| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shrinivas K Kulkarni, Pattipati S Naid. Pathophysiology and drug therapy of tardive dyskinesia: current concepts and future perspectives. Drugs of today (Barcelona, Spain : 1998). vol 39. issue 1. 2003-08-01. PMID:12669107. |
these include dopaminergic hypersensitivity, disturbed balance between dopamine and cholinergic systems, dysfunctions of striatonigral gabaergic neurons and excitotoxicity. |
2003-08-01 |
2023-08-12 |
Not clear |
| Wassilios Meissner, Sandra Dovero, Bernard Bioulac, Christian E Gross, Erwan Bezar. Compensatory regulation of striatal neuropeptide gene expression occurs before changes in metabolic activity of basal ganglia nuclei. Neurobiology of disease. vol 13. issue 1. 2003-07-31. PMID:12758066. |
we hypothesize that, after the striatal dopaminergic homeostasis breakdown, a modification in the expression of several striatal markers (neuropeptide precursors and dopamine receptors) may occur before a change in the activity of both globus pallidus (gp) and substantia nigra pars reticulata (snr) in response to a partial nigrostriatal lesion. |
2003-07-31 |
2023-08-12 |
mouse |
| M D Julian, A B Martin, B Cuellar, F Rodriguez De Fonseca, M Navarro, R Moratalla, L M Garcia-Segur. Neuroanatomical relationship between type 1 cannabinoid receptors and dopaminergic systems in the rat basal ganglia. Neuroscience. vol 119. issue 1. 2003-07-28. PMID:12763090. |
in turn, afferent dopaminergic fibers from the substantia nigra innervate cb1 receptor-expressing striatal neurons that are known to also express dopamine receptors. |
2003-07-28 |
2023-08-12 |
rat |
| K Shimizu, K Matsubara, K Ohtaki, S Fujimaru, O Saito, H Shion. Paraquat induces long-lasting dopamine overflow through the excitotoxic pathway in the striatum of freely moving rats. Brain research. vol 976. issue 2. 2003-07-28. PMID:12763259. |
gbr-12909, a selective dopamine transporter inhibitor, reduced paraquat uptake into the striatal tissue including dopaminergic terminals. |
2003-07-28 |
2023-08-12 |
rat |
| K Shimizu, K Matsubara, K Ohtaki, S Fujimaru, O Saito, H Shion. Paraquat induces long-lasting dopamine overflow through the excitotoxic pathway in the striatum of freely moving rats. Brain research. vol 976. issue 2. 2003-07-28. PMID:12763259. |
released no would diffuse to dopaminergic terminals and further induce mitochondrial dysfunction by the formation of peroxynitrite, resulting in continuous and long-lasting dopamine overflow. |
2003-07-28 |
2023-08-12 |
rat |
| Carlos Fonck, Michel Baudr. Rapid reduction of ATP synthesis and lack of free radical formation by MPP+ in rat brain synaptosomes and mitochondria. Brain research. vol 975. issue 1-2. 2003-07-28. PMID:12763610. |
mptp is metabolized in the brain to mpp(+), which is taken up into dopaminergic neurons via the dopamine transporter and assumed to impair mitochondrial function. |
2003-07-28 |
2023-08-12 |
rat |
| W-S Huang, K-H Ma, Y-H Chou, C-Y Chen, R-S Liu, J-C Li. 99mTc-TRODAT-1 SPECT in healthy and 6-OHDA lesioned parkinsonian monkeys: comparison with 18F-FDOPA PET. Nuclear medicine communications. vol 24. issue 1. 2003-07-22. PMID:12501023. |
parkinson's disease (pd) is a degeneration of the nigrostriatal dopaminergic pathway, leading to a selective loss of dopamine in the striatum. |
2003-07-22 |
2023-08-12 |
monkey |
| W-S Huang, K-H Ma, Y-H Chou, C-Y Chen, R-S Liu, J-C Li. 99mTc-TRODAT-1 SPECT in healthy and 6-OHDA lesioned parkinsonian monkeys: comparison with 18F-FDOPA PET. Nuclear medicine communications. vol 24. issue 1. 2003-07-22. PMID:12501023. |
99mtc-trodat-1 is a recently developed radiotracer that selectively binds to the dopamine transporters, which are significant because loss of these transporters corresponds with a loss of dopaminergic neurons. |
2003-07-22 |
2023-08-12 |
monkey |
| Hilmi Islami, R Shabani, Adem Rama, M Disba, B Dida, E Aziz. [In vitro effects of acetylcholine, dopamine, histamine and serotonin on tracheal smooth muscle response during hypersecretion and normal secretion of tracheal glands]. Medicinski arhiv. vol 57. issue 2. 2003-07-22. PMID:12822376. |
on the contrary, dopamine and serotonine have not provoked statistically significant answers of these structures (p > 0.1), what illustrates that also dopaminergic and serotoninergic receptors at tracheobronchila system are not sufficient developed in this age of life. |
2003-07-22 |
2023-08-12 |
Not clear |
| Teus van Laa. Levodopa-induced response fluctuations in patients with Parkinson's disease: strategies for management. CNS drugs. vol 17. issue 7. 2003-07-17. PMID:12751918. |
continuous stimulation of dopamine receptors with dopaminergic agents is one of the crucial basic steps in the treatment of patients at an advanced stage of parkinson's disease, and the preferential use of dopamine receptor agonists has proven to be successful in the prevention and treatment of response fluctuations. |
2003-07-17 |
2023-08-12 |
Not clear |
| Thomas M Loonam, Pierre A H Noailles, Jing Yu, Judy P Q Zhu, Jesus A Angul. Substance P and cholecystokinin regulate neurochemical responses to cocaine and methamphetamine in the striatum. Life sciences. vol 73. issue 6. 2003-07-17. PMID:12801594. |
