| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuting Tang, Keith T Demares. Distinctive and synergistic signaling of human adenosine A2a and dopamine D2L receptors in CHO cells. Journal of receptor and signal transduction research. vol 25. issue 3. 2005-11-22. PMID:16194932. |
adenosine a(2a) receptor (a(2a)r) colocalizes with dopamine d(2) receptor (d(2)r) in the basal ganglia and modulates d(2)r-mediated dopaminergic activities. |
2005-11-22 |
2023-08-12 |
mouse |
| Juliana C Perry, Débora C Hipólide, Sergio Tufik, Ronan D Martins, Cláudio Da Cunha, Roberto Andreatini, Maria Aparecida B F Vita. Intra-nigral MPTP lesion in rats: behavioral and autoradiography studies. Experimental neurology. vol 195. issue 2. 2005-11-21. PMID:16005872. |
these results suggest that compensatory plastic changes occur in d1 dopamine receptors after partial lesion of nigral dopaminergic neurons. |
2005-11-21 |
2023-08-12 |
rat |
| Elzbieta Lorenc-Koci, Krystyna Gołembiowska, Jadwiga Warda. 1,2,3,4-Tetrahydroisoquinoline protects terminals of dopaminergic neurons in the striatum against the malonate-induced neurotoxicity. Brain research. vol 1051. issue 1-2. 2005-11-15. PMID:16004976. |
malonate, a reversible inhibitor of the mitochondrial enzyme succinate dehydrogenase, is frequently used as a model neurotoxin to produce lesion of the nigrostriatal dopaminergic system in animals due to particular sensitivity of dopamine neurons to mild energy impairment. |
2005-11-15 |
2023-08-12 |
rat |
| Michelle Porritt, Davor Stanic, David Finkelstein, Peter Batchelor, Sharon Lockhart, Andrew Hughes, Renate Kalnins, David Howell. Dopaminergic innervation of the human striatum in Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society. vol 20. issue 7. 2005-11-14. PMID:15726582. |
in parkinson's disease (pd), dopaminergic input to the caudate nucleus and a band of putaminal tissue abutting the external globus pallidus seems well preserved on immunohistochemical staining for the dopamine transporter. |
2005-11-14 |
2023-08-12 |
human |
| Albert Cot, Carles Falcón, Cristina Crespo, Josep Sempau, Deborah Pareto, Santiago Bullich, Francisco Lomeña, Francisco Calviño, Javier Pavía, Domènec Ro. Absolute quantification in dopaminergic neurotransmission SPECT using a Monte Carlo-based scatter correction and fully 3-dimensional reconstruction. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 46. issue 9. 2005-11-14. PMID:16157533. |
dopamine transporter (dat) ligands have been developed for in vivo imaging of the dopaminergic system in spect. |
2005-11-14 |
2023-08-12 |
Not clear |
| Pao-Chi Liao, Yu-Min Kuo, Hen-Chia Hsu, Chienfang G Cherng, Lung Y. Local proteins associated with methamphetamine-induced nigrostriatal dopaminergic neurotoxicity. Journal of neurochemistry. vol 95. issue 1. 2005-11-08. PMID:16181420. |
infusion of anisomycin into striatum and substantia nigra both abolished the ma-induced striatal dopamine (da) and dihydroxyphenylacetic acid (dopac) depletions, indicating a critical role of local protein synthesis in determining such dopaminergic toxicity. |
2005-11-08 |
2023-08-12 |
Not clear |
| Andrew W Bergen, Meredith Yeager, Robert A Welch, Kashif Haque, J Kelly Ganjei, Marianne B M van den Bree, Chiara Mazzanti, Irma Nardi, Manfred M Fichter, Katherine A Halmi, Allan S Kaplan, Michael Strober, Janet Treasure, D Blake Woodside, Cynthia M Bulik, Silviu-Alin Bacanu, Bernie Devlin, Wade H Berrettini, David Goldman, Walter H Kay. Association of multiple DRD2 polymorphisms with anorexia nervosa. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 30. issue 9. 2005-11-07. PMID:15920508. |
to investigate whether the dopaminergic system plays a role in the etiology of anorexia nervosa (an) via the dopamine d2 receptor, we investigated association and transmission disequilibrium at seven single-nucleotide polymorphisms (snps) spanning about 75 kbp of the gene drd2. |
