| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J R Dochert. Pharmacology of stimulants prohibited by the World Anti-Doping Agency (WADA). British journal of pharmacology. vol 154. issue 3. 2008-07-31. PMID:18500382. |
the majority of stimulants on the list act on the monoaminergic systems: adrenergic (sympathetic, transmitter noradrenaline), dopaminergic (transmitter dopamine) and serotonergic (transmitter serotonin, 5-ht). |
2008-07-31 |
2023-08-12 |
Not clear |
| Jacek Wójcikowski, Krystyna Gołembiowska, Władysława Anna Danie. Regulation of liver cytochrome P450 by activation of brain dopaminergic system: physiological and pharmacological implications. Biochemical pharmacology. vol 76. issue 2. 2008-07-31. PMID:18538745. |
stimulation of dopaminergic receptors in the pituitary, a target for the tuberoinfundibular pathway, by dopamine (a d(1)/d(2) receptor agonist) administered intraperitoneally caused a significant increase in the activities and protein levels of cyp2b, cyp2c11 and cyp3a, a substantial increase in the blood plasma level of growth hormone (gh) and a significant decrease in triiodothyronine (t(3)) level. |
2008-07-31 |
2023-08-12 |
Not clear |
| Saeid Abbasi Maleki, Morteza Samini, Vahab Babapour, Shahram Ejtemaei Mehr, Siyamak Cheraghiyan, Mir H Khayat Nour. Potentiation of morphine-induced conditioned place preference with concurrent use of amantadine and fluvoxamine by the intraperitoneal and intracerebroventricular injection in rat. Behavioural brain research. vol 190. issue 2. 2008-07-30. PMID:18378011. |
morphine produces reinforcement (reward) effect by activation of mu receptors which facilitated dopaminergic transmission through dopamine release. |
2008-07-30 |
2023-08-12 |
human |
| Alberto Costa, Antonella Peppe, Livia Brusa, Carlo Caltagirone, Ilaria Gatto, Giovanni Augusto Carlesim. Dopaminergic modulation of prospective memory in Parkinson's disease. Behavioural neurology. vol 19. issue 1-2. 2008-07-29. PMID:18413916. |
however, although the dopamine dependency of cognitive dysfunction in pd has been widely investigated, poor is known on the dopaminergic modulation of pm. |
2008-07-29 |
2023-08-12 |
Not clear |
| Alberto Costa, Antonella Peppe, Livia Brusa, Carlo Caltagirone, Ilaria Gatto, Giovanni Augusto Carlesim. Dopaminergic modulation of prospective memory in Parkinson's disease. Behavioural neurology. vol 19. issue 1-2. 2008-07-29. PMID:18413916. |
these results support a critical role of dopaminergic modulation in prospective memory processes in pd patients, possibly through the replacement of dopamine levels in fronto-striatal pathways. |
2008-07-29 |
2023-08-12 |
Not clear |
| Feng Lan, Jinchong Xu, Xiaoyan Zhang, Vincent Wai-Sun Wong, Xiaoxia Li, Aili Lu, Wenjing Lu, Li Shen, Lingsong L. Hepatocyte growth factor promotes proliferation and migration in immortalized progenitor cells. Neuroreport. vol 19. issue 7. 2008-07-29. PMID:18418254. |
we show that the cells were able to differentiate into dopaminergic neurons and release dopamine. |
2008-07-29 |
2023-08-12 |
human |
| Andrea Panzacchi, Rosa Maria Moresco, Valentina Garibotto, Angelo Antonini, Clara Gobbo, Ioannis U Isaias, Stefano Goldwurm, Lorena Bonaldi, Assunta Carpinelli, Gianni Pezzoli, Ferruccio Fazio, Daniela Peran. A voxel-based PET study of dopamine transporters in Parkinson's disease: relevance of age at onset. Neurobiology of disease. vol 31. issue 1. 2008-07-29. PMID:18502656. |
we used positron emission tomography (pet) and the dopamine transporter (dat) ligand [(11)c]fecit to measure loss of nigrostriatal dopaminergic neurons in early phase of early onset (eopd) and late onset parkinson's disease (lopd). |
2008-07-29 |
2023-08-12 |
human |
