| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Karima Chergui, Per Svenningsson, Paul Greengar. Cyclin-dependent kinase 5 regulates dopaminergic and glutamatergic transmission in the striatum. Proceedings of the National Academy of Sciences of the United States of America. vol 101. issue 7. 2004-03-16. PMID:14769920. |
these findings, together with the known ability of cdk5 inhibitors to prevent degeneration of dopaminergic neurons, suggest that this class of compounds could potentially be used as a novel treatment for disorders associated with dopamine deficiency, such as parkinson's disease. |
2004-03-16 |
2023-08-12 |
mouse |
| Iometopane: (123)I beta-CIT, dopascan injection, GPI 200, RTI 55. Drugs in R&D. vol 4. issue 5. 2004-03-15. PMID:12952503. |
the ability of iometopane to bind to the dopamine transporter on presynaptic dopaminergic nerve terminal in the striatum (caudate nucleus and putamen) has been used to differentiate the uptake of the agent by the neurons in the striatum in patients with a parkinsonian disorder (parkinson's disease and progressive supranuclear palsy) from patients without a parkinsonian disorder (essential tremor and healthy controls) with high sensitivity and specificity. |
2004-03-15 |
2023-08-12 |
Not clear |
| Rinat Tabakman, Shimon Lecht, Philip Lazarovic. Neuroprotection by monoamine oxidase B inhibitors: a therapeutic strategy for Parkinson's disease? BioEssays : news and reviews in molecular, cellular and developmental biology. vol 26. issue 1. 2004-03-15. PMID:14696044. |
parkinsonism (pd) is a neurodegenerative disorder of the brain resulting in dopamine deficiency caused by the progressive death of dopaminergic neurons. |
2004-03-15 |
2023-08-12 |
Not clear |
| Paola Devoto, Giovanna Flore, Luigi Pira, Giorgio Longu, Gian Luigi Gess. Alpha2-adrenoceptor mediated co-release of dopamine and noradrenaline from noradrenergic neurons in the cerebral cortex. Journal of neurochemistry. vol 88. issue 4. 2004-03-15. PMID:14756822. |
previous results suggest that extracellular dopamine (da) in the rat cerebral cortex originates from dopaminergic and noradrenergic terminals. |
2004-03-15 |
2023-08-12 |
rat |
| Hélène Legros, François Janin, Nathalie Dourmap, Jean-Jacques Bonnet, Jean Costenti. Semi-chronic increase in striatal level of 3,4-dihydroxyphenylacetaldehyde does not result in alteration of nigrostriatal dopaminergic neurones. Journal of neuroscience research. vol 75. issue 3. 2004-03-12. PMID:14743456. |
a 30-day treatment with disulfiram (100 mg/kg i.p., once every 2 days) and l-dopa-benserazide (100 mg/kg + 25 mg/kg, two times/day) did not affect either indexes used to assess integrity of the nigrostriatal dopaminergic neurones (i.e., the striatal content in dopamine and binding to the vesicular monoamine transporter on striatal membranes). |
2004-03-12 |
2023-08-12 |
rat |
| Kimberly A Leite-Morris, Eugene Y Fukudome, Marwa H Shoeb, Gary B Kapla. GABA(B) receptor activation in the ventral tegmental area inhibits the acquisition and expression of opiate-induced motor sensitization. The Journal of pharmacology and experimental therapeutics. vol 308. issue 2. 2004-03-11. PMID:14610238. |
repeated activation of mu-opioid receptors localized on gamma-aminobutyric acid (gaba) neurons in the vta enhances dopaminergic cell activity and stimulates dopamine release in the nucleus accumbens. |
2004-03-11 |
2023-08-12 |
mouse |
