| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D Alvarez-Fischer, G Blessmann, C Trosowski, M Béhé, T Schurrat, A Hartmann, T M Behr, W H Oertel, G U Höglinger, H Höffke. Quantitative [(123)I]FP-CIT pinhole SPECT imaging predicts striatal dopamine levels, but not number of nigral neurons in different mouse models of Parkinson's disease. NeuroImage. vol 38. issue 1. 2007-11-26. PMID:17716921. |
our data demonstrate that the striatal [(123)i]fp-cit binding measured by spect in vivo precisely predicts the striatal dopamine concentrations, but does not necessarily correlate with the nigral dopaminergic cell number. |
2007-11-26 |
2023-08-12 |
mouse |
| Buyean Lee, Stephanie Groman, Edythe D London, James David Jentsc. Dopamine D2/D3 receptors play a specific role in the reversal of a learned visual discrimination in monkeys. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 32. issue 10. 2007-11-20. PMID:17299511. |
to characterize the dopaminergic mechanisms involved in this function, we quantified the effects of subtype-specific dopamine (da) receptor antagonists on acquisition, retention, and reversal of a visual discrimination task in non-human primates (chlorocebus aethiops sabaeus). |
2007-11-20 |
2023-08-12 |
human |
| Abesh Kumar Bhattacharjee, Lindsey M Meister, Lisa Chang, Richard P Bazinet, Laura White, Stanley I Rapopor. In vivo imaging of disturbed pre- and post-synaptic dopaminergic signaling via arachidonic acid in a rat model of Parkinson's disease. NeuroImage. vol 37. issue 4. 2007-11-20. PMID:17681816. |
parkinson's disease involves loss of dopamine (da)-producing neurons in the substantia nigra, associated with fewer pre-synaptic da transporters (dats) but more post-synaptic dopaminergic d2 receptors in terminal areas of these neurons. |
2007-11-20 |
2023-08-12 |
rat |
| Ronald Dorenbos, Massimo Contini, Hajime Hirasawa, Stefano Gustincich, Elio Raviol. Expression of circadian clock genes in retinal dopaminergic cells. Visual neuroscience. vol 24. issue 4. 2007-11-20. PMID:17705893. |
dopaminergic amacrine (da) cells represent an especially interesting candidate as a site of the retinal oscillator because of the crucial role of dopamine in light adaptation, and the widespread distribution of dopamine receptors in the retina. |
2007-11-20 |
2023-08-12 |
mouse |
| Emilie Lacombe, Carole Carcenac, Sabrina Boulet, Claude Feuerstein, Anne Bertrand, Annie Poupard, Marc Savast. High-frequency stimulation of the subthalamic nucleus prolongs the increase in striatal dopamine induced by acute l-3,4-dihydroxyphenylalanine in dopaminergic denervated rats. The European journal of neuroscience. vol 26. issue 6. 2007-11-20. PMID:17822436. |
high-frequency stimulation of the subthalamic nucleus prolongs the increase in striatal dopamine induced by acute l-3,4-dihydroxyphenylalanine in dopaminergic denervated rats. |
2007-11-20 |
2023-08-12 |
rat |
| Emilie Lacombe, Carole Carcenac, Sabrina Boulet, Claude Feuerstein, Anne Bertrand, Annie Poupard, Marc Savast. High-frequency stimulation of the subthalamic nucleus prolongs the increase in striatal dopamine induced by acute l-3,4-dihydroxyphenylalanine in dopaminergic denervated rats. The European journal of neuroscience. vol 26. issue 6. 2007-11-20. PMID:17822436. |
we investigated the effect of stn-hfs on striatal extracellular concentrations of dopamine and its metabolites following acute l-dopa administration in intact or partially dopaminergic denervated (da-pl) rats. |
2007-11-20 |
2023-08-12 |
rat |
| Patricia A Lawlor, Matthew J Durin. Gene therapy for Parkinson's disease. Expert reviews in molecular medicine. vol 6. issue 5. 2007-11-13. PMID:15000692. |
parkinson's disease (pd) is a debilitating neurodegenerative disorder arising from loss of dopaminergic neurons in the substantia nigra pars compacta and subsequent depletion of striatal dopamine levels, which results in distressing motor symptoms. |
2007-11-13 |
2023-08-12 |
Not clear |
| Patricia A Lawlor, Matthew J Durin. Gene therapy for Parkinson's disease. Expert reviews in molecular medicine. vol 6. issue 5. 2007-11-13. PMID:15000692. |
the multifactorial aetiology of idiopathic pd means that it is unlikely any single gene will cure the disease, and as a result at least three separate gene-transfer strategies are currently being pursued: transfer of genes for enzymes involved in dopamine production; transfer of genes for growth factors involved in dopaminergic cell survival and regeneration; and transfer of genes to reset neuronal circuitry by switching cellular phenotype. |
2007-11-13 |
2023-08-12 |
Not clear |
| Ashish Dhir, S K Kulkarn. Involvement of dopamine (DA)/serotonin (5-HT)/sigma (sigma) receptor modulation in mediating the antidepressant action of ropinirole hydrochloride, a D2/D3 dopamine receptor agonist. Brain research bulletin. vol 74. issue 1-3. 2007-11-13. PMID:17683790. |
chronic treatment with antidepressant drugs has been reported to alter dopaminergic neurotransmission, most notably a sensitization of behavioural responses to agonists acting at d2/d3 dopamine receptors within the nucleus accumbens. |
2007-11-13 |
2023-08-12 |
mouse |
| Marina E Embor. Nonhuman primate models of Parkinson's disease. ILAR journal. vol 48. issue 4. 2007-11-13. PMID:17712221. |
