| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Margarita Moreno, Jose Manuel Trigo, Leticia Escuredo, Fernando Rodríguez de Fonseca, Miguel Navarr. Perinatal exposure to delta 9-tetrahydrocannabinol increases presynaptic dopamine D2 receptor sensitivity: a behavioral study in rats. Pharmacology, biochemistry, and behavior. vol 75. issue 3. 2004-04-08. PMID:12895674. |
these effects suggest that perinatal exposure to delta(9)-thc affects the functionality of dopaminergic autoreceptors, inducing a greater sensitivity to the presynaptic actions of dopamine d(2) receptor agonists. |
2004-04-08 |
2023-08-12 |
rat |
| Holger Fuchs, Wolfgang Haube. Dopaminergic innervation of the rat globus pallidus characterized by microdialysis and immunohistochemistry. Experimental brain research. vol 154. issue 1. 2004-04-07. PMID:14508630. |
these findings are in line with the notion that a degenerative loss of nigral dopaminergic cell bodies might also affect the dopamine input of extrastriatal structures such as the globus pallidus. |
2004-04-07 |
2023-08-12 |
rat |
| Holger Fuchs, Wolfgang Haube. Dopaminergic innervation of the rat globus pallidus characterized by microdialysis and immunohistochemistry. Experimental brain research. vol 154. issue 1. 2004-04-07. PMID:14508630. |
the tetrodotoxin-sensitivity of pallidal dopamine demonstrates the functional significance of the nigropallidal dopaminergic innervation. |
2004-04-07 |
2023-08-12 |
rat |
| Vincent Castagné, Michaël Rougemont, Michel Cuenod, Kim Q D. Low brain glutathione and ascorbic acid associated with dopamine uptake inhibition during rat's development induce long-term cognitive deficit: relevance to schizophrenia. Neurobiology of disease. vol 15. issue 1. 2004-04-07. PMID:14751774. |
moreover, as hyperactivity of the dopaminergic system may be associated with schizophrenia, some rats were treated with the dopamine uptake inhibitor gbr 12909. |
2004-04-07 |
2023-08-12 |
rat |
| Mei-Chun Hsiao, Kun-Ju Lin, Chia-Yih Liu, Kai-Yuan Tzen, Tzu-Chen Ye. Dopamine transporter change in drug-naive schizophrenia: an imaging study with 99mTc-TRODAT-1. Schizophrenia research. vol 65. issue 1. 2004-04-06. PMID:14623373. |
the aim of this study was to use a specific dopamine transporter (dat) ligand, 99mtc-trodat-1 with single photon emission computed tomography (spect) to investigate the densities of dat in the striatal dopaminergic system in patients with schizophrenia. |
2004-04-06 |
2023-08-12 |
human |
| M Ozaki, Y Masuda, S Kishioka, H Yamamot. Actions of domperidone on the opioid system in isolated guinea-pig ileum: differences between dopamine antagonists on opioid system. Autonomic & autacoid pharmacology. vol 23. issue 1. 2004-04-02. PMID:14565539. |
to validate the relationship between the dopaminergic, opioidergic and cholinergic nervous systems, we evaluated the effect of domperidone, a dopamine (d2) antagonist, on the opioid system in myenteric plexus-longitudinal muscle preparation isolated from the guinea-pig ileum. |
2004-04-02 |
2023-08-12 |
Not clear |
| Gloria A Cabezas, Zafar H Israili, Manuel Velasc. The actions of dopamine on the airways. American journal of therapeutics. vol 10. issue 6. 2004-04-02. PMID:14624291. |
we have examined the possible modulating effect of dopamine on bronchial diameter by administering inhaled dopamine and the da2 dopaminergic blocker metoclopramide to subjects with various degrees of bronchial tone. |
2004-04-02 |
2023-08-12 |
human |
