| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Christina Z Floresca, John A Schet. Dopamine receptor microdomains involved in molecular recognition and the regulation of drug affinity and function. Journal of receptor and signal transduction research. vol 24. issue 3. 2005-03-07. PMID:15521362. |
a cationic protonatable amine moiety on dopaminergic ligands forms a high affinity reinforced ionic bond with an anionic aspartic acid at position 3.32 of dopamine receptors. |
2005-03-07 |
2023-08-12 |
Not clear |
| Fu-In Tang, Ien-Lan We. Vitamin B-6 deficiency prolongs the time course of evoked dopamine release from rat striatum. The Journal of nutrition. vol 134. issue 12. 2005-03-07. PMID:15570036. |
to investigate the possible physiologic alterations in the dopaminergic nervous system in vitamin b-6 deficiency, dopamine release in the striatum of vitamin b-6-deficient rats was determined using in vivo electrochemistry. |
2005-03-07 |
2023-08-12 |
rat |
| Fu-In Tang, Ien-Lan We. Vitamin B-6 deficiency prolongs the time course of evoked dopamine release from rat striatum. The Journal of nutrition. vol 134. issue 12. 2005-03-07. PMID:15570036. |
the results indicate that the cellular content of dopamine does not reflect the functional state of dopaminergic neurons in vitamin b-6 deficiency. |
2005-03-07 |
2023-08-12 |
rat |
| Bernard Le Foll, Jorge Diaz, Pierre Sokolof. Neuroadaptations to hyperdopaminergia in dopamine D3 receptor-deficient mice. Life sciences. vol 76. issue 11. 2005-03-07. PMID:15642598. |
this behavior, which is under the control of d1r stimulation, may be related to an increased dopaminergic tone, since no changes in the gene expression of dopamine d1 and d2 receptors were noticed in the striatum of these mice. |
2005-03-07 |
2023-08-12 |
mouse |
| I C Sumaya, D M Byers, L N Irwin, S Del Val, D E Mos. Circadian-dependent effect of melatonin on dopaminergic D2 antagonist-induced hypokinesia and agonist-induced stereotypies in rats. Pharmacology, biochemistry, and behavior. vol 78. issue 4. 2005-03-04. PMID:15301928. |
although a melatonin/dopamine relationship has been well established in nonmotor systems wherein dopamine and melatonin share an antagonist relationship, less clear is the role melatonin may play in extrapyramidal dopaminergic function. |
2005-03-04 |
2023-08-12 |
rat |
| Andreas Schobe. Classic toxin-induced animal models of Parkinson's disease: 6-OHDA and MPTP. Cell and tissue research. vol 318. issue 1. 2005-03-04. PMID:15503155. |
pd is characterized by massive degeneration of dopaminergic neurons in the substantia nigra, the loss of striatal dopaminergic fibers and a dramatic reduction of the striatal dopamine levels. |
2005-03-04 |
2023-08-12 |
human |
| Mikko Airavaara, Anu Planken, Helena Gäddnäs, Timo Petteri Piepponen, Mart Saarma, Liisa Ahte. Increased extracellular dopamine concentrations and FosB/DeltaFosB expression in striatal brain areas of heterozygous GDNF knockout mice. The European journal of neuroscience. vol 20. issue 9. 2005-03-04. PMID:15525275. |
to study whether reduced levels of endogenous gdnf affect the striatal dopaminergic transmission we estimated the basal extracellular levels of dopamine in vivo, the basal expression of fosb-related proteins in striatal brain areas as well as the effects of acute and repeated cocaine on locomotor activity and dopamine output in mice lacking one gdnf allele (heterozygous gdnf+/- mice). |
2005-03-04 |
2023-08-12 |
mouse |
| K Fusa, I Takahashi, S Watanabe, Y Aono, H Ikeda, T Saigusa, H Nagase, T Suzuki, N Koshikawa, A R Cool. The non-peptidic delta opioid receptor agonist TAN-67 enhances dopamine efflux in the nucleus accumbens of freely moving rats via a mechanism that involves both glutamate and free radicals. Neuroscience. vol 130. issue 3. 2005-03-01. PMID:15590157. |
these results show that both enantiomers of tan-67 enhance the release of reserpine sensitive, vesicular dopamine and alpha-methyl-p-tyrosine sensitive, cytosolic dopamine from dopaminergic nerve terminals in the nucleus accumbens in a way that is independent of neural activity; activation of delta opioid receptors plays no role in these events. |
2005-03-01 |
2023-08-12 |
mouse |
| K Fusa, I Takahashi, S Watanabe, Y Aono, H Ikeda, T Saigusa, H Nagase, T Suzuki, N Koshikawa, A R Cool. The non-peptidic delta opioid receptor agonist TAN-67 enhances dopamine efflux in the nucleus accumbens of freely moving rats via a mechanism that involves both glutamate and free radicals. Neuroscience. vol 130. issue 3. 2005-03-01. PMID:15590157. |
all together, the results suggest that (-)-tan-67 can generate a burst of free radicals that in turn trigger a release of glutamate that ultimately via activation of nmda receptors enhances the release of dopamine from dopaminergic nerve terminals in the nucleus accumbens. |
2005-03-01 |
2023-08-12 |
mouse |
| Jason R Cannon, Richard F Keep, Ya Hua, Rudy J Richardson, Timothy Schallert, Guohua X. Thrombin preconditioning provides protection in a 6-hydroxydopamine Parkinson's disease model. Neuroscience letters. vol 373. issue 3. 2005-03-01. PMID:15619541. |
