| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Y Nakano, A C Hirko, A D Smith, M Oka, R Dawson, J Peris, N Terada, E M Meye. Presynaptic dopaminergic properties of differentiated mouse embryonic stem cells. Neurochemistry international. vol 45. issue 7. 2004-11-09. PMID:15337306. |
these and other important dopaminergic genes found expressed in these cultures by rt-pcr included nurr1, vesicular monoamine transporter 2 (vmat2), th, dopamine transporter (dat), and glial cell line-derived neurotrophic factor (gdnf) receptors c-ret and gfralpha1. |
2004-11-09 |
2023-08-12 |
mouse |
| Virginia Peinado, José Carlos González, María Luisa Lere. Effect of 17-beta-estradiol on dopamine, serotonine and GABA striatal levels in 6-hydroxydopamine-treated rats. Toxicology. vol 204. issue 2-3. 2004-11-08. PMID:15388241. |
intrastriatal injection (16microg) of the neurotoxic dopaminergic agent 6-hydroxydopamine (6-ohda) in ovariectomized rats caused important reductions in striatal dopamine (da) and serotonin (5-ht) levels and an increase in gaba content. |
2004-11-08 |
2023-08-12 |
rat |
| Norio Ogawa, Masato Asanuma, Ko Miyosh. [Mechanism of specific dopaminergic neuronal death in Parkinson's disease]. Nihon rinsho. Japanese journal of clinical medicine. vol 62. issue 9. 2004-11-06. PMID:15462376. |
parkinson's disease (pd) is characterized by progressive degeneration of dopaminergic (daergic) neurons of the nigrostriatal system, with resulting reduction in striatal dopamine (da) concentration. |
2004-11-06 |
2023-08-12 |
Not clear |
| Etsuro Matsubar. [The recent advance of treatment of Parkinson's disease]. Nihon rinsho. Japanese journal of clinical medicine. vol 62. issue 9. 2004-11-06. PMID:15462392. |
the primary pathology of parkinson's disease is the degeneration of dopaminergic neurons in the nigrostriatal pathway, resulting in a significant reduction in striatum dopamine concentration which is responsible for the altered motor functions. |
2004-11-06 |
2023-08-12 |
Not clear |
| Adam Przybyłkowski, Iwona Kurkowska-Jastrzebska, Ilona Joniec, Agnieszka Ciesielska, Anna Członkowska, Andrzej Członkowsk. Cyclooxygenases mRNA and protein expression in striata in the experimental mouse model of Parkinson's disease induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine administration to mouse. Brain research. vol 1019. issue 1-2. 2004-11-04. PMID:15306248. |
mptp causes an acute damage of dopaminergic neurons especially in the nigrostriatal dopaminergic system, thus diminishing dopamine (da) content in striatum and decreasing the number of dopaminergic cells in the pars compacta of the substantia nigra (sn). |
2004-11-04 |
2023-08-12 |
mouse |
| Lifen Zhang, Fu-Ming Zhou, John A Dan. Cholinergic drugs for Alzheimer's disease enhance in vitro dopamine release. Molecular pharmacology. vol 66. issue 3. 2004-11-03. PMID:15322245. |
furthermore, these results suggest that acting via nicotinic receptors, these drugs may serve presently untapped therapeutic roles by altering dopamine release in other disorders involving dopaminergic systems. |
2004-11-03 |
2023-08-12 |
mouse |
| Il-Woong Seol, Na Youn Kuo, Kyeong Man Ki. Effects of dopaminergic drugs on the mast cell degranulation and nitric oxide generation in RAW 264.7 cells. Archives of pharmacal research. vol 27. issue 1. 2004-11-02. PMID:14969346. |
the results suggested that these dopaminergic agents, when used for the treatment of dopamine receptors-related diseases, such as schizophrenia or parkinsons disease, might have additional beneficial effects. |
2004-11-02 |
2023-08-12 |
Not clear |
