| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nicola J Drummond, Karamjit Singh Dolt, Maurice A Canham, Peter Kilbride, G John Morris, Tilo Kunat. Cryopreservation of Human Midbrain Dopaminergic Neural Progenitor Cells Poised for Neuronal Differentiation. Frontiers in cell and developmental biology. vol 8. 2021-03-17. PMID:33224948. |
cryopreservation of human midbrain dopaminergic neural progenitor cells poised for neuronal differentiation. |
2021-03-17 |
2023-08-13 |
human |
| Nicola J Drummond, Karamjit Singh Dolt, Maurice A Canham, Peter Kilbride, G John Morris, Tilo Kunat. Cryopreservation of Human Midbrain Dopaminergic Neural Progenitor Cells Poised for Neuronal Differentiation. Frontiers in cell and developmental biology. vol 8. 2021-03-17. PMID:33224948. |
human pluripotent stem cells can be differentiated into midbrain dopaminergic (mda) neurons by directing cells through a floor plate progenitor stage. |
2021-03-17 |
2023-08-13 |
human |
| Bing Gong, Lingling Jiao, Xixun Du, Yong Li, Mingxia Bi, Qian Jiao, Hong Jian. Ghrelin promotes midbrain neural stem cells differentiation to dopaminergic neurons through Wnt/β-catenin pathway. Journal of cellular physiology. vol 235. issue 11. 2021-03-16. PMID:32329059. |
ghrelin promotes midbrain neural stem cells differentiation to dopaminergic neurons through wnt/β-catenin pathway. |
2021-03-16 |
2023-08-13 |
Not clear |
| Luyan Jiao, Meige Zheng, Jinhai Duan, Ting Wu, Zhao Li, Lin Liu, Xianhong Xiang, Xiaolu Tang, Jinyang He, Xingjian Li, Guofeng Zhang, Jinhui Ding, Huaibin Cai, Xian Li. Tau knockout exacerbates degeneration of parvalbumin-positive neurons in substantia nigra pars reticulata in Parkinson's disease-related α-synuclein A53T mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 34. issue 9. 2021-03-16. PMID:33000527. |
to investigate how the expression of tau affects α-syn-induced neurodegeneration in vivo, we generated triple transgenic mice that overexpressed α-syn a53t mutation in the midbrain dopaminergic neurons (mdans) with different expression levels of tau. |
2021-03-16 |
2023-08-13 |
mouse |
| Nadja Mannal, Katharina Kleiner, Michael Fauler, Antonios Dougalis, Christina Poetschke, Birgit Lis. Multi-Electrode Array Analysis Identifies Complex Dopamine Responses and Glucose Sensing Properties of Substantia Nigra Neurons in Mouse Brain Slices. Frontiers in synaptic neuroscience. vol 13. 2021-03-16. PMID:33716704. |
dopaminergic (da) midbrain neurons within the substantia nigra (sn) display an autonomous pacemaker activity that is crucial for dopamine release and voluntary movement control. |
2021-03-16 |
2023-08-13 |
mouse |
| Charleen Salesse, Julien Charest, Hélène Doucet-Beaupré, Anne-Marie Castonguay, Simon Labrecque, Paul De Koninck, Martin Lévesqu. Opposite Control of Excitatory and Inhibitory Synapse Formation by Slitrk2 and Slitrk5 on Dopamine Neurons Modulates Hyperactivity Behavior. Cell reports. vol 30. issue 7. 2021-03-09. PMID:32075770. |
here, transcription factors lmx1a and lmx1b are shown to be essential for midbrain dopaminergic (mda) neuron excitatory synaptic inputs and dendritic development. |
2021-03-09 |
2023-08-13 |
Not clear |
| Giulia Gaggi, Andrea Di Credico, Pascal Izzicupo, Francesco Alviano, Michele Di Mauro, Angela Di Baldassarre, Barbara Ghinass. Human Mesenchymal Stromal Cells Unveil an Unexpected Differentiation Potential toward the Dopaminergic Neuronal Lineage. International journal of molecular sciences. vol 21. issue 18. 2021-03-05. PMID:32916865. |
we finally obtained a homogeneous population of cells resembling the morphology of primary midbrain dopaminergic neurons that expressed the functional dopaminergic markers th, dat, and nurr1. |