although tpc did not protect against the dopamine depletion associated with this severe model, it did reduce dopaminergic terminal loss and ventricular enlargement as compared to saline-treated animals. |
2005-03-01 |
2023-08-12 |
rat |
| W A Luft, P M Iuvone, W K Stel. Spatial, temporal, and intensive determinants of dopamine release in the chick retina. Visual neuroscience. vol 21. issue 4. 2005-02-28. PMID:15579225. |
apart from the fact that the rates of dopamine synthesis and release are increased by increasing illumination, the visual image parameters that influence dopaminergic function are mostly unknown. |
2005-02-28 |
2023-08-12 |
chicken |
| W A Luft, P M Iuvone, W K Stel. Spatial, temporal, and intensive determinants of dopamine release in the chick retina. Visual neuroscience. vol 21. issue 4. 2005-02-28. PMID:15579225. |
our purpose here was to identify visual stimulus parameters that activate dopaminergic amacrine cells and elicit dopamine release. |
2005-02-28 |
2023-08-12 |
chicken |
| W A Luft, P M Iuvone, W K Stel. Spatial, temporal, and intensive determinants of dopamine release in the chick retina. Visual neuroscience. vol 21. issue 4. 2005-02-28. PMID:15579225. |
activation of dopaminergic neurons, labeled for tyrosine hydroxylase (th), was assessed with immunocytochemistry for c-fos, and dopamine release was measured by hplc analysis of dopamine metabolite accumulation in the vitreous body. |
2005-02-28 |
2023-08-12 |
chicken |
| Iwona Kurkowska-Jastrzebska, Tomasz Litwin, Ilona Joniec, Agnieszka Ciesielska, Adam Przybyłkowski, Andrzej Członkowski, Anna Członkowsk. Dexamethasone protects against dopaminergic neurons damage in a mouse model of Parkinson's disease. International immunopharmacology. vol 4. issue 10-11. 2005-02-23. PMID:15313429. |
we observed the same protection in both situations: less dopamine depletion and less decrease in the number of dopaminergic cells in the substantia nigra (sn). |
2005-02-23 |
2023-08-12 |
mouse |
| J Srinivasan, Werner J Schmid. The effect of the alpha2-adrenoreceptor antagonist idazoxan against 6-hydroxydopamine-induced Parkinsonism in rats: multiple facets of action? Naunyn-Schmiedeberg's archives of pharmacology. vol 369. issue 6. 2005-02-22. PMID:15118809. |
since dopaminergic and serotonergic mechanisms are thought to account for the anti-cataleptic/anti-parkinsonian property of idazoxan, dopamine, 5-hydroxytryptamine (5-ht) and its metabolites in the regions of the basal ganglia and prefrontal cortex were analysed by hplc. |
2005-02-22 |
2023-08-12 |
rat |
| Suneil K Kalia, Sang Lee, Patrice D Smith, Li Liu, Stephen J Crocker, Thorhildur E Thorarinsdottir, John R Glover, Edward A Fon, David S Park, Andres M Lozan. BAG5 inhibits parkin and enhances dopaminergic neuron degeneration. Neuron. vol 44. issue 6. 2005-02-22. PMID:15603737. |
finally, bag5 enhances dopamine neuron death in an in vivo model of pd, whereas a mutant that inhibits bag5 activity attenuates dopaminergic neurodegeneration. |
2005-02-22 |
2023-08-12 |
Not clear |
| Masato Asanuma, Ikuko Miyazaki, Youichirou Higashi, Takeshi Tsuji, Norio Ogaw. Specific gene expression and possible involvement of inflammation in methamphetamine-induced neurotoxicity. Annals of the New York Academy of Sciences. vol 1025. 2005-02-18. PMID:15542702. |
to reveal specific gene expression in methamphetamine (meth) -induced dopamine neurotoxicity, temporal characteristics of meth-induced changes in gene expression in dopaminergic neuronal cells were examined using the cdna array and the differential display method. |
2005-02-18 |
2023-08-12 |
Not clear |
| F Gagné, C Blaise, J Hello. Endocrine disruption and health effects of caged mussels, Elliptio complanata, placed downstream from a primary-treated municipal effluent plume for 1 year. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. vol 138. issue 1. 2005-02-17. PMID:15313444. |
dopamine levels were found to be decreased (1.5-fold), but dopamine atp-dependent transport activity was increased 1.8-fold, suggesting reduced dopaminergic activity. |
2005-02-17 |
2023-08-12 |
Not clear |
| N Khodayari, M Garshasbi, F Fadai, A Rahimi, L Hafizi, A Ebrahimi, H Najmabadi, Mina Ohad. Association of the dopamine transporter gene (DAT1) core promoter polymorphism -67T variant with schizophrenia. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 129B. issue 1. 2005-02-16. PMID:15274029. |
the dopamine transporter (dat1) mediates the active reuptake of dopamine from the synapses and thereby plays a key role in the regulation of the dopaminergic neurotransmission. |
2005-02-16 |
2023-08-12 |
Not clear |
| Sanna Janhunen, Liisa Ahte. Comparison of the effects of nicotine and epibatidine on the striatal extracellular dopamine. European journal of pharmacology. vol 494. issue 2-3. 2005-02-14. PMID:15212971. |
these findings indicate that the nicotinic mechanisms controlling dopamine release and metabolism in the nigrostriatal and mesolimbic dopaminergic pathways differ fundamentally. |
2005-02-14 |
2023-08-12 |
rat |