| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jay W McLaren, David C Herman, Richard F Brubaker, Cherie B Nau, Laura L Wayman, Maria Grazia Ciarniello, Maria Teresa Rosignoli, Paolo Dionisi. Effect of ibopamine on aqueous humor production in normotensive humans. Investigative ophthalmology & visual science. vol 44. issue 11. 2003-11-20. PMID:14578408. |
ibopamine is a prodrug of epinine (deoxyepinephrine) that exhibits activity at dopaminergic and adrenergic receptors. |
2003-11-20 |
2023-08-12 |
human |
| E Bujdosó, M Jászberényi, J Farkas, G Tóth, M Wollemann, G Telegd. Behavioral and neuroendocrine actions of the Met-enkephalin-related peptide MERF. Hormones and behavior. vol 43. issue 2. 2003-11-19. PMID:12694640. |
to investigate the direct effect of merf on the dopaminergic system, dopamine release of striatal slices was measured in a superfusion system. |
2003-11-19 |
2023-08-12 |
mouse |
| Satoshi Ikemot. Involvement of the olfactory tubercle in cocaine reward: intracranial self-administration studies. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 28. 2003-11-17. PMID:14561857. |
evidence from pharmacological studies indicates that it is the ability of cocaine to block dopamine uptake and elevate extracellular dopamine concentrations, and thus increase dopaminergic receptor activation, that makes cocaine rewarding. |
2003-11-17 |
2023-08-12 |
Not clear |
| C J van der Schyf, K Castagnoli, S Palmer, L Hazelwood, N Castagnol. Melatonin fails to protect against long-term MPTP-induced dopamine depletion in mouse striatum. Neurotoxicity research. vol 1. issue 4. 2003-11-12. PMID:12835094. |
mptp is bioactivated by brain monoamine oxidase b (mao-b) to its neurotoxic pyridinium metabolite 1-methyl-4-phenylpyridinium (mpp(+)) which destroys dopaminergic nerve terminals leading to the depletion of neostriatal dopamine (da) and 3,4-dihydroxyphenylacetic acid (dopac). |
2003-11-12 |
2023-08-12 |
mouse |
| T Wilczok, K Stepien, A Dzierzega-Lecznar, A Zajdel, A Wilczo. Model neuromelanins as antioxidative agents during lipid peroxidation. Neurotoxicity research. vol 1. issue 2. 2003-11-12. PMID:12835109. |
the oxidative pathway of dopamine metabolism in the human brain leads to formation and accumulation of neuromelanin in the cytoplasm of most nigrostriatal dopaminergic neurons. |
2003-11-12 |
2023-08-12 |
human |
| Naji Tabet, Zuzana Walker, David Mantle, Durval Costa, Martin Orrel. In vivo dopamine pre-synaptic receptors and antioxidant activities in patients with Alzheimer's disease, dementia with Lewy bodies and in controls. A preliminary report. Dementia and geriatric cognitive disorders. vol 16. issue 1. 2003-11-10. PMID:12714800. |
the state of nigrostriatal dopaminergic system was also assessed in vivo by using a radioactive ligand with an affinity for the dopamine pre-synaptic receptors and by imaging with single-photon emission tomography. |
2003-11-10 |
2023-08-12 |
human |
| Naji Tabet, Zuzana Walker, David Mantle, Durval Costa, Martin Orrel. In vivo dopamine pre-synaptic receptors and antioxidant activities in patients with Alzheimer's disease, dementia with Lewy bodies and in controls. A preliminary report. Dementia and geriatric cognitive disorders. vol 16. issue 1. 2003-11-10. PMID:12714800. |
this may occur due to increased free radical production from the degeneration of dopaminergic cells and auto-oxidation of dopamine, the availability of which may be maintained in early-stage dlb disease as a result of the compensatory increase in its turnover from the remaining dopaminergic cells. |
2003-11-10 |
2023-08-12 |
