| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Neal Castagnoli, Jacobus P Petzer, Salome Steyn, Kay Castagnoli, Jiang-Fan Chen, Michael A Schwarzschild, Cornelis J Van der Schy. Monoamine oxidase B inhibition and neuroprotection: studies on selective adenosine A2A receptor antagonists. Neurology. vol 61. issue 11 Suppl 6. 2004-02-11. PMID:14663013. |
the principal therapeutic agents used in the management of parkinson's disease (pd) enhance nigrostriatal dopaminergic flux through either replenishment of depleted dopamine stores or the action of dopaminergic agonists. |
2004-02-11 |
2023-08-12 |
mouse |
| Hiroshi Kase, S Aoyama, M Ichimura, K Ikeda, A Ishii, T Kanda, K Koga, N Koike, M Kurokawa, Y Kuwana, A Mori, J Nakamura, H Nonaka, M Ochi, M Saki, J Shimada, T Shindou, S Shiozaki, F Suzuki, M Takeda, K Yanagawa, P J Richardson, P Jenner, P Bedard, E Borrelli, R A Hauser, T N Chas. Progress in pursuit of therapeutic A2A antagonists: the adenosine A2A receptor selective antagonist KW6002: research and development toward a novel nondopaminergic therapy for Parkinson's disease. Neurology. vol 61. issue 11 Suppl 6. 2004-02-11. PMID:14663020. |
experiments with dopamine d2 receptor knockout mice showed that a2a receptors can function and anti-pd activities of a2a antagonists can occur independent of the dopaminergic system. |
2004-02-11 |
2023-08-12 |
mouse |
| J F Rodríguez-Landa, C M Contrera. A review of clinical and experimental observations about antidepressant actions and side effects produced by Hypericum perforatum extracts. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 10. issue 8. 2004-02-11. PMID:14692732. |
although some clinical and experimental studies suggest it has some properties similar to conventional antidepressants, the proposed mechanism of action seems to be multiple: a non-selective blockade of the reuptake of serotonin, noradrenaline and dopamine; an increase in density of serotonergic and dopaminergic receptors and an increased affinity for gabaergic receptors; moreover, the inhibition of monoaminoxidase enzyme activity has been involved. |
2004-02-11 |
2023-08-12 |
Not clear |
| Maria Concetta Morale, Pier Andrea Serra, Maria Rosaria Delogu, Rossana Migheli, Gaia Rocchitta, Cataldo Tirolo, Salvo Caniglia, Nuccio Testa, Francesca L'Episcopo, Florinda Gennuso, Giovanna M Scoto, Nicholas Barden, Egidio Miele, Maria Speranza Desole, Bianca Marchett. Glucocorticoid receptor deficiency increases vulnerability of the nigrostriatal dopaminergic system: critical role of glial nitric oxide. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 18. issue 1. 2004-02-09. PMID:14630699. |
the gr deficiency of tg mice exacerbates mptp-induced toxicity to dopaminergic neurons, as revealed by both severe loss of tyrosine hydroxylase positive nigral neurons and sharp decreases in striatal levels of dopamine and its metabolites. |
2004-02-09 |
2023-08-12 |
mouse |
| Peter Jenne. The MPTP-treated primate as a model of motor complications in PD: primate model of motor complications. Neurology. vol 61. issue 6 Suppl 3. 2004-02-05. PMID:14504374. |
in contrast, long-acting dopamine agonists (das) induce a far lower incidence of dyskinesia, and continuous dopaminergic stimulation may provide a means of avoiding its onset. |
2004-02-05 |
2023-08-12 |
Not clear |
| Paolo Baron. Clinical strategies to prevent and delay motor complications. Neurology. vol 61. issue 6 Suppl 3. 2004-02-05. PMID:14504375. |
current evidence suggests that motor complications associated with long-term l-dopa treatment in patients with parkinson's disease (pd) are the consequence of two factors: the disease course, with progressive destruction of dopaminergic terminals, and the pulsatile nonphysiologic stimulation of dopamine receptors caused by multiple administrations of l-dopa. |