2021-03-05 |
2023-08-13 |
human |
| Glenda E Gillies, Kanwar Virdee, Ilse Pienaar, Felwah Al-Zaid, Jeffrey W Dalle. Enduring, Sexually Dimorphic Impact of In Utero Exposure to Elevated Levels of Glucocorticoids on Midbrain Dopaminergic Populations. Brain sciences. vol 7. issue 1. 2021-03-04. PMID:28042822. |
enduring, sexually dimorphic impact of in utero exposure to elevated levels of glucocorticoids on midbrain dopaminergic populations. |
2021-03-04 |
2023-08-13 |
human |
| Glenda E Gillies, Kanwar Virdee, Ilse Pienaar, Felwah Al-Zaid, Jeffrey W Dalle. Enduring, Sexually Dimorphic Impact of In Utero Exposure to Elevated Levels of Glucocorticoids on Midbrain Dopaminergic Populations. Brain sciences. vol 7. issue 1. 2021-03-04. PMID:28042822. |
in order to understand the underlying neural processes, particular interest has focused on the midbrain dopaminergic systems, which are critical regulators of normal adaptive behaviours, cognitive and sensorimotor functions. |
2021-03-04 |
2023-08-13 |
human |
| Glenda E Gillies, Kanwar Virdee, Ilse Pienaar, Felwah Al-Zaid, Jeffrey W Dalle. Enduring, Sexually Dimorphic Impact of In Utero Exposure to Elevated Levels of Glucocorticoids on Midbrain Dopaminergic Populations. Brain sciences. vol 7. issue 1. 2021-03-04. PMID:28042822. |
although such substantial neurobiological changes might presage marked behavioural effects, in utero gc exposure had only a modest or no effect, depending on sex, on a range of conditioned and unconditioned behaviours known to depend on midbrain dopaminergic transmission. |
2021-03-04 |
2023-08-13 |
human |
| Glenda E Gillies, Kanwar Virdee, Ilse Pienaar, Felwah Al-Zaid, Jeffrey W Dalle. Enduring, Sexually Dimorphic Impact of In Utero Exposure to Elevated Levels of Glucocorticoids on Midbrain Dopaminergic Populations. Brain sciences. vol 7. issue 1. 2021-03-04. PMID:28042822. |
collectively, these findings suggest that apparent behavioural normality in certain tests, but not others, arises from agt-induced adaptations or compensatory mechanisms within the midbrain dopaminergic systems, which preserve some, but not all functions. |
2021-03-04 |
2023-08-13 |
human |
| Glenda E Gillies, Kanwar Virdee, Ilse Pienaar, Felwah Al-Zaid, Jeffrey W Dalle. Enduring, Sexually Dimorphic Impact of In Utero Exposure to Elevated Levels of Glucocorticoids on Midbrain Dopaminergic Populations. Brain sciences. vol 7. issue 1. 2021-03-04. PMID:28042822. |
behavioural "normality" is thus achieved by the midbrain dopaminergic network operating outside its normal limits (in a state of allostasis), rendering it at greater risk to malfunction when challenged in later life. |
2021-03-04 |
2023-08-13 |
human |
| Glenda E Gillies, Kanwar Virdee, Ilse Pienaar, Felwah Al-Zaid, Jeffrey W Dalle. Enduring, Sexually Dimorphic Impact of In Utero Exposure to Elevated Levels of Glucocorticoids on Midbrain Dopaminergic Populations. Brain sciences. vol 7. issue 1. 2021-03-04. PMID:28042822. |
sex-specific neurobiological programming of midbrain dopaminergic systems may, therefore, have psychopathological relevance for the sex bias commonly found in brain disorders associated with these systems, and which have a neurodevelopmental component, including schizophrenia, adhd (attention/deficit hyperactivity disorders), autism, depression and substance abuse. |
2021-03-04 |
2023-08-13 |
human |
| Yi-Chun Chang, Wai-Yu Li, Lukas Jyuhn-Hsiarn Lee, Li-Jen Le. Interplay of Prenatal and Postnatal Risk Factors in the Behavioral and Histological Features of a "Two-Hit" Non-Genetic Mouse Model of Schizophrenia. International journal of molecular sciences. vol 21. issue 22. 2021-03-03. PMID:33198225. |
