| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| N D Kitrey, P Clément, J Bernabé, L Alexandre, F Giulian. Microinjection of the preferential dopamine receptor D3 agonist 7-hydroxy-N,N-di-n-propylaminotetralin hydrobromide into the hypothalamic medial preoptic area induced ejaculation in anesthetized rats. Neuroscience. vol 149. issue 3. 2008-01-16. PMID:17916409. |
the pivotal role of the medial preoptic area (mpoa) of the hypothalamus in the dopaminergic cerebral control of ejaculation has been investigated for years; nevertheless the function of different dopamine receptors subclasses and their exact interrelations merit additional research. |
2008-01-16 |
2023-08-12 |
human |
| Shankar J Chinta, M J Kumar, Michael Hsu, Subramanian Rajagopalan, Deepinder Kaur, Anand Rane, David G Nicholls, Jinah Choi, Julie K Anderse. Inducible alterations of glutathione levels in adult dopaminergic midbrain neurons result in nigrostriatal degeneration. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 51. 2008-01-14. PMID:18094238. |
one of the earliest detectable biochemical alterations that occurs in the parkinsonian brain is a marked reduction in sn levels of total glutathione (glutathione plus glutathione disulfide), occurring before losses in mitochondrial complex i (ci) activity, striatal dopamine levels, or midbrain dopaminergic neurodegeneration associated with the disease. |
2008-01-14 |
2023-08-12 |
mouse |
| Ulrike M Krämer, Toni Cunillera, Estela Càmara, Josep Marco-Pallarés, David Cucurell, Wido Nager, Peter Bauer, Rebecca Schüle, Ludger Schöls, Antoni Rodriguez-Fornells, Thomas F Münt. The impact of catechol-O-methyltransferase and dopamine D4 receptor genotypes on neurophysiological markers of performance monitoring. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 51. 2008-01-14. PMID:18094258. |
here, we studied the impact of two polymorphisms affecting dopaminergic functioning in the prefrontal cortex [catechol-o-methyltransferase (comt) val108/158met and dopamine d4 receptor (drd4) single-nucleotide polymorphism (snp)-521] on neurophysiological correlates of performance monitoring. |
2008-01-14 |
2023-08-12 |
human |
| Sebastian Kowsky, Charlotte Pöppelmeyer, Edgar R Kramer, Björn H Falkenburger, Anja Kruse, Rüdiger Klein, Jörg B Schul. RET signaling does not modulate MPTP toxicity but is required for regeneration of dopaminergic axon terminals. Proceedings of the National Academy of Sciences of the United States of America. vol 104. issue 50. 2008-01-11. PMID:18056810. |
however, ret ablation abolished the regeneration of dopaminergic fibers and terminals, as well as the partial recovery of striatal dopamine concentrations, that was observed in control mice between days 14 and 90 after mptp treatment. |
2008-01-11 |
2023-08-12 |
mouse |
| Vural Ozdemir, M Mazen Jamal, Klara Osapay, Martin R Jadus, Zsuzsanna Sandor, Mehrtash Hashemzadeh, Sandor Szab. Cosegregation of gastrointestinal ulcers and schizophrenia in a large national inpatient discharge database: revisiting the "brain-gut axis" hypothesis in ulcer pathogenesis. Journal of investigative medicine : the official publication of the American Federation for Clinical Research. vol 55. issue 6. 2008-01-10. PMID:17963681. |
the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,36-tetrahydropyridine (mptp) depletes central dopamine and induces lesions in the substantia nigra, and, if given in high doses, mptp induces a parkinson disease-like syndrome and gastric ulcers. |
2008-01-10 |
2023-08-12 |
Not clear |
| S Akerman, P J Goadsb. Dopamine and migraine: biology and clinical implications. Cephalalgia : an international journal of headache. vol 27. issue 11. 2008-01-10. PMID:17970991. |
there are various non-specific dopamine d(2) receptor antagonists that show good clinical efficacy in migraine, and also a number of polymorphisms of dopaminergic genes related to migraine. |
2008-01-10 |
2023-08-12 |
Not clear |