| Gail Chapman, Blaine L Beaman, David A Loeffler, Dianne M Camp, Edward F Domino, Dennis W Dickson, William G Ellis, Ibsen Chen, Susan E Bachus, Peter A LeWit. In situ hybridization for detection of nocardial 16S rRNA: reactivity within intracellular inclusions in experimentally infected cynomolgus monkeys--and in Lewy body-containing human brain specimens. Experimental neurology. vol 184. issue 2. 2004-04-02. PMID:14769363. |
our previous studies found that experimental infection of balb/c mice with the gram-positive bacterium nocardia asteroides induced a parkinsonian-type syndrome with levodopa-responsive movement abnormalities, loss of nigrostriatal dopaminergic neurons, depletion of striatal dopamine, and intraneuronal inclusions in the substantia nigra (sn) with an appearance similar to lewy bodies. |
2004-04-02 |
2023-08-12 |
mouse |
| Jason R Richardson, Gary W Mille. Acute exposure to aroclor 1016 or 1260 differentially affects dopamine transporter and vesicular monoamine transporter 2 levels. Toxicology letters. vol 148. issue 1-2. 2004-04-02. PMID:15019086. |
polychlorinated biphenyls (pcbs) have been shown to specifically target the dopaminergic nervous system, resulting in long-term reduction of striatal dopamine (da) levels. |
2004-04-02 |
2023-08-12 |
Not clear |
| Kálmán Magyar, Béla Szend. (-)-Deprenyl, a selective MAO-B inhibitor, with apoptotic and anti-apoptotic properties. Neurotoxicology. vol 25. issue 1-2. 2004-04-01. PMID:14697898. |
(-)-deprenyl potentiates the effect of dopamine, it has antioxidant activity and prevents the toxicity of the dopaminergic (6-oh-dopamine; 1-methyl-4-phenyl-1,2,3,6-tetrahydro-pyridine (mptp)), the noradrenergic (dsp-4) and cholinergic (af64a) neurotoxins after pre-treatment. |
2004-04-01 |
2023-08-12 |
human |
| Kálmán Magyar, Béla Szend. (-)-Deprenyl, a selective MAO-B inhibitor, with apoptotic and anti-apoptotic properties. Neurotoxicology. vol 25. issue 1-2. 2004-04-01. PMID:14697898. |
when (-)-deprenyl was administered with levodopa in a long-term treatment of parkinsonian patients, it induces adverse events (nausea, dizziness, confusion, hallucination, insomnia and cardiovascular changes), which could be due to dopamine potentiation in dopaminergic systems (limbic system), other than the nigrostriatal pathway. |
2004-04-01 |
2023-08-12 |
human |
| M Jabourian, S Bourgoin, S Pérez, G Godeheu, J Glowinski, M-L Keme. Mu opioid control of the N-methyl-D-aspartate-evoked release of [3H]-acetylcholine in the limbic territory of the rat striatum in vitro: diurnal variations and implication of a dopamine link. Neuroscience. vol 123. issue 3. 2004-03-31. PMID:14706785. |
experiments were performed 2 (morning) or 8 (afternoon) h after light onset, in either the presence or absence (alpha-methyl-p-tyrosine, an inhibitor of dopamine synthesis) of dopaminergic transmission. |
2004-03-31 |
2023-08-12 |
rat |
| George R Uh. Dopamine transporter: basic science and human variation of a key molecule for dopaminergic function, locomotion, and parkinsonism. Movement disorders : official journal of the Movement Disorder Society. vol 18 Suppl 7. 2004-03-29. PMID:14531049. |
dopamine transporter: basic science and human variation of a key molecule for dopaminergic function, locomotion, and parkinsonism. |
2004-03-29 |
2023-08-12 |
human |
| I G Sil'ki. [The influence of neuromodulators on the synaptic plasticity in dopaminergic structures of the midbrain (hypothetical mechanism)]. Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova. vol 53. issue 4. 2004-03-26. PMID:14598554. |
