| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Richter, U Ebert, J N Nobrega, J J Vallbacka, M Fedrowitz, W Lösche. Immunohistochemical and neurochemical studies on nigral and striatal functions in the circling (ci) rat, a genetic animal model with spontaneous rotational behavior. Neuroscience. vol 89. issue 2. 1999-05-07. PMID:10077328. |
immunohistochemical labeling of dopaminergic neurons and fibers in substantia nigra pars compacta, ventral tegmental area, and striatum did not indicate any significant neurodegeneration or asymmetry that could explain the lateralization in dopamine levels in striatum of ci rats. |
1999-05-07 |
2023-08-12 |
rat |
| D A McRitchie, H Cartwright, S M Pond, C J van der Schyf, N Castagnoli, D G van der Nest, G M Hallida. The midbrain dopaminergic cell groups in the baboon Papio ursinus. Brain research bulletin. vol 47. issue 6. 1999-05-06. PMID:10078618. |
the major difference between the organization of human and baboon midbrain dopaminergic neurons is the anteroposterior extent of the dense cell clusters within the sn pars compacta. |
1999-05-06 |
2023-08-12 |
human |
| D S Albers, S W Weiss, M J Iadarola, D G Standaer. Immunohistochemical localization of N-methyl-D-aspartate and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor subunits in the substantia nigra pars compacta of the rat. Neuroscience. vol 89. issue 1. 1999-04-26. PMID:10051230. |
together, these data demonstrate that dopaminergic neurons in the substantia nigra pars compacta express primarily glutamate receptor 1, glutamate receptor 2/3 and n-methyl-d-aspartate receptor 1 isoforms containing the alternative c2' terminus. |
1999-04-26 |
2023-08-12 |
rat |
| T L Walters, I Irwin, K Delfani, J W Langston, A M Janso. Diethyldithiocarbamate causes nigral cell loss and dopamine depletion with nontoxic doses of MPTP. Experimental neurology. vol 156. issue 1. 1999-04-21. PMID:10192777. |
the purpose of the present study was twofold: (i) to carefully characterize the effects of ddc on mptp-induced degeneration of dopaminergic neurons in substantia nigra pars compacta using unbiased, stereological cell counting techniques and (ii) to determine whether or not ddc can convert a nontoxic dose of mptp into one which is clearly toxic on dopaminergic neurons in the substantia nigra. |
1999-04-21 |
2023-08-12 |
mouse |
| J M Burgunde. Pathophysiology of akinetic movement disorders: a paradigm for studies in fibromyalgia? Zeitschrift fur Rheumatologie. vol 57 Suppl 2. 1999-04-07. PMID:10025078. |
the reason of this dysfunction in parkinson's disease is a decreased nigral dopaminergic efferent innervation due to a neuronal degeneration in the pars compacta of the substantia nigra. |
1999-04-07 |
2023-08-12 |
Not clear |
| A Volenec, T S Zetterström, T P Flaniga. 6-OHDA denervation substantially decreases DCC mRNA levels in rat substantia nigra compacta. Neuroreport. vol 9. issue 16. 1999-02-26. PMID:9858358. |
recently the transcript encoding dcc has been shown to be expressed in a variety of rat brain regions, including the substantia nigra pars compacta and the striatum, which encompasses the nigrostriatal dopaminergic system. |
1999-02-26 |
2023-08-12 |
rat |
| T Nishio, S Furukawa, I Akiguchi, N Sunohar. Medial nigral dopamine neurons have rich neurotrophin support in humans. Neuroreport. vol 9. issue 12. 1998-12-29. PMID:9760132. |
to assess the action of neurotrophin in human dopaminergic neurons, we studied the immunolocalization of neurotrophins or trks in human substantia nigra pars compacta (snc). |
1998-12-29 |
2023-08-12 |
human |
| C Flores, D Rodaros, J Stewar. Long-lasting induction of astrocytic basic fibroblast growth factor by repeated injections of amphetamine: blockade by concurrent treatment with a glutamate antagonist. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 18. issue 22. 1998-12-11. PMID:9801391. |
these changes are initiated by drug actions in the somatodendritic regions of midbrain dopaminergic neurons in the ventral tegmental area (vta) and substantia nigra pars compacta (snc) and continue to develop for a period of time after termination of drug treatment. |
1998-12-11 |
2023-08-12 |
Not clear |
| E M Sorenson, T Shiroyama, S T Kita. Postsynaptic nicotinic receptors on dopaminergic neurons in the substantia nigra pars compacta of the rat. Neuroscience. vol 87. issue 3. 1998-12-03. PMID:9758232. |
postsynaptic nicotinic receptors on dopaminergic neurons in the substantia nigra pars compacta of the rat. |
1998-12-03 |
2023-08-12 |
rat |
| E M Sorenson, T Shiroyama, S T Kita. Postsynaptic nicotinic receptors on dopaminergic neurons in the substantia nigra pars compacta of the rat. Neuroscience. vol 87. issue 3. 1998-12-03. PMID:9758232. |
previous studies have shown that application of nicotinic agonists in the substantia nigra pars compacta increases the firing rate of dopaminergic neurons. |
1998-12-03 |
2023-08-12 |
rat |