| Karuppagounder S Senthilkumar, Karuppagounder S Saravanan, Goutam Chandra, Kizhakke M Sindhu, A Jayakrishnan, Kochupurackal P Mohanakuma. Unilateral implantation of dopamine-loaded biodegradable hydrogel in the striatum attenuates motor abnormalities in the 6-hydroxydopamine model of hemi-parkinsonism. Behavioural brain research. vol 184. issue 1. 2008-01-09. PMID:17765334. |
dopaminergic functional recovery following controlled release of dopamine from biodegradable polymer matrices implanted in the lesioned striatum was investigated in a hemiparkinsonian animal model. |
2008-01-09 |
2023-08-12 |
Not clear |
| I G Sil'ki. The contribution of synaptic plasticity in the basal ganglia to the processing of visual information. Neuroscience and behavioral physiology. vol 37. issue 8. 2008-01-08. PMID:17922242. |
dopamine released in response to a visual stimulus modulates the efficiencies of "strong" and "weak" corticostriatal inputs in different directions, and the subsequent reorganization of activity in the circuit leads to disinhibition (inhibition) of the activity of those cortical neurons which are "strongly" ("weakly") excited by the visual stimulus simultaneously with dopaminergic cells. |
2008-01-08 |
2023-08-12 |
Not clear |
| I G Sil'ki. The contribution of synaptic plasticity in the basal ganglia to the processing of visual information. Neuroscience and behavioral physiology. vol 37. issue 8. 2008-01-08. PMID:17922242. |
the prefrontal cortex, excited by the visual stimulus via the mediodorsal nucleus of the thalamus, mediates the descending influence on the activity of dopaminergic cells, simultaneously controlling dopamine release in different areas of the striatum and thus facilitating the mutual selection of neural reflections of the individual properties of the visual stimulus and their binding into an integral image. |
2008-01-08 |
2023-08-12 |
Not clear |
| Mehrzad Cohenpour, Haim Gola. [Nuclear neuroimaging of dopamine transporter in Parkinsonism--role in routine clinical practice]. Harefuah. vol 146. issue 9. 2008-01-07. PMID:17969308. |
brain spect imaging of the dopamine transporter (dat) with specific radioligands is a sensitive method for examining the integrity of the presynaptic dopaminergic system. |
2008-01-07 |
2023-08-12 |
Not clear |
| Sergi Ferré, Luigi F Agnati, Francisco Ciruela, Carme Lluis, Amina S Woods, Kjell Fuxe, Rafael Franc. Neurotransmitter receptor heteromers and their integrative role in 'local modules': the striatal spine module. Brain research reviews. vol 55. issue 1. 2008-01-04. PMID:17408563. |
finally, dopamine d(2) receptor-non-alpha(7) nicotinic acetylcholine receptor heteromers, which are located in dopaminergic terminals, introduce the new concept of autoreceptor heteromer. |
2008-01-04 |
2023-08-12 |
Not clear |
| Robert Pal, Marko Zivin, Aleksandra Milutinovic, Branimir Jernej, Gordana Glava. Effect of apomorphine on striatal synaptotagmin 7 mRNA levels in reserpinized rats. Neuroscience letters. vol 424. issue 3. 2008-01-04. PMID:17719177. |
we treated rats with systemic reserpine injections that rapidly depletes dopamine throughout the brain, but leaves dopaminergic neurons spared from destruction. |
2008-01-04 |
2023-08-12 |
rat |
| Shih-Jen Tsa. Glatiramer acetate could be a potential therapeutic agent for Parkinson's disease through its neuroprotective and anti-inflammatory effects. Medical hypotheses. vol 69. issue 6. 2008-01-03. PMID:17548170. |
the hallmark pathologic feature of pd is dopamine deficiency, caused by the degeneration of nigrostriatal dopaminergic neurons. |
2008-01-03 |
2023-08-12 |
mouse |
| Ikuko Miyazaki, Masato Asanuma, Hiroaki Hozumi, Ko Miyoshi, Norio Sogaw. Protective effects of metallothionein against dopamine quinone-induced dopaminergic neurotoxicity. FEBS letters. vol 581. issue 25. 2008-01-03. PMID:17910954. |
protective effects of metallothionein against dopamine quinone-induced dopaminergic neurotoxicity. |
2008-01-03 |
2023-08-12 |
mouse |
