| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kamisha L Johnson-Davis, Jannine G Truong, Annette E Fleckenstein, Diana G Wilkin. Alterations in vesicular dopamine uptake contribute to tolerance to the neurotoxic effects of methamphetamine. The Journal of pharmacology and experimental therapeutics. vol 309. issue 2. 2004-06-21. PMID:14747615. |
hence, the purpose of this study was to explore the role of the vmat-2 and dopamine transporter in the induction of tolerance to the longterm persistent dopaminergic deficits caused by methamphetamine. |
2004-06-21 |
2023-08-12 |
rat |
| Michael W Jakowec, Kerry Nixon, Elizabeth Hogg, Tom McNeill, Giselle M Petzinge. Tyrosine hydroxylase and dopamine transporter expression following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurodegeneration of the mouse nigrostriatal pathway. Journal of neuroscience research. vol 76. issue 4. 2004-06-21. PMID:15114626. |
administration of the neurotoxicant 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) to c57bl/6 mice targets nigrostriatal dopaminergic neurons, leading to cell death and the depletion of striatal dopamine. |
2004-06-21 |
2023-08-12 |
mouse |
| Michael W Jakowec, Kerry Nixon, Elizabeth Hogg, Tom McNeill, Giselle M Petzinge. Tyrosine hydroxylase and dopamine transporter expression following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurodegeneration of the mouse nigrostriatal pathway. Journal of neuroscience research. vol 76. issue 4. 2004-06-21. PMID:15114626. |
after mptp lesioning in young adult mice, surviving nigrostriatal dopaminergic neurons display robust and reproducible return of striatal dopamine weeks to months after injury. |
2004-06-21 |
2023-08-12 |
mouse |
| Michael W Jakowec, Kerry Nixon, Elizabeth Hogg, Tom McNeill, Giselle M Petzinge. Tyrosine hydroxylase and dopamine transporter expression following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurodegeneration of the mouse nigrostriatal pathway. Journal of neuroscience research. vol 76. issue 4. 2004-06-21. PMID:15114626. |
these results suggest that th and dat may differ in their time course of expression in surviving dopaminergic neurons and may play a role in mediating the return of striatal dopamine. |
2004-06-21 |
2023-08-12 |
mouse |
| Hiroaki Matsubayashi, Taku Amano, Takahiro Seki, Masashi Sasa, Norio Saka. Electrophysiological characterization of nicotine-induced excitation of dopaminergic neurons in the rat substantia nigra. Journal of pharmacological sciences. vol 93. issue 2. 2004-06-18. PMID:14578581. |
nicotine directly acts on postsynaptic alpha4beta2 type nicotinic receptors and induces inward currents, resulting in excitation of dopaminergic neurons in the substantia nigra and subsequent enhancement of dopamine release in the corpus striatum. |
2004-06-18 |
2023-08-12 |
rat |
| Ruth Reeves, Mona Thiruchelvam, Eric K Richfield, Deborah A Cory-Slecht. Behavioral sensitization and long-term neurochemical alterations associated with the fungicide triadimefon. Pharmacology, biochemistry, and behavior. vol 76. issue 2. 2004-06-18. PMID:14592684. |
tdf induction/expression of behavioral sensitization was associated with long-term, perhaps permanent modulation of dopaminergic function that included increases in striatal dihydroxyphenylacetic acid (dopac) and da turnover, increases in medial prefrontal cortex (mpfc) dopamine transporter (dat) binding, as well as decreases in da d1 and increases in da d2 and dat receptor binding that appeared to target the nucleus accumbens shell (nas) subregion. |
2004-06-18 |
2023-08-12 |
mouse |
