| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R L Commissaris, M Tavakoli-Nezhad, A J Barron, D K Pitt. Effects of chronic low-level oral lead exposure on prepulse inhibition of acoustic startle in the rat. Neurotoxicology and teratology. vol 22. issue 1. 2000-02-14. PMID:10642114. |
given the strong link between the modulation of ppi and dopaminergic neurotransmission in the nucleus accumbens, the present data support the hypothesis that chronic low-level oral lead exposure facilitates dopamine neurotransmission in the nucleus accumbens. |
2000-02-14 |
2023-08-12 |
rat |
| S R Sinclair, J W Fawcett, S B Dunnet. Dopamine cells in nigral grafts differentiate prior to implantation. The European journal of neuroscience. vol 11. issue 12. 2000-02-10. PMID:10594660. |
precursor cells that would differentiate into dopaminergic neurons beyond e14 if left in situ in the intact ventral mesencephalon do not readily differentiate into mature dopamine neurons following transplantation. |
2000-02-10 |
2023-08-12 |
rat |
| S R Sinclair, J W Fawcett, S B Dunnet. Dopamine cells in nigral grafts differentiate prior to implantation. The European journal of neuroscience. vol 11. issue 12. 2000-02-10. PMID:10594660. |
if we are to enhance yields of functional dopamine-rich transplants, then we must identify strategies both to protect predifferentiated dopamine neurons in the grafts and to promote differentiation of a dopaminergic phenotype in precursor cells that continue to divide within the grafts following transplantation into an adult host environment. |
2000-02-10 |
2023-08-12 |
rat |
| D S Latchman, R S Coffi. Viral vectors in the treatment of Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society. vol 15. issue 1. 2000-02-10. PMID:10634236. |
parkinson's disease is an obvious target for the development of gene therapy procedures which could involve both the delivery of the gene encoding tyrosine hydroxylase to boost dopamine production or the delivery of genes encoding neurotrophic factors such as gdnf to promote the survival of dopaminergic neurons. |
2000-02-10 |
2023-08-12 |
Not clear |
| S J Oh, I B Kim, E J Lee, K Y Kim, H I Kim, M H Chu. Immunocytological localization of dopamine in the guinea pig retina. Cell and tissue research. vol 298. issue 3. 2000-02-09. PMID:10639746. |
we examined dopaminergic neurons in the guinea pig retina; antisera against tyrosine hydroxylase (th), dopamine beta-hydroxylase (dbh), phenylethanolamine n-methyltransferase (pnmt) and an antiserum against gamma-aminobutyric acid (gaba) were used. |
2000-02-09 |
2023-08-12 |
Not clear |
| M Markianos, J Hatzimanolis, L Lykoura. Switch from neuroleptics to clozapine does not influence pituitary-gonadal axis hormone levels in male schizophrenic patients. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 9. issue 6. 2000-02-08. PMID:10625122. |
hypothalamic dopaminergic and serotonergic inputs participate in the regulation of pituitary hormones, and drugs that block central dopamine and serotonin receptors are expected to influence the hypothalamus-pituitary-gonadal (hpg) and -adrenal (hpa) axes. |
2000-02-08 |
2023-08-12 |
Not clear |
| G Gobbi, L Janir. Clozapine blocks dopamine, 5-HT2 and 5-HT3 responses in the medial prefrontal cortex: an in vivo microiontophoretic study. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 10. issue 1. 2000-02-02. PMID:10647096. |
it is concluded that clozapine at the mpfc level exerts a complex modulatory activity on dopamine receptors, that is directly at the dopaminergic receptors and through 5-ht receptors on the same neurons. |
2000-02-02 |
2023-08-12 |
Not clear |
| M Velasco, A Luchsinge. Dopamine: pharmacologic and therapeutic aspects. American journal of therapeutics. vol 5. issue 1. 2000-01-31. PMID:10099036. |
it has been widely established that dopamine and its agonists play an important role in cardiovascular, renal, hormonal, and central nervous system regulation through stimulation of alpha and beta adrenergic and dopaminergic receptors. |
2000-01-31 |
2023-08-12 |
Not clear |
| M Glagow, J Ewer. Apomorphine alters prey-catching patterns in the common toad: behavioral experiments and (14)C-2-deoxyglucose brain mapping studies. Brain, behavior and evolution. vol 54. issue 4. 2000-01-31. PMID:10592384. |
previous studies on the dopaminergic modulation of visuomotor functions in amphibians showed that the dopamine agonist apomorphine (apo) alters prey-catching strategies. |
2000-01-31 |
2023-08-12 |
rat |
| I N Krasnova, E R Bychkov, V I Lioudyno, O E Zubareva, S A Dambinov. Intracerebroventricular administration of substance P increases dopamine content in the brain of 6-hydroxydopamine-lesioned rats. Neuroscience. vol 95. issue 1. 2000-01-31. PMID:10619467. |
the results of this study suggest that substance p helps to restore dopamine deficit in the brain in an animal model of parkinson's disease, with the positive effects being more prominent on the nigrostriatal than on the mesocorticolimbic dopaminergic system, but substance p(5-11) is not responsible for this effect. |
