| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hongjun Li, Zhanlong He, Ting Su, Yanbing Ma, Shuaiyao Lu, Changbai Dai, Maosheng Su. Protective action of recombinant neurturin on dopaminergic neurons in substantia nigra in a rhesus monkey model of Parkinson's disease. Neurological research. vol 25. issue 3. 2003-06-06. PMID:12739234. |
parkinson's disease (pd) is a neurodegenerative disease characterized by muscular trembling palsy due to lack of dopamine (da) in the substantia nigra-striatum (nigrostriatal) system resulting from the degeneration and necrosis of dopaminergic neurons. |
2003-06-06 |
2023-08-12 |
human |
| S J Crocker, P Liston, H Anisman, C J Lee, P D Smith, N Earl, C S Thompson, D S Park, R G Korneluk, G S Robertso. Attenuation of MPTP-induced neurotoxicity and behavioural impairment in NSE-XIAP transgenic mice. Neurobiology of disease. vol 12. issue 2. 2003-05-30. PMID:12667469. |
we demonstrate that nigrostriatal dopamine neurons of nse-xiap mice were resistant to the damaging effects of the dopaminergic neurotoxin mptp. |
2003-05-30 |
2023-08-12 |
mouse |
| Nobuyo Ohtani, Tomohide Goto, Christian Waeber, Pradeep G Bhid. Dopamine modulates cell cycle in the lateral ganglionic eminence. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 7. 2003-05-30. PMID:12684471. |
these data reveal a novel developmental role for dopamine and underscore the relevance of dopaminergic signaling in brain development. |
2003-05-30 |
2023-08-12 |
Not clear |
| Raul R Gainetdinov, Laura M Bohn, Tatyana D Sotnikova, Michel Cyr, Aki Laakso, Alexander D Macrae, Gonzalo E Torres, Kyeong Man Kim, Robert J Lefkowitz, Marc G Caron, Richard T Premon. Dopaminergic supersensitivity in G protein-coupled receptor kinase 6-deficient mice. Neuron. vol 38. issue 2. 2003-05-28. PMID:12718862. |
the present study indicates that postsynaptic d2-like dopamine receptors are physiological targets for grk6 and suggests that this regulatory mechanism contributes to central dopaminergic supersensitivity. |
2003-05-28 |
2023-08-12 |
mouse |
| Y Kotake, S Ohta, I Kanazawa, M Sakura. Neurotoxicity of an endogenous brain amine, 1-benzyl-1,2,3,4-tetrahydroisoquinoline, in organotypic slice co-culture of mesencephalon and striatum. Neuroscience. vol 117. issue 1. 2003-05-21. PMID:12605893. |
thus a low concentration of 1-benzyl-1,2,3,4-tetrahydroisoquinoline may first induce a decrease in the dopamine content then shrinkage of the cell body, followed by the slow death of dopaminergic neurons over a long period. |
2003-05-21 |
2023-08-12 |
mouse |
| Monica L Andersen, Magda Bignotto, Sergio Tufi. Cocaine-induced genital reflexes during paradoxical sleep deprivation and recovery. Physiology & behavior. vol 78. issue 2. 2003-05-20. PMID:12576123. |
even short periods of psd probably cause supersensitivity of dopamine (da) receptors and exacerbate the effects of cocaine on dopaminergic pathways to induce frequent pe and ej. |
2003-05-20 |
2023-08-12 |
rat |
| Alexander Strobel, Frank M Spinath, Alois Angleitner, Rainer Riemann, Klaus-Peter Lesc. Lack of association between polymorphisms of the dopamine D4 receptor gene and personality. Neuropsychobiology. vol 47. issue 1. 2003-05-15. PMID:12606846. |
recent studies have suggested a role of two polymorphisms of the dopamine d(4) receptor gene (drd4 exon iii and -521c/t) in the modulation of personality traits such as "novelty seeking" or "extraversion", which are supposed to be modulated by individual differences in dopaminergic function. |
2003-05-15 |
2023-08-12 |
human |
| A R Lingford-Hughes, S J C Davies, S McIver, T M Williams, M R C Daglish, D J Nut. Addiction. British medical bulletin. vol 65. 2003-05-15. PMID:12697627. |
the neurochemistry of addiction, particularly involving dopamine, serotonin, opiate and gaba, has been studied with pet and spect and similarities between all drugs of abuse have been found such as reduced dopaminergic markers. |
2003-05-15 |
2023-08-12 |
Not clear |
| Carlos A Paladini, Siobhan Robinson, Hitoshi Morikawa, John T Williams, Richard D Palmite. Dopamine controls the firing pattern of dopamine neurons via a network feedback mechanism. Proceedings of the National Academy of Sciences of the United States of America. vol 100. issue 5. 2003-05-13. PMID:12604788. |
in this study, the effects of dopamine on the firing patterns of dopaminergic neurons in vivo and their electrophysiological characteristics in vitro were examined by using a genetic dopamine-deficient (dd) mouse model. |
2003-05-13 |
2023-08-12 |
mouse |
| Maryka Quik, Jocelyn D Sum, Paul Whiteaker, Sarah E McCallum, Michael J Marks, John Musachio, J Michael McIntosh, Allan C Collins, Sharon R Grad. Differential declines in striatal nicotinic receptor subtype function after nigrostriatal damage in mice. Molecular pharmacology. vol 63. issue 5. 2003-05-13. PMID:12695545. |
