| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mika Shimoji, Li Zhang, Allen S Mandir, Valina L Dawson, Ted M Dawso. Absence of inclusion body formation in the MPTP mouse model of Parkinson's disease. Brain research. Molecular brain research. vol 134. issue 1. 2005-06-13. PMID:15790534. |
the dopaminergic neurotoxin, mptp, replicates many of the pathological signs and motoric features of pd in primates and rodents by selective destruction of dopamine (da) neurons of the substantia nigra. |
2005-06-13 |
2023-08-12 |
mouse |
| Giia-Sheun Peng, Guorong Li, Nian-Sheng Tzeng, Po-See Chen, De-Maw Chuang, Yaw-Don Hsu, Sufen Yang, Jau-Shyong Hon. Valproate pretreatment protects dopaminergic neurons from LPS-induced neurotoxicity in rat primary midbrain cultures: role of microglia. Brain research. Molecular brain research. vol 134. issue 1. 2005-06-13. PMID:15790540. |
results showed that pretreatment with 0.6 mm vpa for 48 h robustly attenuated lps-induced degeneration of dopaminergic neurons as determined by [(3)h] dopamine uptake and counting of the number of th-ir neurons. |
2005-06-13 |
2023-08-12 |
rat |
| Frits-Axel Wiesel, Gunnar Edman, Lena Flyckt, Asa Eriksson, Håkan Nyman, Nikolaos Venizelos, Lars Bjerkensted. Kinetics of tyrosine transport and cognitive functioning in schizophrenia. Schizophrenia research. vol 74. issue 1. 2005-06-09. PMID:15694757. |
a lack of tyrosine for dopamine synthesis with impairment of dopaminergic transmission could impair cognitive functioning. |
2005-06-09 |
2023-08-12 |
Not clear |
| Jarosław Maciaczyk, Cyprian Swietaszczyk, Heliodor A Kasprza. [Surgical treatment of Parkinson's disease]. Przeglad lekarski. vol 61. issue 12. 2005-06-09. PMID:15850334. |
the decline of dopamine concentration caused by death of dopaminergic neurons is responsible for the appearance of symptoms typical for the mentioned disease. |
2005-06-09 |
2023-08-12 |
Not clear |
| Gesine Dreisbach, Johannes Müller, Thomas Goschke, Alexander Strobel, Katja Schulze, Klaus-Peter Lesch, Burkhard Brock. Dopamine and cognitive control: the influence of spontaneous eyeblink rate and dopamine gene polymorphisms on perseveration and distractibility. Behavioral neuroscience. vol 119. issue 2. 2005-06-07. PMID:15839794. |
the authors show that central dopaminergic activity, as indicated by spontaneous eyeblink rate and dopamine gene polymorphisms, plays an important role in the modulation of this balance. |
2005-06-07 |
2023-08-12 |
human |
| Annemieke Kavelaars, Pieter M Cobelens, Marc A T Teunis, Cobi J Heijne. Changes in innate and acquired immune responses in mice with targeted deletion of the dopamine transporter gene. Journal of neuroimmunology. vol 161. issue 1-2. 2005-05-27. PMID:15748955. |
the dopamine transporter (dat) is responsible for the re-uptake of dopamine into presynaptic nerve terminals and thereby controls dopaminergic neurotransmission. |
2005-05-27 |
2023-08-12 |
mouse |
| Andrew Sharott, Peter J Magill, Daniel Harnack, Andreas Kupsch, Wassilios Meissner, Peter Brow. Dopamine depletion increases the power and coherence of beta-oscillations in the cerebral cortex and subthalamic nucleus of the awake rat. The European journal of neuroscience. vol 21. issue 5. 2005-05-27. PMID:15813951. |
taken together, these results support a crucial role for dopamine in the modulation of population activity in cortico-basal ganglia circuits, whereby dopaminergic mechanisms effectively filter out synchronized, rhythmic activity at beta-frequencies at the systems level, and shift temporal couplings in these circuits to higher frequencies. |
2005-05-27 |
2023-08-12 |
human |
| I-Ching Chou, Chang-Hai Tsai, Cheng-Chun Lee, Haung-Tsung Kuo, Yu-An Hsu, Chia-Ing Li, Fuu-Jen Tsa. Association analysis between Tourette's syndrome and dopamine D1 receptor gene in Taiwanese children. Psychiatric genetics. vol 14. issue 4. 2005-05-24. PMID:15564897. |
the dopamine 1 receptor (drd1) gene is a candidate gene in the study of the etiology of neuropsychiatric diseases that may involve dopaminergic abnormalities. |
2005-05-24 |
2023-08-12 |
Not clear |
| Qin Chen, Yi He, Keyi Yan. Gene therapy for Parkinson's disease: progress and challenges. Current gene therapy. vol 5. issue 1. 2005-05-24. PMID:15638712. |
among the numerous candidate genes that have been tested as therapeutic agents, those encoding tyrosine hydroxylase, guanosine triphosphate cyclohydrolase i and aromatic l-amino acid decarboxylase all boost dopamine production, while glial cell line-derived neurotrophic factor promotes the survival of dopaminergic neurons and is generally believed to possess the greatest potential for successful restoration of the dopaminergic system. |
2005-05-24 |
2023-08-12 |
Not clear |
| Daniel M Togasaki, Peter Protell, Louis C S Tan, J William Langston, Donato A Di Monte, Maryka Qui. Dyskinesias in normal squirrel monkeys induced by nomifensine and levodopa. Neuropharmacology. vol 48. issue 3. 2005-05-24. PMID:15721172. |
they might involve impairment of the buffering capacity for dopamine, resulting from loss of nigral dopaminergic cells and the subsequent degeneration of their terminals in striatum. |
