| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mona Thiruchelvam, Olga Prokopenko, Deborah A Cory-Slechta, Eric K Richfield, Brian Buckley, Oleg Mirochnitchenk. [WITHDRAWN] Overexpression of superoxide dismutase or glutathione peroxidase protects against the paraquat + maneb-induced Parkinson disease phenotype. The Journal of biological chemistry. vol 280. issue 23. 2005-08-02. PMID:15824117. |
non-transgenic mice chronically exposed to paraquat + maneb exhibited significant reductions in locomotor activity, levels of striatal dopamine and metabolites, and dopaminergic neurons in the substantia nigra pars compacta. |
2005-08-02 |
2023-08-12 |
mouse |
| Ali Sajadi, Matthias Bauer, Beat Thöny, Patrick Aebische. Long-term glial cell line-derived neurotrophic factor overexpression in the intact nigrostriatal system in rats leads to a decrease of dopamine and increase of tetrahydrobiopterin production. Journal of neurochemistry. vol 93. issue 6. 2005-08-02. PMID:15935064. |
however, gdnf overexpression in the dopaminergic pathway leads to a time-dependent down-regulation of tyrosine hydroxylase (th), a key enzyme in dopamine synthesis. |
2005-08-02 |
2023-08-12 |
rat |
| Ali Sajadi, Matthias Bauer, Beat Thöny, Patrick Aebische. Long-term glial cell line-derived neurotrophic factor overexpression in the intact nigrostriatal system in rats leads to a decrease of dopamine and increase of tetrahydrobiopterin production. Journal of neurochemistry. vol 93. issue 6. 2005-08-02. PMID:15935064. |
further, we observed a down-regulation of th enzyme activity in morphologically intact striatal dopaminergic nerve terminals, as well as a significant decrease of dopamine levels in striatal tissue samples. |
2005-08-02 |
2023-08-12 |
rat |
| B G Garcia, Y Wei, J A Moron, R Z Lin, J A Javitch, A Gall. Akt is essential for insulin modulation of amphetamine-induced human dopamine transporter cell-surface redistribution. Molecular pharmacology. vol 68. issue 1. 2005-08-01. PMID:15795321. |
uptake by the dopamine transporter (dat) is the primary pathway for the clearance of extracellular dopamine (da) and consequently for regulating the magnitude and duration of dopaminergic signaling. |
2005-08-01 |
2023-08-12 |
human |
| F-Q Li, T Wang, Z Pei, B Liu, J-S Hon. Inhibition of microglial activation by the herbal flavonoid baicalein attenuates inflammation-mediated degeneration of dopaminergic neurons. Journal of neural transmission (Vienna, Austria : 1996). vol 112. issue 3. 2005-07-29. PMID:15503194. |
lps-induced damage to dopaminergic neurons was evaluated by uptake capacity for [3h]dopamine and tyrosine hydroxylase (th)-immunocytochemistry. |
2005-07-29 |
2023-08-12 |
rat |
| Firoj Hossain Khan, Tanusree Sen, Arpan Kumar Maiti, Sirsendu Jana, Uttara Chatterjee, Sasanka Chakrabart. Inhibition of rat brain mitochondrial electron transport chain activity by dopamine oxidation products during extended in vitro incubation: implications for Parkinson's disease. Biochimica et biophysica acta. vol 1741. issue 1-2. 2005-07-29. PMID:15925494. |
the mitochondrial dysfunction induced by dopamine during extended periods of incubation as reported here have important implications in the context of dopaminergic neuronal death in parkinson's disease (pd). |
2005-07-29 |
2023-08-12 |
rat |
| Garret D Stuber, R Mark Wightman, Regina M Carell. Extinction of cocaine self-administration reveals functionally and temporally distinct dopaminergic signals in the nucleus accumbens. Neuron. vol 46. issue 4. 2005-07-29. PMID:15944133. |
