| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| W Y Chan, D L McKinzie, S Bose, S N Mitchell, J M Witkin, R C Thompson, A Christopoulos, S Lazareno, N J M Birdsall, F P Bymaster, C C Felde. Allosteric modulation of the muscarinic M4 receptor as an approach to treating schizophrenia. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 31. 2008-09-25. PMID:18678919. |
muscarinic acetylcholine (ach) receptors regulate dopamine levels in key areas of the brain involved in psychosis, with the m(4) subtype emerging as a key regulator of dopaminergic hyperactivity. |
2008-09-25 |
2023-08-12 |
human |
| James R Conno. Pathophysiology of restless legs syndrome: evidence for iron involvement. Current neurology and neuroscience reports. vol 8. issue 2. 2008-09-24. PMID:18460286. |
these data are reviewed and related to the dopaminergic system because of the use of dopamine agents in treating restless legs syndrome. |
2008-09-24 |
2023-08-12 |
Not clear |
| Jason N Jaworski, Stephen T Hansen, Michael J Kuhar, Gregory P Mar. Injection of CART (cocaine- and amphetamine-regulated transcript) peptide into the nucleus accumbens reduces cocaine self-administration in rats. Behavioural brain research. vol 191. issue 2. 2008-09-24. PMID:18485497. |
intra-nacc injections of cart peptide also inhibit locomotion produced by microinfusions of dopamine into the nacc, suggesting that the effects of cart peptides may be due to an interaction with the dopaminergic system in the nacc. |
2008-09-24 |
2023-08-12 |
rat |
| Deranda B Lester, Anthony D Miller, Tiffany D Pate, Charles D Blah. Midbrain acetylcholine and glutamate receptors modulate accumbal dopamine release. Neuroreport. vol 19. issue 9. 2008-09-24. PMID:18521007. |
these findings suggest that acetylcholine and ionotropic glutamate receptors influence rapid dopaminergic activity and thus the communication of behaviorally relevant information from ventral tegmental area dopamine cells to forebrain areas. |
2008-09-24 |
2023-08-12 |
mouse |
| Daniela Cologno, Giulio Cicarelli, Vittorio Petretta, Florindo d'Onofrio, Gennaro Busson. High prevalence of Dopaminergic Premonitory Symptoms in migraine patients with Restless Legs Syndrome: a pathogenetic link? Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 29 Suppl 1. 2008-09-24. PMID:18545925. |
these results could support a hypothetical dopaminergic imbalance in rls and migraine, as the dopamine is involved in the pathogenesis of both disorders and it is responsible for the migraine dps reported above. |
2008-09-24 |
2023-08-12 |
Not clear |
| Douglas C Jones, Gary W Mille. The effects of environmental neurotoxicants on the dopaminergic system: A possible role in drug addiction. Biochemical pharmacology. vol 76. issue 5. 2008-09-16. PMID:18555207. |
endocrine disrupters such as bisphenol a, mimic estrogenic activity and impact various dopaminergic processes to enhance mesolimbic dopamine activity resulting in hyperactivity, attention deficits, and a heightened sensitivity to drugs of abuse. |
2008-09-16 |
2023-08-12 |
human |
| Freddy Contreras, Christian Foullioux, Betsy Pacheco, Charbel Maroun, Hector Bolívar, Mary Lares, Elliuz Leal, Raquel Cano, Valmore Bermúdez, Manuel Velasc. Effect of drugs interacting with the dopaminergic receptors on glucose levels and insulin release in healthy and type 2 diabetic subjects. American journal of therapeutics. vol 15. issue 4. 2008-09-16. PMID:18645345. |
dopamine agonists play an important role in the regulation of the central nervous-cardiovascular, renal, and hormonal systems through stimulation of dopaminergic (da1 and da2) and alpha- and beta-adrenergic receptors. |
2008-09-16 |
2023-08-12 |
mouse |
| Freddy Contreras, Christian Foullioux, Betsy Pacheco, Charbel Maroun, Hector Bolívar, Mary Lares, Elliuz Leal, Raquel Cano, Valmore Bermúdez, Manuel Velasc. Effect of drugs interacting with the dopaminergic receptors on glucose levels and insulin release in healthy and type 2 diabetic subjects. American journal of therapeutics. vol 15. issue 4. 2008-09-16. PMID:18645345. |
the aim of the present study was to evaluate the interaction of the dopaminergic and endocrine systems by determining the effect of the dopaminergic antagonist, metoclopramide, and dopamine on insulin secretion and cardiovascular response by blockade and activation of dopamine receptors in healthy and type 2 diabetic subjects. |
2008-09-16 |
2023-08-12 |
mouse |
| Roberta Castino, Gloria Lazzeri, Paola Lenzi, Natascia Bellio, Carlo Follo, Michela Ferrucci, Francesco Fornai, Ciro Isidor. Suppression of autophagy precipitates neuronal cell death following low doses of methamphetamine. Journal of neurochemistry. vol 106. issue 3. 2008-09-15. PMID:18489716. |
methamphetamine abuse is toxic to dopaminergic neurons, causing nigrostriatal denervation and striatal dopamine loss. |
2008-09-15 |
2023-08-12 |
Not clear |