those striatal binding and functional measures of nachrs that decreased with mptp treatment correlated with dopamine transporter declines, an observation suggesting that the binding and functional changes in nachrs are limited to dopaminergic terminals. |
2003-05-13 |
2023-08-12 |
mouse |
| Purificación Tejedor-Real, Nicole Faucon Biguet, Sylvie Dumas, Jacques Malle. Tyrosine hydroxylase mRNA and protein are down-regulated by chronic clozapine in both the mesocorticolimbic and the nigrostriatal systems. Journal of neuroscience research. vol 72. issue 1. 2003-05-12. PMID:12645084. |
because tyrosine hydroxylase is the rate-limiting enzyme in the biosynthesis of dopamine, we studied the effect of chronic clozapine in both dopaminergic systems. |
2003-05-12 |
2023-08-12 |
Not clear |
| Cheryl L Holmes, Keith R Walle. Bad medicine: low-dose dopamine in the ICU. Chest. vol 123. issue 4. 2003-05-08. PMID:12684320. |
low-dose dopamine administration (ie, doses < 5 microg/kg/min) has been advocated for 30 years as therapy in oliguric patients on the basis of its action on dopaminergic renal receptors. |
2003-05-08 |
2023-08-12 |
Not clear |
| L Schwieler, D S Delbro, G Engberg, S Erhard. The anaesthetic agent propofol interacts with GABA(B)-receptors: an electrophysiological study in rat. Life sciences. vol 72. issue 24. 2003-05-07. PMID:12679195. |
for this purpose the action of propofol on a gaba-receptor mediated regulation of dopamine neurons was analyzed with extracellular single unit recordings of dopaminergic neurons of the substantia nigra in chloral hydrate anaesthetized rats. |
2003-05-07 |
2023-08-12 |
rat |
| G D Phillips, E Setzu, A Vugler, P K Hitchcot. An immunohistochemical examination of the effects of sensitisation on the mesotelencephalic dopaminergic response to d-amphetamine. Neuroscience. vol 117. issue 3. 2003-05-05. PMID:12617978. |
the dopaminergic response to d-amphetamine with or without prior repeated experience with the drug was investigated immunohistochemically in key target regions of the mesotelencephalic dopamine system using antibodies raised against glutaraldehyde-conjugated dopamine. |
2003-05-05 |
2023-08-12 |
rat |
| G D Phillips, E Setzu, A Vugler, P K Hitchcot. Immunohistochemical assessment of mesotelencephalic dopamine activity during the acquisition and expression of Pavlovian versus instrumental behaviours. Neuroscience. vol 117. issue 3. 2003-05-05. PMID:12617979. |
dopaminergic activity during pavlovian or instrumental learning in key target regions of the mesotelencephalic dopamine system was investigated immunohistochemically using antibodies raised against glutaraldehyde-conjugated dopamine. |
2003-05-05 |
2023-08-12 |
Not clear |
| Luca Pania, Gian Luigi Gessa. Dopaminergic deficit and mood disorders. International clinical psychopharmacology. vol 17 Suppl 4. 2003-05-02. PMID:12685916. |
the same has not occurred for dopamine, notwithstanding the fact that the crucial role of the mesolimbic dopaminergic system in behaviour has been known to researchers for many years. |
2003-05-02 |
2023-08-12 |
Not clear |
| Luca Pania, Gian Luigi Gessa. Dopaminergic deficit and mood disorders. International clinical psychopharmacology. vol 17 Suppl 4. 2003-05-02. PMID:12685916. |
the objective of this article is to provide an overview of the animal data that demonstrate the importance of dopamine in animal behaviour and suggest that dopaminergic deficiency may cause a number of psychiatric symptoms in man. |
2003-05-02 |
2023-08-12 |
Not clear |
| P-O Fernagut, S Chalon, E Diguet, D Guilloteau, F Tison, M Jabe. Motor behaviour deficits and their histopathological and functional correlates in the nigrostriatal system of dopamine transporter knockout mice. Neuroscience. vol 116. issue 4. 2003-04-30. PMID:12617953. |
there was no significant difference in the number of dopaminergic neurons in the substantia nigra between dopamine transporter knockout mutant mice and dopamine transporter knockout wild type mice. |
2003-04-30 |
2023-08-12 |
mouse |
| Carlos Mora-Ferrer, Volker Gangluf. D2-dopamine receptor blockade modulates temporal resolution in goldfish. Visual neuroscience. vol 19. issue 6. 2003-04-29. PMID:12688674. |
flicker fusion frequency (fff) was measured before and after bilateral intravitreal injections of d1- or d2-dopamine receptor (d1-/d2-r) antagonists, or after depletion of retinal dopamine by bilateral intravitreal injections of the dopaminergic neurotoxin 6-hydroxydopamine (6-ohda). |
2003-04-29 |
2023-08-12 |
Not clear |
| Regina Katzenschlager, Durval Costa, Willibald Gerschlager, John O'Sullivan, Jan Zijlmans, Svetoslav Gacinovic, Walter Pirker, Adrian Wills, Kailash Bhatia, Andrew J Lees, Peter Brow. [123I]-FP-CIT-SPECT demonstrates dopaminergic deficit in orthostatic tremor. Annals of neurology. vol 53. issue 4. 2003-04-28. PMID:12666116. |
there is increasing evidence of a potential role of the dopaminergic system in orthostatic tremor (ot): association with parkinsonism and treatment effects of l-dopa and dopamine agonists have been reported. |
2003-04-28 |
2023-08-12 |
Not clear |