| Jianyong Wang, Helen M Duhart, Zengjun Xu, Tucker A Patterson, Glenn D Newport, Syed F Al. Comparison of the time courses of selective gene expression and dopaminergic depletion induced by MPP+ in MN9D cells. Neurochemistry international. vol 52. issue 6. 2008-07-28. PMID:18069091. |
our data showed that dopamine content was significantly decreased after 0.5h of mpp+ (200 microm) exposure and was completely depleted after 40 h. the expression of gpr37, which is closely related to the pathogenesis of autosomal recessive juvenile parkinsonism, was up-regulated after 0.5h, and stayed up-regulated up to 48 h. txnip, which is critical to the adjustment of cellular redox status, was down-regulated after 1h and stayed down-regulated up to 48 h. ldh1 and cdo1, which are also involved in oxidative stress, were down-regulated after 16 h and stayed down-regulated up to 48 h. two pro-apoptotic genes, egln3 and bnip3, were down-regulated after 2 and 4h, and stayed down-regulated up to 48 h. these findings suggested that the time course of expression for multiple genes correlated with the dopaminergic depletion; and mpp+-induced neurotoxicity in mn9d cells could be used as a model to further explore the roles of these and other genes in the pathogenesis and possible treatment of pd. |
2008-07-28 |
2023-08-12 |
Not clear |
| Bimla Nehru, Ranjeet Verma, Pooja Khanna, Suresh Kumar Sharm. Behavioral alterations in rotenone model of Parkinson's disease: attenuation by co-treatment of centrophenoxine. Brain research. vol 1201. 2008-07-28. PMID:18308296. |
it destroys dopaminergic neurons selectively, causing deficiency of dopamine in striatum which leads to impaired motor functions. |
2008-07-28 |
2023-08-12 |
rat |
| Isabella Tessari, Marco Bisaglia, Francesco Valle, Bruno Samorì, Elisabetta Bergantino, Stefano Mammi, Luigi Bubacc. The reaction of alpha-synuclein with tyrosinase: possible implications for Parkinson disease. The Journal of biological chemistry. vol 283. issue 24. 2008-07-24. PMID:18390556. |
several different pathways have been identified for the production of oxidative stress conditions in nigral dopaminergic neurons, including a pathological accumulation of cytosolic dopamine with the subsequent production of toxic reactive oxygen species or the formation of highly reactive quinone species. |
2008-07-24 |
2023-08-12 |
Not clear |
| I G Sil'ki. The role of dopamine-dependent negative feedback in the hippocampus-basal ganglia-thalamus-hippocampus loop in the extinction of responses. Neuroscience and behavioral physiology. vol 38. issue 4. 2008-07-24. PMID:18401733. |
however, increases in dopamine levels and activation of d2 receptors on striopallidal cells, facilitating depression of hippocampal inputs, prevent disinhibition of dopaminergic neurons, such that their responses start to decline. |
2008-07-24 |
2023-08-12 |
Not clear |
| J C Lewers, I Ceballos-Picot, T L Shirley, L Mockel, K Egami, H A Jinna. Consequences of impaired purine recycling in dopaminergic neurons. Neuroscience. vol 152. issue 3. 2008-07-21. PMID:18313225. |
to investigate the nature of the relationship between hprt deficiency and dopamine, the mouse mn9d dopaminergic neuronal cell line was used to prepare 10 sublines lacking hprt. |
2008-07-21 |
2023-08-12 |
mouse |
| Muhammad M Hossain, Nikolay M Filipo. Alteration of dopamine uptake into rat striatal vesicles and synaptosomes caused by an in vitro exposure to atrazine and some of its metabolites. Toxicology. vol 248. issue 1. 2008-07-21. PMID:18423833. |
studies have shown that both in vivo and in vitro exposure to the herbicide atrazine (atr) results in dopaminergic neurotoxicity manifested by decreased striatal dopamine (da) levels. |
2008-07-21 |
2023-08-12 |
rat |
| Cécile Lavoute, Michel Weiss, Jean-Claude Rostai. Alterations in nigral NMDA and GABAA receptor control of the striatal dopamine level after repetitive exposures to nitrogen narcosis. Experimental neurology. vol 212. issue 1. 2008-07-17. PMID:18452916. |