2004-02-05 |
2023-08-12 |
Not clear |
| Paolo Baron. Clinical strategies to prevent and delay motor complications. Neurology. vol 61. issue 6 Suppl 3. 2004-02-05. PMID:14504375. |
pharmacokinetic considerations suggest that continuous dopaminergic stimulation (cds) may be achieved either by using long-acting dopamine agonists (das) or by continuously delivering l-dopa. |
2004-02-05 |
2023-08-12 |
Not clear |
| Diego Garcia-Borreguero, Per Odin, Carolina Serran. Restless legs syndrome and PD: a review of the evidence for a possible association. Neurology. vol 61. issue 6 Suppl 3. 2004-02-05. PMID:14504380. |
furthermore, dopaminergic drugs have shown therapeutic efficacy in various large-scale therapeutic trials, and dopamine agonists now represent the first line of treatment. |
2004-02-05 |
2023-08-12 |
Not clear |
| C Warren Olanow, Fabrizio Stocch. COMT inhibitors in Parkinson's disease: can they prevent and/or reverse levodopa-induced motor complications? Neurology. vol 62. issue 1 Suppl 1. 2004-02-04. PMID:14718683. |
evidence that motor complications are related to intermittent or pulsatile stimulation of striatal dopamine receptors has led to the use of long-acting dopaminergic therapies that provide more continuous dopaminergic stimulation (cds). |
2004-02-04 |
2023-08-12 |
Not clear |
| Minoru Narita, Masahiro Shibasaki, Keisuke Mizuo, Tsutomu Suzuk. Changes in G-protein activity mediated through the stimulation of dopamine and GABA(B) receptors in the mesolimbic dopaminergic system of morphine-sensitized mice. Addiction biology. vol 8. issue 3. 2004-01-29. PMID:13129834. |
changes in g-protein activity mediated through the stimulation of dopamine and gaba(b) receptors in the mesolimbic dopaminergic system of morphine-sensitized mice. |
2004-01-29 |
2023-08-12 |
mouse |
| Pierre Champy, Günter U Höglinger, Jean Féger, Christophe Gleye, Reynald Hocquemiller, Alain Laurens, Vincent Guérineau, Olivier Laprévote, Fadia Medja, Anne Lombès, Patrick P Michel, Annie Lannuzel, Etienne C Hirsch, Merle Ruber. Annonacin, a lipophilic inhibitor of mitochondrial complex I, induces nigral and striatal neurodegeneration in rats: possible relevance for atypical parkinsonism in Guadeloupe. Journal of neurochemistry. vol 88. issue 1. 2004-01-29. PMID:14675150. |
stereological cell counts showed significant loss of dopaminergic neurones in the substantia nigra (-31.7%), and cholinergic (-37.9%) and dopamine and cyclic amp-regulated phosphoprotein (darpp-32)-immunoreactive gabaergic neurones (-39.3%) in the striatum, accompanied by a significant increase in the number of astrocytes (35.4%) and microglial cells (73.4%). |
2004-01-29 |
2023-08-12 |
rat |
| Ravi Kumar Kurup, Parameswara Achutha Kuru. A hypothalamic digoxin-mediated model for autism. The International journal of neuroscience. vol 113. issue 11. 2004-01-28. PMID:14585753. |
increased nicotine levels can produce increased dopaminergic transmission in the presence of low dopamine levels. |
2004-01-28 |
2023-08-12 |
Not clear |
| E Paolucci, N Berretta, A Tozzi, G Bernardi, N B Mercur. Depression of mGluR-mediated IPSCs by 5-HT in dopamine neurons of the rat substantia nigra pars compacta. The European journal of neuroscience. vol 18. issue 10. 2004-01-26. PMID:14656323. |
dopamine neurons of the substantia nigra pars compacta receive a prominent serotonin (5-ht) projection from the dorsal raphe nucleus and important functional interactions between the serotonergic and the dopaminergic system have been postulated. |
2004-01-26 |
2023-08-12 |
rat |
| Ryuichi Fukui, Per Svenningsson, Toyojiro Matsuishi, Hideho Higashi, Angus C Nairn, Paul Greengard, Akinori Nish. Effect of methylphenidate on dopamine/DARPP signalling in adult, but not young, mice. Journal of neurochemistry. vol 87. issue 6. 2004-01-26. PMID:14713295. |