human |
| Takafumi Hasegawa, Michiko Matsuzaki, Atsushi Takeda, Akio Kikuchi, Katsutoshi Furukawa, Shigeki Shibahara, Yasuto Itoyam. Increased dopamine and its metabolites in SH-SY5Y neuroblastoma cells that express tyrosinase. Journal of neurochemistry. vol 87. issue 2. 2003-11-06. PMID:14511124. |
oxidized metabolites of dopamine, known as dopamine quinone derivatives, are thought to play a pivotal role in the degeneration of dopaminergic neurons. |
2003-11-06 |
2023-08-12 |
human |
| Andrew D Lawrence, Jonathan Dowson, Gillian L Foxall, Ruth Summerfield, Trevor W Robbins, Barbara J Sahakia. Impaired visual discrimination learning in anorexia nervosa. Appetite. vol 40. issue 1. 2003-10-30. PMID:12631509. |
in a dynamic categorization task involving the learning of a series of two-alternative forced-choice visual discriminations, conceptually identical to one shown to activate dopamine neurons in primates, and sensitive to dopaminergic manipulations in humans, patients with an showed a deficit in learning that was most pronounced in the early stages of acquisition. |
2003-10-30 |
2023-08-12 |
Not clear |
| F Viallet, T Witja. [Neuroplasticity and Parkinson disease]. Revue neurologique. vol 158 Spec no 1. 2003-10-30. PMID:12690663. |
after a brief survey of some general aspects of plasticity in the cns, the present tutorial review illustrates with recent data from the literature the modes of plastic changes during the course of ipd, either resulting from dopaminergic denervation (hyperactivity of remaining dopaminergic neurons with increase of their excitatory cholinergic innervation in the substantia nigra, enhancement of the corticostriatal glutamatergic synaptic activity at the striatal level) or due to dopaminergic treatment (change in phosphorylation state of the striatal glutamate receptors, internalization of d1 dopamine receptors). |
2003-10-30 |
2023-08-12 |
Not clear |
| A Nieoullon, M Amalri. [Dopaminergic receptors: structural features and functional implications]. Revue neurologique. vol 158 Spec no 1. 2003-10-30. PMID:12690665. |
in this respect, in parkinson's disease dopamine depletion will favour adaptive responses at the cellular level which likely involve differentially the dopaminergic receptor subtypes. |
2003-10-30 |
2023-08-12 |
Not clear |
| M Gerlach, K Double, H Reichmann, P Riedere. Arguments for the use of dopamine receptor agonists in clinical and preclinical Parkinson's disease. Journal of neural transmission. Supplementum. issue 65. 2003-10-20. PMID:12946055. |
dopamine receptor agonists exert their symptomatic effect by directly activating dopamine receptors, bypassing the presynaptic synthesis of dopamine and the degenerating nigro-striatal dopaminergic system. |
2003-10-20 |
2023-08-12 |
Not clear |
| Elisabet Hermanson, Bertrand Joseph, Diogo Castro, Eva Lindqvist, Piia Aarnisalo, Asa Wallén, Gerard Benoit, Bastian Hengerer, Lars Olson, Thomas Perlman. Nurr1 regulates dopamine synthesis and storage in MN9D dopamine cells. Experimental cell research. vol 288. issue 2. 2003-10-17. PMID:12915123. |
nurr1 continues to be expressed in adult da neurons but the role for nurr1 in inducing and regulating basic dopaminergic functions such as dopamine synthesis and storage has remained unknown. |
2003-10-17 |
2023-08-12 |
Not clear |
| K Gołembiowska, J Konieczny, S Wolfarth, K Ossowsk. Neuroprotective action of MPEP, a selective mGluR5 antagonist, in methamphetamine-induced dopaminergic neurotoxicity is associated with a decrease in dopamine outflow and inhibition of hyperthermia in rats. Neuropharmacology. vol 45. issue 4. 2003-10-15. PMID:12907309. |