during self-administration of cocaine, two dopaminergic signals, measured with 100 ms resolution, occurred immediately before and after the lever press (termed pre- and post-response dopamine transients). |
2005-07-29 |
2023-08-12 |
Not clear |
| Joseph Biederma. Attention-deficit/hyperactivity disorder: a selective overview. Biological psychiatry. vol 57. issue 11. 2005-07-29. PMID:15949990. |
medication with dopaminergic and noradrenergic activity seems to reduce adhd symptoms by blocking dopamine and norepinephrine reuptake. |
2005-07-29 |
2023-08-12 |
Not clear |
| Bertha K Madras, Gregory M Miller, Alan J Fischma. The dopamine transporter and attention-deficit/hyperactivity disorder. Biological psychiatry. vol 57. issue 11. 2005-07-29. PMID:15950014. |
thus, adhd medications targeting dat or net might disperse dopamine widely and consign dopamine storage and release to regulation by noradrenergic, as well as dopaminergic neurons. |
2005-07-29 |
2023-08-12 |
human |
| Paola Dazzan, Kevin D Morgan, Ken Orr, Gerard Hutchinson, Xavier Chitnis, John Suckling, Paul Fearon, Philip K McGuire, Rosemarie M Mallett, Peter B Jones, Julian Leff, Robin M Murra. Different effects of typical and atypical antipsychotics on grey matter in first episode psychosis: the AESOP study. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 30. issue 4. 2005-07-28. PMID:15702141. |
typical antipsychotic drugs act on the dopaminergic system, blocking the dopamine type 2 (d2) receptors. |
2005-07-28 |
2023-08-12 |
human |
| Eddie Castañeda, Sheila Fleming, Melanie A Paquette, Kim Boat, John Moffett, Ewa K Stachowiak, David C Bloom, Michal K Stachowia. Assessment of recovery in the hemiparkinson rat: drug-induced rotation is inadequate. Physiology & behavior. vol 84. issue 4. 2005-07-26. PMID:15811387. |
we suggest that th-expressing astrocytes may reverse post-synaptic dopamine (da) receptor supersensitivity; however, sensorimotor and motor abilities are not restored due to a failure by th-expressing astrocytes to reestablish dopaminergic circuitry. |
2005-07-26 |
2023-08-12 |
rat |
| Shingo Kariya, Makito Hirano, Nobuyuki Takahashi, Yoshiko Furiya, Satoshi Uen. Lack of association between polymorphic microsatellites of the VMAT2 gene and Parkinson's disease in Japan. Journal of the neurological sciences. vol 232. issue 1-2. 2005-07-21. PMID:15850588. |
the etiology of parkinson's disease (pd) remains unclear; however, generation of reactive oxygen species during oxidation of dopamine (da) could be one of the factors leading to selective loss of nigral dopaminergic neurons in pd. |
2005-07-21 |
2023-08-12 |
human |
| Viktoria Johansson, Svante Winberg, Björn Thrandur Björnsso. Growth hormone-induced stimulation of swimming and feeding behaviour of rainbow trout is abolished by the D1 dopamine antagonist SCH23390. General and comparative endocrinology. vol 141. issue 1. 2005-07-15. PMID:15707603. |
to further examine the role of the dopaminergic system in the mediation of gh effects on locomotion and foraging, gh- and sham-implanted juvenile rainbow trout were injected with the selective d1 dopamine antagonist sch23390 or vehicle. |
2005-07-15 |
2023-08-12 |
Not clear |
| D L Bliwise, A Freeman, C D Ingram, D B Rye, S Chakravorty, R L Watt. Randomized, double-blind, placebo-controlled, short-term trial of ropinirole in restless legs syndrome. Sleep medicine. vol 6. issue 2. 2005-07-15. PMID:15716217. |