| Anthony J Baucum, Kristi S Rau, Evan L Riddle, Glen R Hanson, Annette E Fleckenstei. Methamphetamine increases dopamine transporter higher molecular weight complex formation via a dopamine- and hyperthermia-associated mechanism. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 13. 2004-06-18. PMID:15056723. |
multiple high-dose administrations of methamphetamine (meth) both rapidly (within hours) decrease plasmalemmal dopamine (da) uptake and cause long-term deficits in da transporter (dat) levels and other dopaminergic parameters persisting weeks to months in rat striatum. |
2004-06-18 |
2023-08-12 |
rat |
| Jean-Marc Taymans, Hossein Kami Kia, Robby Claes, Catarina Cruz, Josée Leysen, Xavier Langloi. Dopamine receptor-mediated regulation of RGS2 and RGS4 mRNA differentially depends on ascending dopamine projections and time. The European journal of neuroscience. vol 19. issue 8. 2004-06-18. PMID:15090051. |
first, dopamine type 1 (receptor) (d1)- and dopamine type 2 (receptor) (d2)-mediated regulator of g-protein signalling (rgs) gene regulation was investigated in animals with deleted ascending dopaminergic pathways. |
2004-06-18 |
2023-08-12 |
rat |
| Daniele Lecca, Giovanna Piras, Peter Driscoll, Osvaldo Giorgi, Maria G Cord. A differential activation of dopamine output in the shell and core of the nucleus accumbens is associated with the motor responses to addictive drugs: a brain dialysis study in Roman high- and low-avoidance rats. Neuropharmacology. vol 46. issue 5. 2004-06-15. PMID:14996546. |
addictive substances like morphine and psychostimulants induce a preferential increase in dopamine (da) output in the nucleus accumbens (nac), a major terminal field of the mesolimbic dopaminergic projection. |
2004-06-15 |
2023-08-12 |
rat |
| M T Oliveira, A C Rego, T R A Macedo, C R Oliveir. Drugs of abuse induce apoptotic features in PC12 cells. Annals of the New York Academy of Sciences. vol 1010. 2004-06-15. PMID:15033808. |
as dopamine may act as a neurotoxin, in this study, we analyzed the effects of the drugs of abuse, cocaine, heroin, and amphetamine, on the neurodegeneration of pc12 cells, a dopaminergic cell line, by evaluating the activity of caspase-3 and mitochondrial cytochrome c release. |
2004-06-15 |
2023-08-12 |
Not clear |
| F Blandini, A Mangiagalli, M Cosentino, F Marino, A Samuele, E Rasini, R Fancellu, E Martignoni, G Riboldazzi, D Calandrella, G M Frigo, G Napp. Peripheral markers of apoptosis in Parkinson's disease: the effect of dopaminergic drugs. Annals of the New York Academy of Sciences. vol 1010. 2004-06-15. PMID:15033810. |
in this study, we measured the lymphocyte levels of proteins involved in apoptosis regulation, such as bcl-2, the peripheral benzodiazepine receptor (pbr), caspase-3, and cu/zn superoxide dismutase (cu/zn sod), in patients with parkinson's disease (pd), either untreated or under therapy with dopaminergic agents (l-dopa alone or l-dopa + dopamine agonists) and in healthy volunteers. |
2004-06-15 |
2023-08-12 |
human |
| Cristina Colombo, Marco Cosentino, Franca Marino, Emanuela Rasini, Maria Ossola, Fabio Blandini, Anna Mangiagalli, Alberta Samuele, Marco Ferrari, Raffaella Bombelli, Sergio Lecchini, Giuseppe Nappi, Gianmario Frig. Dopaminergic modulation of apoptosis in human peripheral blood mononuclear cells: possible relevance for Parkinson's disease. Annals of the New York Academy of Sciences. vol 1010. 2004-06-15. PMID:15033811. |
dopamine (da) modulates apoptosis in neuronal and non-neuronal cells, and dopaminergic pathways contribute to neurodegenerative disease. |
2004-06-15 |
2023-08-12 |
human |
| Julian T Pittman, Celia A Dodd, Bradley G Klei. Immunohistochemical changes in the mouse striatum induced by the pyrethroid insecticide permethrin. International journal of toxicology. vol 22. issue 5. 2004-06-14. PMID:14555407. |
