| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Leu-Fen H Lin, Lee L Rubin, Mei X. A non-peptidyl neurotrophic small molecule for midbrain dopaminergic neurons. Journal of neurochemistry. vol 89. issue 6. 2004-07-22. PMID:15189341. |
in embryonic midbrain cultures, cur-162590 increased dopamine uptake and the number of dopaminergic neurons without altering the number of total neurons or astroglia or the uptake of gaba or serotonin. |
2004-07-22 |
2023-08-12 |
Not clear |
| Andreas Hermann, Manfred Gerlach, Johannes Schwarz, Alexander Storc. Neurorestoration in Parkinson's disease by cell replacement and endogenous regeneration. Expert opinion on biological therapy. vol 4. issue 2. 2004-07-21. PMID:14998773. |
parkinson's disease (pd) is characterised by a continuous and selective loss of dopaminergic neurons in the substantia nigra pars compacta with a subsequent reduction of the neurotransmitter dopamine. |
2004-07-21 |
2023-08-12 |
Not clear |
| Phillip G Greco, Paul A Garri. In vivo interaction of cocaine with the dopamine transporter as measured by voltammetry. European journal of pharmacology. vol 479. issue 1-3. 2004-07-20. PMID:14612143. |
other factors such as diffusion and whether dopaminergic signaling is tonic or phasic also determine the effects of cocaine on striatal dopamine levels. |
2004-07-20 |
2023-08-12 |
Not clear |
| Ole V Mortensen, Susan G Amar. Dynamic regulation of the dopamine transporter. European journal of pharmacology. vol 479. issue 1-3. 2004-07-20. PMID:14612147. |
presynaptic receptors for dopamine and other neurotransmitters (auto-receptors and hetero-receptors) present on dopaminergic neurons are poised to regulate the activity of the dopamine transporter acutely through their actions on intracellular signaling systems. |
2004-07-20 |
2023-08-12 |
Not clear |
| Lindsey Ken. Recent advances in the genetics of attention deficit hyperactivity disorder. Current psychiatry reports. vol 6. issue 2. 2004-07-20. PMID:15038917. |
association findings for several candidate genes within the dopaminergic system, the drd4 and drd5 receptor genes and the dopamine transporter gene, dat1, have been well replicated, and the first of several ongoing genome linkage scan study results have been published. |
2004-07-20 |
2023-08-12 |
Not clear |
| Peter Jenne. Dopamine agonists, receptor selectivity and dyskinesia induction in Parkinson's disease. Current opinion in neurology. vol 16 Suppl 1. 2004-07-20. PMID:15180131. |
long-acting dopamine agonists providing continuous, rather than pulsatile, dopaminergic stimulation appear able to avoid dyskinesia induction. |
2004-07-20 |
2023-08-12 |
Not clear |
| Johannes Schwar. Rationale for dopamine agonist use as monotherapy in Parkinson's disease. Current opinion in neurology. vol 16 Suppl 1. 2004-07-20. PMID:15180135. |
evidence is also mounting in preclinical models that dopamine agonists protect dopaminergic neurons from the toxic effects of oxidative stress and the by-products of dopamine and l-dopa metabolism. |
2004-07-20 |
2023-08-12 |
Not clear |
| Steven B Foster, Monika Z Wrona, Jilin Han, Glenn Dryhurs. The parkinsonian neurotoxin 1-methyl-4-phenylpyridinium (MPP(+)) mediates release of l-3,4-dihydroxyphenylalanine (l-DOPA) and inhibition of l-DOPA decarboxylase in the rat striatum: a microdialysis study. Chemical research in toxicology. vol 16. issue 10. 2004-07-19. PMID:14565778. |
early steps in the neurotoxic mechanism evoked by mpp(+) include a profound dopaminergic energy impairment, which mediates a massive release of dopamine (da), glutathione (gsh), and cysteine (cysh). |
2004-07-19 |
2023-08-12 |
human |
| Eva de Lago, Rosario de Miguel, Isabel Lastres-Becker, José A Ramos, Javier Fernández-Rui. Involvement of vanilloid-like receptors in the effects of anandamide on motor behavior and nigrostriatal dopaminergic activity: in vivo and in vitro evidence. Brain research. vol 1007. issue 1-2. 2004-07-19. PMID:15064146. |
as a second objective, we explored whether anandamide is able to directly influence nigrostriatal dopaminergic function by examining its effects on in vitro dopamine (da) release using perifused striatal fragments. |
2004-07-19 |
2023-08-12 |
rat |
| Catherine Pasqualini, Bernadette Vidal, Nadine Le Belle, Miskal Sbaihi, Finn-Arne Weltzien, Philippe Vernier, Yonathan Zohar, Sylvie Dufou. [An antagonist to GnRH in the control of reproduction in teleost fish: dopaminergic inhibition. Ancestral origin and differential conservation within vertebrates?]. Journal de la Societe de biologie. vol 198. issue 1. 2004-07-19. PMID:15146957. |
subsequent in vivo and in vitro studies identified dopamine as grif, and neuroanatomical investigations have demonstrated that dopaminergic neurones in the anterior preoptic area projecting to the pituitary represent the anatomical substrate for grif activity. |
2004-07-19 |
2023-08-12 |
Not clear |
| Wynn H T Pan, Sze-Yuan Yang, Shi-Kwang Li. Neurochemical interaction between dopaminergic and noradrenergic neurons in the medial prefrontal cortex. Synapse (New York, N.Y.). vol 53. issue 1. 2004-07-16. PMID:15150740. |
growing evidence indicates that there is an interaction between the transmission of dopamine (da) and norepinephrine (ne) in the noradrenergic and dopaminergic projections that converge in the medial prefrontal cortex (mpfc). |
