| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Toshifumi Matsui, Takae Ebihara, Takashi Ohrui, Mutsuo Yamaya, Hiroyuki Arai, Hidetada Sasak. [Cerebrovascular disease and pneumonia in the elderly]. Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics. vol 40. issue 4. 2003-09-09. PMID:12934558. |
moreover, use of a dopamine agonist such as amantadine hydrochloride and a folic acid supplement that are known to potentiate dopaminergic neurons also prevented aspiration pneumonia. |
2003-09-09 |
2023-08-12 |
Not clear |
| Monica Levy Andersen, Magda Bignotto, Sergio Tufi. Facilitation of ejaculation after methamphetamine administration in paradoxical sleep deprived rats. Brain research. vol 978. issue 1-2. 2003-09-08. PMID:12834895. |
since psd induces dopaminergic alterations and dopamine (da) has a key role in male sexual behavior, plasma da was also measured. |
2003-09-08 |
2023-08-12 |
rat |
| Giulio Nanni, Simona Scheggi, Benedetta Leggio, Silvia Grappi, Flavio Masi, Riccardo Rauggi, Maria Graziella De Monti. Acquisition of an appetitive behavior prevents development of stress-induced neurochemical modifications in rat nucleus accumbens. Journal of neuroscience research. vol 73. issue 4. 2003-09-08. PMID:12898542. |
these results support the hypothesis that changes induced in pre- and postsynaptic dopaminergic transmission by chronic stress exposure are related to decreased dopamine output. |
2003-09-08 |
2023-08-12 |
rat |
| Wen-Sheng Huang, Yung-Hsiao Chiang, Jiann-Chyun Lin, Yuan-Hwa Chou, Cheng-Yi Cheng, Ren-Shyan Li. Crossover study of (99m)Tc-TRODAT-1 SPECT and (18)F-FDOPA PET in Parkinson's disease patients. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 44. issue 7. 2003-09-04. PMID:12843212. |
99mtc-trodat-1 ([2-[[2-[[[3-(4-chlorophenyl)-8-methyl-8-azabicyclo[3,2,1]oct-2-yl]methyl](2-mercaptoethyl)amino]ethyl]amino]ethanethiolato(3-)-n2,n2',s2,s2']oxo-[1r-(exo-exo)]) is a potential agent for dopamine transporter (dat) spect, whereas 6-(18)f-fluoro-l-dopa ((18)f-fdopa) pet has been used for the quantitative assessment of presynaptic nigrostriatal dopaminergic function. |
2003-09-04 |
2023-08-12 |
Not clear |
| S Engelborghs, B Marescau, P P De Dey. Amino acids and biogenic amines in cerebrospinal fluid of patients with Parkinson's disease. Neurochemical research. vol 28. issue 8. 2003-09-03. PMID:12834252. |
significantly lower concentrations of the dopamine metabolite 3,4-dihydroxyphenylacetic acid in the parkinson's disease group might reflect dopaminergic cell loss. |
2003-09-03 |
2023-08-12 |
Not clear |
| Naheed R Mirza, Dan Peters, Robin G Spark. Xanomeline and the antipsychotic potential of muscarinic receptor subtype selective agonists. CNS drug reviews. vol 9. issue 2. 2003-09-02. PMID:12847557. |
in general, xanomeline has an antipsychotic-like profile in various dopamine models of psychosis and this agrees with the known interactions between the cholinergic and dopaminergic systems in the brain. |
2003-09-02 |
2023-08-12 |
human |
| M Gerlach, P Riedere. [Current preclinical findings on substances against Parkinson's disease]. Der Nervenarzt. vol 74 Suppl 1. 2003-08-28. PMID:12624677. |
in the case of pd, the main strategies are to develop (1) alternatives to l-dopa therapy for alleviating the striatal dopamine deficit while avoiding or retarding the long-term l-dopa syndrome, (2) antidyskinetic approaches, and (3) neuroprotective drugs aimed at causal treatment of pd which is able to preserve the remaining dopaminergic neurones and to halt or at least retard the disease process. |
2003-08-28 |
2023-08-12 |
Not clear |