these highly addictive agents induce the release of dopamine (da) (and other catecholamines) from dopaminergic terminals of the striatum. |
2003-07-17 |
2023-08-12 |
mouse |
| Paul R Dobner, Ariel Y Deutch, Jim Fade. Neurotensin: dual roles in psychostimulant and antipsychotic drug responses. Life sciences. vol 73. issue 6. 2003-07-17. PMID:12801600. |
all clinically effective apds exhibit significant affinities for dopamine d(2) receptors, supporting the hypothesis that an increase in dopaminergic tone contributes to schizophrenic symptoms. |
2003-07-17 |
2023-08-12 |
mouse |
| Benedetta Leggio, Flavio Masi, Silvia Grappi, Giulio Nanni, Carla Gambarana, Giancarlo Colombo, Maria Graziella de Monti. Sardinian alcohol-preferring and non-preferring rats show different reactivity to aversive stimuli and a similar response to a natural reward. Brain research. vol 973. issue 2. 2003-07-16. PMID:12738071. |
as the mesocorticolimbic dopaminergic system plays a relevant role in the response to rewarding or aversive stimuli, extraneuronal dopamine levels and cocaine-induced dopamine accumulation in the nucleus accumbens shell (nacs) and medial prefrontal cortex (mpfc) were studied by microdialysis in the three groups of rats. |
2003-07-16 |
2023-08-12 |
rat |
| Yoshimi Iwayama-Shigeno, Kazuo Yamada, Tomoko Toyota, Hiromitsu Shimizu, Eiji Hattori, Kiyoshi Yoshitsugu, Tetsuya Fujisawa, Yukako Yoshida, Toshio Kobayashi, Michio Toru, Akeo Kurumaji, Sevilla Detera-Wadleigh, Takeo Yoshikaw. Distribution of haplotypes derived from three common variants of the NR4A2 gene in Japanese patients with schizophrenia. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 118B. issue 1. 2003-07-14. PMID:12627459. |
dysregulation in dopaminergic neurotransmission might play a role in the pathogenesis of schizophrenia, and therefore genetic components of the dopamine (da) pathway may confer risk. |
2003-07-14 |
2023-08-12 |
Not clear |
| A Strobel, S Debener, D Schmidt, R Hünnerkopf, K-P Lesch, B Brock. Allelic variation in serotonin transporter function associated with the intensity dependence of the auditory evoked potential. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 118B. issue 1. 2003-07-14. PMID:12627465. |
because dopaminergic influences on the intensity dependence have also been reported, we furthermore explored the role of a functional polymorphism in the dopamine d4 receptor gene (drd4 exon iii) in the modulation of the aep intensity dependence. |
2003-07-14 |
2023-08-12 |
Not clear |
| M Gassen, I Lamensdorf, T Armony, J P M Finberg, M B H Youdi. Attenuation of methamphetamine induced dopaminergic neurotoxicity by flupirtine: microdialysis study on dopamine release and free radical generation. Journal of neural transmission (Vienna, Austria : 1996). vol 110. issue 2. 2003-07-11. PMID:12589576. |
attenuation of methamphetamine induced dopaminergic neurotoxicity by flupirtine: microdialysis study on dopamine release and free radical generation. |
2003-07-11 |
2023-08-12 |
mouse |
| Brian Dean, Robyn Bradbury, David Leon Copolo. Cannabis-sensitive dopaminergic markers in postmortem central nervous system: changes in schizophrenia. Biological psychiatry. vol 53. issue 7. 2003-07-11. PMID:12679236. |
this study investigated if changes in pre-synaptic markers on dopaminergic neurons (dopamine transporter [dat], tyrosine hydroxylase [th]) were present in the caudate from subjects with schizophrenia who had delta(9)(-)tetrahydrocannabinol (thc) in their blood at autopsy. |
2003-07-11 |
2023-08-12 |
human |
| Pepijn van den Munckhof, Kelvin C Luk, Line Ste-Marie, Jane Montgomery, Pierre J Blanchet, Abbas F Sadikot, Jacques Droui. Pitx3 is required for motor activity and for survival of a subset of midbrain dopaminergic neurons. Development (Cambridge, England). vol 130. issue 11. 2003-07-11. PMID:12702666. |
mesencephalic dopaminergic (mesda) neurons play crucial roles in motor and behavioral processes; their loss in parkinson's disease (pd) results in striatal dopamine (da) deficiency and hypokinetic movement disorder. |
2003-07-11 |
2023-08-12 |
mouse |
| Akira Arai, Kazuya Kannari, Huo Shen, Tetsuya Maeda, Toshihiro Suda, Muneo Matsunag. Amantadine increases L-DOPA-derived extracellular dopamine in the striatum of 6-hydroxydopamine-lesioned rats. Brain research. vol 972. issue 1-2. 2003-07-11. PMID:12711097. |
we investigated the effect of amantadine on l-dopa-derived extracellular dopamine (da) levels and aromatic l-amino acid decarboxylase (aadc) activity in the striatum of rats with nigrostriatal dopaminergic denervation by 6-hydroxydopamine (6-ohda). |
2003-07-11 |
2023-08-12 |
rat |
| O M Schlüter, F Fornai, M G Alessandrí, S Takamori, M Geppert, R Jahn, T C Südho. Role of alpha-synuclein in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism in mice. Neuroscience. vol 118. issue 4. 2003-07-11. PMID:12732244. |
in humans, mutations in the alpha-synuclein gene or exposure to the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) produce parkinson's disease with loss of dopaminergic neurons and depletion of nigrostriatal dopamine. |
2003-07-11 |
2023-08-12 |
mouse |