| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K Y Tseng, C Roubert, L Do, M Rubinstein, M A Kelly, D K Grandy, M J Low, O S Gershanik, M G Murer, B Giros, R Raisman-Vozar. Selective increase of Nurr1 mRNA expression in mesencephalic dopaminergic neurons of D2 dopamine receptor-deficient mice. Brain research. Molecular brain research. vol 80. issue 1. 2001-03-01. PMID:11039723. |
selective increase of nurr1 mrna expression in mesencephalic dopaminergic neurons of d2 dopamine receptor-deficient mice. |
2001-03-01 |
2023-08-12 |
mouse |
| K Y Tseng, C Roubert, L Do, M Rubinstein, M A Kelly, D K Grandy, M J Low, O S Gershanik, M G Murer, B Giros, R Raisman-Vozar. Selective increase of Nurr1 mRNA expression in mesencephalic dopaminergic neurons of D2 dopamine receptor-deficient mice. Brain research. Molecular brain research. vol 80. issue 1. 2001-03-01. PMID:11039723. |
among the cell groups studied, mesencephalic dopaminergic neurons are unique in that they express both nurr1 and the d2 dopamine receptor, and synthesize dopamine. |
2001-03-01 |
2023-08-12 |
mouse |
| S Dresel, J Krause, K H Krause, C LaFougere, K Brinkbäumer, H F Kung, K Hahn, K Tatsc. Attention deficit hyperactivity disorder: binding of [99mTc]TRODAT-1 to the dopamine transporter before and after methylphenidate treatment. European journal of nuclear medicine. vol 27. issue 10. 2001-03-01. PMID:11083541. |
involvement of the dopaminergic system has been suggested in patients suffering from attention deficit hyperactivity disorder (adhd) since the symptoms can be successfully treated with methylphenidate, a potent blocker of the dopamine transporter (dat). |
2001-03-01 |
2023-08-12 |
human |
| D C German, C L Liang, K F Manaye, K Lane, P K Sonsall. Pharmacological inactivation of the vesicular monoamine transporter can enhance 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurodegeneration of midbrain dopaminergic neurons, but not locus coeruleus noradrenergic neurons. Neuroscience. vol 101. issue 4. 2001-03-01. PMID:11113355. |
mice in which pharmacological blockage of the vesicular monoamine transporter enhanced the effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity in the depletion of striatal dopamine concentrations also exhibited enhanced degeneration of substantia nigra dopaminergic neurons. |
2001-03-01 |
2023-08-12 |
mouse |
| H Kawai, Y Kotake, S Oht. Dopamine transporter and catechol-O-methyltransferase activities are required for the toxicity of 1-(3',4'-dihydroxybenzyl)-1,2,3, 4-tetrahydroisoquinoline. Chemical research in toxicology. vol 13. issue 12. 2001-03-01. PMID:11123971. |
it is taken up into dopaminergic neurons via the dopamine transporter, inhibits mitochondrial respiration, and induces parkinsonism in mice. |
2001-03-01 |
2023-08-12 |
mouse |
| H Kawai, Y Kotake, S Oht. Dopamine transporter and catechol-O-methyltransferase activities are required for the toxicity of 1-(3',4'-dihydroxybenzyl)-1,2,3, 4-tetrahydroisoquinoline. Chemical research in toxicology. vol 13. issue 12. 2001-03-01. PMID:11123971. |
thus, we consider that 1 is taken up into dopaminergic neurons via the dopamine transporter and then converted by comt to 5, which has cytotoxic and parkinsonism-inducing activities. |
2001-03-01 |
2023-08-12 |
mouse |
| T González-Hernández, P Barroso-Chinea, A Acevedo, E Salido, M Rodrígue. Colocalization of tyrosine hydroxylase and GAD65 mRNA in mesostriatal neurons. The European journal of neuroscience. vol 13. issue 1. 2001-03-01. PMID:11135004. |
in this study, we used the combination of immunocytochemistry for tyrosine hydroxylase (th; a marker of dopaminergic neurons), in situ hybridization (ish) for two different isoforms of glutamic acid decarboxylase (gad65 and gad67, the rate-limiting enzyme in gaba synthesis) and retrograde tracing techniques to investigate the possible existence of nigrostriatal neurons containing both neurotransmitters (dopamine and gaba) in the rat. |
2001-03-01 |
2023-08-12 |
rat |
| W Maruyama, M Nao. [Studies on endogenous toxins as pathogenic factors in idiopathic parkinson's disease]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 116. issue 6. 2001-03-01. PMID:11188501. |
n-methyl (r)salsolinol [nm (r) sal] is a candidate of dopaminergic neurotoxins, and is synthesized from dopamine by 2 enzymes: (r) salsolinol synthase and a neutral (r) salsolinol n-methyltransferase (nnmt). |
2001-03-01 |
2023-08-12 |
human |
| L Studer, M Csete, S H Lee, N Kabbani, J Walikonis, B Wold, R McKa. Enhanced proliferation, survival, and dopaminergic differentiation of CNS precursors in lowered oxygen. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 19. 2001-02-22. PMID:11007896. |
together, the increases in total cell number and percentage of dopaminergic neurons resulted in a ninefold net increase in dopamine neuron yield. |
2001-02-22 |
2023-08-12 |
rat |
| R Ito, J W Dalley, S R Howes, T W Robbins, B J Everit. Dissociation in conditioned dopamine release in the nucleus accumbens core and shell in response to cocaine cues and during cocaine-seeking behavior in rats. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 19. 2001-02-22. PMID:11007908. |