2005-11-07 |
2023-08-12 |
Not clear |
| Guilherme Messas, Ivanor Meira-Lima, Marília Turchi, Olavo Franco, Camila Guindalini, Adauto Castelo, Ronaldo Laranjeira, Homero Vallad. Association study of dopamine D2 and D3 receptor gene polymorphisms with cocaine dependence. Psychiatric genetics. vol 15. issue 3. 2005-11-07. PMID:16094250. |
the reinforcing properties of cocaine are related to the dopaminergic system, and, in particular, the dopamine receptors have been linked to the reward mechanisms. |
2005-11-07 |
2023-08-12 |
Not clear |
| Shigeyoshi Fuziwara, Ayako Suzuki, Kaori Inoue, Mitsuhiro Dend. Dopamine D2-like receptor agonists accelerate barrier repair and inhibit the epidermal hyperplasia induced by barrier disruption. The Journal of investigative dermatology. vol 125. issue 4. 2005-11-03. PMID:16185279. |
two families of g protein-coupled receptors of the neurotransmitter dopamine, i.e., dopamine 1-like family (d1-like receptor) and dopamine 2-like family (d2-like receptor), show dopaminergic activity in nerve cells. |
2005-11-03 |
2023-08-12 |
Not clear |
| Carsten Scheller, Sieghart Sopper, Meta Jenuwein, Eva Neuen-Jacob, Thomas Tatschner, Edna Grünblatt, Volker ter Meulen, Peter Riederer, Eleni Koutsilier. Early impairment in dopaminergic neurotransmission in brains of SIV-infected rhesus monkeys due to microglia activation. Journal of neurochemistry. vol 95. issue 2. 2005-11-02. PMID:16190867. |
pharmacological manipulation of dopaminergic tone with l-dopa and selegiline showed that the reduction in creb expression was due to reduced levels of dopamine. |
2005-11-02 |
2023-08-12 |
monkey |
| I G Sil'ki. [Possible mechanisms of involvement of the subthalamic nucleus and structures interconnected with this nucleus in movement disorders evoked by dopamine depletion]. Uspekhi fiziologicheskikh nauk. vol 36. issue 2. 2005-11-01. PMID:15909665. |
it is assumed that high-frequency stimulation of the stn can reduce or eliminate parkinsonian symptoms not only owing to inhibition of activity of gabaergic neurons in the output basal ganglia nuclei, projected into the thalamus or pedunculopontine nucleus, but also due to excitation of glutamatergic or cholinergic neurons in the output nuclei, and due to potentiation of excitatory inputs to preserved dopaminergic neurons and subsequent rise in dopamine concentration. |
2005-11-01 |
2023-08-12 |
Not clear |
| A J Lawrence, C L Parish, F Chen, D J Lodge, E V Krstew, K Card, D I Finkelstein, M K Horn. Chronic corticotropin-releasing factor type 1 receptor antagonism with antalarmin regulates the dopaminergic system of Fawn-Hooded rats. Journal of neurochemistry. vol 94. issue 6. 2005-10-27. PMID:16000149. |
following chronic antalarmin the density of dopaminergic terminals within the basal ganglia and amygdaloid complex were reduced, as was dopamine transporter binding within the striatum. |
2005-10-27 |
2023-08-12 |
rat |
| Abraham Kovoor, Petra Seyffarth, Jana Ebert, Sami Barghshoon, Ching-Kang Chen, Sigrid Schwarz, Jeffrey D Axelrod, Benjamin N R Cheyette, Melvin I Simon, Henry A Lester, Johannes Schwar. D2 dopamine receptors colocalize regulator of G-protein signaling 9-2 (RGS9-2) via the RGS9 DEP domain, and RGS9 knock-out mice develop dyskinesias associated with dopamine pathways. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 8. 2005-10-26. PMID:15728856. |
we report that rgs9 knock-out mice develop abnormal involuntary movements when inhibition of dopaminergic transmission is followed by activation of d2-like dopamine receptors (drs). |
2005-10-26 |
2023-08-12 |
mouse |
| Brian J Snyder, C Warren Olano. Stem cell treatment for Parkinson's disease: an update for 2005. Current opinion in neurology. vol 18. issue 4. 2005-10-24. PMID:16003112. |