according to this mechanism, activation of gi/0 protein-coupled dopamine d2 autoreceptors and opioid kappa (mu) receptors on dopaminergic (inhibitory) cells promotes the ltd of excitatory inputs to these cells and decrease in their activity. |
2004-03-26 |
2023-08-12 |
Not clear |
| Elisa Mengual, Virginia M Picke. Regional and subcellular compartmentation of the dopamine transporter and tyrosine hydroxylase in the rat ventral pallidum. The Journal of comparative neurology. vol 468. issue 3. 2004-03-26. PMID:14681933. |
the vp catecholaminergic innervation is derived from midbrain dopaminergic neurons that differ in expression levels of the dopamine transporter (dat) and from brainstem noradrenergic neurons without dat. |
2004-03-26 |
2023-08-12 |
rat |
| M Strittmatter, M Grauer, E Isenberg, G Hamann, C Fischer, K H Hoffmann, F Blaes, K Schimrig. [Substance P, somatostatin and monoaminergic transmitters in the cerebrospinal fluid of patients with chronic idiopathic trigeminal neuralgia]. Schmerz (Berlin, Germany). vol 10. issue 5. 2004-03-24. PMID:12799848. |
as markers for the dopaminergic system, we determined csf levels of dopamine and its metabolite homovanillic acid (hva). |
2004-03-24 |
2023-08-12 |
Not clear |
| Sushil K Sharma, Manuchair Ebad. Metallothionein attenuates 3-morpholinosydnonimine (SIN-1)-induced oxidative stress in dopaminergic neurons. Antioxidants & redox signaling. vol 5. issue 3. 2004-03-24. PMID:12880480. |
sin-1-induced oxidation of dopamine to dihydroxyphenylacetaldehyde was attenuated in metallothionein-transgenic fetal stem cells and in cells transfected with a mitochondrial genome, and enhanced in aging mitochondrial genome knockout cells, in metallothionein double-knockout cells and caspase-3 gene-overexpressing dopaminergic neurons. |
2004-03-24 |
2023-08-12 |
Not clear |
| Wenya Wang, Leyu Shi, Yuanbin Xie, Chi Ma, Wenming Li, Xingwen Su, Shoujian Huang, Ruzhu Chen, Zhenyu Zhu, Zixu Mao, Yifan Han, Mingtao L. SP600125, a new JNK inhibitor, protects dopaminergic neurons in the MPTP model of Parkinson's disease. Neuroscience research. vol 48. issue 2. 2004-03-24. PMID:14741394. |
our data showed that mptp-induced phospho-c-jun of substantial nigral neurons, caused apoptosis of dopaminergic neurons, and decreased the dopamine level in striatal area. |
2004-03-24 |
2023-08-12 |
mouse |
| Wenya Wang, Leyu Shi, Yuanbin Xie, Chi Ma, Wenming Li, Xingwen Su, Shoujian Huang, Ruzhu Chen, Zhenyu Zhu, Zixu Mao, Yifan Han, Mingtao L. SP600125, a new JNK inhibitor, protects dopaminergic neurons in the MPTP model of Parkinson's disease. Neuroscience research. vol 48. issue 2. 2004-03-24. PMID:14741394. |
we found that inhibiting jnk with sp600125 reduced the levels of c-jun phosphorylation, protected dopaminergic neurons from apoptosis, and partly restored the level of dopamine in mptp-induced pd in c57bl/6n mice. |
2004-03-24 |
2023-08-12 |
mouse |
| Karima Chergui, Per Svenningsson, Paul Greengar. Cyclin-dependent kinase 5 regulates dopaminergic and glutamatergic transmission in the striatum. Proceedings of the National Academy of Sciences of the United States of America. vol 101. issue 7. 2004-03-16. PMID:14769920. |
using mice with a point mutation of the cdk5 site of the postsynaptic protein darpp-32 (dopamine- and camp-regulated phosphoprotein, molecular mass of 32 kda), in the absence or in the presence of a dopamine d1 receptor antagonist, we provide evidence that cdk5 inhibitors potentiate dopaminergic transmission at both presynaptic and postsynaptic locations. |
2004-03-16 |
2023-08-12 |
mouse |