| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Masaya Hashimoto, Keiichi Kawasaki, Masahiko Suzuki, Kazuko Mitani, Shigeo Murayama, Masahiro Mishina, Keiichi Oda, Yuichi Kimura, Kiichi Ishiwata, Kenji Ishii, Kiyoharu Inou. Presynaptic and postsynaptic nigrostriatal dopaminergic functions in multiple system atrophy. Neuroreport. vol 19. issue 2. 2008-03-24. PMID:18185098. |
a simultaneous evaluation of presynaptic and postsynaptic dopaminergic positron emission tomography markers, the dopamine transporters and the dopamine d2-like receptors, was performed in eight patients with parkinsonian phenotype of multiple system atrophy. |
2008-03-24 |
2023-08-12 |
Not clear |
| Khaled Radad, Gabriele Gille, Wolf-Dieter Rausc. Dopaminergic neurons are preferentially sensitive to long-term rotenone toxicity in primary cell culture. Toxicology in vitro : an international journal published in association with BIBRA. vol 22. issue 1. 2008-03-20. PMID:17923380. |
parkinson's disease (pd) is a chronic neurodegenerative disorder characterized by the death of dopaminergic neurons in the substantia nigra pars compacta (snpc) and the subsequent decrease of dopamine levels in the striatum. |
2008-03-20 |
2023-08-12 |
mouse |
| Evelyn H Schlenke. In hamsters the D1 receptor antagonist SCH23390 depresses ventilation during hypoxia. Brain research. vol 1187. 2008-03-17. PMID:18036574. |
during exposure of animals to hypoxia, brain and blood dopamine levels increase stimulating dopaminergic receptors which influence the integrated ventilatory response to low oxygen. |
2008-03-17 |
2023-08-12 |
Not clear |
| Peter Riederer, Manfred Gerlach, Thomas Müller, Heinz Reichman. Relating mode of action to clinical practice: dopaminergic agents in Parkinson's disease. Parkinsonism & related disorders. vol 13. issue 8. 2008-03-14. PMID:17919963. |
this article reviews the three main classes of dopaminergic pd therapy (levodopa, monoamine oxidase inhibitors and dopamine agonists). |
2008-03-14 |
2023-08-12 |
Not clear |
| Georg Juckel, Wolfram Kawohl, Ina Giegling, Paraskevi Mavrogiorgou, Christine Winter, Oliver Pogarell, Christoph Mulert, Ulrich Hegerl, Dan Rujesc. Association of catechol-O-methyltransferase variants with loudness dependence of auditory evoked potentials. Human psychopharmacology. vol 23. issue 2. 2008-03-14. PMID:18081002. |
as dopamine transporter availabilities also correlate with ldaep, a dopaminergic influence is probable. |
2008-03-14 |
2023-08-12 |
Not clear |
| Kimberlee D'Ardenne, Samuel M McClure, Leigh E Nystrom, Jonathan D Cohe. BOLD responses reflecting dopaminergic signals in the human ventral tegmental area. Science (New York, N.Y.). vol 319. issue 5867. 2008-03-13. PMID:18309087. |
although studies in nonhuman species provide direct support for this theory, functional magnetic resonance imaging (fmri) studies in humans have focused on brain areas targeted by dopamine neurons [ventral striatum (vstr)] rather than on brainstem dopaminergic nuclei [ventral tegmental area (vta) and substantia nigra]. |
2008-03-13 |
2023-08-12 |
human |
| Mark Stacy, Andrew Galbreat. Optimizing long-term therapy for Parkinson disease: levodopa, dopamine agonists, and treatment-associated dyskinesia. Clinical neuropharmacology. vol 31. issue 1. 2008-03-11. PMID:18303491. |
the treatment of parkinson disease (pd) involves pharmacological treatment, often with levodopa or dopamine agonists, to restore the dopaminergic deficit associated with parkinsonian symptoms. |
2008-03-11 |
2023-08-12 |
Not clear |
| Michael X Cohen, Artus Krohn-Grimberghe, Christian E Elger, Bernd Webe. Dopamine gene predicts the brain's response to dopaminergic drug. The European journal of neuroscience. vol 26. issue 12. 2008-03-06. PMID:18088284. |
dopamine gene predicts the brain's response to dopaminergic drug. |
2008-03-06 |
2023-08-12 |
human |
| Michael X Cohen, Artus Krohn-Grimberghe, Christian E Elger, Bernd Webe. Dopamine gene predicts the brain's response to dopaminergic drug. The European journal of neuroscience. vol 26. issue 12. 2008-03-06. PMID:18088284. |
dopamine is critical for reward-based decision making, yet dopaminergic drugs can have opposite effects in different individuals. |
2008-03-06 |
2023-08-12 |
human |
| Michael X Cohen, Artus Krohn-Grimberghe, Christian E Elger, Bernd Webe. Dopamine gene predicts the brain's response to dopaminergic drug. The European journal of neuroscience. vol 26. issue 12. 2008-03-06. PMID:18088284. |
here, we used functional mri to test the hypothesis that genetic variation in the expression of dopamine d2 receptors in the human brain predicts opposing dopaminergic drug effects during reversal learning. |
