| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| G Dziewczapolski, G Murer, Y Agid, O Gershanik, R Raisman-Vozar. Absence of neurotoxicity of chronic L-DOPA in 6-hydroxydopamine-lesioned rats. Neuroreport. vol 8. issue 4. 1997-07-14. PMID:9141075. |
we investigated the effects of 6 months' oral treatment with l-dihydroxy-phenylalanine (l-dopa)/carbidopa on the remaining dopaminergic neurones of the substantia nigra pars compacta (snc) and the ventral tegmental area (vta) of rats with moderate or severe 6-hydroxydopamine (6-ohda)-induced lesions and sham-operated animals. |
1997-07-14 |
2023-08-12 |
rat |
| O K Hassani, C François, J Yelnik, J Fége. Evidence for a dopaminergic innervation of the subthalamic nucleus in the rat. Brain research. vol 749. issue 1. 1997-06-10. PMID:9070631. |
the dopaminergic connection from the substantia nigra pars compacta (snc) and the ventral tegmental area (vta) to the subthalamic nucleus in the rat was investigated using anterograde and retrograde tracers. |
1997-06-10 |
2023-08-12 |
rat |
| M Chritin, V Blanchard, R Raisman-Vozari, C Feuerstein, Y Agid, F Javoy-Agid, M Savast. DA uptake sites, D1 and D2 receptors, D2 and preproenkephalin mRNAs and Fos immunoreactivity in rat striatal subregions after partial dopaminergic degeneration. The European journal of neuroscience. vol 8. issue 12. 1997-05-29. PMID:8996800. |
autoradiography of dopaminergic uptake sites performed with a specific marker ([3h]gbr 12935) allowed the precise determination of dopaminergic denervated and non-denervated areas in the striatum 1 month after partial lesion of the substantia nigra pars compacta. |
1997-05-29 |
2023-08-12 |
rat |
| P Szot, C E Reigel, S S White, R C Veit. Alterations in mRNA expression of systems that regulate neurotransmitter synaptic content in seizure-naive genetically epilepsy-prone rat (GEPR): transporter proteins and rate-limiting synthesizing enzymes for norepinephrine, dopamine and serotonin. Brain research. Molecular brain research. vol 43. issue 1-2. 1997-05-29. PMID:9037538. |
th and da transporter (dat) mrna was measured in the dopaminergic neurons of the substantia nigra pars compacta (snpc), ventral tegmental area (vta) and zona incerta (zi), dat mrna level was significantly reduced in all dopaminergic neurons in the gepr-3 compared to sd rats and gepr-9, while th mrna level was significantly elevated in the snpc/vta equally in gepr-3 and gepr-9 compared to sd rats. |
1997-05-29 |
2023-08-12 |
rat |
| C Adelbrecht, Y Agid, R Raisman-Vozar. Effect of the weaver mutation on the expression of dopamine membrane transporter, tyrosine hydroxylase and vesicular monoamine transporter in dopaminergic neurons of the substantia nigra and the ventral tegmental area. Brain research. Molecular brain research. vol 43. issue 1-2. 1997-05-29. PMID:9037545. |
quantitative in situ hybridization of three different dopaminergic markers: dopamine membrane transporter (dat), tyrosine hydroxylase (th), and vesicular monoamine transporter (vmat2) was performed on individual dopaminergic cells of the substantia nigra pars compacta (snc) and the ventral tegmental area (vta) in 2-month-old wv/wv mice, in order to investigate the metabolic state of remaining dopaminergic cell bodies and gain further insight into modifications observed on dopaminergic nerve terminals in the striatum and the nucleus accumbens. |
1997-05-29 |
2023-08-12 |
mouse |
| C D Hardman, G M Halliday, D A McRitchie, H R Cartwright, J G Morri. Progressive supranuclear palsy affects both the substantia nigra pars compacta and reticulata. Experimental neurology. vol 144. issue 1. 1997-05-20. PMID:9126169. |
severe neurodegeneration within the dopaminergic pars compacta was seen in all cases of progressive supranuclear palsy and all cases of parkinson's disease compared with controls. |
1997-05-20 |
2023-08-12 |
Not clear |
