| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J H Jun, C W Schindle. Dextromethorphan alters methamphetamine self-administration in the rat. Pharmacology, biochemistry, and behavior. vol 67. issue 3. 2001-04-19. PMID:11164066. |
various lines of evidence indicate that methamphetamine (meth) self-administration in rats is under dopaminergic control, and nmda receptors have been shown to control the release of dopamine at its synapse. |
2001-04-19 |
2023-08-12 |
rat |
| A M Ouagazzal, I Crees. Intra-accumbens infusion of D(3) receptor agonists reduces spontaneous and dopamine-induced locomotion. Pharmacology, biochemistry, and behavior. vol 67. issue 3. 2001-04-19. PMID:11164096. |
the present study investigated whether pd 128907 and 7-oh-dpat, described as preferential dopamine (da) d(3) receptor agonists, produce hypolocomotion by acting at postsynaptic dopaminergic receptors within the nucleus accumbens. |
2001-04-19 |
2023-08-12 |
Not clear |
| J Booij, P Bergmans, A Winogrodzka, J D Speelman, E C Wolter. Imaging of dopamine transporters with [123I]FP-CIT SPECT does not suggest a significant effect of age on the symptomatic threshold of disease in Parkinson's disease. Synapse (New York, N.Y.). vol 39. issue 2. 2001-04-19. PMID:11180497. |
with natural aging there is loss of dopaminergic cells in the substantia nigra and, consequently, loss of dopamine transporters in the striatum. |
2001-04-19 |
2023-08-12 |
Not clear |
| E F Espejo, J Miñan. Adrenergic hyperactivity and metanephrine excess in the nucleus accumbens after prefrontocortical dopamine depletion. Journal of neurophysiology. vol 85. issue 3. 2001-04-19. PMID:11247995. |
to sum up, prefrontocortical dopamine depletion induces motor and emotional disturbances in rats and alters the neurochemical profile of the nucleus accumbens, not only inducing dopaminergic and noradrenergic hyperactivity but also leading to adrenaline and metanephrine excess. |
2001-04-19 |
2023-08-12 |
rat |
| P Weingarten, J Bermak, Q Y Zho. Evidence for non-oxidative dopamine cytotoxicity: potent activation of NF-kappa B and lack of protection by anti-oxidants. Journal of neurochemistry. vol 76. issue 6. 2001-04-12. PMID:11259497. |
mitigating intracellular dopamine toxicity could be a novel strategy of slowing the progressive degeneration of dopaminergic neurons in parkinson's disease. |
2001-04-12 |
2023-08-12 |
Not clear |
| T Boraud, E Bezard, B Bioulac, C E Gros. Dopamine agonist-induced dyskinesias are correlated to both firing pattern and frequency alterations of pallidal neurones in the MPTP-treated monkey. Brain : a journal of neurology. vol 124. issue Pt 3. 2001-04-05. PMID:11222455. |
in this study, electrophysiological single-unit recordings of the neuronal activity of the globus pallidus internalis (gpi), the main basal ganglia output structure, and the globus pallidus externalis (gpe) were recorded continuously in both normal and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine treated subhuman primates before and after the administration of three dopamine agonists--apomorphine (a dopaminergic mixed agonist), skf-38393 (a d1 partial agonist) and piribedil (a d2/d3 agonist)--at doses known to induce dyskinesias in the parkinsonian monkey. |
2001-04-05 |
2023-08-12 |
monkey |
| K Kannari, H Yamato, H Shen, M Tomiyama, T Suda, M Matsunag. Activation of 5-HT(1A) but not 5-HT(1B) receptors attenuates an increase in extracellular dopamine derived from exogenously administered L-DOPA in the striatum with nigrostriatal denervation. Journal of neurochemistry. vol 76. issue 5. 2001-04-05. PMID:11238719. |
in order to determine whether l-dopa-derived extracellular dopamine (da) in the striatum with dopaminergic denervation is affected by activation of serotonin autoreceptors (5-ht(1a) and 5-ht(1b) receptors), we applied in vivo brain microdialysis technique to 6-hydroxydopamine-lesioned rats and examined the effects of the selective 5-ht(1a) receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-oh-dpat) and the selective 5-ht(1b) receptor agonist cgs-12066 a on l-dopa-derived extracellular da levels. |
2001-04-05 |
2023-08-12 |
rat |
| P Sacchetti, T R Mitchell, J G Granneman, M J Banno. Nurr1 enhances transcription of the human dopamine transporter gene through a novel mechanism. Journal of neurochemistry. vol 76. issue 5. 2001-04-05. PMID:11238740. |
to address this issue, we analyzed the effects of nurr1 on the transcriptional expression of the human dopamine transporter gene (hdat), one of the most specific phenotypic markers for dopaminergic neurons. |
2001-04-05 |
2023-08-12 |
human |
| R A Barke. Prospects for the treatment of Parkinson's disease using neural grafts. Expert opinion on pharmacotherapy. vol 1. issue 5. 2001-04-05. PMID:11249498. |
to date, the mainstay of treatment for patients with pd has been drugs that activate the dopaminergic network, namely the dopamine precursor l-dopa and dopamine receptor agonists. |
2001-04-05 |
2023-08-12 |
Not clear |