| Hyun Jin Choi, Seong Who Kim, So Yeon Lee, Onyou Hwan. Dopamine-dependent cytotoxicity of tetrahydrobiopterin: a possible mechanism for selective neurodegeneration in Parkinson's disease. Journal of neurochemistry. vol 86. issue 1. 2003-08-26. PMID:12807434. |
this study shows that bh4-induced dopaminergic cell death is primarily mediated by dopamine, evidenced by findings that (i) bh4 toxicity is increased in proportion to cellular dopamine content; (ii) non-dopaminergic cells become susceptible to bh4 upon exposure to dopamine; and (iii) depletion of dopamine attenuates bh4 toxicity in dopamine-producing cells. |
2003-08-26 |
2023-08-12 |
Not clear |
| Hyun Jin Choi, Seong Who Kim, So Yeon Lee, Onyou Hwan. Dopamine-dependent cytotoxicity of tetrahydrobiopterin: a possible mechanism for selective neurodegeneration in Parkinson's disease. Journal of neurochemistry. vol 86. issue 1. 2003-08-26. PMID:12807434. |
these data taken together suggest that the presence of both bh4 and dopamine is important in rendering dopaminergic cells vulnerable and that this involves formation of reactive dopamine quinone products. |
2003-08-26 |
2023-08-12 |
Not clear |
| M O Mikhailov. Comparison of changes in glutamate levels in the nucleus accumbens of the rat brain during food consumption in conditions of blockade of dopamine D1 and D2 receptors. Neuroscience and behavioral physiology. vol 33. issue 5. 2003-08-26. PMID:12921172. |
these data suggest that glutamate levels during food consumption are controlled by the dopaminergic system of the nucleus accumbens, mediated by d2 but not d1 dopamine receptors. |
2003-08-26 |
2023-08-12 |
rat |
| Sören Peters, Boris Suchan, Joanna Rusin, Irene Daum, Odo Köster, Horst Przuntek, Thomas Müller, Gebhard Schmi. Apomorphine reduces BOLD signal in fMRI during voluntary movement in Parkinsonian patients. Neuroreport. vol 14. issue 6. 2003-08-22. PMID:12858037. |
one conceivable explanation for our singular results would be preferred binding of apomorphine to presynaptic dopaminergic receptors, leading to inhibition of endogenous dopamine release and resultant diminished dopaminergic stimulation, reflected in diminished cerebral activation patterns. |
2003-08-22 |
2023-08-12 |
Not clear |
| Rebecca Graumann, Irmgard Paris, Pedro Martinez-Alvarado, Pamela Rumanque, Carolina Perez-Pastene, Sergio P Cardenas, Pablo Marin, Fernando Diaz-Grez, Raul Caviedes, Pablo Caviedes, Juan Segura-Aguila. Oxidation of dopamine to aminochrome as a mechanism for neurodegeneration of dopaminergic systems in Parkinson's disease. Possible neuroprotective role of DT-diaphorase. Polish journal of pharmacology. vol 54. issue 6. 2003-08-15. PMID:12866711. |
oxidation of dopamine to aminochrome as a mechanism for neurodegeneration of dopaminergic systems in parkinson's disease. |
2003-08-15 |
2023-08-12 |
rat |
| Rebecca Graumann, Irmgard Paris, Pedro Martinez-Alvarado, Pamela Rumanque, Carolina Perez-Pastene, Sergio P Cardenas, Pablo Marin, Fernando Diaz-Grez, Raul Caviedes, Pablo Caviedes, Juan Segura-Aguila. Oxidation of dopamine to aminochrome as a mechanism for neurodegeneration of dopaminergic systems in Parkinson's disease. Possible neuroprotective role of DT-diaphorase. Polish journal of pharmacology. vol 54. issue 6. 2003-08-15. PMID:12866711. |
we propose that the degeneration of dopaminergic nigrostriatal system in this condition may depend on: (a) existence of free dopamine which oxidizes to aminochrome as a consequence of: (i) overproduction of dopamine; (ii) inhibition and/or low expression of synaptic vesicle catecholamine transporter; (iii) inhibition or low expression of monoamine oxidases; (b) one-electron reduction of aminochrome to leukoaminochrome o-semiquinone radical, which induces neurotoxicity, due to inhibition of dt-diaphorase or the existence of a polymorphism with a point mutation (c --> t) in the cdna 609 expressing an inactive dt-diaphorase. |
