| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lichuan Yang, Shuei Sugama, Ronald P Mischak, Mahmoud Kiaei, Nicolas Bizat, Emmanuel Brouillet, Tong H Joh, M Flint Bea. A novel systemically active caspase inhibitor attenuates the toxicities of MPTP, malonate, and 3NP in vivo. Neurobiology of disease. vol 17. issue 2. 2004-12-21. PMID:15474362. |
q-vd-oph significantly reduced dopamine depletion in striatum produced by mptp administration and prevented mptp-induced loss of dopaminergic neurons in the substantia nigra. |
2004-12-21 |
2023-08-12 |
Not clear |
| Martien J H Kas, Ruud van den Bos, Annemarie M Baars, Marianne Lubbers, Heidi M B Lesscher, Jacquelien J G Hillebrand, Alwin G Schuller, John E Pintar, Berry M Spruij. Mu-opioid receptor knockout mice show diminished food-anticipatory activity. The European journal of neuroscience. vol 20. issue 6. 2004-12-20. PMID:15355329. |
as we observed that mu-knockout mice tended to show a stronger locomotor activity response than wildtype mice to the indirect dopamine agonist d-amphetamine, it appears that the dopaminergic system per se is intact and sensitive to activation. |
2004-12-20 |
2023-08-12 |
mouse |
| Laurea M Diaz, Rajani Maiya, Matthew A Sullivan, Yunqing Han, Heather A Walton, Stephen L Boehm, Susan E Bergeson, R Dayne Mayfield, Richard A Morriset. Sindbis viral-mediated expression of eGFP-dopamine D1 receptors in situ with real-time two-photon microscopic detection. Journal of neuroscience methods. vol 139. issue 1. 2004-12-15. PMID:15351518. |
dopamine d1 receptors (d1drs) mediate a major component of dopaminergic neurotransmission, and alterations in their synaptic and subcellular distribution may underlie a variety of neurological diseases. |
2004-12-15 |
2023-08-12 |
mouse |
| Ute Krügel, Thomas Schraft, Ralph Regenthal, Peter Illes, Holger Kittne. Purinergic modulation of extracellular glutamate levels in the nucleus accumbens in vivo. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 22. issue 7. 2004-12-15. PMID:15465287. |
because of the known interference of dopaminergic and glutamatergic mechanisms in this area the experiments were performed with animals intra-accumbally treated with 6-hydroxydopamine (6-ohda) to deplete dopamine pools. |
2004-12-15 |
2023-08-12 |
rat |
| C Sitaru, V Cristea, S M Flore. Restless legs syndrome--relevant aspects for internal medicine specialists. Romanian journal of internal medicine = Revue roumaine de medecine interne. vol 37. issue 3. 2004-12-15. PMID:15532306. |
treatment of first choice consists of dopaminergic drugs or dopamine agonist, opioids and benzodiazepines. |
2004-12-15 |
2023-08-12 |
Not clear |
| Nathalie Bock, Gunther H Moll, Maike Wicker, Jürgen Pilz, Eckart Rüther, Tobias Banaschewski, Gerald Huether, Aribert Rothenberge. Early administration of tiapride to young rats without long-lasting changes in the development of the dopaminergic system. Pharmacopsychiatry. vol 37. issue 4. 2004-12-14. PMID:15467972. |
therefore, this study in rats describes tiapride's effects on several parameters of dopaminergic activity (dopamine transporter, d2 receptor, dopamine, dopac, and homovanillic acid in the striatum) seen after tiapride administration (30 mg/kg/day) to prepubertal (from day 25-39) and postpubertal (from day 50-64) rats. |
2004-12-14 |
2023-08-12 |
rat |
| Tomás González-Hernández, Pedro Barroso-Chinea, Ignacio De La Cruz Muros, María Del Mar Pérez-Delgado, Manuel Rodrígue. Expression of dopamine and vesicular monoamine transporters and differential vulnerability of mesostriatal dopaminergic neurons. The Journal of comparative neurology. vol 479. issue 2. 2004-12-13. PMID:15452855. |
expression of dopamine and vesicular monoamine transporters and differential vulnerability of mesostriatal dopaminergic neurons. |
2004-12-13 |
