| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| David A Loeffler, Dianne M Camp, Shirley Qu, Blaine L Beaman, Peter A LeWit. Characterization of dopamine-depleting activity of Nocardia asteroides strain GUH-2 culture filtrate on PC12 cells. Microbial pathogenesis. vol 37. issue 2. 2004-10-25. PMID:15312847. |
the head shaking is temporarily inhibited by treatment with dopamine's precursor levodopa, suggesting that abnormalities in dopaminergic neurotransmission may be involved in these movement abnormalities. |
2004-10-25 |
2023-08-12 |
mouse |
| Antonella Stroppolo, Chai Tian, Barbara Guinea, Vicki Olm, Roxanne Sheffield, John Sommer, Michelle E Ehrlic. 17beta-Estradiol promotes striatal medium size spiny neuronal maturation in vitro. Neuroendocrinology. vol 79. issue 5. 2004-10-22. PMID:15218319. |
it receives a large dopaminergic input from the substantia nigra, and 96% of the msns express darpp-32, a dopamine and cyclic amp-regulated phosphoprotein and key mediator of dopamine function. |
2004-10-22 |
2023-08-12 |
Not clear |
| G V Idova, M A Cheido, E N Zhukova, L V Devoin. Stimulation of the immune response during activation of the dopaminergic system in mice with opposite types of behavior. Neuroscience and behavioral physiology. vol 34. issue 4. 2004-10-21. PMID:15341221. |
changes in the activity of the dopaminergic system were induced with skf-38393, a selective agonist of dopamine d1 receptors, and with p-chlorophenylalanine (pcpa), which we have previously shown to activate d2 receptors. |
2004-10-21 |
2023-08-12 |
mouse |
| Edward G Meloni, Michael Davi. The substantia nigra pars reticulata mediates the enhancement of startle by the dopamine D1 receptor agonist SKF 82958 in rats. Psychopharmacology. vol 174. issue 2. 2004-10-19. PMID:14735289. |
because dopaminergic and gaba ergic mechanisms may interact in the snr, we tested the contribution of both dopamine and gaba receptors in the snr on the enhancement of startle by the dopamine d1 agonist skf 82958. |
2004-10-19 |
2023-08-12 |
rat |
| Geraldine Rogers, Peter Joyce, Roger Mulder, Douglas Sellman, Allison Miller, Melanie Allington, Robin Olds, Elisabeth Wells, Martin Kenned. Association of a duplicated repeat polymorphism in the 5'-untranslated region of the DRD4 gene with novelty seeking. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 126B. issue 1. 2004-10-19. PMID:15048656. |
dopaminergic genes have been prime candidates in the search for the genetic factors underlying ns because of the central role that dopamine plays in the brain's reward system. |
2004-10-19 |
2023-08-12 |
human |
| Yogita Chudasama, Trevor W Robbin. Dopaminergic modulation of visual attention and working memory in the rodent prefrontal cortex. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 29. issue 9. 2004-10-18. PMID:15138446. |
converging evidence suggests that dopaminergic projections to the prefrontal cortex (pfc) modulate both attention and working memory processes that may be related to either insufficient or excessive dopamine activity specific to a d1 receptor mechanism. |
2004-10-18 |
2023-08-12 |
Not clear |
| Claire Matson Cannon, Mustafa R Bseikr. Is dopamine required for natural reward? Physiology & behavior. vol 81. issue 5. 2004-10-18. PMID:15234179. |
dopamine systems are activated in animals drinking sugar solutions, and lesions of dopaminergic neurons or pharmacological blockade of da receptors seem to reduce the reward value of both sweet tastes and drugs of abuse. |
2004-10-18 |
2023-08-12 |
mouse |
| Yizhou Ye, Wang Xi, Yueqing Peng, Yizheng Wang, Aike Gu. Long-term but not short-term blockade of dopamine release in Drosophila impairs orientation during flight in a visual attention paradigm. The European journal of neuroscience. vol 20. issue 4. 2004-10-14. PMID:15305868. |
the examination of several different transgenic flies in a single-target visual attention paradigm showed that flies lost their orientation ability if dopamine release was blocked from the beginning of the development of dopaminergic neurons. |
2004-10-14 |
2023-08-12 |
drosophila_melanogaster |
| Yizhou Ye, Wang Xi, Yueqing Peng, Yizheng Wang, Aike Gu. Long-term but not short-term blockade of dopamine release in Drosophila impairs orientation during flight in a visual attention paradigm. The European journal of neuroscience. vol 20. issue 4. 2004-10-14. PMID:15305868. |
behavioral assays revealed that flies with permanent j-domain protein down-regulation specifically in dopaminergic neurons have an attention defect similar to that induced by long-term blockade of dopamine release. |
2004-10-14 |
2023-08-12 |
drosophila_melanogaster |
| Kerstin Håkansson, Laura Pozzi, Alessandro Usiello, John Haycock, Emiliana Borrelli, Gilberto Fison. Regulation of striatal tyrosine hydroxylase phosphorylation by acute and chronic haloperidol. The European journal of neuroscience. vol 20. issue 4. 2004-10-14. PMID:15305880. |
according to this model, haloperidol increases th activity via blockade of dopamine d2 receptors, disinhibition of dopaminergic projection neurons and erk1/2-dependent phosphorylation of th at ser31 and ser40. |
2004-10-14 |
2023-08-12 |
mouse |
| Vesna Sossi, Raúl de la Fuente-Fernández, James E Holden, Michael Schulzer, Thomas J Ruth, Jon Stoess. Changes of dopamine turnover in the progression of Parkinson's disease as measured by positron emission tomography: their relation to disease-compensatory mechanisms. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 24. issue 8. 2004-10-08. PMID:15362717. |
