maintained in spite of the reduced dopamine synthesis. |
2000-11-07 |
2023-08-12 |
mouse |
| M J Bourque, L E Trudea. GDNF enhances the synaptic efficacy of dopaminergic neurons in culture. The European journal of neuroscience. vol 12. issue 9. 2000-11-07. PMID:10998101. |
previous studies have shown that single dopaminergic neurons in culture can co-release glutamate in addition to dopamine, leading to the generation of a fast excitatory autaptic current via glutamate receptors. |
2000-11-07 |
2023-08-12 |
rat |
| M P Joyce, S Raypor. Mesoaccumbens dopamine neuron synapses reconstructed in vitro are glutamatergic. Neuroscience. vol 99. issue 3. 2000-11-07. PMID:11029537. |
immunostaining revealed dopamine neuron varicosities that were predominantly dopaminergic, ones that were predominantly glutamatergic, and ones that were both dopaminergic and glutamatergic. |
2000-11-07 |
2023-08-12 |
Not clear |
| M P Joyce, S Raypor. Mesoaccumbens dopamine neuron synapses reconstructed in vitro are glutamatergic. Neuroscience. vol 99. issue 3. 2000-11-07. PMID:11029537. |
in some cell pairs, the evoked autaptic and synaptic responses were discordant, suggesting that d2 receptors may be differentially trafficked to different presynaptic varicosities.thus, dopamine neurons appear to mediate both slow dopaminergic and fast glutamatergic actions via separate sets of synapses. |
2000-11-07 |
2023-08-12 |
Not clear |
| P Svenningsson, L Gunne, P E Andre. L-DOPA produces strong induction of c-fos messenger RNA in dopamine-denervated cortical and striatal areas of the common marmoset. Neuroscience. vol 99. issue 3. 2000-11-07. PMID:11029538. |
the effects of l-dopa probably depend both on a direct activation of supersensitized dopamine receptors by dopamine produced in the few remaining, but hyperactive, dopaminergic nerve terminals and in serotonergic nerve terminals, as well as on indirect actions of l-dopa related to activation of circuitries connecting cerebral cortex and basal ganglia structures. |
2000-11-07 |
2023-08-12 |
marmoset |
| G Lucas, P De Deurwaerdère, G Porras, U Spampinat. Endogenous serotonin enhances the release of dopamine in the striatum only when nigro-striatal dopaminergic transmission is activated. Neuropharmacology. vol 39. issue 11. 2000-11-03. PMID:10963742. |
endogenous serotonin enhances the release of dopamine in the striatum only when nigro-striatal dopaminergic transmission is activated. |
2000-11-03 |
2023-08-12 |
rat |
| N M de Bruin, E L van Luijtelaar, S J Jansen, A R Cools, B A Ellenbroe. Dopamine characteristics in different rat genotypes: the relation to absence epilepsy. Neuroscience research. vol 38. issue 2. 2000-11-01. PMID:11000443. |
assuming that haloperidol decreases dopaminergic transmission in the nigrostriatal system via inhibition of the dopamine receptors and enhances dopaminergic transmission in the mesolimbic system via inhibition of the noradrenergic receptors, it was postulated that haloperidol would enhance the difference in dopaminergic reactivity between both systems in favor of the accumbens. |
2000-11-01 |
2023-08-12 |
rat |
| G Hédou, S Chasserot-Golaz, V Kemmel, S Gobaille, G Roussel, J C Artault, C Andriamampandry, D Aunis, M Maitr. Immunohistochemical studies of the localization of neurons containing the enzyme that synthesizes dopamine, GABA, or gamma-hydroxybutyrate in the rat substantia nigra and striatum. The Journal of comparative neurology. vol 426. issue 4. 2000-11-01. PMID:11027398. |
to investigate the distribution of ghb neurons in this pathway and the anatomic relationships between dopaminergic and ghb neurons, immunocytochemical identification of dopamine, gaba, and ghb neurons was carried out in the substantia nigra and striatum of the rat. |
2000-11-01 |
2023-08-12 |
rat |
| G Hédou, S Chasserot-Golaz, V Kemmel, S Gobaille, G Roussel, J C Artault, C Andriamampandry, D Aunis, M Maitr. Immunohistochemical studies of the localization of neurons containing the enzyme that synthesizes dopamine, GABA, or gamma-hydroxybutyrate in the rat substantia nigra and striatum. The Journal of comparative neurology. vol 426. issue 4. 2000-11-01. PMID:11027398. |
on the basis of these results, a clear anatomo-functional relationship between ghb and dopamine networks cannot be defined; however, we propose the modulation by ghb of striatal intrinsic neurons that could then interfere with the presynaptic control of dopaminergic activity. |
2000-11-01 |
2023-08-12 |
rat |