| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Rivera, A Peñafiel, M Megías, L F Agnati, J F López-Téllez, B Gago, A Gutiérrez, A de la Calle, K Fux. Cellular localization and distribution of dopamine D(4) receptors in the rat cerebral cortex and their relationship with the cortical dopaminergic and noradrenergic nerve terminal networks. Neuroscience. vol 155. issue 3. 2008-12-18. PMID:18620029. |
cellular localization and distribution of dopamine d(4) receptors in the rat cerebral cortex and their relationship with the cortical dopaminergic and noradrenergic nerve terminal networks. |
2008-12-18 |
2023-08-12 |
rat |
| A Rivera, A Peñafiel, M Megías, L F Agnati, J F López-Téllez, B Gago, A Gutiérrez, A de la Calle, K Fux. Cellular localization and distribution of dopamine D(4) receptors in the rat cerebral cortex and their relationship with the cortical dopaminergic and noradrenergic nerve terminal networks. Neuroscience. vol 155. issue 3. 2008-12-18. PMID:18620029. |
in the present work we have studied in detail the regional and cellular localization of the dopamine d(4) receptor immunoreactivity (ir) in the rat cerebral cortex and its relationship to the dopaminergic and noradrenergic nerve terminal networks, since both dopamine and noradrenaline have a high affinity for this receptor. |
2008-12-18 |
2023-08-12 |
rat |
| Daniel Alvarez-Fischer, Serge Guerreiro, Stéphane Hunot, Françoise Saurini, Marc Marien, Pierre Sokoloff, Etienne C Hirsch, Andreas Hartmann, Patrick P Miche. Modelling Parkinson-like neurodegeneration via osmotic minipump delivery of MPTP and probenecid. Journal of neurochemistry. vol 107. issue 3. 2008-12-16. PMID:18761710. |
our results show, however, that mptp infusion via alzet osmotic minipumps (40 mg/kg/day) produces only a transient depletion in striatal dopamine (da) without causing dopaminergic cell loss in the substantia nigra. |
2008-12-16 |
2023-08-12 |
mouse |
| Shih-Ya Hung, Houng-Chi Liou, Kai-Hsiang Kang, Ruey-Meei Wu, Chun-Chiang Wen, Wen-Mei F. Overexpression of heme oxygenase-1 protects dopaminergic neurons against 1-methyl-4-phenylpyridinium-induced neurotoxicity. Molecular pharmacology. vol 74. issue 6. 2008-12-16. PMID:18799798. |
it was found that overexpression of ho-1 significantly increased the survival rate of dopaminergic neurons; reduced the production of tumor necrosis factor alpha (tnf-alpha) and interleukin-1beta (il-1beta) in substantia nigra; antagonized the reduction of striatal dopamine content induced by mpp(+); and also up-regulated brain-derived neurotrophic factor (bdnf) and glial cell line-derived neurotrophic factor (gdnf) expression in substantia nigra. |
2008-12-16 |
2023-08-12 |
human |
| V Bagga, S B Dunnett, R A Fricker-Gate. Ascorbic acid increases the number of dopamine neurons in vitro and in transplants to the 6-OHDA-lesioned rat brain. Cell transplantation. vol 17. issue 7. 2008-12-16. PMID:19044203. |
while the increased number of dopamine neurons observed in our study following ascorbic acid treatment may reflect a selective survival effect, our in vitro results suggest that ascorbic acid may act to increase the number dopamine neurons, both in culture and following transplantation, by stimulating dopaminergic differentiation of neural precursors from the fetal ventral mesencephalon. |
2008-12-16 |
2023-08-12 |
rat |
| Zhenquan Jia, Hong Zhu, Bhaba R Misra, Yunbo Li, Hara P Misr. Dopamine as a potent inducer of cellular glutathione and NAD(P)H:quinone oxidoreductase 1 in PC12 neuronal cells: a potential adaptive mechanism for dopaminergic neuroprotection. Neurochemical research. vol 33. issue 11. 2008-12-12. PMID:18368484. |
dopamine as a potent inducer of cellular glutathione and nad(p)h:quinone oxidoreductase 1 in pc12 neuronal cells: a potential adaptive mechanism for dopaminergic neuroprotection. |