this comparison of changes in ki and edv as a function of disease progression indicates that a relatively slower decrease in dopamine synthesis and a relatively faster increase in turnover in early disease likely act as compensatory mechanisms, and that the clinical onset of pd reflects a global failure of dopaminergic compensatory mechanisms. |
2004-10-08 |
2023-08-12 |
human |
| M Gallego, R Setién, M J Izquierdo, O Casis, E Casi. Diabetes-induced biochemical changes in central and peripheral catecholaminergic systems. Physiological research. vol 52. issue 6. 2004-10-05. PMID:14640895. |
the dopamine content is reduced in the dopaminergic nigrostriatal system only. |
2004-10-05 |
2023-08-12 |
Not clear |
| Alessandra T Peana, M Graziella De Montis, Eugenio Nieddu, M Teresa Spano, Paolo S D'Aquila, Proto Pippi. Profile of spinal and supra-spinal antinociception of (-)-linalool. European journal of pharmacology. vol 485. issue 1-3. 2004-10-05. PMID:14757137. |
in addition, to determine the possible involvement of the cholinergic, opioidergic and dopaminergic systems, we tested the effects of atropine, pirenzepine, a muscarinic m1 receptor antagonist, naloxone, sulpiride, a dopamine d2 receptor antagonist and (r)-(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1h-3-benzazepine (sch-23390), a dopamine d1 receptor antagonist on (-)-linalool-induced antinociception. |
2004-10-05 |
2023-08-12 |
Not clear |
| G Schmid, B Suchan, J Rusin, I Daum, O Köster, H Przuntek, Th Müller, S Peter. Impact of apomorphine on BOLD signal during movement in normals. Journal of neural transmission. Supplementum. issue 68. 2004-10-05. PMID:15354391. |
one conceivable explanation for our singular results would be preferred binding of apomorphine to presynaptic dopaminergic receptors, leading to inhibition of endogenous dopamine release and resultant diminished dopaminergic stimulation, reflected in diminished cerebral activation patterns. |
2004-10-05 |
2023-08-12 |
human |
| Th Müller, S Benz, Ch Börnke, S Muhlack, D Woitalla, H Przunte. Worsened motor test performance following acute apomorphine injection in previously untreated patients with Parkinson's disease. Journal of neural transmission. Supplementum. issue 68. 2004-10-05. PMID:15354392. |
tolerance to sedative effects of apomorphine in treated pd patients or sensitivity of employed motor tests to presynaptic dopaminergic autoreceptor mediated inhibition of endogenous dopamine release or postsynaptic dopaminergic overstimulation with resulting decreased cognitive function in previously untreated pd patients hypothetically caused this discrepancy between outcomes of subjective clinical rating and objective motor test performance. |
2004-10-05 |
2023-08-12 |
human |
| Miho Hamada, Hideho Higashi, Angus C Nairn, Paul Greengard, Akinori Nish. Differential regulation of dopamine D1 and D2 signaling by nicotine in neostriatal neurons. Journal of neurochemistry. vol 90. issue 5. 2004-09-30. PMID:15312165. |
nicotine, acting on nicotinic acetylcholine receptors (nachrs) expressed at pre-synaptic dopaminergic terminals, has been shown to stimulate the release of dopamine in the neostriatum. |
2004-09-30 |
2023-08-12 |
mouse |
| Miho Hamada, Hideho Higashi, Angus C Nairn, Paul Greengard, Akinori Nish. Differential regulation of dopamine D1 and D2 signaling by nicotine in neostriatal neurons. Journal of neurochemistry. vol 90. issue 5. 2004-09-30. PMID:15312165. |
nicotine at a low concentration (1 microm) activated dopamine d2 receptor signaling in striatopallidal/indirect pathway neurons, likely by activating alpha4beta2* nachrs at dopaminergic terminals. |
2004-09-30 |
2023-08-12 |
mouse |
| Miho Hamada, Hideho Higashi, Angus C Nairn, Paul Greengard, Akinori Nish. Differential regulation of dopamine D1 and D2 signaling by nicotine in neostriatal neurons. Journal of neurochemistry. vol 90. issue 5. 2004-09-30. PMID:15312165. |
nicotine at a high concentration (100 microm) activated dopamine d1 receptor signaling in striatonigral/direct pathway neurons, likely by activating (i) alpha4beta2* nachrs at dopaminergic terminals and (ii) alpha7 nachrs at glutamatergic terminals, which, by stimulating the release of glutamate, activated nmda/ampa receptors at dopaminergic terminals. |
2004-09-30 |
2023-08-12 |
mouse |
| René Hummerich, Gerald Reischl, Walter Ehrlichmann, Hans-Jürgen Machulla, Andreas Heinz, Patrick Schlos. DASB -in vitro binding characteristics on human recombinant monoamine transporters with regard to its potential as positron emission tomography (PET) tracer. Journal of neurochemistry. vol 90. issue 5. 2004-09-30. PMID:15312176. |
previous positron emission tomography (pet) and single photon emission computed tomography (spect) studies were often carried out using radioligands that bind with high affinity to serts in the brainstem but also exhibit high affinity for dopamine and norepinephrine transporters and therefore did not allow quantification of serotonergic innervations in brain regions also containing dopaminergic or noradrenergic terminals. |
2004-09-30 |
2023-08-12 |
human |
| D James Surmeie. Homeostatic regulation of dopaminergic neurons without dopamine. Proceedings of the National Academy of Sciences of the United States of America. vol 101. issue 36. 2004-09-30. PMID:15340144. |
homeostatic regulation of dopaminergic neurons without dopamine. |
2004-09-30 |
2023-08-12 |
Not clear |