| Katsuya Suemaru, Shuntaro Kohnomi, Kenta Umeda, Hiroaki Arak. [Evaluation of antipsychotic and relative drugs using disruption of prepulse inhibition as an animal model for schizophrenia]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. vol 28. issue 3. 2008-09-11. PMID:18646597. |
in rodents, ppi can be disrupted by methamphetamine or phencyclidine, which causes psychotomimetic symptoms, and the dopaminergic agonist-induced ppi is reversed by dopamine d2 receptor antagonists and a dopaminergic partial agonist aripiprazole. |
2008-09-11 |
2023-08-12 |
mouse |
| Paul F Smit. Inflammation in Parkinson's disease: an update. Current opinion in investigational drugs (London, England : 2000). vol 9. issue 5. 2008-09-05. PMID:18465657. |
the loss of the dopaminergic projection from the snpc deprives the striatum of dopamine and results in a myriad of motor signs, including tremor, rigidity and ataxia. |
2008-09-05 |
2023-08-12 |
Not clear |
| Ikuko Miyazaki, Masato Asanum. Dopaminergic neuron-specific oxidative stress caused by dopamine itself. Acta medica Okayama. vol 62. issue 3. 2008-09-04. PMID:18596830. |
dopaminergic neuron-specific oxidative stress caused by dopamine itself. |
2008-09-04 |
2023-08-12 |
Not clear |
| Ikuko Miyazaki, Masato Asanum. Dopaminergic neuron-specific oxidative stress caused by dopamine itself. Acta medica Okayama. vol 62. issue 3. 2008-09-04. PMID:18596830. |
oxidative stress, including the reactive oxygen or nitrogen species generated in the enzymatical oxidationor auto-oxidation of an excess amount of dopamine, is thought to play an important role in dopaminergic neurotoxicity. |
2008-09-04 |
2023-08-12 |
Not clear |
| Ikuko Miyazaki, Masato Asanum. Dopaminergic neuron-specific oxidative stress caused by dopamine itself. Acta medica Okayama. vol 62. issue 3. 2008-09-04. PMID:18596830. |
dopamine and its metabolites containing 2 hydroxyl residues exert cytotoxicityin dopaminergic neuronal cells, primarily due to the generation of highly reactive dopamine and dopa quinones. |
2008-09-04 |
2023-08-12 |
Not clear |
| Hong Jiang, Lin-Jing Li, Jun Wang, Jun-Xia Xi. Ghrelin antagonizes MPTP-induced neurotoxicity to the dopaminergic neurons in mouse substantia nigra. Experimental neurology. vol 212. issue 2. 2008-09-02. PMID:18577498. |
we observed that ghrelin, acting through ghs-r 1a, inhibited mptp-induced dopaminergic neuronal loss in the snpc as well as dopamine depletion in the striatum. |
2008-09-02 |
2023-08-12 |
mouse |
| E M Torres, E Dowd, S B Dunnet. Recovery of functional deficits following early donor age ventral mesencephalic grafts in a rat model of Parkinson's disease. Neuroscience. vol 154. issue 2. 2008-08-29. PMID:18468807. |
it has previously been reported that dopaminergic grafts derived from early donor age, embryonic age 12-day-old (e12) rat embryos produced a fivefold greater yield of dopamine neurons than those derived from conventional e14 donors. |
2008-08-29 |
2023-08-12 |
human |
| A Sarkaki, M Badavi, N Hoseiny, M K Gharibnaseri, F Rahi. Postmenopausal effects of intrastriatal estrogen on catalepsy and pallidal electroencephalogram in an animal model of Parkinson's disease. Neuroscience. vol 154. issue 3. 2008-08-29. PMID:18472223. |
because of its modulatory effect estrogen may protect dopaminergic neurons from injury and may interfere with the uptake of 6-hydroxydopamine (6-ohda) into the nigral dopaminergic neurons or alter dopamine release and uptake in remaining neurons. |
2008-08-29 |
2023-08-12 |
rat |
| Jan Booij, Paul Kem. Dopamine transporter imaging with [(123)I]FP-CIT SPECT: potential effects of drugs. European journal of nuclear medicine and molecular imaging. vol 35. issue 2. 2008-08-26. PMID:17968545. |
[(123)i]n-omega-fluoropropyl-2beta-carbomethoxy-3beta-{4-iodophenyl}nortropane ([(123)i]fp-cit) single photon emission computed tomography (spect) is a frequently and routinely used technique to detect or exclude dopaminergic degeneration by imaging the dopamine transporter (dat) in parkinsonian and demented patients. |
2008-08-26 |
2023-08-12 |
Not clear |
| Yao-Ying Ma, Xiang-Dang Shi, Ji-Sheng Han, Cai-Lian Cu. Peripheral electrical stimulation-induced suppression of morphine-induced CCP in rats: a role for dopamine in the nucleus accumbens. Brain research. vol 1212. 2008-08-26. PMID:18442811. |
considering that opioids were known to elevate dopamine (da) activity in the mesolimbic brain, the present study was designed to further analyze the possible involvement of the mesolimbic dopaminergic system (mlds) in the suppressive effect of pes on the rewarding effects of morphine in sd male rats. |
2008-08-26 |
2023-08-12 |
rat |
| Rainer Spanagel, Falk Kiefe. Drugs for relapse prevention of alcoholism: ten years of progress. Trends in pharmacological sciences. vol 29. issue 3. 2008-08-25. PMID:18262663. |
the dopaminergic system has long featured in alcoholism research; hitherto disappointing results from clinical studies could improve following the discovery that dopamine d3 receptor antagonism produces consistent and robust results in preclinical studies. |
2008-08-25 |
2023-08-12 |
Not clear |