2008-12-12 |
2023-08-12 |
Not clear |
| Zhenquan Jia, Hong Zhu, Bhaba R Misra, Yunbo Li, Hara P Misr. Dopamine as a potent inducer of cellular glutathione and NAD(P)H:quinone oxidoreductase 1 in PC12 neuronal cells: a potential adaptive mechanism for dopaminergic neuroprotection. Neurochemical research. vol 33. issue 11. 2008-12-12. PMID:18368484. |
dopamine auto-oxidation and the consequent formation of reactive oxygen species and electrophilic quinone molecules have been implicated in dopaminergic neuronal cell death in parkinson's disease. |
2008-12-12 |
2023-08-12 |
Not clear |
| Zhenquan Jia, Hong Zhu, Bhaba R Misra, Yunbo Li, Hara P Misr. Dopamine as a potent inducer of cellular glutathione and NAD(P)H:quinone oxidoreductase 1 in PC12 neuronal cells: a potential adaptive mechanism for dopaminergic neuroprotection. Neurochemical research. vol 33. issue 11. 2008-12-12. PMID:18368484. |
we reported here that in pc12 dopaminergic neuronal cells dopamine at noncytotoxic concentrations (50-150 mum) potently induced cellular glutathione (gsh) and the phase 2 enzyme nad(p)h:quinone oxidoreductase 1 (nqo1), two critical cellular defenses in detoxification of ros and electrophilic quinone molecules. |
2008-12-12 |
2023-08-12 |
Not clear |
| Zhenquan Jia, Hong Zhu, Bhaba R Misra, Yunbo Li, Hara P Misr. Dopamine as a potent inducer of cellular glutathione and NAD(P)H:quinone oxidoreductase 1 in PC12 neuronal cells: a potential adaptive mechanism for dopaminergic neuroprotection. Neurochemical research. vol 33. issue 11. 2008-12-12. PMID:18368484. |
in view of the critical roles of gsh and nqo1 in protecting against dopaminergic neuron degeneration, the above findings implicate that upregulation of both gsh and nqo1 by dopamine at noncytotoxic concentrations may serve as an important adaptive mechanism for dopaminergic neuroprotection. |
2008-12-12 |
2023-08-12 |
Not clear |
| Vatsala Thirumalai, Hollis T Clin. Endogenous dopamine suppresses initiation of swimming in prefeeding zebrafish larvae. Journal of neurophysiology. vol 100. issue 3. 2008-12-12. PMID:18562547. |
application of dopamine either to the isolated spinal cord or locally within the cord does not decrease episode frequency, whereas dopamine application to the brain silences episodes, suggesting a supraspinal locus of dopaminergic action. |
2008-12-12 |
2023-08-12 |
zebrafish |
| Ezia Guatteo, Maria Letizia Cucchiaroni, Luca Sebastianelli, Giorgio Bernardi, Nicola Biagio Mercur. The midbrain slice preparation. An in vitro model to select potential anti-parkinsonian drugs? Parkinsonism & related disorders. vol 14 Suppl 2. 2008-12-12. PMID:18583176. |
the firing activity of dopaminergic cells throughout dopamine-mediated mechanisms is inhibited not only by dopamine direct agonists but also by substances that increase the release or synthesis, or block the uptake or reduce degradation of dopamine in the brain. |
2008-12-12 |
2023-08-12 |
Not clear |
| Mauro Fasano, Tiziana Alberio, Monica Colapinto, Silvia Mila, Leonardo Lopian. Proteomics as a tool to investigate cell models for dopamine toxicity. Parkinsonism & related disorders. vol 14 Suppl 2. 2008-12-12. PMID:18585082. |
dopaminergic neurons are particularly exposed to oxidative stress because dopamine metabolism gives rise to endogenous toxins. |
2008-12-12 |
2023-08-12 |
Not clear |
| Marat V Avshalumov, Jyoti C Patel, Margaret E Ric. AMPA receptor-dependent H2O2 generation in striatal medium spiny neurons but not dopamine axons: one source of a retrograde signal that can inhibit dopamine release. Journal of neurophysiology. vol 100. issue 3. 2008-12-12. PMID:18632893. |
although regulation of glutamatergic transmission by dopamine is increasingly well understood, regulation of dopaminergic transmission by glutamate remains uncertain given the apparent absence of ionotropic glutamate receptors on dopaminergic axons in dorsal striatum. |
