| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gregory T Collins, Diane M Calinski, Amy Hauck Newman, Peter Grundt, James H Wood. Food restriction alters N'-propyl-4,5,6,7-tetrahydrobenzothiazole-2,6-diamine dihydrochloride (pramipexole)-induced yawning, hypothermia, and locomotor activity in rats: evidence for sensitization of dopamine D2 receptor-mediated effects. The Journal of pharmacology and experimental therapeutics. vol 325. issue 2. 2008-05-19. PMID:18305018. |
behavioral and molecular studies suggest that augmented dopaminergic responses observed in food-restricted animals result from a sensitization of the dopamine d2 receptor; however, little is known about how food restriction affects dopamine d3 receptor function. |
2008-05-19 |
2023-08-12 |
rat |
| Alessandra Recchia, David Rota, Patrizia Debetto, Daniele Peroni, Diego Guidolin, Alessandro Negro, Stephen D Skaper, Pietro Giust. Generation of a alpha-synuclein-based rat model of Parkinson's disease. Neurobiology of disease. vol 30. issue 1. 2008-05-19. PMID:18313315. |
dopaminergic cell loss was evaluated both by tyrosine hydroxylase immunohistochemistry and by hplc analysis of dopamine and its catabolite 3,4 dihydroxyphenylacetic acid. |
2008-05-19 |
2023-08-12 |
human |
| M Bousquet, M Saint-Pierre, C Julien, N Salem, F Cicchetti, F Calo. Beneficial effects of dietary omega-3 polyunsaturated fatty acid on toxin-induced neuronal degeneration in an animal model of Parkinson's disease. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 22. issue 4. 2008-05-16. PMID:18032633. |
although n-3 pufa dietary treatment had no effect on striatal dopaminergic terminals, the high n-3 pufa diet protected against the mptp-induced decrease in dopamine (p<0.05 vs. mptp mice on control diet) and its metabolite dihydroxyphenylacetic acid (p<0.05 vs. mptp mice on control diet) in the striatum. |
2008-05-16 |
2023-08-12 |
mouse |
| Wen-Juh Hwang, Wei-Jen Yao, Ying-Kai Fu, An-Shoei Yan. [99mTc]TRODAT-1/[123I]IBZM SPECT studies of the dopaminergic system in Tourette syndrome. Psychiatry research. vol 162. issue 2. 2008-05-16. PMID:18248965. |
the good clinical effectiveness of dopamine depleter and receptor antagonists on tics suggests dopaminergic hyperactivity in tourette syndrome (ts). |
2008-05-16 |
2023-08-12 |
Not clear |
| Wen-Juh Hwang, Wei-Jen Yao, Ying-Kai Fu, An-Shoei Yan. [99mTc]TRODAT-1/[123I]IBZM SPECT studies of the dopaminergic system in Tourette syndrome. Psychiatry research. vol 162. issue 2. 2008-05-16. PMID:18248965. |
in this case-control study of 10 ts patients and 15 age-matched healthy controls, we evaluated (i) presynaptic and postsynaptic striatal dopaminergic function using [(99m)tc]trodat-1/[(123)i]ibzm single photon emission computed tomography (spect) and (ii) correlations between dopamine transporter (dat)/d2 receptor binding sites and tic severity scores. |
2008-05-16 |
2023-08-12 |
Not clear |
| Wen-Juh Hwang, Wei-Jen Yao, Ying-Kai Fu, An-Shoei Yan. [99mTc]TRODAT-1/[123I]IBZM SPECT studies of the dopaminergic system in Tourette syndrome. Psychiatry research. vol 162. issue 2. 2008-05-16. PMID:18248965. |
however, functional abnormalities of the dopaminergic system, e.g., alterations in the synaptic release of endogenous dopamine, cannot be completely ruled out. |
2008-05-16 |
2023-08-12 |
Not clear |
| Hamid Mostafavi Abdolmaleky, Cassandra L Smith, Jin-Rong Zhou, Sam Thiagalinga. Epigenetic alterations of the dopaminergic system in major psychiatric disorders. Methods in molecular biology (Clifton, N.J.). vol 448. 2008-05-15. PMID:18370235. |
we use the genes of the extended dopaminergic (daergic) system such as membrane-bound catechol-o-methyltransferase (mb-comt), monoamine oxidase a (maoa), dopamine transporter 1 (dat1), tyrosine hydroxylase (th), dopamine (da) receptors1 and 2 (drd1/2), and related genes (e.g., reelin [reln] and brain-derived neurotrophic factor [bdnf]) to illustrate the associations between differential promoter dna methylations and disease phenotype. |