2008-03-06 |
2023-08-12 |
human |
| Klaus B Fink, Manfred Göther. 5-HT receptor regulation of neurotransmitter release. Pharmacological reviews. vol 59. issue 4. 2008-03-06. PMID:18160701. |
this review focuses on 1) the function of presynaptic 5-hydroxytryptamine (5-ht) heteroreceptors on axon terminals of central cholinergic, dopaminergic, noradrenergic, or gabaergic neurons and 2) the role of gabaergic interneurons expressing 5-ht heteroreceptors in the regulation of acetylcholine, dopamine, or noradrenaline release. |
2008-03-06 |
2023-08-12 |
Not clear |
| Kathleen A Maguire-Zeiss, Timothy R Mhyre, Howard J Federof. Gazing into the future: Parkinson's disease gene therapeutics to modify natural history. Experimental neurology. vol 209. issue 1. 2008-03-05. PMID:18035353. |
pd gene therapy clinical trials have primarily focused on increasing the production of dopamine (da) through supplemental amino acid decarboxylase (aadc) expression, neurotrophic support for surviving dopaminergic neurons (dan) or altering brain circuitry to compensate for da neuron loss. |
2008-03-05 |
2023-08-12 |
Not clear |
| Jia Liu, Hong-Yun Huan. How to improve the survival of the fetal ventral mesencephalic cell transplanted in Parkinson's disease? Neuroscience bulletin. vol 23. issue 6. 2008-03-04. PMID:18064069. |
the major limitations are the poor survival of grafted dopamine (da) neurons and restricted dopaminergic reinnervation of host striatum. |
2008-03-04 |
2023-08-12 |
Not clear |
| Brototi Roy, Umesh Ra. Role of adrenoceptor-coupled second messenger system in sympatho-adrenomedullary modulation of splenic macrophage functions in live fish Channa punctatus. General and comparative endocrinology. vol 155. issue 2. 2008-02-26. PMID:17574246. |
however, dopamine (da) regulates phagocytosis solely via the dopaminergic receptor. |
2008-02-26 |
2023-08-12 |
Not clear |
| George W Hubert, Douglas C Jones, Mark C Moffett, George Rogge, Michael J Kuha. CART peptides as modulators of dopamine and psychostimulants and interactions with the mesolimbic dopaminergic system. Biochemical pharmacology. vol 75. issue 1. 2008-02-26. PMID:17854774. |
cart peptides as modulators of dopamine and psychostimulants and interactions with the mesolimbic dopaminergic system. |
2008-02-26 |
2023-08-12 |
Not clear |
| Frederic Boyer, Jean-Luc Dreye. Alpha-synuclein in the nucleus accumbens induces changes in cocaine behaviour in rats. The European journal of neuroscience. vol 26. issue 10. 2008-02-25. PMID:18001274. |
it interacts with the dopamine transporter, and regulates dopaminergic content, neurotransmission and synaptic strength of dopaminergic neurons. |
2008-02-25 |
2023-08-12 |
rat |
| A Floel, G Garraux, B Xu, C Breitenstein, S Knecht, P Herscovitch, L G Cohe. Levodopa increases memory encoding and dopamine release in the striatum in the elderly. Neurobiology of aging. vol 29. issue 2. 2008-02-21. PMID:17098331. |
these results demonstrate that levodopa may ameliorate dopamine deficiencies in the elderly by replenishing dopaminergic presynaptic stores, actively engaged in phasic dopamine release during motor training. |
2008-02-21 |
2023-08-12 |
Not clear |
| Thomas J Feuerstei. Presynaptic receptors for dopamine, histamine, and serotonin. Handbook of experimental pharmacology. issue 184. 2008-02-20. PMID:18064418. |
presynaptic receptors for dopamine, histamine and serotonin that are located on dopaminergic, histaminergic and sertonergic axon terminals, respectively, function as autoreceptors. |
2008-02-20 |
2023-08-12 |
Not clear |
| Anthony H V Schapir. Future directions in the treatment of Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society. vol 22 Suppl 17. 2008-02-20. PMID:18175401. |
dopaminergic therapies in the form of levodopa, dopamine agonists, or monoamine oxidase b inhibitors significantly improve the characteristic motor symptoms of bradykinesia and rigidity, with a beneficial effect upon tremor in a proportion of patients. |
2008-02-20 |
2023-08-12 |
Not clear |
| I Rite, S Argüelles, J L Venero, S García-Rodriguez, A Ayala, J Cano, A Machad. Proteomic identification of biomarkers in the cerebrospinal fluid in a rat model of nigrostriatal dopaminergic degeneration. Journal of neuroscience research. vol 85. issue 16. 2008-02-19. PMID:17705290. |
in this model, the degeneration of dopaminergic neurons was completed in 14 days, with a loss of about 50% dopaminergic neurons in the substantia nigra and a loss of more than 80% dopamine terminals in the striatum, with a similar diminution of dopamine levels in both structures. |
2008-02-19 |
2023-08-12 |
rat |