2008-12-12 |
2023-08-12 |
Not clear |
| Eric Ch Wolters, Ysbrand D van der Werf, Odile A van den Heuve. Parkinson's disease-related disorders in the impulsive-compulsive spectrum. Journal of neurology. vol 255 Suppl 5. 2008-12-12. PMID:18787882. |
these patients may develop plastic changes in the striatal matrix leading to hyperkinesia, caused by extracellular striatal dopaminergic fluctuations due to pulsatile dopamine replacement therapy. |
2008-12-12 |
2023-08-12 |
Not clear |
| Eric Ch Wolters, Ysbrand D van der Werf, Odile A van den Heuve. Parkinson's disease-related disorders in the impulsive-compulsive spectrum. Journal of neurology. vol 255 Suppl 5. 2008-12-12. PMID:18787882. |
in the multifactorial (intrinsic and extrinsic) dopamine dependency and dysregulation syndromes, addictive behaviour might best be helped by psychosocial strategies, and punding by continuous dopaminergic receptor stimulation (or amantadine), hypothesized to reduce the plastic changes-induced hypersensitization. |
2008-12-12 |
2023-08-12 |
Not clear |
| Mónica Padilla-de la Torre, Javier Franco-Pérez, Abel Santamaría, Sonia Galvan, Edith González, Carlos Pa. Effect of acetaldehyde on behavioral and neurochemical changes induced by MK-801 in rats. Annals of the New York Academy of Sciences. vol 1139. 2008-12-09. PMID:18991871. |
ach might exert some control on dopaminergic transmission through the formation of other compounds with dopamine, which eventually may modify dopamine content and its metabolism. |
2008-12-09 |
2023-08-12 |
rat |
| Cristina Crespo, Judith Gallego, Albert Cot, Carles Falcón, Santiago Bullich, Deborah Pareto, Pablo Aguiar, Josep Sempau, Francisco Lomeña, Francisco Calviño, Javier Pavía, Domènec Ro. Quantification of dopaminergic neurotransmission SPECT studies with 123I-labelled radioligands. A comparison between different imaging systems and data acquisition protocols using Monte Carlo simulation. European journal of nuclear medicine and molecular imaging. vol 35. issue 7. 2008-12-04. PMID:18335217. |
(123)i-labelled radioligands are commonly used for single-photon emission computed tomography (spect) imaging of the dopaminergic system to study the dopamine transporter binding. |
2008-12-04 |
2023-08-12 |
Not clear |
| Igor Bombin, Celso Arango, María Mayoral, Josefina Castro-Fornieles, Ana Gonzalez-Pinto, Cristina Gonzalez-Gomez, Dolores Moreno, Mara Parellada, Inmaculada Baeza, Montserrat Graell, Soraya Otero, Pilar A Saiz, Ana Patiño-Garci. DRD3, but not COMT or DRD2, genotype affects executive functions in healthy and first-episode psychosis adolescents. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 147B. issue 6. 2008-12-04. PMID:18351593. |
catechol-o-methyltransferase (comt) and dopamine receptors 2 (drd2) and 3 (drd3) have been associated with a higher risk of developing psychosis and with dopaminergic system (das) regulation. |
2008-12-04 |
2023-08-12 |
human |
| Han-Qing Chen, Xi-Jin Wang, Zheng-Yu Jin, Xue-Ming Xu, Jian-Wei Zhao, Zheng-Jun Xi. Protective effect of isoflavones from Trifolium pratense on dopaminergic neurons. Neuroscience research. vol 62. issue 2. 2008-12-02. PMID:18675857. |
the results showed that all five isoflavones attenuated lps-induced decrease in dopamine uptake and the number of dopaminergic neurons in a dose-dependent manner in rat mesencephalic neuron-glia cultures. |
2008-12-02 |
2023-08-12 |
rat |
| Antti Pertovaara, Hong We. Dual influence of the striatum on neuropathic hypersensitivity. Pain. vol 137. issue 1. 2008-12-01. PMID:17870240. |
this antihypersensitivity effect is predominantly ipsilateral and it descends via parallel dopaminergic and serotoninergic pathways to act on spinal dopamine d2 and 5-ht(1a) receptors, respectively. |
2008-12-01 |
2023-08-12 |
rat |