2000-01-31 |
2023-08-12 |
rat |
| F H Previ. Dopamine and the origins of human intelligence. Brain and cognition. vol 41. issue 3. 2000-01-27. PMID:10585240. |
a dopaminergic expansion during early hominid evolution could have enabled successful chase-hunting in the savannas of sub-saharan africa, given the critical role of dopamine in counteracting hyperthermia during endurance activity. |
2000-01-27 |
2023-08-12 |
human |
| S Okuyam. [Atypical antipsychotic profiles of sigma receptor ligands]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 114. issue 1. 2000-01-21. PMID:10562961. |
the mode of action of ne-100 is estimated to be the indirect modulation of the nmda/pcp-receptor ion channel complex and the modulation of dopamine release from the dopaminergic nerve terminals. |
2000-01-21 |
2023-08-12 |
Not clear |
| R Lints, S W Emmon. Patterning of dopaminergic neurotransmitter identity among Caenorhabditis elegans ray sensory neurons by a TGFbeta family signaling pathway and a Hox gene. Development (Cambridge, England). vol 126. issue 24. 2000-01-21. PMID:10572056. |
we used expression of a tyrosine hydroxylase reporter transgene as well as direct assays for dopamine to study the genetic requirements for adoption of the dopaminergic cell fate. |
2000-01-21 |
2023-08-12 |
caenorhabditis_elegans |
| G Ebersbach, M Stöck, J Müller, G Wenning, J Wissel, W Poew. Worsening of motor performance in patients with Parkinson's disease following transdermal nicotine administration. Movement disorders : official journal of the Movement Disorder Society. vol 14. issue 6. 2000-01-20. PMID:10584678. |
a negative response to subthreshold dopaminergic stimulation, resulting from an inhibitory effect of low striatal dopamine concentrations acting on a subset of dopamine receptors, might possibly account for this finding. |
2000-01-20 |
2023-08-12 |
Not clear |
| K Kannari, H Tanaka, T Maeda, M Tomiyama, T Suda, M Matsunag. Reserpine pretreatment prevents increases in extracellular striatal dopamine following L-DOPA administration in rats with nigrostriatal denervation. Journal of neurochemistry. vol 74. issue 1. 2000-01-18. PMID:10617128. |
the influence of l-dopa and reserpine on extracellular dopamine (da) levels in the striatum of intact and dopaminergic denervated rats was studied using the brain microdialysis technique. |
2000-01-18 |
2023-08-12 |
rat |
| H Salim, S Ferré, A Dalal, R A Peterfreund, K Fuxe, J D Vincent, P M Lled. Activation of adenosine A1 and A2A receptors modulates dopamine D2 receptor-induced responses in stably transfected human neuroblastoma cells. Journal of neurochemistry. vol 74. issue 1. 2000-01-18. PMID:10617149. |
adenosine can influence dopaminergic neurotransmission in the basal ganglia via postsynaptic interaction between adenosine a2a and dopamine d2 receptors. |
2000-01-18 |
2023-08-12 |
human |
| J Guardia, A M Catafau, F Batlle, J C Martín, L Segura, B Gonzalvo, G Prat, I Carrió, M Casa. Striatal dopaminergic D(2) receptor density measured by [(123)I]iodobenzamide SPECT in the prediction of treatment outcome of alcohol-dependent patients. The American journal of psychiatry. vol 157. issue 1. 2000-01-18. PMID:10618027. |
the authors' goal was to study striatal dopaminergic dopamine 2 (d(2)) receptors as a biological marker of early relapse in detoxified alcoholic patients by using [(123)i]iodobenzamide ([123i]ibzm) single photon emission computed tomography (spect). |
2000-01-18 |
2023-08-12 |
Not clear |
| G M Daniels, S G Amar. Regulated trafficking of the human dopamine transporter. Clathrin-mediated internalization and lysosomal degradation in response to phorbol esters. The Journal of biological chemistry. vol 274. issue 50. 2000-01-13. PMID:10585462. |
the dopamine transporter plays an essential role in the modulation of dopaminergic neurotransmission by mediating the reuptake of dopamine into presynaptic neurons. |
2000-01-13 |
2023-08-12 |
human |
| J E Demaria, G M Nagy, A A Lerant, M I Fekete, C W Levenson, M E Freema. Dopamine transporters participate in the physiological regulation of prolactin. Endocrinology. vol 141. issue 1. 2000-01-13. PMID:10614659. |
three populations of hypothalamic neuroendocrine dopaminergic (neda) neurons, arising from the arcuate and periventricular nuclei of the hypothalamus release dopamine (da) that acts at the pituitary gland to regulate the secretion of prl. |
2000-01-13 |
2023-08-12 |
rat |
| W Hauber, S Lut. Dopamine D1 or D2 receptor blockade in the globus pallidus produces akinesia in the rat. Behavioural brain research. vol 106. issue 1-2. 2000-01-11. PMID:10595430. |
the findings further imply that defective dopaminergic transmission in the gp might contribute to akinesia due to lesion- or drug-induced dopamine hypofunction in experimental animals and in neurodegenerative diseases, e.g. |
2000-01-11 |
2023-08-12 |
rat |