2003-08-15 |
2023-08-12 |
rat |
| Agnieszka Pałucha, Andrzej Pil. On the role of metabotropic glutamate receptors in the mechanisms of action of antidepressants. Polish journal of pharmacology. vol 54. issue 6. 2003-08-15. PMID:12866712. |
most conventional antidepressant drugs influence serotoninergic, adrenergic, and/or dopaminergic systems, increasing serotonin, norepinephrine and dopamine synaptic availability. |
2003-08-15 |
2023-08-12 |
Not clear |
| Yasushi Kitaoka, Toshio Kumai, Kazuyuki Isenoumi, Yuka Kitaoka, Masamitsu Motoki, Shinichi Kobayashi, Satoki Uen. Neuroprotective effect of nitric oxide against NMDA-induced neurotoxicity in the rat retina is associated with tyrosine hydroxylase expression. Brain research. vol 977. issue 1. 2003-08-14. PMID:12788512. |
n-methyl-d-aspartate (nmda) may affect dopaminergic cells, which contain tyrosine hydroxylase (th), the rate-limiting enzyme in dopamine synthesis. |
2003-08-14 |
2023-08-12 |
rat |
| H Umemori, H Ogura, N Tozawa, K Mikoshiba, H Nishizumi, T Yamamot. Impairment of N-methyl-D-aspartate receptor-controlled motor activity in LYN-deficient mice. Neuroscience. vol 118. issue 3. 2003-08-08. PMID:12710978. |
s.c. injection of methylphenidate, which causes accumulation of dopamine in synapses, reveals that dopaminergic pathway is normal in lyn-/- mice. |
2003-08-08 |
2023-08-12 |
mouse |
| P A Garris, E A Budygin, P E M Phillips, B J Venton, D L Robinson, B P Bergstrom, G V Rebec, R M Wightma. A role for presynaptic mechanisms in the actions of nomifensine and haloperidol. Neuroscience. vol 118. issue 3. 2003-08-08. PMID:12710989. |
psychomotor stimulants and neuroleptics exert multiple effects on dopaminergic signaling and produce the dopamine (da)-related behaviors of motor activation and catalepsy, respectively. |
2003-08-08 |
2023-08-12 |
Not clear |
| Stefan R Pulver, Vatsala Thirumalai, Kathryn S Richards, Eve Marde. Dopamine and histamine in the developing stomatogastric system of the lobster Homarus americanus. The Journal of comparative neurology. vol 462. issue 4. 2003-08-08. PMID:12811809. |
bath application of dopamine increased the frequency of the pyloric rhythm in embryos, and evidence for dopaminergic activation of peripherally initiated spiking in motor axons was seen. |
2003-08-08 |
2023-08-12 |
lobster |
| b' Horst H Simon, Lavinia Bhatt, Daniel Gherbassi, Paola Sgad\\xc3\\xb3, Lavinia Alber\\xc3\\xa. Midbrain dopaminergic neurons: determination of their developmental fate by transcription factors. Annals of the New York Academy of Sciences. vol 991. 2003-08-04. PMID:12846972.' |
midbrain dopaminergic neurons are the main source of dopamine in the mammalian central nervous system and are associated with one of the most prominent human neurological disorders, parkinson's disease. |
2003-08-04 |
2023-08-12 |
human |
| Timothy J Collier, Kathy Steece-Collier, Susan McGuire, Caryl E Sortwel. Cellular models to study dopaminergic injury responses. Annals of the New York Academy of Sciences. vol 991. 2003-08-04. PMID:12846983. |
the study of immature midbrain dopamine (da) neurons and dopaminergic cell lines in culture provides an opportunity to analyze mechanisms of cell death and avenues of potential intervention relevant to parkinson's disease (pd) in a controlled environment. |
2003-08-04 |
2023-08-12 |
Not clear |