2008-05-15 |
2023-08-12 |
Not clear |
| Göran Bertilsson, Cesare Patrone, Olof Zachrisson, Annica Andersson, Karin Dannaeus, Jessica Heidrich, Jarkko Kortesmaa, Alex Mercer, Elisabet Nielsen, Harriet Rönnholm, Lilian Wikströ. Peptide hormone exendin-4 stimulates subventricular zone neurogenesis in the adult rodent brain and induces recovery in an animal model of Parkinson's disease. Journal of neuroscience research. vol 86. issue 2. 2008-05-13. PMID:17803225. |
in conclusion, our results show that exendin-4 is able to promote adult neurogenesis in vitro and in vivo, normalize dopamine imbalance, and increase the number of cells positive for markers of dopaminergic neurons in the substantia nigra in a model of parkinson's disease. |
2008-05-13 |
2023-08-12 |
rat |
| Subbiah P Sivam, Subbiah Pugazhenthi, Vidya Pugazhenthi, Heath Brow. L-DOPA-induced activation of striatal p38MAPK and CREB in neonatal dopaminergic denervated rat: relevance to self-injurious behavior. Journal of neuroscience research. vol 86. issue 2. 2008-05-13. PMID:17893915. |
the destruction of nigrostriatal dopaminergic neurons with 6-hydroxydopamine (6ohda) during the neonatal period results in dopamine (da) loss and susceptibility for self-injurious behavior (sib) when challenged with l-dihydroxyphenylalanine (l-dopa), via a supersensitive d1 receptor-mediated mechanism. |
2008-05-13 |
2023-08-12 |
rat |
| Shixing Zhang, Yan Yin, Huimin Lu, Aike Gu. Increased dopaminergic signaling impairs aversive olfactory memory retention in Drosophila. Biochemical and biophysical research communications. vol 370. issue 1. 2008-05-12. PMID:18342622. |
memory was restored by blocking dopaminergic neuronal output during heat stress, suggesting that dopamine is involved in heat stress-induced memory impairment in flies. |
2008-05-12 |
2023-08-12 |
drosophila_melanogaster |
| Paul S Fishma. Paradoxical aspects of parkinsonian tremor. Movement disorders : official journal of the Movement Disorder Society. vol 23. issue 2. 2008-05-08. PMID:17973325. |
patients with only resting tremor show dopaminergic deficits with radioligand imaging, but severity of tremor correlates poorly in such dopamine imaging studies. |
2008-05-08 |
2023-08-12 |
Not clear |
| Francisco Coria, María del Puig Cozar-Santiag. Rasagiline improves freezing in a patient with primary progressive freezing gait. Movement disorders : official journal of the Movement Disorder Society. vol 23. issue 3. 2008-05-08. PMID:18067186. |
single photon emission tomography (spect) with a radiolabeled ligand of the dopamine transporter (dat-spect) showed integrity of striatal dopaminergic terminals, whereas brain perfusion spect disclosed multiple areas of decreased perfusion in frontal and parietal lobes, as well as in the subcortical gray nuclei of both sides. |
2008-05-08 |
2023-08-12 |
Not clear |
| Henry Sershen, Andrea Balla, John M Aspromonte, Shan Xie, Thomas B Cooper, Daniel C Javit. Characterization of interactions between phencyclidine and amphetamine in rodent prefrontal cortex and striatum: implications in NMDA/glycine-site-mediated dopaminergic dysregulation and dopamine transporter function. Neurochemistry international. vol 52. issue 1-2. 2008-05-05. PMID:17716783. |
characterization of interactions between phencyclidine and amphetamine in rodent prefrontal cortex and striatum: implications in nmda/glycine-site-mediated dopaminergic dysregulation and dopamine transporter function. |
2008-05-05 |
2023-08-12 |
Not clear |
| Chun-Hung Lin, Jui-Yen Huang, Cheng-Hsin Ching, Jih-Ing Chuan. Melatonin reduces the neuronal loss, downregulation of dopamine transporter, and upregulation of D2 receptor in rotenone-induced parkinsonian rats. Journal of pineal research. vol 44. issue 2. 2008-05-05. PMID:18289173. |