2023-08-12 |
human |
| Shannon L Macauley, Alexander D Horsch, Marinus Oterdoom, Ming H Zheng, Gregory R Stewar. The effects of transforming growth factor-beta2 on dopaminergic graft survival. Cell transplantation. vol 13. issue 3. 2004-12-10. PMID:15191162. |
dopaminergic cell transplantation is a promising therapeutic approach for the treatment of parkinson's disease, the potential of which is limited due to poor survival and low dopamine content within engrafted tissue. |
2004-12-10 |
2023-08-12 |
rat |
| Kyoko Goto, Akinori Ueki, Hiroyuki Iso, Yoshio Morit. Involvement of nucleus accumbens dopaminergic transmission in acoustic startle: observations concerning prepulse inhibition in rats with entorhinal cortex lesions. Psychiatry and clinical neurosciences. vol 58. issue 4. 2004-12-07. PMID:15298660. |
the entorhinal cortex and the sensorimotor gating system thus may be related via dopaminergic connections in the nucleus accumbens, even though dopamine release did not coincide completely with acoustic startle stimuli. |
2004-12-07 |
2023-08-12 |
rat |
| Giovanna Mangani, Franco Canestrari, Arnaldo Berloni, Michela Maione, Silvia Pagliarani, Filippo Mangan. Gas chromatographic--mass spectrometric determination of phenylacetic acid in human blood. Annali di chimica. vol 94. issue 9-10. 2004-12-07. PMID:15506622. |
phenyl acetic acid, a metabolite of 2-phenyl ethylamine, acts as a neuromodulator in the nigrostriatal dopaminergic pathway stimulating the release of dopamine. |
2004-12-07 |
2023-08-12 |
human |
| Neal R Swerdlow, Jody M Shoemaker, Pamela P Auerbach, Leia Pitcher, Jana Goins, Amanda Platte. Heritable differences in the dopaminergic regulation of sensorimotor gating. II. Temporal, pharmacologic and generational analyses of apomorphine effects on prepulse inhibition. Psychopharmacology. vol 174. issue 4. 2004-12-02. PMID:15300359. |
the disruption of prepulse inhibition (ppi) of startle in rats by dopamine agonists has been used in a predictive model for antipsychotics, and more recently, to study the neural basis of strain differences in dopaminergic function. |
2004-12-02 |
2023-08-12 |
rat |
| Stéphane Thobois, François Vingerhoets, Valerie Fraix, Jing Xie-Brustolin, Hélène Mollion, Nicolas Costes, Patrick Mertens, Alim-Louis Benabid, Pierre Pollak, Emmanuel Broussoll. Role of dopaminergic treatment in dopamine receptor down-regulation in advanced Parkinson disease: a positron emission tomographic study. Archives of neurology. vol 61. issue 11. 2004-12-02. PMID:15534182. |
in patients with advanced parkinson disease (pd) who are undergoing long-term treatment with a dopaminergic medication, a down-regulation of striatal dopamine d2 receptor expression has been demonstrated and interpreted as a consequence of either the disease itself or dopaminergic drug administration. |
2004-12-02 |
2023-08-12 |
Not clear |
| S Thobois, M Jahanshahi, S Pinto, R Frackowiak, P Limousin-Dowse. PET and SPECT functional imaging studies in Parkinsonian syndromes: from the lesion to its consequences. NeuroImage. vol 23. issue 1. 2004-11-30. PMID:15325346. |
modification of dopamine receptors expression is observed during pd, but the respective contribution of dopaminergic drugs and the disease process towards these changes is still debated. |
2004-11-30 |
2023-08-12 |
Not clear |
| Paola Devoto, Giovanna Flore, Luigi Pira, Giorgio Longu, Gian Luigi Gess. Mirtazapine-induced corelease of dopamine and noradrenaline from noradrenergic neurons in the medial prefrontal and occipital cortex. European journal of pharmacology. vol 487. issue 1-3. 2004-11-24. PMID:15033381. |
by means of microdialysis, the effect of mirtazapine on extracellular dopamine, 3,4-dihydroxyphenylacetic acid (dopac) and noradrenaline in the medial prefrontal cortex, densely innervated by dopaminergic and noradrenergic neurons, and in the occipital cortex, receiving equal noradrenergic but scarce dopaminergic projections, was compared. |
