| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A P Payne, J M Campbell, D Russell, G Favor, R G Sutcliffe, N K Bennett, R W Davies, T W Ston. The AS/AGU rat: a spontaneous model of disruption and degeneration in the nigrostriatal dopaminergic system. Journal of anatomy. vol 196 ( Pt 4). 2000-08-22. PMID:10923993. |
subsequently a depletion of whole tissue dopamine levels occurs and, later still, loss of dopaminergic cells in the substantia nigra pars compacta. |
2000-08-22 |
2023-08-12 |
rat |
| F Blandini, G Nappi, C Tassorelli, E Martignon. Functional changes of the basal ganglia circuitry in Parkinson's disease. Progress in neurobiology. vol 62. issue 1. 2000-08-15. PMID:10821982. |
in parkinson's disease, the degeneration of dopaminergic neurons of the substantia nigra pars compacta triggers a cascade of functional changes affecting the whole basal ganglia network. |
2000-08-15 |
2023-08-12 |
Not clear |
| F Blandini, G Nappi, C Tassorelli, E Martignon. Functional changes of the basal ganglia circuitry in Parkinson's disease. Progress in neurobiology. vol 62. issue 1. 2000-08-15. PMID:10821982. |
in particular, given the reciprocal innervation of the substantia nigra pars compacta and the subthalamic nucleus, the dopaminergic deficit might influence the subthalamic activity, directly. |
2000-08-15 |
2023-08-12 |
Not clear |
| E Perry, C Martin-Ruiz, M Lee, M Griffiths, M Johnson, M Piggott, V Haroutunian, J D Buxbaum, J Nãsland, K Davis, C Gotti, F Clementi, S Tzartos, O Cohen, H Soreq, E Jaros, R Perry, C Ballard, I McKeith, J Cour. Nicotinic receptor subtypes in human brain ageing, Alzheimer and Lewy body diseases. European journal of pharmacology. vol 393. issue 1-3. 2000-08-11. PMID:10771016. |
tobacco use in normal elderly individuals is associated with increased alpha4 immunoreactivity in the cortex and lower densities of amyloid-beta plaques, and with greater numbers of dopaminergic neurons in the substantia nigra pars compacta. |
2000-08-11 |
2023-08-12 |
mouse |
| K Tsuboi, T A Kimber, C W Shult. Calretinin-containing axons and neurons are resistant to an intrastriatal 6-hydroxydopamine lesion. Brain research. vol 866. issue 1-2. 2000-08-07. PMID:10825480. |
dopaminergic neurons containing cr in the substantia nigra pars compacta (snpc) were relatively spared compared to those that did not contain cr. |
2000-08-07 |
2023-08-12 |
rat |
| X Lu, G Bing, T Hag. Naloxone prevents microglia-induced degeneration of dopaminergic substantia nigra neurons in adult rats. Neuroscience. vol 97. issue 2. 2000-07-27. PMID:10799760. |
here, we tested in adult rats whether injection of bacterial lipopolysaccharide (which causes inflammation and microglial activation) just above the substantia nigra, results in the death of dopaminergic substantia nigra pars compacta neurons. |
2000-07-27 |
2023-08-12 |
rat |
| A Fernandez-Gonzalez, I Pérez-Otaño, J I Morga. MPTP selectively induces haem oxygenase-1 expression in striatal astrocytes. The European journal of neuroscience. vol 12. issue 5. 2000-07-24. PMID:10792435. |
parkinson's disease (pd) is characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta with accompanying evidence of increased oxidative damage, deficits in mitochondrial function and iron deposition. |
2000-07-24 |
2023-08-12 |
mouse |
| D I Finkelstein, D Stanic, C L Parish, D Tomas, K Dickson, M K Horn. Axonal sprouting following lesions of the rat substantia nigra. Neuroscience. vol 97. issue 1. 2000-06-23. PMID:10877666. |
parkinson's disease is characterized by the progressive loss of dopaminergic neurons in the substantia nigra pars compacta. |
2000-06-23 |
2023-08-12 |
rat |
| D I Finkelstein, D Stanic, C L Parish, D Tomas, K Dickson, M K Horn. Axonal sprouting following lesions of the rat substantia nigra. Neuroscience. vol 97. issue 1. 2000-06-23. PMID:10877666. |
this study quantified the extent of compensatory axonal sprouting following injury of dopaminergic neurons within the substantia nigra pars compacta. |
2000-06-23 |
2023-08-12 |
rat |
| D I Finkelstein, D Stanic, C L Parish, D Tomas, K Dickson, M K Horn. Axonal sprouting following lesions of the rat substantia nigra. Neuroscience. vol 97. issue 1. 2000-06-23. PMID:10877666. |
it was concluded that substantial compensation in the form of sprouting and new dopaminergic synapse formation occurs following lesions of the substantia nigra pars compacta. |
2000-06-23 |
2023-08-12 |
rat |
| P Shashidharan, B C Kramer, R H Walker, C W Olanow, M F Bri. Immunohistochemical localization and distribution of torsinA in normal human and rat brain. Brain research. vol 853. issue 2. 2000-06-21. PMID:10640617. |
immunohistochemical studies of normal human and rat brain reveal the presence of torsina in the dopaminergic neurons of the substantia nigra pars compacta (snc), in addition to many other regions, including neocortex, hippocampus, and cerebellum. |
