| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Bonci, P Grillner, N B Mercuri, G Bernard. L-Type calcium channels mediate a slow excitatory synaptic transmission in rat midbrain dopaminergic neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 18. issue 17. 1998-09-09. PMID:9712641. |
patch pipettes were used to record whole-cell synaptic currents under voltage-clamp in dopaminergic neurons in slices of rat substantia nigra pars compacta and ventral tegmental area. |
1998-09-09 |
2023-08-12 |
rat |
| E Bezard, C E Gros. Compensatory mechanisms in experimental and human parkinsonism: towards a dynamic approach. Progress in neurobiology. vol 55. issue 2. 1998-08-20. PMID:9618745. |
the intrinsic properties of the dopaminergic neurones of the substantia nigra pars compacta (snc) which degenerate during parkinson's disease are described in detail. |
1998-08-20 |
2023-08-12 |
human |
| I Nagatsu, K Ikemoto, T Takeuchi, R Arai, N Karasawa, T Fujii, T Nagats. Phenylethanolamine-N-methyltransferase - immunoreactive nerve terminals afferent to the mouse substantia nigra. Neuroscience letters. vol 245. issue 1. 1998-07-14. PMID:9596351. |
in the substantia nigra pars compacta, many phenylethanolamine-n-methyltransferase immunoreactive (pnmt-ir) terminals as well as serotonin-ir terminals were observed for the first time to be very closely situated to the tyrosine hydroxylase (th)-ir, aromatic l-amino acid decarboxylase-ir, and gtp cyclohydrolase i (gch)-ir dopaminergic cells [nagatsu, i., arai, r., sakai, m., yamawaki, y., takeuchi, t., karasawa, n. and nagatsu, t., neurosci. |
1998-07-14 |
2023-08-12 |
mouse |
| S Brené, C Messer, E J Nestle. Expression of messenger RNAs encoding ionotropic glutamate receptors in rat brain: regulation by haloperidol. Neuroscience. vol 84. issue 3. 1998-07-01. PMID:9579786. |
in the dopaminergic cell groups of the substantia nigra pars compacta and the ventral tegmental area, the flip form of both glur1 and glur2 dominated over the flop form. |
1998-07-01 |
2023-08-12 |
rat |
| M Gassen, A Gross, M B Youdi. Apomorphine enantiomers protect cultured pheochromocytoma (PC12) cells from oxidative stress induced by H2O2 and 6-hydroxydopamine. Movement disorders : official journal of the Movement Disorder Society. vol 13. issue 2. 1998-06-15. PMID:9539336. |
a significant body of evidence has been provided to support the hypothesis that oxidant stress may be responsible for the degeneration of dopaminergic neurons in the substantia nigra pars compacta in parkinson's disease. |
1998-06-15 |
2023-08-12 |
rat |
| N S Kolomeets, N A Uranov. [Synaptic contacts in schizophrenia: study with immunocytochemical identification of dopaminergic neurons]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. vol 97. issue 12. 1998-06-09. PMID:9591064. |
the altered presynaptic terminals were preferentially located on distal (small and middle diameter) tp dendrites in pars compacta of sn, where practically all dendrites revealed belonged to dopaminergic neurons and formed asymmetric contacts with short active zones in most cases. |
1998-06-09 |
2023-08-12 |
Not clear |
| R Kötter, M Feizelmeie. Species-dependence and relationship of morphological and electrophysiological properties in nigral compacta neurons. Progress in neurobiology. vol 54. issue 5. 1998-05-28. PMID:9550193. |
the use of animal models in studying disorders of dopaminergic transmission in humans, such as parkinson's disease, depends on the assumption that morphological and electrophysiological properties of dopaminergic neurons in the pars compacta of the substantia nigra are relatively constant from rodents to monkeys and humans. |
1998-05-28 |
2023-08-12 |
rat |
| S J Augood, J B Penney, I K Friberg, X O Breakefield, A B Young, L J Ozelius, D G Standaer. Expression of the early-onset torsion dystonia gene (DYT1) in human brain. Annals of neurology. vol 43. issue 5. 1998-05-21. PMID:9585364. |
the prominent expression of the dyt1 gene within the substantia nigra pars compacta, which provides dopaminergic innervation to the basal ganglia, implicates a disturbance of dopaminergic function in the pathophysiology of early-onset torsion dystonia. |
1998-05-21 |
2023-08-12 |
human |
| T Gasser, B Müller-Myhsok, Z K Wszolek, R Oehlmann, D B Calne, V Bonifati, B Bereznai, E Fabrizio, P Vieregge, R D Horstman. A susceptibility locus for Parkinson's disease maps to chromosome 2p13. Nature genetics. vol 18. issue 3. 1998-03-30. PMID:9500549. |
parkinson's disease (pd) is a common degenerative neurologic disorder, which is pathologically characterized by a selective degeneration of dopaminergic neurons of the substantia nigra pars compacta, and the presence of characteristic eosinophilic inclusions, known as lewy-bodies in affected brain areas. |
1998-03-30 |
2023-08-12 |
Not clear |
| M A Soriano, C Justicia, I Ferrer, E Rodríguez-Farré, A M Plana. Striatal infarction in the rat causes a transient reduction of tyrosine hydroxylase immunoreactivity in the ipsilateral substantia nigra. Neurobiology of disease. vol 4. issue 5. 1998-02-24. PMID:9440126. |
dopaminergic neurons of the substantia nigra pars compacta were examined in the rat brain following striatal infarction subsequent to transient focal cerebral ischemia. |