because the uptake of mpp(+) is mediated by the dopamine transporter (dat), we used a cell-permeable rotenone-induced pd model to investigate the role of dat and dopamine d2 receptor (d2r) on dopaminergic neuronal loss. |
2008-05-05 |
2023-08-12 |
rat |
| Yen Kuang Yang, Wei Jen Yao, Tzung Lieh Yeh, I Hui Lee, Po See Chen, Ru Band Lu, Nan Tsing Chi. Decreased dopamine transporter availability in male smokers -- a dual isotope SPECT study. Progress in neuro-psychopharmacology & biological psychiatry. vol 32. issue 1. 2008-05-02. PMID:17900774. |
to delineate the role of tobacco addiction in central pre- and post-synaptic dopaminergic activities, we analyzed the central d2-family receptors, the dopamine transporters (dat), and degrees of dependence in male smokers. |
2008-05-02 |
2023-08-12 |
Not clear |
| Daniel Alvarez-Fischer, Carmen Henze, Corinna Strenzke, Jan Westrich, Boris Ferger, Günter U Höglinger, Wolfgang H Oertel, Andreas Hartman. Characterization of the striatal 6-OHDA model of Parkinson's disease in wild type and alpha-synuclein-deleted mice. Experimental neurology. vol 210. issue 1. 2008-05-02. PMID:18053987. |
the aim of the present study was to characterize the time course of intra-striatal 6-ohda lesions in mice with regard to i) dopaminergic cell loss, ii) dopamine concentrations in the substantia nigra and the striatum, iii) hydroxylation products in substantia nigra and striatum and iv) behavioural impairment. |
2008-05-02 |
2023-08-12 |
mouse |
| Anupom Borah, Kochupurackal P Mohanakuma. Long-term L-DOPA treatment causes indiscriminate increase in dopamine levels at the cost of serotonin synthesis in discrete brain regions of rats. Cellular and molecular neurobiology. vol 27. issue 8. 2008-05-01. PMID:17934805. |
in the present study we investigated 5-hydroxytryptamine (5-ht) and dopamine concentrations in serotonergic and dopaminergic nuclei following chronic administration of l-dopa to find whether the neurotransmitter synthesis in these brain areas are compensated. |
2008-05-01 |
2023-08-12 |
rat |
| Masafumi Ihara, Nobuyuki Yamasaki, Akari Hagiwara, Ai Tanigaki, Ayumi Kitano, Rie Hikawa, Hidekazu Tomimoto, Makoto Noda, Masashi Takanashi, Hideo Mori, Nobutaka Hattori, Tsuyoshi Miyakawa, Makoto Kinoshit. Sept4, a component of presynaptic scaffold and Lewy bodies, is required for the suppression of alpha-synuclein neurotoxicity. Neuron. vol 53. issue 4. 2008-04-28. PMID:17296554. |
here, we show the physiological association of sept4 with alpha-synuclein, the dopamine transporter, and other presynaptic proteins in dopaminergic neurons; mice lacking sept4 exhibit diminished dopaminergic neurotransmission due to scarcity of these presynaptic proteins. |
2008-04-28 |
2023-08-12 |
mouse |
| Kaya Bork, Christoph Kannicht, Sabine Nöhring, Werner Reutter, Wenke Weidemann, Gerald W Hart, Rüdiger Horstkort. N-propanoylmannosamine interferes with O-GlcNAc modification of the tyrosine 3-monooxygenase and stimulates dopamine secretion. Journal of neuroscience research. vol 86. issue 3. 2008-04-28. PMID:17896794. |
the most consistent neurochemical abnormality in parkinson's disease is degeneration of dopaminergic neurons in the substantia nigra, leading to a reduction of striatal dopamine levels. |
2008-04-28 |
2023-08-12 |
Not clear |
| R Exley, S J Crag. Presynaptic nicotinic receptors: a dynamic and diverse cholinergic filter of striatal dopamine neurotransmission. British journal of pharmacology. vol 153 Suppl 1. 2008-04-28. PMID:18037926. |
here, rather than simply enhancing (or inhibiting) dopamine release, nachrs perform the role of a presynaptic filter, whose influence on dopamine release probability depends on presynaptic activity in dopaminergic as well as cholinergic neurons. |
2008-04-28 |
2023-08-12 |
Not clear |