| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| V F Sahach, M M Tkachenko, M V Shapova. [The length-force dependence of vascular smooth muscles and the nitric oxide system in a chronic deficiency of mesostriatal dopamine]. Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994). vol 45. issue 6. 2000-03-15. PMID:10687075. |
this study investigated the influence of the chronic cerebral dopamine deficiency after 6-hydroxydopamine lesions of dopaminergic mesostriatal system and no pathways on the length-tension relation in vascular smooth muscles to their distension. |
2000-03-15 |
2023-08-12 |
rat |
| G Cai, X Zhen, K Uryu, E Friedma. Activation of extracellular signal-regulated protein kinases is associated with a sensitized locomotor response to D(2) dopamine receptor stimulation in unilateral 6-hydroxydopamine-lesioned rats. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 5. 2000-03-09. PMID:10684886. |
in the present study, dopamine receptor-mediated regulation of extracellular signal-regulated kinases (erks) was examined in rats in which the nigrostriatal dopaminergic pathway was unilaterally lesioned by 6-hydroxydopamine (6-ohda). |
2000-03-09 |
2023-08-12 |
rat |
| A Terasmaa, U B Finnman, C Owman, S Ferré, K Fuxe, A Rinke. Modulation of [(35)S]GTPgammaS binding to chinese hamster ovary cell membranes by D(2(short)) dopamine receptors. Neuroscience letters. vol 280. issue 2. 2000-03-09. PMID:10686396. |
among 18 dopaminergic ligands studied dopamine, npa, apomorphine and quinpirole were full agonists in activation of [(35)s]gtpgammas binding, while seven ligands were partial agonists with efficacies from 16 to 69% of the effect of dopamine and seven ligands were antagonists having no effect on the basal level of [(35)s]gtpgammas binding, but inhibited dopamine-dependent activation in a dose-response manner. |
2000-03-09 |
2023-08-12 |
rat |
| J Zhang, V Kravtsov, V Amarnath, M J Picklo, D G Graham, T J Montin. Enhancement of dopaminergic neurotoxicity by the mercapturate of dopamine: relevance to Parkinson's disease. Journal of neurochemistry. vol 74. issue 3. 2000-03-09. PMID:10693927. |
enhancement of dopaminergic neurotoxicity by the mercapturate of dopamine: relevance to parkinson's disease. |
2000-03-09 |
2023-08-12 |
rat |
| J Zhang, V Kravtsov, V Amarnath, M J Picklo, D G Graham, T J Montin. Enhancement of dopaminergic neurotoxicity by the mercapturate of dopamine: relevance to Parkinson's disease. Journal of neurochemistry. vol 74. issue 3. 2000-03-09. PMID:10693927. |
the mechanisms that underlie dopaminergic neurodegeneration in parkinson's disease (pd) are not known but have been proposed to involve oxidation of dopamine and related catechols. |
2000-03-09 |
2023-08-12 |
rat |
| M van den Buuse, K M Webbe. Endothelin and dopamine release. Progress in neurobiology. vol 60. issue 4. 2000-03-07. PMID:10670706. |
moreover, lesion studies showed that et(b) receptors are present on dopaminergic neuronal terminals in striatum and studies with local administration of endothelins into the ventral striatum showed that activation of these receptors causes dopamine release, as measured both with in vivo voltammetry and behavioural methods. |
2000-03-07 |
2023-08-12 |
Not clear |
| D A MacGregor, T E Smith, R C Prielipp, J F Butterworth, R L James, P E Scuder. Pharmacokinetics of dopamine in healthy male subjects. Anesthesiology. vol 92. issue 2. 2000-03-06. PMID:10691218. |
dopamine is an agonist of alpha, beta, and dopaminergic receptors with varying hemodynamic effects depending on the dose of drug being administered. |
2000-03-06 |
2023-08-12 |
human |
| D Boulay, R Depoortere, G Perrault, D J Sange. Decreased locomotor activity after microinjection of dopamine D2/D3 receptor agonists and antagonists into lobule 9/10 of the cerebellum: a D3 receptor mediated effect? Progress in neuro-psychopharmacology & biological psychiatry. vol 24. issue 1. 2000-03-02. PMID:10659982. |
the restricted localization of dopamine (da) d3 receptors in the rat cerebellum lobule 9/10 appears to provide a method for investigating the in vivo selectivity of dopaminergic compounds for the d3 receptor subtype. |
2000-03-02 |
2023-08-12 |
rat |
| Z Puschban, C Scherfler, R Granata, P Laboyrie, N P Quinn, P Jenner, W Poewe, G K Wennin. Autoradiographic study of striatal dopamine re-uptake sites and dopamine D1 and D2 receptors in a 6-hydroxydopamine and quinolinic acid double-lesion rat model of striatonigral degeneration (multiple system atrophy) and effects of embryonic ventral mesencephalic, striatal or co-grafts. Neuroscience. vol 95. issue 2. 2000-02-29. PMID:10658617. |
striatal [3h]mazindol binding on the lesioned side (excluding the demarcated graft area) revealed a marked loss of dopamine re-uptake sites across all treatment groups, indicating missing graft-induced dopaminergic re-innervation of the host. |
2000-02-29 |
2023-08-12 |
rat |
| S Ueda, M Aikawa, A Ishizuya-Oka, S Yamaoka, N Koibuchi, K Yoshimot. Age-related dopamine deficiency in the mesostriatal dopamine system of zitter mutant rats: regional fiber vulnerability in the striatum and the olfactory tubercle. Neuroscience. vol 95. issue 2. 2000-02-29. PMID:10658618. |
to test the oxidant stress hypothesis of dopaminergic degeneration, age-related changes in the mesostriatal dopamine neuron system were compared between zitter mutant rats which have abnormal metabolism of oxygen species in the brain and sprague-dawley rat as a control using the neurochemistry and immunohistochemistry. |