| K Nakamura, M Ahmed, E Barr, J M Leiden, U J Kan. The localization and functional contribution of striatal aromatic L-amino acid decarboxylase to L-3,4-dihydroxyphenylalanine decarboxylation in rodent parkinsonian models. Cell transplantation. vol 9. issue 5. 2001-03-29. PMID:11144954. |
given the loss of aadc-containing nigrostriatal dopaminergic neurons in pd, however, the location of residual aadc that converts l-dopa into dopamine remains controversial. |
2001-03-29 |
2023-08-12 |
rat |
| N A Muma, J M Lee, L Gorman, B A Heidenreich, I Mitrovic, T C Napie. 6-hydroxydopamine-induced lesions of dopaminergic neurons alter the function of postsynaptic cholinergic neurons without changing cytoskeletal proteins. Experimental neurology. vol 168. issue 1. 2001-03-29. PMID:11170728. |
the 6-hydroxydopamine injections robustly reduced the number of monoaminergic cell bodies in the lateral midbrain and dramatically decreased dopamine and its major metabolites in dopaminergic projection sites. |
2001-03-29 |
2023-08-12 |
rat |
| G Glavan, R Zorec, K Babic, D Sket, M Zivi. Dopaminergic regulation of synaptotagmin I and IV mRNAs in hemiparkinsonian rats. Neuroreport. vol 11. issue 18. 2001-03-29. PMID:11192626. |
we show that chronic dopaminergic denervation resulted in a small down-regulation of striatal syt i mrna, whereas acute treatment with skf-82958, a dopamine d1 receptor agonist, induced a massive syt iv mrna upregulation in the striatum on the lesioned side. |
2001-03-29 |
2023-08-12 |
rat |
| V D Nair, R K Mishr. Molecular cloning, localization and characterization of a 40-kDa catecholamine-regulated protein. Journal of neurochemistry. vol 76. issue 4. 2001-03-22. PMID:11181834. |
immunolocalization studies using mabs to dopamine show that it colocalizes with crp40 in the vesicles of dopaminergic neuroblastoma sh-sy5y cells. |
2001-03-22 |
2023-08-12 |
cattle |
| R Linke, J Gostomzyk, K Hahn, K Tatsc. [123I]IPT binding to the presynaptic dopamine transporter: variation of intra- and interobserver data evaluation in parkinsonian patients and controls. European journal of nuclear medicine. vol 27. issue 12. 2001-03-22. PMID:11189944. |
imaging the presynaptic dopamine transporter with cocaine analogues and single-photon emission tomography (spet) has proven to be a potential diagnostic tool for classifying the extent and degree of dopaminergic nerve cell loss. |
2001-03-22 |
2023-08-12 |
Not clear |
| M Yamaya, M Yanai, T Ohrui, H Arai, H Sasak. Interventions to prevent pneumonia among older adults. Journal of the American Geriatrics Society. vol 49. issue 1. 2001-03-22. PMID:11207848. |
similarly, since the production of substance p is regulated by dopaminergic neurons in the cerebral basal ganglia, treatment with dopamine analogs or potentiating drugs such as amantadine (and, of course, prevention of cerebral vascular disease, which can result in basal ganglia strokes) should affect the incidence of pneumonia. |
2001-03-22 |
2023-08-12 |
Not clear |
| S Doolen, N R Zahnise. Protein tyrosine kinase inhibitors alter human dopamine transporter activity in Xenopus oocytes. The Journal of pharmacology and experimental therapeutics. vol 296. issue 3. 2001-03-15. PMID:11181926. |
the dopamine (da) transporter (dat) regulates dopaminergic synaptic transmission by controlling extracellular levels of da. |
2001-03-15 |
2023-08-12 |
human |
| A Khullar, P Chue, P Tibb. Quetiapine and obsessive-compulsive symptoms (OCS): case report and review of atypical antipsychotic-induced OCS. Journal of psychiatry & neuroscience : JPN. vol 26. issue 1. 2001-03-15. PMID:11212595. |
mechanisms, including 5-ht2a and 5-ht2c antagonism, serotonergic regulation of dopamine systems and putative dopaminergic subtypes of ocs and ocd, are discussed. |
2001-03-15 |
2023-08-12 |
Not clear |
| E Růzicka, F el Massioui, B Pillon, B Dubois, B Renault, Y Agi. The effects of apomorphine on attentional processing in Parkinson's disease. Sbornik lekarsky. vol 100. issue 2. 2001-03-15. PMID:11220166. |
the contrasting effects of dopaminergic stimulation on the motor performance and on some aspects of cognitive processing suggest the existence of complex interactions within pre- and postsynaptic brain dopamine receptors, and an intervention of segregated basal ganglia-prefrontal cortex loops in motor and cognitive behaviour. |
2001-03-15 |
2023-08-12 |
Not clear |
| J L Ridet, N Déglon, P Aebische. Gene transfer techniques for the delivery of GDNF in Parkinson's disease. Novartis Foundation symposium. vol 231. 2001-03-08. PMID:11131539. |
among neurotrophic molecules, the potential of the glial cell line-derived neurotrophic factor (gdnf) to protect the nigral dopaminergic neurons and/or rescue striatal dopamine levels has been extensively documented. |
2001-03-08 |
2023-08-12 |
Not clear |
| A Björklun. Cell replacement strategies for neurodegenerative disorders. Novartis Foundation symposium. vol 231. 2001-03-08. PMID:11131546. |
clinical trials have so far focused on the use of implants of embryonic mesencephalic tissue containing already fate-committed dopaminergic neuroblasts with the capacity to develop into fully mature dopamine neurons in their new location in the host brain. |
2001-03-08 |
2023-08-12 |
Not clear |