2005-05-24 |
2023-08-12 |
monkey |
| Nivedita Nanda, Gopal Krushna Pal, Bidhan Chandra Kone. Effect of dopamine injection into caudate nucleus on immune responsiveness in rats: a pilot study. Immunology letters. vol 96. issue 1. 2005-05-20. PMID:15585318. |
the observed changes following dopamine or dopamine antagonist into caudate nucleus indicate that dopaminergic pathway of caudate nucleus negatively modulates humoral immunity in rats. |
2005-05-20 |
2023-08-12 |
rat |
| Jun Wang, Michael J Banno. Sp1 and Sp3 activate transcription of the human dopamine transporter gene. Journal of neurochemistry. vol 93. issue 2. 2005-05-20. PMID:15816870. |
our results indicate that the sp1 family of proteins plays an important role in controlling the expression of the dopamine transporter gene within dopaminergic neurons. |
2005-05-20 |
2023-08-12 |
human |
| Yu Koike, M A Frey, F Sahiar, R Dodge, S Mohle. Effects of HZE particle on the nigrostriatal dopaminergic system in a future Mars mission. Acta astronautica. vol 56. issue 3. 2005-05-18. PMID:15754475. |
in particular, a reduction in striatal dopamine content on nigrostriatal dopaminergic system has been reported by investigators using accelerated iron ions in ground-based mammalian studies. |
2005-05-18 |
2023-08-12 |
human |
| James G Greene, Raymond Dingledine, J Timothy Greenamyr. Gene expression profiling of rat midbrain dopamine neurons: implications for selective vulnerability in parkinsonism. Neurobiology of disease. vol 18. issue 1. 2005-05-16. PMID:15649693. |
these results provide the first large scale description of gene expression profiles of dopamine neurons and suggest several avenues for investigation into dopaminergic neuroprotective therapy for pd. |
2005-05-16 |
2023-08-12 |
rat |
| Silvia Marinelli, Tiziana Pascucci, Giorgio Bernardi, Stefano Puglisi-Allegra, Nicola B Mercur. Activation of TRPV1 in the VTA excites dopaminergic neurons and increases chemical- and noxious-induced dopamine release in the nucleus accumbens. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 30. issue 5. 2005-05-12. PMID:15562294. |
activation of trpv1 in the vta excites dopaminergic neurons and increases chemical- and noxious-induced dopamine release in the nucleus accumbens. |
2005-05-12 |
2023-08-12 |
rat |
| Silvia Marinelli, Tiziana Pascucci, Giorgio Bernardi, Stefano Puglisi-Allegra, Nicola B Mercur. Activation of TRPV1 in the VTA excites dopaminergic neurons and increases chemical- and noxious-induced dopamine release in the nucleus accumbens. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 30. issue 5. 2005-05-12. PMID:15562294. |
dopamine (da)-containing neurons of the ventral tegmental area (vta) provide dopaminergic input to the nucleus accumbens and to the prefrontal cortex within the mesolimbic pathway. |
2005-05-12 |
2023-08-12 |
rat |
| Yossef S Levy, Merav Stroomza, Eldad Melamed, Daniel Offe. Embryonic and adult stem cells as a source for cell therapy in Parkinson's disease. Journal of molecular neuroscience : MN. vol 24. issue 3. 2005-05-11. PMID:15655260. |
it is now recognized that cell-replacement strategy will be effective in pd only if the transplanted cells have the same abilities, such as dopamine synthesis and control release, reuptake, and metabolizing dopamine, as the original dopaminergic neurons. |
2005-05-11 |
2023-08-12 |
Not clear |
| Hyun Jin Choi, So Yeon Lee, Yuri Cho, Onyou Hwan. Inhibition of vesicular monoamine transporter enhances vulnerability of dopaminergic cells: relevance to Parkinson's disease. Neurochemistry international. vol 46. issue 4. 2005-05-11. PMID:15707697. |
therefore, it can be concluded that the presence of dopamine in the cytosol seems to contribute to the cells' vulnerability to bh4 and that vesicular monoamine transporter plays a protective role in dopaminergic cells by sequestering dopamine not only from monoamine oxidase but also from bh4-induced oxidative stress. |
2005-05-11 |
2023-08-12 |
Not clear |
| O J Rinne, E Nurmi, H M Ruottinen, J Bergman, O Eskola, O Soli. [(18)F]FDOPA and [(18)F]CFT are both sensitive PET markers to detect presynaptic dopaminergic hypofunction in early Parkinson's disease. Synapse (New York, N.Y.). vol 40. issue 3. 2005-05-09. PMID:11304757. |
these ligands reflect different aspects of presynaptic dopaminergic function, since [(18)f]fdopa mainly reflects 6-[(18)f]fluorodopamine (fluorodopamine) synthesis and storage whereas [(18)f]cft uptake is related to dopamine transporter function. |
2005-05-09 |
2023-08-12 |
human |
| R M Miller, L L Chen, G L Kiser, T L Giesler, T M Kaysser-Kranich, C Palaniappan, H J Federof. Temporal evolution of mouse striatal gene expression following MPTP injury. Neurobiology of aging. vol 26. issue 5. 2005-05-09. PMID:15708451. |
the gradual loss of striatal dopamine and dopaminergic neurons residing in the substantia nigra (sn) causes parkinsonism characterized by slow, halting movements, rigidity, and resting tremor when neuronal loss exceeds a threshold of approximately 80%. |
2005-05-09 |
2023-08-12 |
mouse |