| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sirirat Klongpanichapak, Pansiri Phansuwan-Pujito, Manuchair Ebadi, Piyarat Govitrapon. Melatonin inhibits amphetamine-induced increase in alpha-synuclein and decrease in phosphorylated tyrosine hydroxylase in SK-N-SH cells. Neuroscience letters. vol 436. issue 3. 2008-08-25. PMID:18406059. |
the present study was conducted to investigate the effect of amph on alpha-synuclein in regulating tyrosine hydroxylase (th), a rate limiting enzyme for dopamine synthesis, in cultured human dopaminergic sk-n-sh cells. |
2008-08-25 |
2023-08-12 |
human |
| Erkki Tupala, Merja Häkkinen, Markus Storvik, Jari Tiihone. Striatal dopaminergic terminals in type 1 and type 2 alcoholics measured with [3H]dihydrotetrabenazine and human whole hemisphere autoradiography. Psychiatry research. vol 163. issue 1. 2008-08-22. PMID:18394867. |
however, whether this lower level is due to a lower level of dopamine transporter protein or a lower level of dopaminergic nerve terminals remains unclear. |
2008-08-22 |
2023-08-12 |
human |
| Erkki Tupala, Merja Häkkinen, Markus Storvik, Jari Tiihone. Striatal dopaminergic terminals in type 1 and type 2 alcoholics measured with [3H]dihydrotetrabenazine and human whole hemisphere autoradiography. Psychiatry research. vol 163. issue 1. 2008-08-22. PMID:18394867. |
although type 1 alcoholics have been reported to have up to 36% lower striatal dopamine transporter levels than controls, the results suggest that the density of their dopaminergic nerve terminals is not altered. |
2008-08-22 |
2023-08-12 |
human |
| Zhidong Zhou, Szeyen Kerk, Tit Meng Li. Endogenous dopamine (DA) renders dopaminergic cells vulnerable to challenge of proteasome inhibitor MG132. Free radical research. vol 42. issue 5. 2008-08-21. PMID:18484277. |
endogenous dopamine (da) renders dopaminergic cells vulnerable to challenge of proteasome inhibitor mg132. |
2008-08-21 |
2023-08-12 |
Not clear |
| Ran Wang, Hong Qing, Xiao-Qian Liu, Xiao-Lin Zheng, Yu-Lin Den. Iron contributes to the formation of catechol isoquinolines and oxidative toxicity induced by overdose dopamine in dopaminergic SH-SY5Y cells. Neuroscience bulletin. vol 24. issue 3. 2008-08-21. PMID:18500384. |
iron contributes to the formation of catechol isoquinolines and oxidative toxicity induced by overdose dopamine in dopaminergic sh-sy5y cells. |
2008-08-21 |
2023-08-12 |
Not clear |
| Virginie Czernecki, Michael Schüpbach, Sadek Yaici, Richard Lévy, Eric Bardinet, Jérôme Yelnik, Bruno Dubois, Yves Agi. Apathy following subthalamic stimulation in Parkinson disease: a dopamine responsive symptom. Movement disorders : official journal of the Movement Disorder Society. vol 23. issue 7. 2008-08-14. PMID:18398913. |
to evaluate the effects of the dopamine d2-d3 agonist ropinirole in patients who developed apathy after complete withdrawal from dopaminergic medication following successful subthalamic nucleus (stn) stimulation for advanced parkinson disease (pd). |
2008-08-14 |
2023-08-12 |
Not clear |
| b' Maurizio Avanzi, Mario Baratti, Silvia Cabrini, Elena Uber, Gianni Brighetti, Flavio Bonf\\xc3\\xa. The thrill of reckless driving in patients with Parkinson\'s disease: an additional behavioural phenomenon in dopamine dysregulation syndrome? Parkinsonism & related disorders. vol 14. issue 3. 2008-08-13. PMID:17561433.' |
we believe that this impairment in driving performance, due to deliberate overuse of dopaminergic medication, should be included as a new behavioural phenomenon in dopamine dysregulation syndrome. |
2008-08-13 |
