| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jonathan R Reinwald, Alexander Sartorius, Wolfgang Weber-Fahr, Markus Sack, Robert Becker, Michael Didriksen, Tine B Stensbøl, Adam J Schwarz, Andreas Meyer-Lindenberg, Natalia Gas. Separable neural mechanisms for the pleiotropic association of copy number variants with neuropsychiatric traits. Translational psychiatry. vol 10. issue 1. 2021-06-18. PMID:32170065. |
the combination of cortical hypoconnectivity and dopaminergic hyperconnectivity and reduced cerebellum in 22q11.2 deletion mirrors key neurodevelopmental features of schizophrenia, whereas changes in midbrain and auditory/striatal morphology and topology in 1q21.1 and 15q13.3 rather indicate focal processes possibly linked to the emergence of abnormal salience perception and hallucinations. |
2021-06-18 |
2023-08-13 |
mouse |
| Jérémy Cousineau, Léa Lescouzères, Anne Taupignon, Lorena Delgado-Zabalza, Emmanuel Valjent, Jérôme Baufreton, Morgane Le Bon-Jég. Dopamine D2-Like Receptors Modulate Intrinsic Properties and Synaptic Transmission of Parvalbumin Interneurons in the Mouse Primary Motor Cortex. eNeuro. vol 7. issue 3. 2021-06-18. PMID:32321772. |
the primary motor cortex (m1), which is essential for motor control and the acquisition of motor skills, receives dopaminergic inputs in its superficial and deep layers from the midbrain. |
2021-06-18 |
2023-08-13 |
mouse |
| Miguel Skirzewski, Marie E Cronin, Ricardo Murphy, Wambura Fobbs, Alexxai V Kravitz, Andres Buonann. ErbB4 Null Mice Display Altered Mesocorticolimbic and Nigrostriatal Dopamine Levels as well as Deficits in Cognitive and Motivational Behaviors. eNeuro. vol 7. issue 3. 2021-06-18. PMID:32354758. |
whereas most studies on nrg1-erbb4 signaling have focused on gabaergic interneurons, erbb4 is also expressed by midbrain dopaminergic neurons where it modulates extracellular dopamine (da) levels. |
2021-06-18 |
2023-08-13 |
mouse |
| Bianca Marchett. Nrf2/Wnt resilience orchestrates rejuvenation of glia-neuron dialogue in Parkinson's disease. Redox biology. vol 36. 2021-06-18. PMID:32863224. |
oxidative stress and inflammation have long been recognized to contribute to parkinson's disease (pd), a common movement disorder characterized by the selective loss of midbrain dopaminergic neurons (mdan) of the substantia nigra pars compacta (snpc). |
2021-06-18 |
2023-08-13 |
mouse |
| Francesca Morello, Vootele Voikar, Pihla Parkkinen, Anne Panhelainen, Marko Rosenholm, Aki Makkonen, Tomi Rantamäki, Petteri Piepponen, Teemu Aitta-Aho, Juha Partane. ADHD-like behaviors caused by inactivation of a transcription factor controlling the balance of inhibitory and excitatory neuron development in the mouse anterior brainstem. Translational psychiatry. vol 10. issue 1. 2021-06-18. PMID:33087695. |
the neural circuits regulating motivation and movement include midbrain dopaminergic neurons and associated inhibitory gabaergic and excitatory glutamatergic neurons in the anterior brainstem. |
2021-06-18 |
2023-08-13 |
mouse |
| Anna Radlicka, Kinga Kamińska, Malgorzata Borczyk, Marcin Piechota, Michał Korostyński, Joanna Pera, Elżbieta Lorenc-Koci, Jan Rodriguez Parkitn. Effects of L-DOPA on Gene Expression in the Frontal Cortex of Rats with Unilateral Lesions of Midbrain Dopaminergic Neurons. eNeuro. vol 8. issue 1. 2021-06-18. PMID:33257528. |
effects of l-dopa on gene expression in the frontal cortex of rats with unilateral lesions of midbrain dopaminergic neurons. |
2021-06-18 |
2023-08-13 |
rat |