| K K Yung, Y C Tse, Z G Gao, S Y Choi, F S Kwo. Localization of GABA transaminase immunoreactivity in the rat substantia nigra pars reticulata. Neuroscience letters. vol 253. issue 1. 1998-12-02. PMID:9754804. |
in order to characterize the gaba(t)-immunoreactive neurons, double immunocytochemistry was also performed using tyrosine hydroxylase (th) as a neurochemical marker for dopaminergic neurons in the substantia nigra pars compacta (snc). |
1998-12-02 |
2023-08-12 |
rat |
| G Di Giovanni, M Di Mascio, V Di Matteo, E Esposit. Effects of acute and repeated administration of amisulpride, a dopamine D2/D3 receptor antagonist, on the electrical activity of midbrain dopaminergic neurons. The Journal of pharmacology and experimental therapeutics. vol 287. issue 1. 1998-11-05. PMID:9765321. |
electrophysiological techniques were used to study the effects of amisulpride, a d2/d3 dopamine receptor blocker, on the activity of dopaminergic neurons in the substantia nigra pars compacta (snc) and the ventral tegmental area (vta). |
1998-11-05 |
2023-08-12 |
Not clear |
| C M Kosinski, D G Standaert, C M Testa, J B Penney, A B Youn. Expression of metabotropic glutamate receptor 1 isoforms in the substantia nigra pars compacta of the rat. Neuroscience. vol 86. issue 3. 1998-10-29. PMID:9692717. |
metabotropic glutamate receptors, which are linked via g-proteins to second messenger systems, have been implicated in the physiological regulation of dopaminergic neurons of the substantia nigra pars compacta as well as in neurodegeneration. |
1998-10-29 |
2023-08-12 |
human |
| C M Kosinski, D G Standaert, C M Testa, J B Penney, A B Youn. Expression of metabotropic glutamate receptor 1 isoforms in the substantia nigra pars compacta of the rat. Neuroscience. vol 86. issue 3. 1998-10-29. PMID:9692717. |
these data demonstrate that metabotropic glutamate receptor 1 protein is present within the perikarya and processes of dopaminergic neurons in the substantia nigra pars compacta. |
1998-10-29 |
2023-08-12 |
human |
| S Benisty, F Boissiere, B Faucheux, Y Agid, E C Hirsc. trkB messenger RNA expression in normal human brain and in the substantia nigra of parkinsonian patients: an in situ hybridization study. Neuroscience. vol 86. issue 3. 1998-10-29. PMID:9692719. |
combined immunohistochemistry for tyrosine hydroxylase and in situ hybridization for trkb messenger rna showed that within the substantia nigra pars compacta a major proportion of dopaminergic neurons expressed trkb messenger rna. |
1998-10-29 |
2023-08-12 |
human |
| M Gassen, A Gross, M B Youdi. Apomorphine enantiomers protect cultured pheochromocytoma (PC12) cells from oxidative stress induced by H2O2 and 6-hydroxydopamine. Movement disorders : official journal of the Movement Disorder Society. vol 13. issue 4. 1998-10-28. PMID:9686771. |
a significant body of evidence has been provided to support the hypothesis that oxidant stress may be responsible for the degeneration of dopaminergic neurons in the substantia nigra pars compacta in parkinson's disease. |
1998-10-28 |
2023-08-12 |
rat |
| T Hashimoto, H Mukai, T Kawamata, T Taniguchi, Y Ono, C Tanak. Localization of PKN mRNA in the rat brain. Brain research. Molecular brain research. vol 59. issue 2. 1998-10-28. PMID:9729343. |
pkn mrna was also highly expressed in dopaminergic neurons such as the ventral tegmental area and substantia nigra pars compacta, in serotonergic raphe neurons, and in cholinergic neurons such as nucleus diagonal band, nucleus basalis, and lateral dorsal tegmental nucleus. |
1998-10-28 |
2023-08-12 |
rat |
| K X Huang, D A Bergstrom, D N Ruskin, J R Walter. N-methyl-D-aspartate receptor blockade attenuates D1 dopamine receptor modulation of neuronal activity in rat substantia nigra. Synapse (New York, N.Y.). vol 30. issue 1. 1998-10-22. PMID:9704877. |
the present study examined whether n-methyl-d-aspartate (nmda) receptor antagonists affect the neurophysiological responses of substantia nigra pars compacta (snpc; dopaminergic) and pars reticulata (snpr; non-dopaminergic) neurons to a systemically administered d1 dopamine agonist in two animals models of parkinson's disease, reserpine treatment and nigrostriatal lesion. |
1998-10-22 |
2023-08-12 |
rat |
| N A Tatton, A Maclean-Fraser, W G Tatton, D P Perl, C W Olano. A fluorescent double-labeling method to detect and confirm apoptotic nuclei in Parkinson's disease. Annals of neurology. vol 44. issue 3 Suppl 1. 1998-10-07. PMID:9749586. |
preliminary findings indicate that dopaminergic neurons in the substantia nigra compacta die via apoptosis in parkinson's disease. |
1998-10-07 |
2023-08-12 |
Not clear |
| M C Rodriguez, J A Obeso, C W Olano. Subthalamic nucleus-mediated excitotoxicity in Parkinson's disease: a target for neuroprotection. Annals of neurology. vol 44. issue 3 Suppl 1. 1998-10-07. PMID:9749591. |
in addition, stn neurons provide excitatory innervation to dopaminergic (da) neurons in the substantia nigra pars compacta (snc) that contain glutamate receptors. |
1998-10-07 |
2023-08-12 |
Not clear |