previous studies have suggested that dopaminergic drugs such as l-dopa and dopamine agonists, as well as benzodiazepines and opioids, can treat rls successfully. |
2005-07-15 |
2023-08-12 |
Not clear |
| V Jackson-Lewis, R J Smeyn. MPTP and SNpc DA neuronal vulnerability: role of dopamine, superoxide and nitric oxide in neurotoxicity. Minireview. Neurotoxicity research. vol 7. issue 3. 2005-07-15. PMID:15897154. |
although hypotheses of damage to the dopamine neuron include oxidative stress, growth factor decline, excitotoxicity, inflammation in the snpc and protein aggregation, oxidative stress in the nigrostriatal dopaminergic system garners a significant amount of attention. |
2005-07-15 |
2023-08-12 |
Not clear |
| B M Rabin, J A Joseph, B Shukitt-Hal. Heavy particle irradiation, neurochemistry and behavior: thresholds, dose-response curves and recovery of function. Advances in space research : the official journal of the Committee on Space Research (COSPAR). vol 33. issue 8. 2005-07-13. PMID:15803623. |
in turn, the radiation-induced disruption of dopaminergic function affects a variety of behaviors that are dependent upon the integrity of this system, including motor behavior (upper body strength), amphetamine (dopamine)-mediated taste aversion learning, and operant conditioning (fixed-ratio bar pressing). |
2005-07-13 |
2023-08-12 |
Not clear |
| R Bachner-Melman, I Gritsenko, L Nemanov, A H Zohar, C Dina, R P Ebstei. Dopaminergic polymorphisms associated with self-report measures of human altruism: a fresh phenotype for the dopamine D4 receptor. Molecular psychiatry. vol 10. issue 4. 2005-07-12. PMID:15655563. |
dopaminergic polymorphisms associated with self-report measures of human altruism: a fresh phenotype for the dopamine d4 receptor. |
2005-07-12 |
2023-08-12 |
human |
| Linan Chen, Barbara Cagniard, Tiffany Mathews, Sara Jones, Hyun Chul Koh, Yunmin Ding, Paul M Carvey, Zaodung Ling, Un Jung Kang, Xiaoxi Zhuan. Age-dependent motor deficits and dopaminergic dysfunction in DJ-1 null mice. The Journal of biological chemistry. vol 280. issue 22. 2005-07-12. PMID:15799973. |
neurochemical examination revealed significant changes in striatal dopaminergic function consisting of increased dopamine reuptake rates and elevated tissue dopamine content. |
2005-07-12 |
2023-08-12 |
mouse |
| Erin H Norris, Benoit I Giasson, Roberto Hodara, Shaohua Xu, John Q Trojanowski, Harry Ischiropoulos, Virginia M-Y Le. Reversible inhibition of alpha-synuclein fibrillization by dopaminochrome-mediated conformational alterations. The Journal of biological chemistry. vol 280. issue 22. 2005-07-12. PMID:15817478. |
these results suggest that the dopamine autoxidation can prevent alpha-syn fibrillization in dopaminergic neurons through a novel mechanism. |
2005-07-12 |
2023-08-12 |
Not clear |
| Yutaka Machida, Tomoki Chiba, Atsushi Takayanagi, Yoshikazu Tanaka, Masato Asanuma, Norio Ogawa, Akihiko Koyama, Takeshi Iwatsubo, Shosuke Ito, Poul Hening Jansen, Nobuyoshi Shimizu, Keiji Tanaka, Yoshikuni Mizuno, Nobutaka Hattor. Common anti-apoptotic roles of parkin and alpha-synuclein in human dopaminergic cells. Biochemical and biophysical research communications. vol 332. issue 1. 2005-07-12. PMID:15896322. |
related to this issue, here we show that antisense knockdown of parkin causes apoptotic cell death of human dopaminergic sh-sy5y cells associated with caspase activation and accompanied by accumulation of oxidative dopamine (da) metabolites due to auto-oxidation of dopa and da. |
2005-07-12 |
2023-08-12 |
human |