neuroprotective action of mpep, a selective mglur5 antagonist, in methamphetamine-induced dopaminergic neurotoxicity is associated with a decrease in dopamine outflow and inhibition of hyperthermia in rats. |
2003-10-15 |
2023-08-12 |
rat |
| Felicia Loghin, Abdeslam Chagraoui, Marcelo Asencio, Etienne Comoy, Hernan Speisky, Bruce K Cassels, Philippe Protai. Effects of some antioxidative aporphine derivatives on striatal dopaminergic transmission and on MPTP-induced striatal dopamine depletion in B6CBA mice. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. vol 18. issue 2. 2003-10-14. PMID:12594006. |
effects of some antioxidative aporphine derivatives on striatal dopaminergic transmission and on mptp-induced striatal dopamine depletion in b6cba mice. |
2003-10-14 |
2023-08-12 |
mouse |
| Viviana Ojeda, José Antonio Fuentealba, Danny Galleguillos, María Estela André. Rapid increase of Nurr1 expression in the substantia nigra after 6-hydroxydopamine lesion in the striatum of the rat. Journal of neuroscience research. vol 73. issue 5. 2003-10-14. PMID:12929136. |
these results suggest that nurr1 may be involved in many neuronal functions in the adult central nervous system and, in particular, might be related to the compensation processes that take place in dopaminergic cells in order to normalize extracellular dopamine levels in the striatum. |
2003-10-14 |
2023-08-12 |
rat |
| Antiii J Väänänen, Mikaela Moed, Raimo K Tuominen, Teemu H Helkamaa, Markus Wiksten, Päivi Liesi, Chuang C Chiueh, Pekka Rauhal. Angeli's salt induces neurotoxicity in dopaminergic neurons in vivo and in vitro. Free radical research. vol 37. issue 4. 2003-10-10. PMID:12747732. |
in primary dopaminergic neuronal cultures as reduced [3h] dopamine uptake with concentrations over 200 microm confirming neurotoxicity. |
2003-10-10 |
2023-08-12 |
rat |
| Alberto Auricchio, Paul D Acton, Markus Hildinger, Jean-Pierre Louboutin, Karl Plössl, Erin O'Connor, Hank F Kung, James M Wilso. In vivo quantitative noninvasive imaging of gene transfer by single-photon emission computerized tomography. Human gene therapy. vol 14. issue 3. 2003-10-06. PMID:12639305. |
the dopamine transporter (dat) is normally expressed at high levels, mainly in the dopaminergic neurons of the central nervous system. |
2003-10-06 |
2023-08-12 |
human |
| M J Millan, A Gobert, F Lejeune, A Dekeyne, A Newman-Tancredi, V Pasteau, J-M Rivet, D Cussa. The novel melatonin agonist agomelatine (S20098) is an antagonist at 5-hydroxytryptamine2C receptors, blockade of which enhances the activity of frontocortical dopaminergic and adrenergic pathways. The Journal of pharmacology and experimental therapeutics. vol 306. issue 3. 2003-10-03. PMID:12750432. |
these increases in noradrenaline and dopamine levels were unaffected by the selective melatonin antagonist n-[2-(5-ethyl-benzo[b]thien-3-yl)ethyl] acetamide (s22153) and likely flect blockade of 5-ht2c receptors inhibitory to frontocortical dopaminergic and adrenergic pathways. |
2003-10-03 |
2023-08-12 |
human |
| Sachin Patel, David J Rademacher, Cecilia J Hillar. Differential regulation of the endocannabinoids anandamide and 2-arachidonylglycerol within the limbic forebrain by dopamine receptor activity. The Journal of pharmacology and experimental therapeutics. vol 306. issue 3. 2003-10-03. PMID:12808005. |
because a primary role of dopamine is to modulate this excitatory transmission, we tested the hypothesis that dopaminergic transmission modulates endocannabinoid content in the limbic forebrain. |
2003-10-03 |
2023-08-12 |
mouse |