| Jean-Jacques Bacci, Philippe Kachidian, Lydia Kerkerian-Le Goff, Pascal Sali. Intralaminar thalamic nuclei lesions: widespread impact on dopamine denervation-mediated cellular defects in the rat basal ganglia. Journal of neuropathology and experimental neurology. vol 63. issue 1. 2004-03-10. PMID:14748558. |
altogether, these data reveal a major antagonistic influence of thalamic and dopaminergic afferents onto the basal ganglia and suggest that degeneration of thalamic neurons in parkinson disease may represent an important factor counteracting expression of the defects associated with the dopamine denervation. |
2004-03-10 |
2023-08-12 |
rat |
| Ki-Hwan Lee, Young-Don Kwak, Dong-Hwan Kim, Mi-Yoon Chang, Young-Seek Lee, Yong-Sung Le. Human zinc finger protein 161, a novel transcriptional activator of the dopamine transporter. Biochemical and biophysical research communications. vol 313. issue 4. 2004-03-05. PMID:14706637. |
the dopamine transporter (dat) terminates dopaminergic neurotransmission via reuptake of released dopamine into presynaptic neurons. |
2004-03-05 |
2023-08-12 |
human |
| Ramona M Rodriguiz, Richard Chu, Marc G Caron, William C Wetse. Aberrant responses in social interaction of dopamine transporter knockout mice. Behavioural brain research. vol 148. issue 1-2. 2004-03-01. PMID:14684259. |
the dopamine (da) transporter (dat) controls the temporal and spatial resolution of dopaminergic neurotransmission. |
2004-03-01 |
2023-08-12 |
mouse |
| N Wodarz, G Bobbe, P Eichhammer, H G Weijers, G A Wiesbeck, M Johan. The candidate gene approach in alcoholism: are there gender-specific differences? Archives of women's mental health. vol 6. issue 4. 2004-02-27. PMID:14628173. |
therefore, we evaluated the gender-specific effects of two single nucleotide polymorphisms affecting dopaminergic neurotransmission (dopamine d2 receptor: -141c ins/del polymorphism; dopamine d3 receptor: bal i) in our large sample of primary alcoholics. |
2004-02-27 |
2023-08-12 |
Not clear |
| A Heinz, B Romero, J Gallinat, G Juckel, D R Weinberge. Molecular brain imaging and the neurobiology and genetics of schizophrenia. Pharmacopsychiatry. vol 36 Suppl 3. 2004-02-27. PMID:14677072. |
after puberty, relatively reduced prefrontal control of striatal dopaminergic neurotransmission may lead to unmodulated striatal dopamine (da) activity, and the positive symptoms of acute psychosis. |
2004-02-27 |
2023-08-12 |
Not clear |
| M J Marino, H Awad, O Poisik, M Wittmann, P J Con. Localization and physiological roles of metabotropic glutamate receptors in the direct and indirect pathways of the basal ganglia. Amino acids. vol 23. issue 1-3. 2004-02-26. PMID:12373536. |
unfortunately, there are significant problems with the currently available pharmacological therapies that focus on dopamine replacement or dopaminergic agonists. |
2004-02-26 |
2023-08-12 |
Not clear |
| K Gołembiowska, J Konieczny, K Ossowska, S Wolfart. The role of striatal metabotropic glutamate receptors in degeneration of dopamine neurons: review article. Amino acids. vol 23. issue 1-3. 2004-02-26. PMID:12373538. |
it is concluded that the mpep-produced blockade of mglur5 situated on dopaminergic cells, or the suppression of glutamate release in the subthalamic nucleus or substantia nigra pars reticulata may directly and indirectly cause a decrease in striatal dopamine release. |
2004-02-26 |
2023-08-12 |
rat |
| Juuso Juhila, Antti Haapalinna, Jouni Sirviö, Jukka Sallinen, Aapo Honkanen, Esa R Korpi, Mika Scheini. The alpha2-adrenoceptor antagonist atipamezole reduces the development and expression of d-amphetamine-induced behavioural sensitization. Naunyn-Schmiedeberg's archives of pharmacology. vol 367. issue 3. 2004-02-24. PMID:12644900. |