dopamine transporter, tyrosine hydroxylase, and glial fibrillary acidic protein immunoreactivities were examined in caudate-putamen to distinguish changes in amount of dopamine transporter immunoreactive protein from degeneration or other damage to dopaminergic neuropil. |
2004-06-14 |
2023-08-12 |
mouse |
| Carlos A Rodríguez, Nkechi E Azie, Gregory Adams, Kirsteen Donaldson, Steven F Francom, Brian A Staton, Paul A Bombard. Single oral dose safety, tolerability, and pharmacokinetics of PNU-96391 in healthy volunteers. Journal of clinical pharmacology. vol 44. issue 3. 2004-06-14. PMID:14973308. |
the safety, tolerability, and pharmacokinetics of pnu-96391, an orally active weak dopamine d2 receptor antagonist with modulatory properties of central dopaminergic function, was characterized. |
2004-06-14 |
2023-08-12 |
human |
| Anna Czyrak, Marzena Maćkowiak, Agnieszka Chocyk, Katarzyna Fijał, Krzystof Wedzon. Role of glucocorticoids in the regulation of dopaminergic neurotransmission. Polish journal of pharmacology. vol 55. issue 5. 2004-06-10. PMID:14704461. |
it is postulated, first, that corticosterone, an important stress hormone, regulates the dopaminergic neurotransmission at the level of dopamine d-1 receptors. |
2004-06-10 |
2023-08-12 |
Not clear |
| Lauren M Billings, John F Marshal. Glutamic acid decarboxylase 67 mRNA regulation in two globus pallidus neuron populations by dopamine and the subthalamic nucleus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 12. 2004-06-10. PMID:15044549. |
thus, the pv+ and pv- neurons are influenced in qualitatively similar ways by dopamine and the stn, but these cell types exhibit contrasting degrees of regulation by the dopaminergic and stn perturbations. |
2004-06-10 |
2023-08-12 |
Not clear |
| F Delis, A Mitsacos, P Giompre. Dopamine receptor and transporter levels are altered in the brain of Purkinje Cell Degeneration mutant mice. Neuroscience. vol 125. issue 1. 2004-06-03. PMID:15051164. |
the dopamine transporters, as determined by [3h]win35428 binding, were increased compared with wild-type mice in the ventral mesencephalic dopaminergic nuclei and in the lateral striatum, motor cortex and septum. |
2004-06-03 |
2023-08-12 |
mouse |
| Kathy Dujardin, Bernard Lauren. Dysfunction of the human memory systems: role of the dopaminergic transmission. Current opinion in neurology. vol 16 Suppl 2. 2004-06-03. PMID:15129845. |
the role played by dopamine depletion in these deficits remains a subject of debate as some studies suggest the involvement of the dopaminergic system in cognitive function, although other results do not support it. |
2004-06-03 |
2023-08-12 |
human |
| Anthony E Lang, Jose A Obes. Challenges in Parkinson's disease: restoration of the nigrostriatal dopamine system is not enough. The Lancet. Neurology. vol 3. issue 5. 2004-06-02. PMID:15099546. |
long-acting dopamine agonists are associated with a reduced incidence of these complications and modern surgical approaches and pharmacological methods of providing more continuous dopaminergic stimulation have a substantial ameliorative effect on these problems. |
2004-06-02 |
2023-08-12 |
Not clear |
| Wei Zhang, Tongguang Wang, Liya Qin, Hui-Ming Gao, Belinda Wilson, Syed F Ali, Wanqin Zhang, Jau-Shyong Hong, Bin Li. Neuroprotective effect of dextromethorphan in the MPTP Parkinson's disease model: role of NADPH oxidase. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 18. issue 3. 2004-06-01. PMID:14734632. |
parkinson's disease (pd) is a neurodegenerative movement disorder characterized by a progressive loss of dopaminergic neurons in the substantia nigra and depletion of the neurotransmitter dopamine in the striatum. |
2004-06-01 |
2023-08-12 |
mouse |