2004-07-16 |
2023-08-12 |
rat |
| Alessandra Recchia, Patrizia Debetto, Alessandro Negro, Diego Guidolin, Stephen D Skaper, Pietro Giust. Alpha-synuclein and Parkinson's disease. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 18. issue 6. 2004-07-15. PMID:15054084. |
in dopaminergic neurons, this may promote a vicious cycle in which elevation in cytoplasmic dopamine, oxidative stress, alpha-syn dysfunction, and disruption of vesicle function lead to dopaminergic cell loss and pd. |
2004-07-15 |
2023-08-12 |
human |
| Anita Sidhu, Christophe Wersinger, Philippe Vernie. Does alpha-synuclein modulate dopaminergic synaptic content and tone at the synapse? FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 18. issue 6. 2004-07-15. PMID:15054086. |
although its contributions to normal physiological conditions remain elusive, converging observations suggest that a primary function of this protein in dopaminergic neurons may be the regulation of dopamine content and synaptic tone at the synapse. |
2004-07-15 |
2023-08-12 |
Not clear |
| Anita Sidhu, Christophe Wersinger, Philippe Vernie. Does alpha-synuclein modulate dopaminergic synaptic content and tone at the synapse? FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 18. issue 6. 2004-07-15. PMID:15054086. |
the regulatory role of alpha-synuclein on dopamine metabolism is assessed by discussing the experimental evidence supporting each of these observations in the healthy physiological maintenance of dopaminergic neurons, as well as showing how disruption of these events can initiate the observed neurotoxicity of alpha-synuclein and the genesis of the degenerative processes associated with parkinson's disease. |
2004-07-15 |
2023-08-12 |
Not clear |
| Emilio Fernandez-Espejo, Isabel Caraballo, Fernando Rodriguez de Fonseca, Belen Ferrer, Fadwa El Banoua, Juan A Flores, Beatriz Galan-Rodrigue. Experimental parkinsonism alters anandamide precursor synthesis, and functional deficits are improved by AM404: a modulator of endocannabinoid function. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 29. issue 6. 2004-07-14. PMID:15010694. |
this finding reveals the presence of a homeostatic striatal mechanism emerging after dopaminergic denervation likely tending to enhance low dopamine tone. |
2004-07-14 |
2023-08-12 |
rat |
| J L W Bosboom, E Ch Wolter. Psychotic symptoms in Parkinson's disease: pathophysiology and management. Expert opinion on drug safety. vol 3. issue 3. 2004-07-13. PMID:15155149. |
parkinson's disease (pd) is a chronic neurodegenerative disease, in which mainly dopaminergic neurons in the substantia nigra in the brain degenerate, leading to a depletion of dopamine (da) in the striatum. |
2004-07-13 |
2023-08-12 |
Not clear |
| Elzbieta Lorenc-Koci, Lucyna Antkiewicz-Michaluk, Jadwiga Wardas, Małgorzata Zapała, Joanna Wierońsk. Effect of 1,2,3,4,-tetrahydroisoquinoline administration under conditions of CYP2D inhibition on dopamine metabolism, level of tyrosine hydroxylase protein and the binding of [3H]GBR 12,935 to dopamine transporter in the rat nigrostriatal, dopaminergic system. Brain research. vol 1009. issue 1-2. 2004-07-12. PMID:15120584. |
effect of 1,2,3,4,-tetrahydroisoquinoline administration under conditions of cyp2d inhibition on dopamine metabolism, level of tyrosine hydroxylase protein and the binding of [3h]gbr 12,935 to dopamine transporter in the rat nigrostriatal, dopaminergic system. |
2004-07-12 |
2023-08-12 |
rat |
| Kristopher M Kahlig, Jonathan A Javitch, Aurelio Gall. Amphetamine regulation of dopamine transport. Combined measurements of transporter currents and transporter imaging support the endocytosis of an active carrier. The Journal of biological chemistry. vol 279. issue 10. 2004-07-06. PMID:14699142. |
dopaminergic neurotransmission is fine-tuned by the rate of removal of dopamine (da) from the extracellular space via the na(+)/cl(-)-dependent da transporter (dat). |
2004-07-06 |
2023-08-12 |
human |
| Christoph Czermak, Michael Lehofer, Elke M Wagner, Barbara Prietl, Gregor Gorkiewicz, Leonidas Lemonis, Alfred Rohrhofer, Thomas Legl, Konrad Schauenstein, Peter M Liebman. Reduced dopamine D3 receptor expression in blood lymphocytes of smokers is negatively correlated with daily number of smoked cigarettes: a peripheral correlate of dopaminergic alterations in smokers. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. vol 6. issue 1. 2004-07-01. PMID:14982687. |
reduced dopamine d3 receptor expression in blood lymphocytes of smokers is negatively correlated with daily number of smoked cigarettes: a peripheral correlate of dopaminergic alterations in smokers. |
2004-07-01 |
2023-08-12 |
human |
| Anita Sidhu, Christophe Wersinger, Philippe Vernie. alpha-Synuclein regulation of the dopaminergic transporter: a possible role in the pathogenesis of Parkinson's disease. FEBS letters. vol 565. issue 1-3. 2004-06-23. PMID:15135042. |
the phenomenon of selective degeneration of dopaminergic neurons in pd may be linked to the potential toxicity of dopamine itself and aberrations in the processes which regulate dopamine content may underlie the pathogenesis of this disease. |
2004-06-23 |
2023-08-12 |
Not clear |