2004-11-24 |
2023-08-12 |
Not clear |
| Paola Devoto, Giovanna Flore, Luigi Pira, Giorgio Longu, Gian Luigi Gess. Mirtazapine-induced corelease of dopamine and noradrenaline from noradrenergic neurons in the medial prefrontal and occipital cortex. European journal of pharmacology. vol 487. issue 1-3. 2004-11-24. PMID:15033381. |
basal extracellular concentration of noradrenaline was similar in both cortices, while dopamine in the occipital cortex was only about 50% lower than in the medial prefrontal cortex, reflecting noradrenergic rather than dopaminergic projections. |
2004-11-24 |
2023-08-12 |
Not clear |
| Shun Yu, Xiaohong Zuo, Yaohua Li, Chen Zhang, Ming Zhou, Yu Alex Zhang, Kenji Uéda, Piu Cha. Inhibition of tyrosine hydroxylase expression in alpha-synuclein-transfected dopaminergic neuronal cells. Neuroscience letters. vol 367. issue 1. 2004-11-24. PMID:15308292. |
although the aberrant expression of alpha-synuclein (alpha-syn) is toxic to dopaminergic neurons, little is known about the correlation between the abnormality of alpha-syn and the expression of tyrosine hydroxylase (th), a rate-limiting enzyme for the synthesis of dopamine neurotransmitter. |
2004-11-24 |
2023-08-12 |
human |
| G Pöpperl, K Tatsch, E Ruzicka, A Storch, T Gasser, J Schwar. Comparison of alpha-dihydroergocryptine and levodopa monotherapy in Parkinson's disease: assessment of changes in DAT binding with [123I]IPT SPECT. Journal of neural transmission (Vienna, Austria : 1996). vol 111. issue 8. 2004-11-19. PMID:15254792. |
aim of this pilot study was to compare the effects of monotherapy with the dopamine agonist alpha-dihydroergocryptine (dec) versus monotherapy with levodopa on nigrostriatal dopaminergic neurons as measured with dopamine transporter (dat) spect. |
2004-11-19 |
2023-08-12 |
Not clear |
| R Ceravolo, D Volterrani, G Gambaccini, S Bernardini, C Rossi, C Logi, G Tognoni, G Manca, G Mariani, U Bonuccelli, L Murr. Presynaptic nigro-striatal function in a group of Alzheimer's disease patients with parkinsonism: evidence from a dopamine transporter imaging study. Journal of neural transmission (Vienna, Austria : 1996). vol 111. issue 8. 2004-11-19. PMID:15254794. |
the lack of dopamine transporter changes in our series of ad-p patients can indicate that dopaminergic presynaptic function is preserved in this population and that different dopaminergic changes such as postsynaptic ones, or different neurotransmitter alterations might underlie the extrapyramidal features in ad. |
2004-11-19 |
2023-08-12 |
Not clear |
| O Vegas, G Beitia, J R Sánchez-Martin, A Arregi, A Azpiro. Behavioral and neurochemical responses in mice bearing tumors submitted to social stress. Behavioural brain research. vol 155. issue 1. 2004-11-15. PMID:15325786. |
similarly, an increase was observed in the density of dopamine(2) (d(2))-receptors in the striatum (srt) and an increase in dopaminergic (dopac/da) and serotonergic (5hiaa/5ht) turnover in the hypothalamus. |
2004-11-15 |
2023-08-12 |
mouse |
| K P Datla, R D Bennett, V Zbarsky, B Ke, Y-F Liang, T Higa, T Bahorun, O I Aruoma, D T Dexte. The antioxidant drink effective microorganism-X (EM-X) pre-treatment attenuates the loss of nigrostriatal dopaminergic neurons in 6-hydroxydopamine-lesion rat model of Parkinson's disease. The Journal of pharmacy and pharmacology. vol 56. issue 5. 2004-11-09. PMID:15142343. |
of tyrosine hydroxylase positive cells (th+ cells) in the substantia nigra pars compacta (snpc)) and functionality (dopamine and its metabolites dopac and hva content in the striata) of nigrostriatal dopaminergic neurons were assessed. |
2004-11-09 |
2023-08-12 |
rat |