| C D Hardman, G M Halliday, D A McRitchie, H R Cartwright, J G Morri. Progressive supranuclear palsy affects both the substantia nigra pars compacta and reticulata. Experimental neurology. vol 144. issue 1. 1997-05-20. PMID:9126169. |
our results show that both the dopaminergic pars compacta and the gabaergic pars reticulata are significantly damaged in cases of progressive supranuclear palsy. |
1997-05-20 |
2023-08-12 |
Not clear |
| J Fallon, R T Matthews, B T Hyman, M F Bea. MPP+ produces progressive neuronal degeneration which is mediated by oxidative stress. Experimental neurology. vol 144. issue 1. 1997-05-20. PMID:9126170. |
when injected into the striatum mpp+ is accumulated by dopaminergic nerve terminals and is then retrogradely transported to the substantia nigra compacta. |
1997-05-20 |
2023-08-12 |
rat |
| V Blanchard, P Anglade, G Dziewczapolski, M Savasta, Y Agid, R Raisman-Vozar. Dopaminergic sprouting in the rat striatum after partial lesion of the substantia nigra. Brain research. vol 709. issue 2. 1997-05-01. PMID:8833770. |
the capacity of the dopaminergic nerve system to reinnervate the denervated adult striatum was analyzed in a model of partial 6-hydroxydopamine-induced unilateral lesion of rat substantia nigra pars compacta. |
1997-05-01 |
2023-08-12 |
rat |
| H Moukhles, O Bosler, J P Bolam, A Vallée, D Umbriaco, M Geffard, G Douce. Quantitative and morphometric data indicate precise cellular interactions between serotonin terminals and postsynaptic targets in rat substantia nigra. Neuroscience. vol 76. issue 4. 1997-04-29. PMID:9027876. |
they indicate that this dense serotonin input to the substantia nigra is very precisely organized, acting through both "non-junctional" and "junctional" modes of neurotransmission in the pars compacta, which projects to the neostriatum and the limbic system, whereas the predominant mode of serotonin transmission appears to be of the "junctional" type in the pars reticulata, where serotonin can finely control the motor output of the basal ganglia by acting on the gaba projection neurons either directly or through the local release of dopamine by dopaminergic dendrites. |
1997-04-29 |
2023-08-12 |
rat |
| T Deacon, J Schumacher, J Dinsmore, C Thomas, P Palmer, S Kott, A Edge, D Penney, S Kassissieh, P Dempsey, O Isacso. Histological evidence of fetal pig neural cell survival after transplantation into a patient with Parkinson's disease. Nature medicine. vol 3. issue 3. 1997-04-01. PMID:9055867. |
the movement disorder in parkinson's disease results from the selective degeneration of a small group of dopaminergic neurons in the substantia nigra pars compacta region of the brain. |
1997-04-01 |
2023-08-12 |
human |
| M D Bevan, A D Smith, J P Bola. The substantia nigra as a site of synaptic integration of functionally diverse information arising from the ventral pallidum and the globus pallidus in the rat. Neuroscience. vol 75. issue 1. 1997-03-25. PMID:8923517. |
by double anterograde tracing and immunocytochemistry at both the light and electron microscopic levels, we show that individual neurons in the substantia nigra pars reticulata and dopaminergic neurons in the pars compacta each receive multiple gabaergic synaptic inputs both from neurons in the ventral pallidum (which receive input from limbic areas via the nucleus accumbens) and from neurons in the globus pallidus (which receive input from associative and sensorimotor cortices via the neostriatum). |
1997-03-25 |
2023-08-12 |
rat |
| G Trépanier, D Furling, J Puymirat, M E Miraul. Immunocytochemical localization of seleno-glutathione peroxidase in the adult mouse brain. Neuroscience. vol 75. issue 1. 1997-03-25. PMID:8923537. |
similarly, many dopaminergic neurons of the substantia nigra pars compacta expressed low levels of glutathione peroxidase antigen, in contrast to the ventral tegmental area, wherein most catecholaminergic cells were strongly positive. |