the dopaminergic innervation of the nucleus accumbens is generally agreed to mediate the primary reinforcing and locomotor effects of psychostimulants, but there is less consensus on conditioned dopamine (da) release during drug-seeking behavior. |
2001-02-22 |
2023-08-12 |
rat |
| S Iwata, M Nomoto, S Kaseda, S Tanoue, M Shimosaka, T Fukud. TH protein and mRNA in nigrostriatal dopaminergic neurons are down-regulated by continuous but not intermittent apomorphine. Brain research. Molecular brain research. vol 82. issue 1-2. 2001-02-22. PMID:11042366. |
levels of tyrosine hydroxylase (th) and th mrna were measured after administration of dopamine agonists for a long period of time to elucidate the long-term feedback inhibition of dopamine synthesis in nigrostriatal dopaminergic neurons. |
2001-02-22 |
2023-08-12 |
Not clear |
| K Ozawa, D S Fan, Y Shen, S Muramatsu, K Fujimoto, K Ikeguchi, M Ogawa, M Urabe, A Kume, I Nakan. Gene therapy of Parkinson's disease using adeno-associated virus (AAV) vectors. Journal of neural transmission. Supplementum. issue 58. 2001-02-22. PMID:11128607. |
parkinson's disease (pd) is characterized by the progressive loss of the dopaminergic neurons in the substantia nigra and a severe decrease in dopamine in the striatum. |
2001-02-22 |
2023-08-12 |
rat |
| b' H Abdelmelek, J M Cottet-Emard, J M Pequignot, H Barr\\xc3\\xa. Spinal cord monoaminergic system response to age and cold-acclimatization in muscovy duckling. Journal of neural transmission (Vienna, Austria : 1996). vol 107. issue 10. 2001-02-22. PMID:11129107.' |
in thermoneutral controls (tn), the high dopamine (da) to norepinephrine (ne) ratios (0.25 at 4 weeks of age and 0.15 at 6 weeks of age) suggest the presence of specific (non precursor) dopaminergic pools in cervical spinal cord. |
2001-02-22 |
2023-08-12 |
Not clear |
| P C Waldmeier, W P Spooren, B Hengere. CGP 3466 protects dopaminergic neurons in lesion models of Parkinson's disease. Naunyn-Schmiedeberg's archives of pharmacology. vol 362. issue 6. 2001-02-22. PMID:11138845. |
cgp 3466 or its hydrogen maleate salt, cgp 3466b, at concentrations between 10(-11) m and 10(-7) m, protected rat embryonic mesencephalic dopaminergic neurons in free-floating or dispersed cell culture from death inflicted by treatment with 1-methyl-4-phenyl pyridinium ion (mpp+) as measured by different readouts such as dopamine uptake, tyrosine hydroxylase activity, and counts of tyrosine hydroxylase-positive cells. |
2001-02-22 |
2023-08-12 |
mouse |
| T J Montine, V Amarnath, M J Picklo, K R Sidell, J Zhang, D G Graha. Dopamine mercapturate can augment dopaminergic neurodegeneration. Drug metabolism reviews. vol 32. issue 3-4. 2001-02-22. PMID:11139134. |
dopamine mercapturate can augment dopaminergic neurodegeneration. |
2001-02-22 |
2023-08-12 |
human |
| T J Montine, V Amarnath, M J Picklo, K R Sidell, J Zhang, D G Graha. Dopamine mercapturate can augment dopaminergic neurodegeneration. Drug metabolism reviews. vol 32. issue 3-4. 2001-02-22. PMID:11139134. |
in dopaminergic cell cultures, dopamine induced apoptosis in a concentration-dependent manner from 5 to 50 microm. |
2001-02-22 |
2023-08-12 |
human |
| T J Montine, V Amarnath, M J Picklo, K R Sidell, J Zhang, D G Graha. Dopamine mercapturate can augment dopaminergic neurodegeneration. Drug metabolism reviews. vol 32. issue 3-4. 2001-02-22. PMID:11139134. |
these data indicate that the mercapturate conjugate of dopamine may augment dopaminergic neurodegeneration and that the mercapturate pathway exists in human substantia nigra. |
2001-02-22 |
2023-08-12 |
human |
| M V Ugriumov, V I Mel'nikova, P V Ershov, I Balan, A Cala. [Non-dopaminergic neurons expressing dopamine synthesis enzymes: differentiation and functional importance]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova. vol 86. issue 10. 2001-02-22. PMID:11200326. |
the study has evaluated in vivo, ex vivo and in vitro ontogenesis and functional significance of the arcuate nucleus neurons expressing either individual enzymes of dopamine synthesis, tyrosine hydroxylase or aromatic l-amino acid decarboxylase as well as both of them (dopaminergic neurons) in rats from the 17th embryonic day to adulthood. |
2001-02-22 |
2023-08-12 |
rat |
| Y Smith, J Z Kieva. Anatomy of the dopamine system in the basal ganglia. Trends in neurosciences. vol 23. issue 10 Suppl. 2001-02-08. PMID:11052217. |
thus, the long-term belief that the effects of dopamine in the basal ganglia were solely mediated through the nigrostriatal system must be changed to take into account extrastriatal dopaminergic projections and intrastriatal dopaminergic neurons. |
2001-02-08 |
2023-08-12 |
Not clear |
| P Calabresi, D Centonze, G Bernard. Electrophysiology of dopamine in normal and denervated striatal neurons. Trends in neurosciences. vol 23. issue 10 Suppl. 2001-02-08. PMID:11052221. |
the therapeutic treatment with exogenous dopamine, therefore, temporarily restores a balanced synaptic excitation of striatal neurons, counteracting pre- and postsynaptically the excessive glutamate release caused by the degeneration of nigrostriatal dopaminergic fibers. |
2001-02-08 |
2023-08-12 |
Not clear |