nitrogen pressure exposure in rats results in decreased dopamine (da) release at the striatal terminals of the substantia nigra pars compacta (snc) dopaminergic neurons, demonstrating the narcotic potency of nitrogen. |
2008-07-17 |
2023-08-12 |
rat |
| Luca Sebastianelli, Ada Ledonne, Maria Cristina Marrone, Giorgio Bernardi, Nicola B Mercur. The L-amino acid carrier inhibitor 2-aminobicyclo[2.2.1]heptane-2-carboxylic acid (BCH) reduces L-dopa-elicited responses in dopaminergic neurons of the substantia nigra pars compacta. Experimental neurology. vol 212. issue 1. 2008-07-17. PMID:18501350. |
it is not yet clear how l-dopa, that is the most effective drug for the treatment of parkinson's disease, enters into the dopaminergic neurons to be transformed into dopamine. |
2008-07-17 |
2023-08-12 |
rat |
| Cassandra M Miller-Butterworth, Jay R Kaplan, John Shaffer, Bernie Devlin, Stephen B Manuck, Robert E Ferrel. Sequence variation in the primate dopamine transporter gene and its relationship to social dominance. Molecular biology and evolution. vol 25. issue 1. 2008-07-16. PMID:17934207. |
dopaminergic activity is modulated by the dopamine transporter (dat), and the gene encoding this transporter is therefore an excellent candidate for studies aiming to identify variants of functional or evolutionary significance. |
2008-07-16 |
2023-08-12 |
human |
| Jyothi K Mallajosyula, Deepinder Kaur, Shankar J Chinta, Subramanian Rajagopalan, Anand Rane, David G Nicholls, Donato A Di Monte, Heather Macarthur, Julie K Anderse. MAO-B elevation in mouse brain astrocytes results in Parkinson's pathology. PloS one. vol 3. issue 2. 2008-07-15. PMID:18286173. |
however, dopamine loss is at least 60% by the time pd is symptomatically detectable, therefore lack of effect of mao-b inhibition in these patients does not negate a role for mao-b in pre-symptomatic dopaminergic loss. |
2008-07-15 |
2023-08-12 |
mouse |
| Jyothi K Mallajosyula, Deepinder Kaur, Shankar J Chinta, Subramanian Rajagopalan, Anand Rane, David G Nicholls, Donato A Di Monte, Heather Macarthur, Julie K Anderse. MAO-B elevation in mouse brain astrocytes results in Parkinson's pathology. PloS one. vol 3. issue 2. 2008-07-15. PMID:18286173. |
mechanistically this may involve increases in membrane permeant h(2)o(2) which can oxidize dopamine within dopaminergic neurons to dopaminochrome which, via interaction with mitochondrial complex i, can result in increased mitochondrial superoxide. |
2008-07-15 |
2023-08-12 |
mouse |
| Dieter Scheller, Nick Dürmüller, Paul Moser, Roger D Porsol. Continuous stimulation of dopaminergic receptors by rotigotine does not interfere with the sleep-wake cycle in the rat. European journal of pharmacology. vol 584. issue 1. 2008-07-10. PMID:18304531. |
it is concluded that a continuous dopaminergic stimulation of dopamine receptors by rotigotine may not only be beneficial for the treatment of the motor symptoms of parkinson's disease but also have additional benefits by not compromising either sleep architecture or circadian rhythm. |
2008-07-10 |
2023-08-12 |
rat |
| Enrique Lanuza, Amparo Novejarque, Joana Martínez-Ricós, Jose Martínez-Hernández, Carmen Agustín-Pavón, Fernando Martínez-Garcí. Sexual pheromones and the evolution of the reward system of the brain: the chemosensory function of the amygdala. Brain research bulletin. vol 75. issue 2-4. 2008-07-10. PMID:18331915. |
behavioural and pharmacological studies (reviewed here) have shown that the females' innate preference for sexual pheromones is not affected by lesions of the dopaminergic cells of the ventral tegmental area, and that the systemic administration of dopamine antagonists do not alter neither the attraction nor the reinforcing effects of these pheromones. |
2008-07-10 |
2023-08-12 |
mouse |