2023-08-12 |
Not clear |
| Sung-Wook Chae, Bok Yun Kang, Onyou Hwang, Hyun Jin Cho. Cyclooxygenase-2 is involved in oxidative damage and alpha-synuclein accumulation in dopaminergic cells. Neuroscience letters. vol 436. issue 2. 2008-08-13. PMID:18403118. |
cox-2 has attracted significant attention as an important source of oxidative stress in dopaminergic neurons due to its potential to oxidize catechols including dopamine. |
2008-08-13 |
2023-08-12 |
Not clear |
| Sung-Wook Chae, Bok Yun Kang, Onyou Hwang, Hyun Jin Cho. Cyclooxygenase-2 is involved in oxidative damage and alpha-synuclein accumulation in dopaminergic cells. Neuroscience letters. vol 436. issue 2. 2008-08-13. PMID:18403118. |
these data suggest that an abnormal increase in cox-2 expression causes dopamine oxidation and contributes to the preferential vulnerability of dopaminergic cells as in pd. |
2008-08-13 |
2023-08-12 |
Not clear |
| Michael Moutoussis, Richard P Bentall, Jonathan Williams, Peter Daya. A temporal difference account of avoidance learning. Network (Bristol, England). vol 19. issue 2. 2008-08-12. PMID:18569725. |
these postulated roles of dopamine in aversive learning can thus account for many of the effects of dopaminergic modulation seen in laboratory models of psychopathological processes. |
2008-08-12 |
2023-08-12 |
human |
| Ferogh A Ahmadi, Tom N Grammatopoulos, Andy M Poczobutt, Susan M Jones, Laurence D Snell, Mita Das, W Michael Zawad. Dopamine selectively sensitizes dopaminergic neurons to rotenone-induced apoptosis. Neurochemical research. vol 33. issue 5. 2008-08-11. PMID:17992568. |
dopamine selectively sensitizes dopaminergic neurons to rotenone-induced apoptosis. |
2008-08-11 |
2023-08-12 |
rat |
| Wai Haung Yu, Yasuji Matsuoka, István Sziráki, Audrey Hashim, John Lafrancois, Henry Sershen, Karen E Duf. Increased dopaminergic neuron sensitivity to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in transgenic mice expressing mutant A53T alpha-synuclein. Neurochemical research. vol 33. issue 5. 2008-08-11. PMID:17999181. |
in this study, we analyzed the levels of dopamine and its metabolites in the olfactory bulb (ob), and nigrostriatal regions of transgenic mice expressing human, mutant a53t alpha-synuclein (alpha-syn tg) and their non-transgenic (ntg) littermates using a sub-toxic, moderate dose of mptp to determine if mutant human alpha-synuclein sensitizes the central dopaminergic systems to oxidative stress. |
2008-08-11 |
2023-08-12 |
mouse |
| Nancy Laurin, Abel Ickowicz, Tejaswee Pathare, Molly Malone, Rosemary Tannock, Russell Schachar, James L Kennedy, Cathy L Bar. No evidence for genetic association between DARPP-32 (PP1R1B) polymorphisms and attention deficit hyperactivity disorder. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 147. issue 3. 2008-08-08. PMID:17948899. |
the dopamine- and camp-regulated phosphoprotein of relative molecular mass of 32 kda (darpp-32) is a key component of dopamine signaling, acting as a converging point for several neurotransmitter systems influencing dopaminergic neurons and regulating a wide variety of downstream effectors. |
2008-08-08 |
2023-08-12 |
human |
| Gaëlle Bouchez, Luc Sensebé, Patrick Vourc'h, Lucette Garreau, Sylvie Bodard, Angélique Rico, Denis Guilloteau, Pierre Charbord, Jean-Claude Besnard, Sylvie Chalo. Partial recovery of dopaminergic pathway after graft of adult mesenchymal stem cells in a rat model of Parkinson's disease. Neurochemistry international. vol 52. issue 7. 2008-08-08. PMID:18372079. |