prenatal infection increased the number of dopaminergic neurons in midbrain, whereas postweaning isolation decreased the gabaergic neurons in cortex. |
2021-03-03 |
2023-08-13 |
mouse |
| Suzanne O Nolan, Jennifer E Zachry, Amy R Johnson, Lillian J Brady, Cody A Siciliano, Erin S Calipar. Direct dopamine terminal regulation by local striatal microcircuitry. Journal of neurochemistry. vol 155. issue 5. 2021-03-02. PMID:32356315. |
here we review how these mechanisms work in concert to influence the timing and magnitude of striatal dopamine signaling, independent of action potential activity at the level of dopaminergic cell bodies in the midbrain, thereby providing a parallel pathway by which dopamine can be modulated. |
2021-03-02 |
2023-08-13 |
Not clear |
| Jenesis D Gayden, Zachary Freyber. Commentary: Ghrelin promotes midbrain neural stem cells differentiation to dopaminergic neurons through the Wnt/β-catenin pathway. Frontiers in cellular neuroscience. vol 14. 2021-03-01. PMID:32973452. |
commentary: ghrelin promotes midbrain neural stem cells differentiation to dopaminergic neurons through the wnt/β-catenin pathway. |
2021-03-01 |
2023-08-13 |
Not clear |
| Sandra Iglesias, Lars Kasper, Samuel J Harrison, Robert Manka, Christoph Mathys, Klaas E Stepha. Cholinergic and dopaminergic effects on prediction error and uncertainty responses during sensory associative learning. NeuroImage. vol 226. 2021-03-01. PMID:33285332. |
in a previous fmri study we found that low-level precision-weighted pes about visual outcomes (that update beliefs about associations) activated the putative dopaminergic midbrain; by contrast, precision-weighted pes about cue-outcome associations (that update beliefs about volatility) activated the cholinergic basal forebrain. |
2021-03-01 |
2023-08-13 |
human |
| Sandra Iglesias, Lars Kasper, Samuel J Harrison, Robert Manka, Christoph Mathys, Klaas E Stepha. Cholinergic and dopaminergic effects on prediction error and uncertainty responses during sensory associative learning. NeuroImage. vol 226. 2021-03-01. PMID:33285332. |
additionally, in the putative dopaminergic midbrain, galantamine compared to placebo enhanced low-level pe responses (in a body-weight dependent manner) and amisulpride enhanced high-level precision activity. |
2021-03-01 |
2023-08-13 |
human |
| Yue Lang, Yu Li, Haojia Yu, Lulu Lin, Xingchi Chen, Sainan Wang, Hui Zhan. HOTAIR drives autophagy in midbrain dopaminergic neurons in the substantia nigra compacta in a mouse model of Parkinson's disease by elevating NPTX2 Aging. vol 12. issue 9. 2021-02-25. PMID:32396526. |
hotair drives autophagy in midbrain dopaminergic neurons in the substantia nigra compacta in a mouse model of parkinson's disease by elevating nptx2 parkinson's disease (pd) is a neurodegenerative disorder characterized by progressive cell loss, largely confined to mesencephalic dopamine neurons of the substantia nigra. |
2021-02-25 |
2023-08-13 |
mouse |
| I-Jung Lee, Che-Yi Chao, Ying-Chen Yang, Jing-Jy Cheng, Chuen-Lin Huang, Chun-Tang Chiou, Hung-Tse Huang, Yao-Haur Kuo, Nai-Kuei Huan. Huang Lian Jie Du Tang attenuates paraquat-induced mitophagy in human SH-SY5Y cells: A traditional decoction with a novel therapeutic potential in treating Parkinson's disease. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 134. 2021-02-24. PMID:33383311. |
besides, paraquat (pq) as an herbicide has been known to impair midbrain dopaminergic neurons, resemblance to the pathology of pd. |
2021-02-24 |
2023-08-13 |
human |