1997-03-25 |
2023-08-12 |
mouse |
| C L Liang, C M Sinton, D C Germa. Midbrain dopaminergic neurons in the mouse: co-localization with Calbindin-D28K and calretinin. Neuroscience. vol 75. issue 2. 1997-03-14. PMID:8931015. |
midbrain dopaminergic neurons were examined at four rostrocaudal levels, and the percentage of cells that contained both tyrosine hydroxylase and either of the two calcium-binding proteins was determined in nucleus a8 (retrorubral field), nucleus a9 (substantia nigra pars compacta, pars reticulata and pars lateralis) and nucleus a10 (nucleus paranigralis, ventral tegmental area, interfascicular nucleus, central linear nucleus). |
1997-03-14 |
2023-08-12 |
mouse |
| Y X Li, R Bertram, J Rinze. Modeling N-methyl-D-aspartate-induced bursting in dopamine neurons. Neuroscience. vol 71. issue 2. 1997-03-13. PMID:9053795. |
burst firing of dopaminergic neurons of the substantia nigra pars compacta can be induced in vitro by the glutamate agonist n-methyl-d-aspartate. |
1997-03-13 |
2023-08-12 |
Not clear |
| K E Bowenkamp, D David, P L Lapchak, M A Henry, A C Granholm, B J Hoffer, T J Mahali. 6-hydroxydopamine induces the loss of the dopaminergic phenotype in substantia nigra neurons of the rat. A possible mechanism for restoration of the nigrostriatal circuit mediated by glial cell line-derived neurotrophic factor. Experimental brain research. vol 111. issue 1. 1997-03-11. PMID:8891630. |
intraparenchymal injections of the neurotoxin 6-hydroxydopamine (6-ohda) into the medial forebrain bundle in rats destroys the dopaminergic neurons in the pars compacta of the substantia nigra. |
1997-03-11 |
2023-08-12 |
rat |
| M Paquet, M Tremblay, J J Soghomonian, Y Smit. AMPA and NMDA glutamate receptor subunits in midbrain dopaminergic neurons in the squirrel monkey: an immunohistochemical and in situ hybridization study. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 17. issue 4. 1997-03-10. PMID:9006980. |
colocalization studies show that nearly all dopaminergic neurons in both the ventral and dorsal tiers of the substantia nigra compacta (snc-v, snc-d) and the ventral tegmental area (vta) are immunoreactive for ampa (glur1, glur2/3, and glur4) and nmdar1 receptor subunits, but not for nmdar2a/b subunits. |
1997-03-10 |
2023-08-12 |
squirrel_monkey |
| K V Baev, K A Greene, F F Marciano, A G Shetter, A N Lieberman, R F Spetzle. Novel heuristics of functional neural networks: implications for future strategies in functional neurosurgery. Stereotactic and functional neurosurgery. vol 65. issue 1-4. 1997-02-27. PMID:8916326. |
a hypothesis is proposed that (a) the skeletomotor basal ganglia-thalamocortical loop functions as a model of the behavior of the body and the environment, and that (b) dopaminergic neurons of the substantia nigra pars compacta comprise the substrates of an error distribution system projecting to the striatum. |
1997-02-27 |
2023-08-12 |
Not clear |
| H L Wang, T W. G alpha q/11 mediates neurotensin excitation of substantia nigra dopaminergic neurons. Brain research. Molecular brain research. vol 36. issue 1. 1997-02-06. PMID:9011762. |
using acutely dissociated substantia nigra pars compacta (snc) dopaminergic (da) neurons, our previous studies indicated that neurotensin (nt) excites snc da neurons by increasing the cationic conductance and reducing the inwardly rectifying k+ conductance. |
1997-02-06 |
2023-08-12 |
Not clear |
| J L Montastruc, O Rascol, J M Senar. New directions in the drug treatment of Parkinson's disease. Drugs & aging. vol 9. issue 3. 1997-01-21. PMID:8877311. |
parkinson's disease, a clinical syndrome with 4 cardinal features (bradykinesia, resting tremor, increased muscular rigidity and impaired postural balance), is mainly caused by the loss of dopaminergic neurons in the substantia nigra pars compacta. |
1997-01-21 |
2023-08-12 |
Not clear |