| Yun Tang, Xiao-Ke Yang, Xin-Wei Zhang, Wen-Tao Wu, Fu-Li Zhang, Hong Jiang, Yan-Ling Liu, Christian Amatore, Wei-Hua Huan. Harpagide, a natural product, promotes synaptic vesicle release as measured by nanoelectrode amperometry. Chemical science. vol 11. issue 3. 2021-06-15. PMID:34123052. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by progressive loss of dopaminergic (daergic) neurons and low level of dopamine (da) in the midbrain. |
2021-06-15 |
2023-08-13 |
Not clear |
| S A Antonov, E V Novosadov. Current State-of-the-Art and Unresolved Problems in Using Human Induced Pluripotent Stem Cell-Derived Dopamine Neurons for Parkinson's Disease Drug Development. International journal of molecular sciences. vol 22. issue 7. 2021-06-11. PMID:33806103. |
as a unique source of midbrain dopaminergic (da) neurons, ips cells provide unparalleled capabilities for investigating the pathogenesis of pd, the development of novel anti-parkinsonian drugs, and personalized therapy design. |
2021-06-11 |
2023-08-13 |
human |
| Shaun Martin, Stefanie Smolders, Chris Van den Haute, Bavo Heeman, Sarah van Veen, David Crosiers, Igor Beletchi, Aline Verstraeten, Helena Gossye, Géraldine Gelders, Philippe Pals, Norin Nabil Hamouda, Sebastiaan Engelborghs, Jean-Jacques Martin, Jan Eggermont, Peter Paul De Deyn, Patrick Cras, Veerle Baekelandt, Peter Vangheluwe, Christine Van Broeckhove. Mutated ATP10B increases Parkinson's disease risk by compromising lysosomal glucosylceramide export. Acta neuropathologica. vol 139. issue 6. 2021-06-08. PMID:32172343. |
parkinson's disease (pd) is a progressive neurodegenerative brain disease presenting with a variety of motor and non-motor symptoms, loss of midbrain dopaminergic neurons in the substantia nigra pars compacta and the occurrence of α-synuclein-positive lewy bodies in surviving neurons. |
2021-06-08 |
2023-08-13 |
Not clear |
| Juhee Lim, Hyo In Kim, Hyun Jin Cho. Regulation of dopaminergic neuronal phenotypes by the estrogen-related receptor gamma ligand GSK4716 via the activation of CREB signaling. Neurochemistry international. vol 136. 2021-06-07. PMID:32173553. |
midbrain dopaminergic (daergic) neurotransmission plays a crucial role in regulating motor, cognitive, and emotional functions. |
2021-06-07 |
2023-08-13 |
Not clear |
| Enrique M Toledo, Shanzheng Yang, Daniel Gyllborg, Kim E van Wijk, Indranil Sinha, Manuel Varas-Godoy, Christopher L Grigsby, Peter Lönnerberg, Saiful Islam, Knut R Steffensen, Sten Linnarsson, Ernest Arena. Srebf1 Controls Midbrain Dopaminergic Neurogenesis. Cell reports. vol 31. issue 5. 2021-06-03. PMID:32375051. |
srebf1 controls midbrain dopaminergic neurogenesis. |
2021-06-03 |
2023-08-13 |
Not clear |
| Enrique M Toledo, Shanzheng Yang, Daniel Gyllborg, Kim E van Wijk, Indranil Sinha, Manuel Varas-Godoy, Christopher L Grigsby, Peter Lönnerberg, Saiful Islam, Knut R Steffensen, Sten Linnarsson, Ernest Arena. Srebf1 Controls Midbrain Dopaminergic Neurogenesis. Cell reports. vol 31. issue 5. 2021-06-03. PMID:32375051. |
liver x receptors (lxrs) and their ligands are potent regulators of midbrain dopaminergic (mda) neurogenesis and differentiation. |
2021-06-03 |
2023-08-13 |
Not clear |
| Thomas Paß, Marlene Aßfalg, Marianna Tolve, Sandra Blaess, Markus Rothermel, Rudolf J Wiesner, Konrad M Rick. The Impact of Mitochondrial Dysfunction on Dopaminergic Neurons in the Olfactory Bulb and Odor Detection. Molecular neurobiology. vol 57. issue 9. 2021-06-03. PMID:32564285. |
mitopark mice are a genetic model for parkinson's disease with severe mitochondrial dysfunction, reproducing the differential vulnerability of dopaminergic neurons in the midbrain. |
2021-06-03 |
2023-08-13 |
mouse |