| Mauro Federici, Luca Sebastianelli, Silvia Natoli, Giorgio Bernardi, Nicola B Mercur. Electrophysiologic changes in ventral midbrain dopaminergic neurons resulting from (+/-) -3,4-methylenedioxymethamphetamine (MDMA-"Ecstasy"). Biological psychiatry. vol 62. issue 6. 2008-01-02. PMID:17511969. |
although dopamine (da) has been implicated in the psychostimulant properties of 3,4-methylenedioxymethamphetamine (mdma), there is no detailed information on its modalities of action on single ventral midbrain dopaminergic neurons. |
2008-01-02 |
2023-08-12 |
Not clear |
| Monika Cs Horvath, Gabor G Kovacs, Viktor Kovari, Katalin Majtenyi, Yasmin L Hurd, Eva Kelle. Heroin abuse is characterized by discrete mesolimbic dopamine and opioid abnormalities and exaggerated nuclear receptor-related 1 transcriptional decline with age. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 49. 2007-12-27. PMID:18057194. |
dysfunction of mesocorticolimbic dopaminergic neurons is considered a common feature of all drugs of abuse, yet few investigations have evaluated the dopamine (da) system in nonstimulant human abusers. |
2007-12-27 |
2023-08-12 |
human |
| Hao-Yang Tan, Qiang Chen, Terry E Goldberg, Venkata S Mattay, Andreas Meyer-Lindenberg, Daniel R Weinberger, Joseph H Callicot. Catechol-O-methyltransferase Val158Met modulation of prefrontal-parietal-striatal brain systems during arithmetic and temporal transformations in working memory. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 49. 2007-12-27. PMID:18057197. |
here, we used the genotype of the val158met polymorphism in catechol-o-methyltransferase (comt) as an index of relative cortical dopamine bioavailability and tuning efficiency, to examine the spatial and subprocess specificity by which dopaminergic modulation occurs within the prefrontal-parietal-striatal network during wm, thus empirically showing that dopamine plays key roles in updating and stabilizing new information at the neural systems level. |
2007-12-27 |
2023-08-12 |
human |
| Rachel T Wragg, Vera Hapiak, Sarah B Miller, Gareth P Harris, John Gray, Patricia R Komuniecki, Richard W Komunieck. Tyramine and octopamine independently inhibit serotonin-stimulated aversive behaviors in Caenorhabditis elegans through two novel amine receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 49. 2007-12-27. PMID:18057198. |
however, although dopamine (da) also inhibits 5-ht-dependent responses to dilute octanol, ta still inhibits in dop-2; dop-1; dop-3 animals that do not respond to da and cat-2(tm346) and pdat-1::ice animals that lack significant dopaminergic signaling, suggesting that da is not an intermediate in ta inhibition. |
2007-12-27 |
2023-08-12 |
caenorhabditis_elegans |
| O P Soldin, M Aschne. Effects of manganese on thyroid hormone homeostasis: potential links. Neurotoxicology. vol 28. issue 5. 2007-12-26. PMID:17576015. |
the involvement of dopamine and dopaminergic receptors in neurodevelopment, as well as tsh modulation, led us to hypothesize that excessive manganese exposure may lead to adverse neurodevelopmental outcomes due to the disruption of thyroid homeostasis via the loss of dopaminergic control of tsh regulation of thyroid hormones. |
2007-12-26 |
2023-08-12 |
Not clear |
| Anthony C Vernon, Virginia Zbarsky, Krishna P Datla, Martin J Croucher, David T Dexte. Subtype selective antagonism of substantia nigra pars compacta Group I metabotropic glutamate receptors protects the nigrostriatal system against 6-hydroxydopamine toxicity in vivo. Journal of neurochemistry. vol 103. issue 3. 2007-12-21. PMID:17714448. |
importantly, subchronic intranigral administration of mpep and ly367385 appeared to slow the degeneration of remaining nigral dopaminergic neurones and prevented further striatal dopamine depletion in animals with established 6-ohda induced nigrostriatal lesions, suggesting that these compounds may significantly influence disease progression in this model. |
2007-12-21 |
2023-08-12 |
Not clear |