2000-02-29 |
2023-08-12 |
rat |
| J D Elsworth, J R Taylor, J R Sladek, T J Collier, D E Redmond, R H Rot. Striatal dopaminergic correlates of stable parkinsonism and degree of recovery in old-world primates one year after MPTP treatment. Neuroscience. vol 95. issue 2. 2000-02-29. PMID:10658619. |
this study examines the relationship between markers of dopamine neuron integrity and dopaminergic metabolic activity in striatal subregions with the degree of parkinsonian disability in 32 monkeys treated with mptp one year earlier. |
2000-02-29 |
2023-08-12 |
monkey |
| M Legault, P P Rompré, R A Wis. Chemical stimulation of the ventral hippocampus elevates nucleus accumbens dopamine by activating dopaminergic neurons of the ventral tegmental area. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 4. 2000-02-25. PMID:10662853. |
chemical stimulation of the ventral hippocampus elevates nucleus accumbens dopamine by activating dopaminergic neurons of the ventral tegmental area. |
2000-02-25 |
2023-08-12 |
rat |
| A Hinney, J Schneider, A Ziegler, G Lehmkuhl, F Poustka, M H Schmidt, H Mayer, W Siegfried, H Remschmidt, J Hebebran. No evidence for involvement of polymorphisms of the dopamine D4 receptor gene in anorexia nervosa, underweight, and obesity. American journal of medical genetics. vol 88. issue 6. 2000-02-24. PMID:10581473. |
the dopaminergic system has been implicated in weight regulation; previous results had suggested a possible involvement of the dopamine d4 receptor gene (drd4). |
2000-02-24 |
2023-08-12 |
Not clear |
| J Schwarz, R Linke, M Kerner, P D Mozley, C Trenkwalder, T Gasser, K Tatsc. Striatal dopamine transporter binding assessed by [I-123]IPT and single photon emission computed tomography in patients with early Parkinson's disease: implications for a preclinical diagnosis. Archives of neurology. vol 57. issue 2. 2000-02-24. PMID:10681078. |
specific binding to dopamine transporters may serve as a tool to detect early loss of nigrostriatal dopaminergic neurons in patients with parkinson's disease. |
2000-02-24 |
2023-08-12 |
Not clear |
| A Palumbo, A Napolitano, P Barone, M d'Ischi. Nitrite- and peroxide-dependent oxidation pathways of dopamine: 6-nitrodopamine and 6-hydroxydopamine formation as potential contributory mechanisms of oxidative stress- and nitric oxide-induced neurotoxicity in neuronal degeneration. Chemical research in toxicology. vol 12. issue 12. 2000-02-17. PMID:10604871. |
collectively, these results outline a complex interplay of no(2)(-)- and peroxide-dependent oxidation pathways of dopamine, which may contribute to impair dopaminergic neurotransmission and induce cytotoxic processes in neurodegenerative disorders. |
2000-02-17 |
2023-08-12 |
rat |
| J M Bostwick, M S Jaffe. Buspirone as an antidote to SSRI-induced bruxism in 4 cases. The Journal of clinical psychiatry. vol 60. issue 12. 2000-02-16. PMID:10665633. |
previous reports have emphasized buspirone's postsynaptic dopaminergic effect as a partial antidote to the suppressed dopamine levels. |
2000-02-16 |
2023-08-12 |
Not clear |
| N B Mercuri, M Federici, G Bernard. Inhibition of catechol-O-methyltransferase (COMT) in the brain does not affect the action of dopamine and levodopa: an in vitro electrophysiological evidence from rat mesencephalic dopamine neurons. Journal of neural transmission (Vienna, Austria : 1996). vol 106. issue 11-12. 2000-02-15. PMID:10651109. |
the lack of modification of the dopaminergic effects by tolcapone suggests that the pharmacological inhibition of intracerebral comt does not have detectable action on dopamine neurotransmission. |
2000-02-15 |
2023-08-12 |
rat |
| D M Donovan, L L Miner, M P Perry, R S Revay, L G Sharpe, S Przedborski, V Kostic, R M Philpot, C L Kirstein, R B Rothman, C W Schindler, G R Uh. Cocaine reward and MPTP toxicity: alteration by regional variant dopamine transporter overexpression. Brain research. Molecular brain research. vol 73. issue 1-2. 2000-02-14. PMID:10581396. |
the dopamine transporter (dat; slc6a3) is densely expressed by the dopaminergic midbrain neurons that play central roles in drug reward and is believed to be a primary site of action for cocaine reward. |
2000-02-14 |
2023-08-12 |
mouse |
| L Chen, D M Segal, C T Moraes, D C Mas. Dopamine transporter mRNA in autopsy studies of chronic cocaine users. Brain research. Molecular brain research. vol 73. issue 1-2. 2000-02-14. PMID:10581411. |
the effects of chronic cocaine abuse on transcriptional regulation of human dopamine transporter (dat) mrna in midbrain dopaminergic neurons was assessed by reverse transcription-polymerase chain reaction (rt-pcr). |
2000-02-14 |
2023-08-12 |
human |
| H Gurden, J P Tassin, T M Ja. Integrity of the mesocortical dopaminergic system is necessary for complete expression of in vivo hippocampal-prefrontal cortex long-term potentiation. Neuroscience. vol 94. issue 4. 2000-02-14. PMID:10625044. |
the present study demonstrates the importance of the integrity of the mesocortical dopaminergic system for long-term potentiation to occur in the hippocampal-prefrontal cortex pathway and suggests a frequency-dependent effect of dopamine on hippocampal-prefrontal cortex transmission. |
2000-02-14 |
2023-08-12 |
rat |