similar to human pd patients, parkinsonian monkeys are responsive to dopamine replacement therapies and present complications associated with their long-term use, a similarity that facilitated the assessment of new symptomatic treatments, such as dopaminergic agonists. |
2007-11-13 |
2023-08-12 |
human |
| J Eric Ahlsko. Beating a dead horse: dopamine and Parkinson disease. Neurology. vol 69. issue 17. 2007-11-13. PMID:17954785. |
we have reached the point of diminishing therapeutic returns with drugs acting on dopamine systems; more dopaminergic medications will provide only modest incremental benefit over current therapies. |
2007-11-13 |
2023-08-12 |
Not clear |
| J A Siuciak, S A McCarthy, D S Chapin, T M Reed, C V Vorhees, D R Repask. Behavioral and neurochemical characterization of mice deficient in the phosphodiesterase-1B (PDE1B) enzyme. Neuropharmacology. vol 53. issue 1. 2007-11-09. PMID:17559891. |
the present studies demonstrate increased striatal dopamine turnover in pde1b knockout mice associated with increased baseline motor activity and an exaggerated locomotor response to dopaminergic stimulants such as methamphetamine and amphetamine. |
2007-11-09 |
2023-08-12 |
mouse |
| Manali Das, Kanchan Mukhopadhya. DAT1 3'-UTR 9R allele: preferential transmission in Indian children with attention deficit hyperactivity disorder. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 144B. issue 6. 2007-11-07. PMID:17440935. |
genetic alterations in the dopaminergic system are frequently observed in association with attention deficit hyperactivity disorder (adhd) and a 40 bp variable number of tandem repeats (vntr) in the 3'-untranslated region (3'-utr) of the dopamine transporter gene (dat1) has been investigated in different populations. |
2007-11-07 |
2023-08-12 |
Not clear |
| Thong C Ma, Michael J Mihm, John Anthony Bauer, Kari R Hoy. Bioenergetic and oxidative effects of free 3-nitrotyrosine in culture: selective vulnerability of dopaminergic neurons and increased sensitivity of non-dopaminergic neurons to dopamine oxidation. Journal of neurochemistry. vol 103. issue 1. 2007-11-07. PMID:17877636. |
bioenergetic and oxidative effects of free 3-nitrotyrosine in culture: selective vulnerability of dopaminergic neurons and increased sensitivity of non-dopaminergic neurons to dopamine oxidation. |
2007-11-07 |
2023-08-12 |
mouse |
| M Martinez de Lagran, A Bortolozzi, O Millan, J D Gispert, J R Gonzalez, M L Arbones, F Artigas, M Diersse. Dopaminergic deficiency in mice with reduced levels of the dual-specificity tyrosine-phosphorylated and regulated kinase 1A, Dyrk1A(+/-). Genes, brain, and behavior. vol 6. issue 6. 2007-11-06. PMID:17137466. |
dopamine (da) is a key neurotransmitter in motor behavior and genetic deletion of certain genes directly related to the dopaminergic system has a strong impact on motor activity. |
2007-11-06 |
2023-08-12 |
mouse |
| Jessica W Lea, Steven C Stoner, Jeremy Lafollett. Agitation associated with aripiprazole initiation. Pharmacotherapy. vol 27. issue 9. 2007-11-06. PMID:17723088. |
the mechanism of partial dopamine agonism observed with aripiprazole may increase dopaminergic activity and worsen positive dopamine-associated symptoms, such as paranoia, agitation, and aggression. |
2007-11-06 |
2023-08-12 |
Not clear |
| Christina H L Teh, Chin Chieh Loh, Kevin K Y Lam, Jia Min Loo, Tie Yan, Tit Meng Li. Neuronal PAS domain protein 1 regulates tyrosine hydroxylase level in dopaminergic neurons. Journal of neuroscience research. vol 85. issue 8. 2007-11-05. PMID:17457889. |
dopamine is the main neurotransmitter present in dopaminergic neurons of the ventral midbrain, where dysfunction of these neurons can lead to parkinson's disease and schizophrenia. |
2007-11-05 |
2023-08-12 |
mouse |
| Roberto Vetrugno, Federica Provini, Pasquale Montagn. Restless legs syndrome and periodic limb movements. Reviews in neurological diseases. vol 3. issue 2. 2007-10-26. PMID:16820753. |
altered circadian rhythmicity in dopamine metabolism and enhanced circadian variations in dopaminergic functions have been reported in the disorder. |
2007-10-26 |
2023-08-12 |
Not clear |
| Roberto Vetrugno, Federica Provini, Pasquale Montagn. Restless legs syndrome and periodic limb movements. Reviews in neurological diseases. vol 3. issue 2. 2007-10-26. PMID:16820753. |
dysfunction or atrophy of a11 cells from the diencephalic-spinal dopamine a11 system has been suggested to explain the efficacy of dopaminergic drugs in relieving rls symptoms and the circadian rhythmicity of rls. |
2007-10-26 |
2023-08-12 |
Not clear |
| Hideko Yamamoto, Etsuko Kamegaya, Yoko Hagino, Kazuhide Imai, Akihiro Fujikawa, Kohei Tamura, Tomoyuki Enokiya, Toshifumi Yamamoto, Takao Takeshima, Hisashi Koga, George R Uhl, Kazutaka Ikeda, Ichiro Sor. Genetic deletion of vesicular monoamine transporter-2 (VMAT2) reduces dopamine transporter activity in mesencephalic neurons in primary culture. Neurochemistry international. vol 51. issue 2-4. 2007-10-25. PMID:17664021. |
we examined mesencephalon dopaminergic cultures prepared from vmat2 wild-type, heterozygous or homozygous knockout (ko) 14-day-old mouse fetuses to determine the number of tyrosine hydroxylase (th)-positive cells and dopamine transporter activity. |
2007-10-25 |
2023-08-12 |
mouse |