the hallmark pathologic feature of parkinson's disease is loss of melanized dopaminergic neurons within the substantia nigra pars compacta coupled with depletion of striatal dopamine. |
2005-10-24 |
2023-08-12 |
Not clear |
| Jannine G Truong, Diana G Wilkins, Jakub Baudys, Dennis J Crouch, Kamisha L Johnson-Davis, James W Gibb, Glen R Hanson, Annette E Fleckenstei. Age-dependent methamphetamine-induced alterations in vesicular monoamine transporter-2 function: implications for neurotoxicity. The Journal of pharmacology and experimental therapeutics. vol 314. issue 3. 2005-10-21. PMID:15901804. |
in addition, postnatal day 90 rats were more susceptible to methamphetamine-induced persistent dopaminergic deficits as assessed by measuring vmat-2 activity and dopamine content 7 days after treatment, even if drug doses were adjusted for age-related pharmacokinetic differences. |
2005-10-21 |
2023-08-12 |
rat |
| Diane T Stephenson, Martin D Meglasson, Mark A Connell, Mary A Childs, Eva Hajos-Korcsok, Marina E Embor. The effects of a selective dopamine D2 receptor agonist on behavioral and pathological outcome in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated squirrel monkeys. The Journal of pharmacology and experimental therapeutics. vol 314. issue 3. 2005-10-21. PMID:15980058. |
in this study, we investigated antiparkinsonian activity of the novel, highly selective dopamine d(2) receptor agonist sumanirole compared with two clinically effective dopaminergic therapies in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) primate model of parkinson's disease. |
2005-10-21 |
2023-08-12 |
monkey |
| William Bara-Jimenez, Francesco Bibbiani, Michael J Morris, Tzvetelina Dimitrova, Abdullah Sherzai, Maral M Mouradian, Thomas N Chas. Effects of serotonin 5-HT1A agonist in advanced Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society. vol 20. issue 8. 2005-10-19. PMID:15791634. |
with severe dopaminergic denervation, exogenous levodopa is largely decarboxylated to dopamine in serotonergic terminals. |
2005-10-19 |
2023-08-12 |
Not clear |
| Jan Lewerenz, Bartosz Zurowski, Lars Jenicke, Tobias Bäumer, Andrew J Lees, Alexander Müncha. Lesion of the dorsorostral midbrain sparing the nigrostriatal tract mimics axial rigidity seen in progressive supranuclear palsy. Movement disorders : official journal of the Movement Disorder Society. vol 20. issue 8. 2005-10-19. PMID:15838851. |
we suggest that dorsorostral midbrain pathology rather than dopamine deficiency due to degeneration of nigrostriatal dopaminergic neurons or basal ganglia nuclei might be responsible for axial rigidity in extension. |
2005-10-19 |
2023-08-12 |
Not clear |
| Karuppagounder S Saravanan, Kizhakke M Sindhu, Kochupurackal P Mohanakuma. Acute intranigral infusion of rotenone in rats causes progressive biochemical lesions in the striatum similar to Parkinson's disease. Brain research. vol 1049. issue 2. 2005-10-19. PMID:15936733. |
a dose of rotenone (6 microg in 1 microl) that caused 55% striatal dopamine depletion when infused into the sn failed to affect serotonin levels in the terminal regions when infused into the nucleus raphe dorsalis, indicating rotenone's specificity of action towards dopaminergic neurons. |
2005-10-19 |
2023-08-12 |
rat |
| W Michael Caudle, Jason R Richardson, Minzheng Wang, Gary W Mille. Perinatal heptachlor exposure increases expression of presynaptic dopaminergic markers in mouse striatum. Neurotoxicology. vol 26. issue 4. 2005-10-19. PMID:16112329. |
studies from our laboratory and others have demonstrated that exposure of laboratory animals to heptachlor alters the levels and function of the dopamine transporter (dat), an integral component of dopaminergic neurotransmission and a gateway for the dopaminergic neurotoxin mptp. |
2005-10-19 |
2023-08-12 |
mouse |