the results suggest that dopamine synthesis and the dopamine transporter are functional at dopaminergic terminals in young mice. |
2004-01-26 |
2023-08-12 |
mouse |
| Zhaoping Liu, E Bradshaw Bunney, Sarah B Appel, Mark S Brodi. Serotonin reduces the hyperpolarization-activated current (Ih) in ventral tegmental area dopamine neurons: involvement of 5-HT2 receptors and protein kinase C. Journal of neurophysiology. vol 90. issue 5. 2004-01-22. PMID:12890794. |
serotonin reduces the hyperpolarization-activated current (ih) in ventral tegmental area dopamine neurons: involvement of 5-ht2 receptors and protein kinase c. dopaminergic neurons of the ventral tegmental area (vta) have been implicated in the rewarding properties of drugs of abuse and in the etiology of schizophrenia; serotonin modulation of these neurons may play a role in these phenomena. |
2004-01-22 |
2023-08-12 |
rat |
| Zhaoping Liu, E Bradshaw Bunney, Sarah B Appel, Mark S Brodi. Serotonin reduces the hyperpolarization-activated current (Ih) in ventral tegmental area dopamine neurons: involvement of 5-HT2 receptors and protein kinase C. Journal of neurophysiology. vol 90. issue 5. 2004-01-22. PMID:12890794. |
these data support the conclusion that serotonin reduces ih in dopaminergic vta neurons by acting at serotonin 5-ht2 receptors, which activate protein kinase c. this reduction of ih may be physiologically important, as the selective inhibitor of ih, zd7288, significantly increased dopamine inhibition of firing rate of dopaminergic vta neurons, an effect that we previously demonstrated with serotonin. |
2004-01-22 |
2023-08-12 |
rat |
| M Reuter, J Henni. Cortisol as an indicator of dopaminergic effects on nicotine craving. Human psychopharmacology. vol 18. issue 6. 2004-01-22. PMID:12923821. |
these findings could imply (a) that differences in basal glucocorticoid levels are associated with differences in craving or (b) that dopamine (da) induced corticoid release is an indicator of the sensitivity of the dopaminergic system. |
2004-01-22 |
2023-08-12 |
human |
| Karen A Moxon, Greg A Gerhardt, Lawrence E Adle. Dopaminergic modulation of the P50 auditory-evoked potential in a computer model of the CA3 region of the hippocampus: its relationship to sensory gating in schizophrenia. Biological cybernetics. vol 88. issue 4. 2004-01-21. PMID:12690485. |
because the p50 auditory-evoked potential amplitudes increased with neuroleptic medication, which reduces dopaminergic neuronal transmission, we hypothesized a role for dopamine in modulating the signal-to-noise (s/n) in the local circuits responsible for sensory gating. |
2004-01-21 |
2023-08-12 |
human |
| Z Rogóz, D Dlaboga, M Dziedzicka-Wasylewsk. Effect of combined treatment with imipramine and amantadine on the central dopamine D2 and D3 receptors in rats. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 54. issue 2. 2004-01-20. PMID:12832726. |
nevertheless, we can conclude that repeated administration of ama, given together with imi, induces the up-regulation of dopamine d2 and d3 receptors in the rat brain, and this effect may explain their synergistic action observed in the behavioral studies involving dopaminergic transmission. |
2004-01-20 |
2023-08-12 |
rat |
| Amanda D Smith, Marci Antion, Michael J Zigmond, Mark C Austi. Effect of 6-hydroxydopamine on striatal GDNF and nigral GFRalpha1 and RET mRNAs in the adult rat. Brain research. Molecular brain research. vol 117. issue 2. 2004-01-20. PMID:14559146. |
we therefore investigated whether changes in striatal gdnf protein and nigral mrna levels of its co-receptors gfralpha1 and ret occur in response to lesions of dopamine (da) neurons and examined the temporal profile of these changes as they relate to the loss of dopaminergic markers. |
2004-01-20 |
2023-08-12 |
rat |