these data demonstrate that graft of adult mesemchymal stem cells reduces behavioral effects induced by 6-hydroxydopamine lesion and partially restores the dopaminergic markers and vesicular striatal pool of dopamine. |
2008-08-08 |
2023-08-12 |
rat |
| M Borg, C Bayreuthe. [Dopamine dysregulation syndrome in Parkinson's disease]. Revue neurologique. vol 164. issue 4. 2008-08-08. PMID:18439923. |
in contrast to the predictable pattern of severe degeneration of ventrolateral nigral dopaminergic cells, there is a smaller and more variable loss of dopamine neurons within the ventral tegmental areas. |
2008-08-08 |
2023-08-12 |
Not clear |
| R G Nair-Roberts, S D Chatelain-Badie, E Benson, H White-Cooper, J P Bolam, M A Ungles. Stereological estimates of dopaminergic, GABAergic and glutamatergic neurons in the ventral tegmental area, substantia nigra and retrorubral field in the rat. Neuroscience. vol 152. issue 4. 2008-08-07. PMID:18355970. |
these results demonstrate that gabaergic and glutamatergic neurons represent large proportions of the neurons in what are traditionally considered as dopamine nuclei and that there are considerable heterogeneities in the proportions of cell types in the different dopaminergic midbrain regions. |
2008-08-07 |
2023-08-12 |
rat |
| Daniel C Javit. Phenomenology, aetiology and treatment of schizophrenia. Novartis Foundation symposium. vol 289. 2008-08-07. PMID:18497092. |
further, nmda receptors are located on brain circuits that regulate dopamine release, suggesting that dopaminergic deficits in schizophrenia may also be secondary to underlying glutamatergic dysfunction. |
2008-08-07 |
2023-08-12 |
Not clear |
| Eva Hedlund, Jan Pruszak, Thomas Lardaro, Wesley Ludwig, Angel Viñuela, Kwang-Soo Kim, Ole Isacso. Embryonic stem cell-derived Pitx3-enhanced green fluorescent protein midbrain dopamine neurons survive enrichment by fluorescence-activated cell sorting and function in an animal model of Parkinson's disease. Stem cells (Dayton, Ohio). vol 26. issue 6. 2008-08-06. PMID:18388307. |
furthermore, postmitotic pitx3-egfp(+) dopamine neurons, which constituted 2%-5% of all live cells in the culture after dissociation, could be highly enriched to >90% purity by facs, and these isolated neurons were viable, extended neurites, and maintained a dopaminergic profile in vitro. |
2008-08-06 |
2023-08-12 |
mouse |
| Eva Hedlund, Jan Pruszak, Thomas Lardaro, Wesley Ludwig, Angel Viñuela, Kwang-Soo Kim, Ole Isacso. Embryonic stem cell-derived Pitx3-enhanced green fluorescent protein midbrain dopamine neurons survive enrichment by fluorescence-activated cell sorting and function in an animal model of Parkinson's disease. Stem cells (Dayton, Ohio). vol 26. issue 6. 2008-08-06. PMID:18388307. |
transplantation to 6-hydroxydopamine-lesioned rats showed that an enriched dopaminergic population could survive and restore both amphetamine- and apomorphine-induced functions, and the grafts contained large numbers of midbrain dopamine neurons, which innervated the host striatum. |
2008-08-06 |
2023-08-12 |
mouse |
| Margarete Zanardo Gomes, Rita Raisman-Vozari, Elaine A Del Be. A nitric oxide synthase inhibitor decreases 6-hydroxydopamine effects on tyrosine hydroxylase and neuronal nitric oxide synthase in the rat nigrostriatal pathway. Brain research. vol 1203. 2008-08-01. PMID:18313645. |
these results suggest that nitric oxide synthase inhibition may decrease the toxic effects of 6-ohda on dopaminergic terminals and on dopamine cell bodies in sub-regions of the sn and on neuronal nitric oxide synthase cell density in the rat brain. |
2008-08-01 |
2023-08-12 |
rat |