| Chima Matsumoto, Takahiro Shinkai, Hiroko Hori, Osamu Ohmori, Jun Nakamur. Polymorphisms of dopamine degradation enzyme (COMT and MAO) genes and tardive dyskinesia in patients with schizophrenia. Psychiatry research. vol 127. issue 1-2. 2004-11-02. PMID:15261699. |
we hypothesized that deranged dopamine degradation enzyme activities might be related to the susceptibility to td through altered dopaminergic neurotransmission in the central nervous system. |
2004-11-02 |
2023-08-12 |
human |
| Akinori Iwashita, Kayoko Mihara, Syunji Yamazaki, Shigeru Matsuura, Junya Ishida, Hirofumi Yamamoto, Kouji Hattori, Nobuya Matsuoka, Seitaro Muto. A new poly(ADP-ribose) polymerase inhibitor, FR261529 [2-(4-chlorophenyl)-5-quinoxalinecarboxamide], ameliorates methamphetamine-induced dopaminergic neurotoxicity in mice. The Journal of pharmacology and experimental therapeutics. vol 310. issue 3. 2004-11-01. PMID:15113847. |
oral administration of fr261529 (10 or 32 mg/kg) attenuated the damage of dopaminergic neurons via marked reduction of parp activity and not via changes in dopamine metabolism or body temperature. |
2004-11-01 |
2023-08-12 |
mouse |
| Evelien Huisman, Harry B M Uylings, Piet V Hooglan. A 100% increase of dopaminergic cells in the olfactory bulb may explain hyposmia in Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society. vol 19. issue 6. 2004-10-28. PMID:15197709. |
to determine whether the olfactory dysfunctions, like the motor symptoms, are associated with a loss of dopamine, the number of dopaminergic cells in the olfactory bulb of parkinson's disease patients was studied using tyrosine hydroxylase immunohistochemistry. |
2004-10-28 |
2023-08-12 |
Not clear |
| Evelien Huisman, Harry B M Uylings, Piet V Hooglan. A 100% increase of dopaminergic cells in the olfactory bulb may explain hyposmia in Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society. vol 19. issue 6. 2004-10-28. PMID:15197709. |
because dopamine is known to inhibit olfactory transmission in the olfactory glomeruli, we suggest that the increase of dopaminergic neurons in the olfactory bulb is responsible for the hyposmia in parkinson patients. |
2004-10-28 |
2023-08-12 |
Not clear |
| S Scheggi, R Rauggi, C Gambarana, A Tagliamonte, M G De Monti. Dopamine and cyclic AMP-regulated phosphoprotein-32 phosphorylation pattern in cocaine and morphine-sensitized rats. Journal of neurochemistry. vol 90. issue 4. 2004-10-28. PMID:15287884. |
morphine-sensitized rats have increased binding and coupling of micro -opioid receptors and increased dopaminergic transmission in striatal areas and, upon morphine challenge, exhibit dopamine d1 receptor-dependent stereotypies. |
2004-10-28 |
2023-08-12 |
rat |
| Donita L Robinson, R Mark Wightma. Nomifensine amplifies subsecond dopamine signals in the ventral striatum of freely-moving rats. Journal of neurochemistry. vol 90. issue 4. 2004-10-28. PMID:15287895. |
administration of 7 mg/kg nomifensine amplified spontaneous dopamine transients by increasing both amplitude and duration, consistent with its known action at the dopamine transporter and emphasizing the dopaminergic origin of the signals. |
2004-10-28 |
2023-08-12 |
rat |
| Ranjita Betarbet, J Timothy Greenamyr. Regulation of dopamine receptor and neuropeptide expression in the basal ganglia of monkeys treated with MPTP. Experimental neurology. vol 189. issue 2. 2004-10-28. PMID:15380489. |
in this study, we simultaneously analyzed the regulation of d1 and d2 dopamine receptors and levels of the neuropeptides, substance p, and enkephalin (enk) in various basal ganglia nuclei following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced dopaminergic denervation of striatum in nonhuman primates. |