2000-06-21 |
2023-08-12 |
human |
| C J Wilson, J C Callawa. Coupled oscillator model of the dopaminergic neuron of the substantia nigra. Journal of neurophysiology. vol 83. issue 5. 2000-06-14. PMID:10805703. |
calcium imaging using fura-2 and whole cell recording revealed the effective location of the oscillator mechanism on dopaminergic neurons of the substantia nigra, pars compacta, in slices from rats aged 15-20 days. |
2000-06-14 |
2023-08-12 |
rat |
| A Rosell, J M Giménez Amay. Considerations upon the anatomical model of reward-based learning in the basal ganglia. Medical hypotheses. vol 54. issue 3. 2000-06-08. PMID:10783473. |
the dopaminergic neurons in the substantia nigra pars compacta (snc) fire in relation to primary rewards and reward-conditioned stimuli, but not to rewards that are expected. |
2000-06-08 |
2023-08-12 |
Not clear |
| F Yantiri, J K Anderse. The role of iron in Parkinson disease and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity. IUBMB life. vol 48. issue 2. 2000-05-25. PMID:10794588. |
parkinson disease (pd) involves the specific degeneration of dopaminergic neurons of the pars compacta of the substantia nigra. |
2000-05-25 |
2023-08-12 |
Not clear |
| P Cazorla, M P Smidt, K L O'Malley, J P Burbac. A response element for the homeodomain transcription factor Ptx3 in the tyrosine hydroxylase gene promoter. Journal of neurochemistry. vol 74. issue 5. 2000-05-25. PMID:10800925. |
we recently isolated a homeodomain transcription factor, named ptx3, that is uniquely expressed in the dopaminergic neurons of the substantia nigra pars compacta and ventral tegmental area, which together form the mesencephalic dopaminergic system. |
2000-05-25 |
2023-08-12 |
human |
| A Hartmann, S Hunot, P P Michel, M P Muriel, S Vyas, B A Faucheux, A Mouatt-Prigent, H Turmel, A Srinivasan, M Ruberg, G I Evan, Y Agid, E C Hirsc. Caspase-3: A vulnerability factor and final effector in apoptotic death of dopaminergic neurons in Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. vol 97. issue 6. 2000-04-25. PMID:10688892. |
using caspase-3 immunohistochemistry on the postmortem human brain, we observed a positive correlation between the degree of neuronal loss in dopaminergic (da) cell groups affected in the mesencephalon of pd patients and the percentage of caspase-3-positive neurons in these cell groups in control subjects and a significant decrease of caspase-3-positive pigmented neurons in the substantia nigra pars compacta of pd patients compared with controls that also could be observed in an animal model of pd. |
2000-04-25 |
2023-08-12 |
human |
| B G Kim, D H Shin, G S Jeon, J H Seo, Y W Kim, B S Jeon, S S Ch. Relative sparing of calretinin containing neurons in the substantia nigra of 6-OHDA treated rat parkinsonian model. Brain research. vol 855. issue 1. 2000-03-17. PMID:10650144. |
using the 6-ohda induced rat parkinsonian model, we examined if calretinin (cr), one of cabp family, could play the similar role in the parkinson's disease because cr is profusely localized in dopaminergic neurons of the substantia nigra pars compacta (snpc) of the rat. |
2000-03-17 |
2023-08-12 |
rat |
| A Charara, T C Heilman, A I Levey, Y Smit. Pre- and postsynaptic localization of GABA(B) receptors in the basal ganglia in monkeys. Neuroscience. vol 95. issue 1. 2000-01-31. PMID:10619469. |
in the striatum, interneurons were more strongly stained than medium-sized projection neurons while in the substantia nigra, dopaminergic neurons of the pars compacta were much more intensely labeled than gabaergic neurons of the pars reticulata. |
2000-01-31 |
2023-08-12 |
monkey |
| T Hida, Y Hasegawa, R Ara. Histochemical study of dopamine-degrading monoamine oxidase activity in dopaminergic neurons of rat brain. Brain research. vol 842. issue 2. 1999-12-21. PMID:10526149. |
the following dopaminergic cell groups were examined: a16 (glomerular layer of the olfactory bulb), a14 (hypothalamic periventricular region), a13 (zona incerta), a12 (arcuate nucleus), a11 (periventricular gray matter of the caudal thalamus), a10 (ventral tegmental area), a9 (substantia nigra pars compacta, snc) and a8 (retrorubral nucleus). |
1999-12-21 |
2023-08-12 |
rat |
| R L Klein, M H Lewis, N Muzyczka, E M Meye. Prevention of 6-hydroxydopamine-induced rotational behavior by BDNF somatic gene transfer. Brain research. vol 847. issue 2. 1999-12-21. PMID:10575102. |
brain-derived neurotrophic factor (bdnf) was expressed via injection of viral vector into the substantia nigra pars compacta (snc) to investigate its influence on nigrostriatal dopaminergic activity and locomotor behavior. |
1999-12-21 |
2023-08-12 |
Not clear |