1998-02-24 |
2023-08-12 |
rat |
| M A Soriano, C Justicia, I Ferrer, E Rodríguez-Farré, A M Plana. Striatal infarction in the rat causes a transient reduction of tyrosine hydroxylase immunoreactivity in the ipsilateral substantia nigra. Neurobiology of disease. vol 4. issue 5. 1998-02-24. PMID:9440126. |
the present results show a transitory reduction of tyrosine hydroxylase immunoreactivity in the ipsilateral substantia nigra pars compacta after focal ischemia and suggest that striatal infarction causes a transient deficit of dopaminergic function. |
1998-02-24 |
2023-08-12 |
rat |
| E Floor, M G Wetze. Increased protein oxidation in human substantia nigra pars compacta in comparison with basal ganglia and prefrontal cortex measured with an improved dinitrophenylhydrazine assay. Journal of neurochemistry. vol 70. issue 1. 1998-02-02. PMID:9422371. |
our results suggest that oxidative stress is elevated in human substantia nigra pars compacta in comparison with other regions and that oxidative damage is higher within the dopaminergic neurons. |
1998-02-02 |
2023-08-12 |
human |
| Y Tashiro, J M Drake, S Chakrabortty, T Hattor. Functional injury of cholinergic, GABAergic and dopaminergic systems in the basal ganglia of adult rat with kaolin-induced hydrocephalus. Brain research. vol 770. issue 1-2. 1998-01-21. PMID:9372201. |
these findings suggest that progressive hydrocephalus results in functional injuries of cholinergic and gabaergic neurons in the neostriatum and dopaminergic neurons in the substantia nigra compacta by mechanical distortion. |
1998-01-21 |
2023-08-12 |
rat |
| U Wüllner, D G Standaert, C M Testa, J B Penney, A B Youn. Differential expression of kainate receptors in the basal ganglia of the developing and adult rat brain. Brain research. vol 768. issue 1-2. 1997-12-18. PMID:9369318. |
glur6 was highly expressed in the striatum and subthalamic nucleus and to a lesser extent in the substantia nigra pars reticulata, while no hybridization signal was detectable in the large, presumably dopaminergic neurons of the substantia nigra pars compacta. |
1997-12-18 |
2023-08-12 |
rat |
| G Murer, C Adelbrecht, I Lauritzen, F Lesage, M Lazdunski, Y Agid, R Raisman-Vozar. An immunocytochemical study on the distribution of two G-protein-gated inward rectifier potassium channels (GIRK2 and GIRK4) in the adult rat brain. Neuroscience. vol 80. issue 2. 1997-10-17. PMID:9284339. |
the presence of g-protein-gated inward rectifier potassium channel-2 immunoreactivity in substantia nigra pars compacta dopaminergic neurons was confirmed by showing its co-localization with tyrosine hydroxylase by double immunocytochemistry, and also by selectively lesioning dopaminergic neurons with the neurotoxin 6-hydroxydopamine. |
1997-10-17 |
2023-08-12 |
human |
| A Rohlfs, G Nikkhah, C Rosenthal, C Rundfeldt, A Brandis, M Samii, W Lösche. Hemispheric asymmetries in spontaneous firing characteristics of substantia nigra pars reticulata neurons following a unilateral 6-hydroxydopamine lesion of the rat nigrostriatal pathway. Brain research. vol 761. issue 2. 1997-09-24. PMID:9252038. |
single unit activity of substantia nigra pars reticulata (snr) neurons was recorded bilaterally in rats subjected to unilateral 6-hydroxydopamine lesions of the ascending mesostriatal dopaminergic pathway, resulting in an almost complete loss of dopaminergic neurons in the ipsilateral sn pars compacta. |
1997-09-24 |
2023-08-12 |
rat |
| J P Sheehan, P E Palmer, G A Helm, J B Tuttl. MPP+ induced apoptotic cell death in SH-SY5Y neuroblastoma cells: an electron microscope study. Journal of neuroscience research. vol 48. issue 3. 1997-08-05. PMID:9160245. |
pd is a common, late-onset neurodegenerative disorder that results in part from the gradual loss of dopaminergic neurons in the substantia nigra pars compacta. |
1997-08-05 |
2023-08-12 |
human |
| H Allain, D Bentué-Ferre. [Parkinson disease: interrogations and solutions]. Presse medicale (Paris, France : 1983). vol 26. issue 19. 1997-08-04. PMID:9232065. |
a neurodegenerative disease: idiopathic parkinson's disease is initially due to a selective and specific destruction of the pars compacta dopaminergic neurons in substantia nigra. |
1997-08-04 |
2023-08-12 |
Not clear |
| A F Miranda, R J Boegman, R J Beninger, K Jhamanda. Protection against quinolinic acid-mediated excitotoxicity in nigrostriatal dopaminergic neurons by endogenous kynurenic acid. Neuroscience. vol 78. issue 4. 1997-07-22. PMID:9174065. |
endogenous excitotoxins have been implicated in the degeneration of dopaminergic neurons in the substantia nigra compacta of patients with parkinson's disease. |
1997-07-22 |
2023-08-12 |
rat |
| E Nalivaiko, J C Michaud, P Soubrié, G Le Fur, P Felt. Tachykinin neurokinin-1 and neurokinin-3 receptor-mediated responses in guinea-pig substantia nigra: an in vitro electrophysiological study. Neuroscience. vol 78. issue 3. 1997-07-21. PMID:9153655. |
although this value was significantly higher than that found for dopaminergic neurons in the pars compacta, senktide-evoked responses were inhibited by sr 142801 (100 nm; n=3). |
1997-07-21 |
2023-08-12 |
Not clear |