2004-10-28 |
2023-08-12 |
monkey |
| D Zanetti, N Civiero, C Balzanelli, M Tonini, A R Antonell. Improvement of vestibular compensation by Levo-sulpiride in acute unilateral labyrinthine dysfunction. Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale. vol 24. issue 2. 2004-10-28. PMID:15468991. |
l-sulpiride is the levorotatory enantiomer of sulpiride, a neuroleptic of the family of benzamide derivatives; it has a characteristic antagonist effect on central da2 dopaminergic receptors and dopamine da1 "autoreceptors". |
2004-10-28 |
2023-08-12 |
Not clear |
| Albert Adell, Francesc Artiga. The somatodendritic release of dopamine in the ventral tegmental area and its regulation by afferent transmitter systems. Neuroscience and biobehavioral reviews. vol 28. issue 4. 2004-10-26. PMID:15289006. |
given the involvement of the mesocorticolimbic dopaminergic systems in the pathogenesis of severe neuropsychiatric disorders such as schizophrenia, the knowledge of the factors that regulate the release of dopamine in the vta could provide new insight into the ethiogenesis of the disease as well as its implication on the mechanisms of action of therapeutic drugs. |
2004-10-26 |
2023-08-12 |
Not clear |
| Juan A Flores, Fadwa El Banoua, Beatriz Galán-Rodríguez, Emilio Fernandez-Espej. Opiate anti-nociception is attenuated following lesion of large dopamine neurons of the periaqueductal grey: critical role for D1 (not D2) dopamine receptors. Pain. vol 110. issue 1-2. 2004-10-25. PMID:15275769. |
the pag possess dopamine neurons, and it is likely that this dopaminergic network participates in anti-nociception. |
2004-10-25 |
2023-08-12 |
rat |
| Juan A Flores, Fadwa El Banoua, Beatriz Galán-Rodríguez, Emilio Fernandez-Espej. Opiate anti-nociception is attenuated following lesion of large dopamine neurons of the periaqueductal grey: critical role for D1 (not D2) dopamine receptors. Pain. vol 110. issue 1-2. 2004-10-25. PMID:15275769. |
the objective was to further study the morphology of the pag dopaminergic network, along with its role in nociception and opiate-induced analgesia in rats, following either dopamine depletion with the toxin 6-hydroxydopamine or local injection of dopaminergic antagonists. |
2004-10-25 |
2023-08-12 |
rat |
| Juan A Flores, Fadwa El Banoua, Beatriz Galán-Rodríguez, Emilio Fernandez-Espej. Opiate anti-nociception is attenuated following lesion of large dopamine neurons of the periaqueductal grey: critical role for D1 (not D2) dopamine receptors. Pain. vol 110. issue 1-2. 2004-10-25. PMID:15275769. |
following dopamine depletion of the pag, large neurons (not small ones) were selectively affected by the toxin (61.9% dopamine cell loss, 80.7% reduction of in vitro dopaminergic peak), and opiate-induced analgesia in the hot-plate test (not the tail-immersion test) was reliably attenuated in lesioned rats (p < 0.01). |
2004-10-25 |
2023-08-12 |
rat |
| Juan A Flores, Fadwa El Banoua, Beatriz Galán-Rodríguez, Emilio Fernandez-Espej. Opiate anti-nociception is attenuated following lesion of large dopamine neurons of the periaqueductal grey: critical role for D1 (not D2) dopamine receptors. Pain. vol 110. issue 1-2. 2004-10-25. PMID:15275769. |
the present study provides evidence that large neurons of the dopaminergic network of the pag participate in supraspinal (not spinal) nociceptive responses after opiates through the involvement of d(1) dopamine receptors. |
2004-10-25 |
2023-08-12 |
rat |