| Thomas Paß, Marlene Aßfalg, Marianna Tolve, Sandra Blaess, Markus Rothermel, Rudolf J Wiesner, Konrad M Rick. The Impact of Mitochondrial Dysfunction on Dopaminergic Neurons in the Olfactory Bulb and Odor Detection. Molecular neurobiology. vol 57. issue 9. 2021-06-03. PMID:32564285. |
interestingly, only the small anaxonic dopaminergic subpopulation, which is continuously replenished by neurogenesis, was moderately reduced in number, much less compared with dopaminergic neurons in the midbrain. |
2021-06-03 |
2023-08-13 |
mouse |
| Thomas Paß, Marlene Aßfalg, Marianna Tolve, Sandra Blaess, Markus Rothermel, Rudolf J Wiesner, Konrad M Rick. The Impact of Mitochondrial Dysfunction on Dopaminergic Neurons in the Olfactory Bulb and Odor Detection. Molecular neurobiology. vol 57. issue 9. 2021-06-03. PMID:32564285. |
these results reveal a high robustness of dopaminergic neurons located in the olfactory bulb towards mitochondrial impairment, in striking contrast to their midbrain counterparts. |
2021-06-03 |
2023-08-13 |
mouse |
| Li Xiang, Guobin Huang, Wenjing Shu, Chunli Gong, Nan Cao, Rui Chen, Jixi Li, Hao Lu, Gaofeng Jian. Role of Chromatin Remodeling Genes and TETs in the Development of Human Midbrain Dopaminergic Neurons. Stem cell reviews and reports. vol 16. issue 4. 2021-06-02. PMID:32367481. |
role of chromatin remodeling genes and tets in the development of human midbrain dopaminergic neurons. |
2021-06-02 |
2023-08-13 |
human |
| Li Xiang, Guobin Huang, Wenjing Shu, Chunli Gong, Nan Cao, Rui Chen, Jixi Li, Hao Lu, Gaofeng Jian. Role of Chromatin Remodeling Genes and TETs in the Development of Human Midbrain Dopaminergic Neurons. Stem cell reviews and reports. vol 16. issue 4. 2021-06-02. PMID:32367481. |
to explore the role of ten-eleven translocation (tets) family of dioxygenases and chromatin remodeling genes in the development of human midbrain dopaminergic (mda) neurons, we globally analyze the epigenetic regulation of gene expression in human induced pluripotent stem cells (ipscs) and ipscs-derived mda neurons. |
2021-06-02 |
2023-08-13 |
human |
| Mahalaxmi Iyer, Mohana Devi Subramaniam, Dhivya Venkatesan, Ssang-Goo Cho, Matias Ryding, Morten Meyer, Balachandar Vellingir. Role of RhoA-ROCK signaling in Parkinson's disease. European journal of pharmacology. vol 894. 2021-05-28. PMID:33345850. |
parkinson's disease (pd) is a complex and widespread neurodegenerative disease characterized by depletion of midbrain dopaminergic (da) neurons. |
2021-05-28 |
2023-08-13 |
Not clear |
| Qianqian Liu, Xinyang Guo, Ziwei Huang, Qiujia He, Dashuai Zhu, Shaozhi Zhang, Ziwei Peng, Yongzhe Che, Xizeng Fen. Anti-neuroinflammatory effects of dimethylaminomylide (DMAMCL, i.e., ACT001) are associated with attenuating the NLRP3 inflammasome in MPTP-induced Parkinson disease in mice. Behavioural brain research. vol 383. 2021-05-25. PMID:32032741. |
in addition, it alleviates dopaminergic neurodegeneration in the nigrostriatal pathway and inhibits oxidative stress, the inflammatory response and activation of the nlrp3 inflammasome in the midbrain of mptp-induced pd mice. |
2021-05-25 |
2023-08-13 |
mouse |
| Katharine M von Herrmann, Faith L Anderson, Eileen M Martinez, Alison L Young, Matthew C Havrd. Slc6a3-dependent expression of a CAPS-associated Nlrp3 allele results in progressive behavioral abnormalities and neuroinflammation in aging mice. Journal of neuroinflammation. vol 17. issue 1. 2021-05-24. PMID:32680528. |
activity of the proinflammatory nlrp3 inflammasome is implicated in alzheimer's and parkinson's disease and our recent studies in patients suggest that dopaminergic neurons within the degenerating mesencephalon express nlrp3 throughout the progression of pd. |
2021-05-24 |
2023-08-13 |
mouse |