these results indicate that alpha(2)-adrenoceptor antagonists modulate the actions of d-amphetamine in a manner not explicable by their enhancing actions on noradrenaline and dopamine release, and may thus provide a novel approach to the treatment of motor complications caused by dopaminergic agents, such as dyskinesias, and perhaps also drug dependence. |
2004-02-24 |
2023-08-12 |
mouse |
| Manuela Contin, Paolo Martinelli, Roberto Riva, Maurizio Dondi, Stefano Fanti, Cinzia Pettinato, Cesa Scaglione, Fiorenzo Albani, Agostino Baruzz. Assessing dopaminergic function in Parkinson's disease: levodopa kinetic-dynamic modeling and SPECT. Journal of neurology. vol 250. issue 12. 2004-02-24. PMID:14673582. |
[(123)i]-fp-cit spect imaging of striatal dopamine transporters has also been introduced for the evaluation of presynaptic dopaminergic homeostasis. |
2004-02-24 |
2023-08-12 |
Not clear |
| M Quik, T Bordia, L Forno, J M McIntos. Loss of alpha-conotoxinMII- and A85380-sensitive nicotinic receptors in Parkinson's disease striatum. Journal of neurochemistry. vol 88. issue 3. 2004-02-24. PMID:14720216. |
correlation analyses between changes in nicotinic receptors and the dopamine transporter in parkinson's disease striatum suggest that alpha-conotoxinmii-sensitive 125i-epibatidine sites (low-affinity sites), 125i-a85380 and 125i-epibatidine sites are localized in part to dopaminergic terminals. |
2004-02-24 |
2023-08-12 |
human |
| Jian Wang, Yan-Mei Si, Zhuo-Lin Liu, Long Y. Cholecystokinin, cholecystokinin-A receptor and cholecystokinin-B receptor gene polymorphisms in Parkinson's disease. Pharmacogenetics. vol 13. issue 6. 2004-02-23. PMID:12777967. |
cholecystokinin modulates the release of dopamine and dopamine-related behaviours in the mesolimbic pathway, where cholecystokinin and dopamine coexist in dopaminergic neurones. |
2004-02-23 |
2023-08-12 |
Not clear |
| Eliyahu Dremencov, Iris Gispan-Herman, Merav Rosenstein, Avivit Mendelman, David H Overstreet, Joseph Zohar, Gal Yadi. The serotonin-dopamine interaction is critical for fast-onset action of antidepressant treatment: in vivo studies in an animal model of depression. Progress in neuro-psychopharmacology & biological psychiatry. vol 28. issue 1. 2004-02-18. PMID:14687868. |
because of the central role of accumbal dopamine in the mediation of motivation and reward, our measurements were focused on dopaminergic neurotransmission in the nucleus accumbens (nac). |
2004-02-18 |
2023-08-12 |
rat |
| Nobuhide Kobori, Jack C Waymire, John W Haycock, Guy L Clifton, Pramod K Das. Enhancement of tyrosine hydroxylase phosphorylation and activity by glial cell line-derived neurotrophic factor. The Journal of biological chemistry. vol 279. issue 3. 2004-02-12. PMID:14570886. |
although glial cell-line derived neurotrophic factor (gdnf) acts as a potent survival factor for dopaminergic neurons, it is not known whether gdnf can directly alter dopamine synthesis. |
2004-02-12 |
2023-08-12 |
human |
| Nobuhide Kobori, Jack C Waymire, John W Haycock, Guy L Clifton, Pramod K Das. Enhancement of tyrosine hydroxylase phosphorylation and activity by glial cell line-derived neurotrophic factor. The Journal of biological chemistry. vol 279. issue 3. 2004-02-12. PMID:14570886. |
our results indicate that, in addition to its role as a survival factor for dopaminergic neurons, gdnf can directly increase dopamine synthesis. |
2004-02-12 |
2023-08-12 |
human |